Amino acid dipepetide frequency for Enterococcus sulfureus ATCC 49903

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.692AlaAla: 5.692 ± 0.127
0.595AlaCys: 0.595 ± 0.031
3.505AlaAsp: 3.505 ± 0.07
4.295AlaGlu: 4.295 ± 0.1
3.521AlaPhe: 3.521 ± 0.075
4.664AlaGly: 4.664 ± 0.095
1.484AlaHis: 1.484 ± 0.044
6.285AlaIle: 6.285 ± 0.12
5.422AlaLys: 5.422 ± 0.105
8.082AlaLeu: 8.082 ± 0.144
2.078AlaMet: 2.078 ± 0.064
2.998AlaAsn: 2.998 ± 0.083
2.181AlaPro: 2.181 ± 0.066
3.731AlaGln: 3.731 ± 0.08
2.688AlaArg: 2.688 ± 0.069
4.578AlaSer: 4.578 ± 0.155
5.02AlaThr: 5.02 ± 0.087
5.015AlaVal: 5.015 ± 0.091
0.595AlaTrp: 0.595 ± 0.033
2.758AlaTyr: 2.758 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.449CysAla: 0.449 ± 0.028
0.08CysCys: 0.08 ± 0.012
0.336CysAsp: 0.336 ± 0.023
0.35CysGlu: 0.35 ± 0.026
0.3CysPhe: 0.3 ± 0.021
0.531CysGly: 0.531 ± 0.031
0.167CysHis: 0.167 ± 0.018
0.407CysIle: 0.407 ± 0.024
0.176CysLys: 0.176 ± 0.017
0.667CysLeu: 0.667 ± 0.035
0.134CysMet: 0.134 ± 0.012
0.228CysAsn: 0.228 ± 0.019
0.26CysPro: 0.26 ± 0.023
0.289CysGln: 0.289 ± 0.021
0.238CysArg: 0.238 ± 0.021
0.33CysSer: 0.33 ± 0.022
0.365CysThr: 0.365 ± 0.026
0.438CysVal: 0.438 ± 0.028
0.052CysTrp: 0.052 ± 0.008
0.257CysTyr: 0.257 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.757AspAla: 3.757 ± 0.078
0.284AspCys: 0.284 ± 0.023
2.351AspAsp: 2.351 ± 0.066
4.013AspGlu: 4.013 ± 0.083
2.575AspPhe: 2.575 ± 0.062
3.395AspGly: 3.395 ± 0.115
1.342AspHis: 1.342 ± 0.039
3.508AspIle: 3.508 ± 0.074
2.717AspLys: 2.717 ± 0.095
4.996AspLeu: 4.996 ± 0.082
1.214AspMet: 1.214 ± 0.042
1.663AspAsn: 1.663 ± 0.059
2.287AspPro: 2.287 ± 0.063
2.933AspGln: 2.933 ± 0.068
2.137AspArg: 2.137 ± 0.058
2.732AspSer: 2.732 ± 0.149
3.235AspThr: 3.235 ± 0.083
3.582AspVal: 3.582 ± 0.086
0.589AspTrp: 0.589 ± 0.03
2.328AspTyr: 2.328 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
5.555GluAla: 5.555 ± 0.128
0.337GluCys: 0.337 ± 0.025
3.334GluAsp: 3.334 ± 0.071
5.862GluGlu: 5.862 ± 0.124
2.691GluPhe: 2.691 ± 0.056
3.577GluGly: 3.577 ± 0.086
1.544GluHis: 1.544 ± 0.054
5.118GluIle: 5.118 ± 0.095
5.308GluLys: 5.308 ± 0.097
7.24GluLeu: 7.24 ± 0.125
2.139GluMet: 2.139 ± 0.061
3.22GluAsn: 3.22 ± 0.085
1.849GluPro: 1.849 ± 0.076
3.894GluGln: 3.894 ± 0.092
2.931GluArg: 2.931 ± 0.081
3.399GluSer: 3.399 ± 0.22
4.593GluThr: 4.593 ± 0.126
4.842GluVal: 4.842 ± 0.093
0.726GluTrp: 0.726 ± 0.039
2.252GluTyr: 2.252 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
3.239PheAla: 3.239 ± 0.073
0.372PheCys: 0.372 ± 0.028
2.921PheAsp: 2.921 ± 0.061
2.841PheGlu: 2.841 ± 0.07
2.613PhePhe: 2.613 ± 0.089
3.386PheGly: 3.386 ± 0.076
0.926PheHis: 0.926 ± 0.046
3.452PheIle: 3.452 ± 0.107
2.204PheLys: 2.204 ± 0.064
4.795PheLeu: 4.795 ± 0.111
1.067PheMet: 1.067 ± 0.042
1.726PheAsn: 1.726 ± 0.055
1.595PhePro: 1.595 ± 0.051
1.659PheGln: 1.659 ± 0.051
1.458PheArg: 1.458 ± 0.047
3.415PheSer: 3.415 ± 0.077
2.921PheThr: 2.921 ± 0.067
3.369PheVal: 3.369 ± 0.087
0.432PheTrp: 0.432 ± 0.024
1.953PheTyr: 1.953 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
4.475GlyAla: 4.475 ± 0.107
0.474GlyCys: 0.474 ± 0.027
2.992GlyAsp: 2.992 ± 0.101
3.944GlyGlu: 3.944 ± 0.09
3.164GlyPhe: 3.164 ± 0.069
4.135GlyGly: 4.135 ± 0.115
1.162GlyHis: 1.162 ± 0.041
5.782GlyIle: 5.782 ± 0.105
4.253GlyLys: 4.253 ± 0.084
6.259GlyLeu: 6.259 ± 0.114
1.877GlyMet: 1.877 ± 0.063
2.469GlyAsn: 2.469 ± 0.075
1.518GlyPro: 1.518 ± 0.041
2.552GlyGln: 2.552 ± 0.067
2.303GlyArg: 2.303 ± 0.063
3.671GlySer: 3.671 ± 0.11
4.158GlyThr: 4.158 ± 0.154
4.753GlyVal: 4.753 ± 0.105
0.72GlyTrp: 0.72 ± 0.042
2.655GlyTyr: 2.655 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
1.541HisAla: 1.541 ± 0.051
0.145HisCys: 0.145 ± 0.014
1.0HisAsp: 1.0 ± 0.038
1.527HisGlu: 1.527 ± 0.057
1.138HisPhe: 1.138 ± 0.04
1.23HisGly: 1.23 ± 0.059
0.708HisHis: 0.708 ± 0.036
1.208HisIle: 1.208 ± 0.041
0.869HisLys: 0.869 ± 0.041
2.168HisLeu: 2.168 ± 0.063
0.489HisMet: 0.489 ± 0.027
0.638HisAsn: 0.638 ± 0.031
1.066HisPro: 1.066 ± 0.039
1.083HisGln: 1.083 ± 0.036
0.778HisArg: 0.778 ± 0.036
1.029HisSer: 1.029 ± 0.042
1.282HisThr: 1.282 ± 0.048
1.4HisVal: 1.4 ± 0.05
0.22HisTrp: 0.22 ± 0.018
1.038HisTyr: 1.038 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
5.933IleAla: 5.933 ± 0.106
0.566IleCys: 0.566 ± 0.034
4.482IleAsp: 4.482 ± 0.089
5.414IleGlu: 5.414 ± 0.106
3.281IlePhe: 3.281 ± 0.082
5.63IleGly: 5.63 ± 0.113
1.479IleHis: 1.479 ± 0.054
4.862IleIle: 4.862 ± 0.11
4.208IleLys: 4.208 ± 0.077
7.158IleLeu: 7.158 ± 0.136
1.609IleMet: 1.609 ± 0.056
2.861IleAsn: 2.861 ± 0.073
3.116IlePro: 3.116 ± 0.084
3.21IleGln: 3.21 ± 0.075
2.863IleArg: 2.863 ± 0.061
4.65IleSer: 4.65 ± 0.197
4.487IleThr: 4.487 ± 0.089
5.605IleVal: 5.605 ± 0.102
0.63IleTrp: 0.63 ± 0.031
2.424IleTyr: 2.424 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.651LysAla: 4.651 ± 0.094
0.182LysCys: 0.182 ± 0.018
3.385LysAsp: 3.385 ± 0.105
6.534LysGlu: 6.534 ± 0.124
1.703LysPhe: 1.703 ± 0.05
3.655LysGly: 3.655 ± 0.082
1.106LysHis: 1.106 ± 0.042
4.424LysIle: 4.424 ± 0.083
5.512LysLys: 5.512 ± 0.112
4.735LysLeu: 4.735 ± 0.083
1.935LysMet: 1.935 ± 0.047
3.078LysAsn: 3.078 ± 0.082
1.858LysPro: 1.858 ± 0.065
3.809LysGln: 3.809 ± 0.076
2.93LysArg: 2.93 ± 0.076
2.962LysSer: 2.962 ± 0.085
4.061LysThr: 4.061 ± 0.074
3.95LysVal: 3.95 ± 0.089
0.644LysTrp: 0.644 ± 0.033
1.713LysTyr: 1.713 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
8.96LeuAla: 8.96 ± 0.138
0.631LeuCys: 0.631 ± 0.026
5.553LeuAsp: 5.553 ± 0.108
6.294LeuGlu: 6.294 ± 0.115
5.193LeuPhe: 5.193 ± 0.123
6.3LeuGly: 6.3 ± 0.106
1.921LeuHis: 1.921 ± 0.059
7.12LeuIle: 7.12 ± 0.129
5.475LeuLys: 5.475 ± 0.104
9.776LeuLeu: 9.776 ± 0.169
2.498LeuMet: 2.498 ± 0.06
3.926LeuAsn: 3.926 ± 0.08
4.19LeuPro: 4.19 ± 0.088
3.603LeuGln: 3.603 ± 0.09
3.463LeuArg: 3.463 ± 0.077
6.948LeuSer: 6.948 ± 0.186
6.908LeuThr: 6.908 ± 0.104
6.951LeuVal: 6.951 ± 0.11
0.757LeuTrp: 0.757 ± 0.034
3.292LeuTyr: 3.292 ± 0.083
0.0LeuXaa: 0.0 ± 0.0
Met
1.928MetAla: 1.928 ± 0.054
0.161MetCys: 0.161 ± 0.015
1.336MetAsp: 1.336 ± 0.046
1.612MetGlu: 1.612 ± 0.048
0.874MetPhe: 0.874 ± 0.04
1.64MetGly: 1.64 ± 0.054
0.468MetHis: 0.468 ± 0.026
2.39MetIle: 2.39 ± 0.062
2.065MetLys: 2.065 ± 0.057
2.12MetLeu: 2.12 ± 0.059
0.808MetMet: 0.808 ± 0.038
1.393MetAsn: 1.393 ± 0.049
0.916MetPro: 0.916 ± 0.033
1.092MetGln: 1.092 ± 0.039
1.022MetArg: 1.022 ± 0.044
1.563MetSer: 1.563 ± 0.059
1.844MetThr: 1.844 ± 0.056
1.577MetVal: 1.577 ± 0.055
0.164MetTrp: 0.164 ± 0.016
0.768MetTyr: 0.768 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
2.755AsnAla: 2.755 ± 0.078
0.225AsnCys: 0.225 ± 0.02
2.047AsnAsp: 2.047 ± 0.054
3.247AsnGlu: 3.247 ± 0.075
1.655AsnPhe: 1.655 ± 0.062
3.092AsnGly: 3.092 ± 0.087
0.917AsnHis: 0.917 ± 0.032
2.617AsnIle: 2.617 ± 0.066
2.229AsnLys: 2.229 ± 0.067
3.678AsnLeu: 3.678 ± 0.085
1.01AsnMet: 1.01 ± 0.04
1.537AsnAsn: 1.537 ± 0.065
1.947AsnPro: 1.947 ± 0.057
2.55AsnGln: 2.55 ± 0.076
1.692AsnArg: 1.692 ± 0.055
2.127AsnSer: 2.127 ± 0.108
2.448AsnThr: 2.448 ± 0.107
2.521AsnVal: 2.521 ± 0.06
0.489AsnTrp: 0.489 ± 0.031
1.605AsnTyr: 1.605 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.216ProAla: 2.216 ± 0.064
0.148ProCys: 0.148 ± 0.016
1.934ProAsp: 1.934 ± 0.057
3.029ProGlu: 3.029 ± 0.073
1.942ProPhe: 1.942 ± 0.058
1.931ProGly: 1.931 ± 0.069
0.68ProHis: 0.68 ± 0.033
2.744ProIle: 2.744 ± 0.071
2.459ProLys: 2.459 ± 0.058
3.539ProLeu: 3.539 ± 0.075
0.842ProMet: 0.842 ± 0.036
1.743ProAsn: 1.743 ± 0.049
0.654ProPro: 0.654 ± 0.032
1.393ProGln: 1.393 ± 0.057
0.992ProArg: 0.992 ± 0.043
2.137ProSer: 2.137 ± 0.056
2.687ProThr: 2.687 ± 0.084
2.725ProVal: 2.725 ± 0.082
0.295ProTrp: 0.295 ± 0.021
1.444ProTyr: 1.444 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
4.543GlnAla: 4.543 ± 0.09
0.156GlnCys: 0.156 ± 0.015
1.992GlnAsp: 1.992 ± 0.059
3.601GlnGlu: 3.601 ± 0.095
1.794GlnPhe: 1.794 ± 0.056
2.312GlnGly: 2.312 ± 0.062
0.989GlnHis: 0.989 ± 0.039
3.069GlnIle: 3.069 ± 0.071
3.373GlnLys: 3.373 ± 0.082
5.404GlnLeu: 5.404 ± 0.116
1.301GlnMet: 1.301 ± 0.045
1.793GlnAsn: 1.793 ± 0.052
1.479GlnPro: 1.479 ± 0.047
2.761GlnGln: 2.761 ± 0.098
1.756GlnArg: 1.756 ± 0.055
2.309GlnSer: 2.309 ± 0.06
3.508GlnThr: 3.508 ± 0.079
3.437GlnVal: 3.437 ± 0.079
0.499GlnTrp: 0.499 ± 0.027
1.499GlnTyr: 1.499 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.466ArgAla: 2.466 ± 0.069
0.206ArgCys: 0.206 ± 0.018
1.704ArgAsp: 1.704 ± 0.053
2.681ArgGlu: 2.681 ± 0.072
2.191ArgPhe: 2.191 ± 0.057
1.979ArgGly: 1.979 ± 0.063
0.788ArgHis: 0.788 ± 0.035
2.799ArgIle: 2.799 ± 0.062
2.559ArgLys: 2.559 ± 0.068
4.155ArgLeu: 4.155 ± 0.102
1.057ArgMet: 1.057 ± 0.037
1.546ArgAsn: 1.546 ± 0.054
1.357ArgPro: 1.357 ± 0.053
1.974ArgGln: 1.974 ± 0.057
1.596ArgArg: 1.596 ± 0.049
1.986ArgSer: 1.986 ± 0.065
2.091ArgThr: 2.091 ± 0.054
2.605ArgVal: 2.605 ± 0.079
0.326ArgTrp: 0.326 ± 0.023
1.796ArgTyr: 1.796 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
3.939SerAla: 3.939 ± 0.147
0.308SerCys: 0.308 ± 0.025
3.02SerAsp: 3.02 ± 0.136
4.038SerGlu: 4.038 ± 0.242
2.937SerPhe: 2.937 ± 0.066
4.245SerGly: 4.245 ± 0.118
1.104SerHis: 1.104 ± 0.042
4.757SerIle: 4.757 ± 0.169
3.347SerLys: 3.347 ± 0.096
6.22SerLeu: 6.22 ± 0.173
1.486SerMet: 1.486 ± 0.058
2.352SerAsn: 2.352 ± 0.136
1.749SerPro: 1.749 ± 0.048
2.543SerGln: 2.543 ± 0.086
2.214SerArg: 2.214 ± 0.081
3.943SerSer: 3.943 ± 0.211
4.434SerThr: 4.434 ± 0.431
3.956SerVal: 3.956 ± 0.112
0.576SerTrp: 0.576 ± 0.031
2.371SerTyr: 2.371 ± 0.079
0.0SerXaa: 0.0 ± 0.0
Thr
4.385ThrAla: 4.385 ± 0.09
0.33ThrCys: 0.33 ± 0.025
3.203ThrAsp: 3.203 ± 0.081
3.536ThrGlu: 3.536 ± 0.1
3.017ThrPhe: 3.017 ± 0.067
4.126ThrGly: 4.126 ± 0.149
1.407ThrHis: 1.407 ± 0.041
5.733ThrIle: 5.733 ± 0.098
4.526ThrLys: 4.526 ± 0.09
6.676ThrLeu: 6.676 ± 0.099
1.477ThrMet: 1.477 ± 0.048
2.768ThrAsn: 2.768 ± 0.08
3.082ThrPro: 3.082 ± 0.134
2.94ThrGln: 2.94 ± 0.08
2.213ThrArg: 2.213 ± 0.061
4.628ThrSer: 4.628 ± 0.492
4.843ThrThr: 4.843 ± 0.133
4.798ThrVal: 4.798 ± 0.146
0.523ThrTrp: 0.523 ± 0.028
2.568ThrTyr: 2.568 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
5.653ValAla: 5.653 ± 0.098
0.539ValCys: 0.539 ± 0.031
3.944ValAsp: 3.944 ± 0.095
4.594ValGlu: 4.594 ± 0.092
3.167ValPhe: 3.167 ± 0.084
4.506ValGly: 4.506 ± 0.099
1.243ValHis: 1.243 ± 0.047
5.217ValIle: 5.217 ± 0.102
4.049ValLys: 4.049 ± 0.09
6.897ValLeu: 6.897 ± 0.12
1.736ValMet: 1.736 ± 0.052
2.672ValAsn: 2.672 ± 0.064
2.601ValPro: 2.601 ± 0.06
2.53ValGln: 2.53 ± 0.068
2.376ValArg: 2.376 ± 0.069
4.542ValSer: 4.542 ± 0.109
4.93ValThr: 4.93 ± 0.146
5.452ValVal: 5.452 ± 0.104
0.531ValTrp: 0.531 ± 0.031
2.448ValTyr: 2.448 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.478TrpAla: 0.478 ± 0.026
0.067TrpCys: 0.067 ± 0.01
0.515TrpAsp: 0.515 ± 0.035
0.538TrpGlu: 0.538 ± 0.029
0.558TrpPhe: 0.558 ± 0.033
0.579TrpGly: 0.579 ± 0.028
0.202TrpHis: 0.202 ± 0.015
0.821TrpIle: 0.821 ± 0.034
0.516TrpLys: 0.516 ± 0.03
1.064TrpLeu: 1.064 ± 0.042
0.256TrpMet: 0.256 ± 0.02
0.423TrpAsn: 0.423 ± 0.029
0.262TrpPro: 0.262 ± 0.021
0.571TrpGln: 0.571 ± 0.029
0.375TrpArg: 0.375 ± 0.024
0.595TrpSer: 0.595 ± 0.034
0.502TrpThr: 0.502 ± 0.028
0.462TrpVal: 0.462 ± 0.028
0.112TrpTrp: 0.112 ± 0.013
0.391TrpTyr: 0.391 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.571TyrAla: 2.571 ± 0.061
0.249TyrCys: 0.249 ± 0.018
2.083TyrAsp: 2.083 ± 0.057
2.461TyrGlu: 2.461 ± 0.071
2.03TyrPhe: 2.03 ± 0.051
2.405TyrGly: 2.405 ± 0.071
0.92TyrHis: 0.92 ± 0.038
2.153TyrIle: 2.153 ± 0.058
1.56TyrLys: 1.56 ± 0.05
4.128TyrLeu: 4.128 ± 0.093
0.727TyrMet: 0.727 ± 0.037
1.355TyrAsn: 1.355 ± 0.046
1.566TyrPro: 1.566 ± 0.058
2.459TyrGln: 2.459 ± 0.06
1.835TyrArg: 1.835 ± 0.056
1.995TyrSer: 1.995 ± 0.095
2.463TyrThr: 2.463 ± 0.077
2.19TyrVal: 2.19 ± 0.06
0.41TyrTrp: 0.41 ± 0.025
1.546TyrTyr: 1.546 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2176 proteins (687799 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski