Amino acid dipepetide frequency for Aspergillus homomorphus (strain CBS 101889)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.525AlaAla: 9.525 ± 0.059	1.159AlaCys: 1.159 ± 0.015	4.31AlaAsp: 4.31 ± 0.03	5.211AlaGlu: 5.211 ± 0.046	3.144AlaPhe: 3.144 ± 0.027	6.023AlaGly: 6.023 ± 0.043	1.964AlaHis: 1.964 ± 0.02	4.259AlaIle: 4.259 ± 0.032	3.627AlaLys: 3.627 ± 0.029	8.131AlaLeu: 8.131 ± 0.045	2.006AlaMet: 2.006 ± 0.02	2.841AlaAsn: 2.841 ± 0.023	4.752AlaPro: 4.752 ± 0.039	3.579AlaGln: 3.579 ± 0.029	5.221AlaArg: 5.221 ± 0.035	7.427AlaSer: 7.427 ± 0.045	5.514AlaThr: 5.514 ± 0.038	5.578AlaVal: 5.578 ± 0.038	1.221AlaTrp: 1.221 ± 0.017	2.264AlaTyr: 2.264 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	1.026CysAla: 1.026 ± 0.014	0.274CysCys: 0.274 ± 0.008	0.691CysAsp: 0.691 ± 0.012	0.62CysGlu: 0.62 ± 0.012	0.566CysPhe: 0.566 ± 0.012	0.97CysGly: 0.97 ± 0.016	0.373CysHis: 0.373 ± 0.009	0.734CysIle: 0.734 ± 0.014	0.477CysLys: 0.477 ± 0.011	1.429CysLeu: 1.429 ± 0.017	0.296CysMet: 0.296 ± 0.007	0.426CysAsn: 0.426 ± 0.009	0.703CysPro: 0.703 ± 0.016	0.479CysGln: 0.479 ± 0.011	0.869CysArg: 0.869 ± 0.015	1.016CysSer: 1.016 ± 0.016	0.735CysThr: 0.735 ± 0.012	0.868CysVal: 0.868 ± 0.013	0.21CysTrp: 0.21 ± 0.006	0.373CysTyr: 0.373 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.65AspAla: 4.65 ± 0.032	0.658AspCys: 0.658 ± 0.013	3.857AspAsp: 3.857 ± 0.041	4.268AspGlu: 4.268 ± 0.04	2.105AspPhe: 2.105 ± 0.021	3.829AspGly: 3.829 ± 0.033	1.319AspHis: 1.319 ± 0.016	2.831AspIle: 2.831 ± 0.023	2.072AspLys: 2.072 ± 0.021	5.2AspLeu: 5.2 ± 0.028	1.15AspMet: 1.15 ± 0.015	1.782AspAsn: 1.782 ± 0.02	3.366AspPro: 3.366 ± 0.028	1.893AspGln: 1.893 ± 0.019	3.213AspArg: 3.213 ± 0.026	4.012AspSer: 4.012 ± 0.033	2.894AspThr: 2.894 ± 0.023	3.485AspVal: 3.485 ± 0.026	0.892AspTrp: 0.892 ± 0.014	1.662AspTyr: 1.662 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.333GluAla: 5.333 ± 0.042	0.631GluCys: 0.631 ± 0.013	3.997GluAsp: 3.997 ± 0.04	5.445GluGlu: 5.445 ± 0.065	1.901GluPhe: 1.901 ± 0.02	3.753GluGly: 3.753 ± 0.033	1.415GluHis: 1.415 ± 0.017	2.969GluIle: 2.969 ± 0.028	3.31GluLys: 3.31 ± 0.034	5.184GluLeu: 5.184 ± 0.039	1.445GluMet: 1.445 ± 0.016	2.143GluAsn: 2.143 ± 0.02	2.843GluPro: 2.843 ± 0.04	2.568GluGln: 2.568 ± 0.023	3.918GluArg: 3.918 ± 0.031	4.267GluSer: 4.267 ± 0.031	3.506GluThr: 3.506 ± 0.028	3.578GluVal: 3.578 ± 0.026	0.878GluTrp: 0.878 ± 0.014	1.655GluTyr: 1.655 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.08PheAla: 3.08 ± 0.026	0.602PheCys: 0.602 ± 0.012	2.208PheAsp: 2.208 ± 0.02	2.061PheGlu: 2.061 ± 0.02	1.673PhePhe: 1.673 ± 0.02	2.75PheGly: 2.75 ± 0.026	0.964PheHis: 0.964 ± 0.013	1.757PheIle: 1.757 ± 0.02	1.308PheLys: 1.308 ± 0.018	3.689PheLeu: 3.689 ± 0.031	0.768PheMet: 0.768 ± 0.011	1.322PheAsn: 1.322 ± 0.016	2.035PhePro: 2.035 ± 0.023	1.423PheGln: 1.423 ± 0.018	2.073PheArg: 2.073 ± 0.022	2.964PheSer: 2.964 ± 0.025	2.155PheThr: 2.155 ± 0.02	2.445PheVal: 2.445 ± 0.023	0.652PheTrp: 0.652 ± 0.011	1.136PheTyr: 1.136 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.363GlyAla: 5.363 ± 0.042	0.943GlyCys: 0.943 ± 0.015	3.497GlyAsp: 3.497 ± 0.029	3.602GlyGlu: 3.602 ± 0.029	2.802GlyPhe: 2.802 ± 0.025	5.573GlyGly: 5.573 ± 0.052	1.686GlyHis: 1.686 ± 0.019	3.355GlyIle: 3.355 ± 0.028	3.067GlyLys: 3.067 ± 0.029	6.33GlyLeu: 6.33 ± 0.039	1.55GlyMet: 1.55 ± 0.016	2.317GlyAsn: 2.317 ± 0.022	3.373GlyPro: 3.373 ± 0.027	2.537GlyGln: 2.537 ± 0.026	4.142GlyArg: 4.142 ± 0.034	5.697GlySer: 5.697 ± 0.036	3.878GlyThr: 3.878 ± 0.029	4.479GlyVal: 4.479 ± 0.034	1.184GlyTrp: 1.184 ± 0.017	2.157GlyTyr: 2.157 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	2.032HisAla: 2.032 ± 0.021	0.372HisCys: 0.372 ± 0.01	1.365HisAsp: 1.365 ± 0.018	1.415HisGlu: 1.415 ± 0.018	0.924HisPhe: 0.924 ± 0.014	1.766HisGly: 1.766 ± 0.018	1.0HisHis: 1.0 ± 0.018	1.237HisIle: 1.237 ± 0.016	0.837HisLys: 0.837 ± 0.013	2.471HisLeu: 2.471 ± 0.023	0.508HisMet: 0.508 ± 0.009	0.864HisAsn: 0.864 ± 0.014	1.846HisPro: 1.846 ± 0.02	1.069HisGln: 1.069 ± 0.016	1.681HisArg: 1.681 ± 0.019	1.921HisSer: 1.921 ± 0.021	1.354HisThr: 1.354 ± 0.017	1.446HisVal: 1.446 ± 0.018	0.379HisTrp: 0.379 ± 0.007	0.752HisTyr: 0.752 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.194IleAla: 4.194 ± 0.031	0.797IleCys: 0.797 ± 0.013	2.749IleAsp: 2.749 ± 0.023	2.702IleGlu: 2.702 ± 0.023	1.984IlePhe: 1.984 ± 0.019	3.041IleGly: 3.041 ± 0.027	1.272IleHis: 1.272 ± 0.015	2.46IleIle: 2.46 ± 0.024	1.902IleLys: 1.902 ± 0.022	4.655IleLeu: 4.655 ± 0.03	0.961IleMet: 0.961 ± 0.014	1.678IleAsn: 1.678 ± 0.019	3.114IlePro: 3.114 ± 0.026	1.904IleGln: 1.904 ± 0.02	2.812IleArg: 2.812 ± 0.024	3.756IleSer: 3.756 ± 0.03	2.792IleThr: 2.792 ± 0.022	3.167IleVal: 3.167 ± 0.024	0.717IleTrp: 0.717 ± 0.012	1.474IleTyr: 1.474 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.801LysAla: 3.801 ± 0.032	0.48LysCys: 0.48 ± 0.011	2.386LysAsp: 2.386 ± 0.026	2.998LysGlu: 2.998 ± 0.035	1.237LysPhe: 1.237 ± 0.019	2.659LysGly: 2.659 ± 0.027	1.062LysHis: 1.062 ± 0.014	2.024LysIle: 2.024 ± 0.02	2.77LysLys: 2.77 ± 0.046	3.75LysLeu: 3.75 ± 0.03	0.886LysMet: 0.886 ± 0.014	1.52LysAsn: 1.52 ± 0.016	2.541LysPro: 2.541 ± 0.026	1.752LysGln: 1.752 ± 0.021	3.137LysArg: 3.137 ± 0.028	3.102LysSer: 3.102 ± 0.026	2.535LysThr: 2.535 ± 0.022	2.598LysVal: 2.598 ± 0.023	0.594LysTrp: 0.594 ± 0.011	1.236LysTyr: 1.236 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.237LeuAla: 8.237 ± 0.049	1.329LeuCys: 1.329 ± 0.018	5.237LeuAsp: 5.237 ± 0.032	5.581LeuGlu: 5.581 ± 0.039	3.48LeuPhe: 3.48 ± 0.028	6.128LeuGly: 6.128 ± 0.041	2.424LeuHis: 2.424 ± 0.021	4.063LeuIle: 4.063 ± 0.029	3.873LeuLys: 3.873 ± 0.033	8.966LeuLeu: 8.966 ± 0.065	1.822LeuMet: 1.822 ± 0.021	3.182LeuAsn: 3.182 ± 0.021	5.692LeuPro: 5.692 ± 0.037	4.03LeuGln: 4.03 ± 0.035	6.184LeuArg: 6.184 ± 0.034	7.632LeuSer: 7.632 ± 0.045	5.135LeuThr: 5.135 ± 0.033	5.777LeuVal: 5.777 ± 0.037	1.272LeuTrp: 1.272 ± 0.018	2.525LeuTyr: 2.525 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.126MetAla: 2.126 ± 0.021	0.247MetCys: 0.247 ± 0.006	1.204MetAsp: 1.204 ± 0.016	1.223MetGlu: 1.223 ± 0.014	0.723MetPhe: 0.723 ± 0.013	1.455MetGly: 1.455 ± 0.016	0.492MetHis: 0.492 ± 0.011	1.016MetIle: 1.016 ± 0.014	0.908MetLys: 0.908 ± 0.012	1.894MetLeu: 1.894 ± 0.021	0.565MetMet: 0.565 ± 0.011	0.772MetAsn: 0.772 ± 0.013	1.19MetPro: 1.19 ± 0.016	0.88MetGln: 0.88 ± 0.013	1.295MetArg: 1.295 ± 0.015	1.844MetSer: 1.844 ± 0.019	1.293MetThr: 1.293 ± 0.016	1.351MetVal: 1.351 ± 0.017	0.261MetTrp: 0.261 ± 0.007	0.504MetTyr: 0.504 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.008AsnAla: 3.008 ± 0.023	0.45AsnCys: 0.45 ± 0.011	1.786AsnAsp: 1.786 ± 0.02	1.917AsnGlu: 1.917 ± 0.018	1.256AsnPhe: 1.256 ± 0.017	2.628AsnGly: 2.628 ± 0.029	0.867AsnHis: 0.867 ± 0.013	1.864AsnIle: 1.864 ± 0.02	1.376AsnLys: 1.376 ± 0.019	3.22AsnLeu: 3.22 ± 0.024	0.769AsnMet: 0.769 ± 0.012	1.416AsnAsn: 1.416 ± 0.021	2.485AsnPro: 2.485 ± 0.024	1.301AsnGln: 1.301 ± 0.016	1.937AsnArg: 1.937 ± 0.02	2.546AsnSer: 2.546 ± 0.024	2.095AsnThr: 2.095 ± 0.022	2.205AsnVal: 2.205 ± 0.022	0.533AsnTrp: 0.533 ± 0.011	1.026AsnTyr: 1.026 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.511ProAla: 5.511 ± 0.047	0.595ProCys: 0.595 ± 0.011	3.198ProAsp: 3.198 ± 0.026	3.856ProGlu: 3.856 ± 0.037	2.094ProPhe: 2.094 ± 0.02	3.917ProGly: 3.917 ± 0.034	1.447ProHis: 1.447 ± 0.02	2.505ProIle: 2.505 ± 0.024	2.346ProLys: 2.346 ± 0.025	4.928ProLeu: 4.928 ± 0.035	1.086ProMet: 1.086 ± 0.014	2.08ProAsn: 2.08 ± 0.024	4.965ProPro: 4.965 ± 0.061	2.501ProGln: 2.501 ± 0.033	3.558ProArg: 3.558 ± 0.03	6.144ProSer: 6.144 ± 0.05	4.1ProThr: 4.1 ± 0.035	3.714ProVal: 3.714 ± 0.033	0.8ProTrp: 0.8 ± 0.014	1.548ProTyr: 1.548 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.589GlnAla: 3.589 ± 0.029	0.491GlnCys: 0.491 ± 0.011	1.992GlnAsp: 1.992 ± 0.018	2.414GlnGlu: 2.414 ± 0.026	1.313GlnPhe: 1.313 ± 0.014	2.47GlnGly: 2.47 ± 0.024	1.152GlnHis: 1.152 ± 0.015	1.919GlnIle: 1.919 ± 0.02	1.83GlnLys: 1.83 ± 0.021	3.645GlnLeu: 3.645 ± 0.027	0.874GlnMet: 0.874 ± 0.013	1.459GlnAsn: 1.459 ± 0.02	2.676GlnPro: 2.676 ± 0.033	2.613GlnGln: 2.613 ± 0.057	2.767GlnArg: 2.767 ± 0.025	3.208GlnSer: 3.208 ± 0.028	2.443GlnThr: 2.443 ± 0.024	2.244GlnVal: 2.244 ± 0.024	0.594GlnTrp: 0.594 ± 0.011	1.171GlnTyr: 1.171 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.979ArgAla: 4.979 ± 0.031	0.82ArgCys: 0.82 ± 0.013	3.396ArgAsp: 3.396 ± 0.032	3.897ArgGlu: 3.897 ± 0.029	2.293ArgPhe: 2.293 ± 0.02	3.816ArgGly: 3.816 ± 0.03	1.669ArgHis: 1.669 ± 0.019	2.943ArgIle: 2.943 ± 0.024	3.309ArgLys: 3.309 ± 0.032	5.917ArgLeu: 5.917 ± 0.038	1.352ArgMet: 1.352 ± 0.016	2.197ArgAsn: 2.197 ± 0.022	3.619ArgPro: 3.619 ± 0.032	2.706ArgGln: 2.706 ± 0.026	5.29ArgArg: 5.29 ± 0.046	4.946ArgSer: 4.946 ± 0.038	3.446ArgThr: 3.446 ± 0.028	3.617ArgVal: 3.617 ± 0.027	0.998ArgTrp: 0.998 ± 0.014	1.775ArgTyr: 1.775 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.961SerAla: 6.961 ± 0.047	0.961SerCys: 0.961 ± 0.016	4.165SerAsp: 4.165 ± 0.03	4.144SerGlu: 4.144 ± 0.033	3.091SerPhe: 3.091 ± 0.027	5.475SerGly: 5.475 ± 0.041	2.076SerHis: 2.076 ± 0.021	3.92SerIle: 3.92 ± 0.029	3.319SerLys: 3.319 ± 0.034	7.578SerLeu: 7.578 ± 0.051	1.655SerMet: 1.655 ± 0.02	2.81SerAsn: 2.81 ± 0.023	5.546SerPro: 5.546 ± 0.043	3.276SerGln: 3.276 ± 0.03	5.153SerArg: 5.153 ± 0.041	9.124SerSer: 9.124 ± 0.075	5.728SerThr: 5.728 ± 0.048	4.687SerVal: 4.687 ± 0.033	1.128SerTrp: 1.128 ± 0.017	2.104SerTyr: 2.104 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.491ThrAla: 5.491 ± 0.041	0.785ThrCys: 0.785 ± 0.012	2.887ThrAsp: 2.887 ± 0.024	3.131ThrGlu: 3.131 ± 0.033	2.238ThrPhe: 2.238 ± 0.022	4.226ThrGly: 4.226 ± 0.03	1.382ThrHis: 1.382 ± 0.018	3.089ThrIle: 3.089 ± 0.029	2.351ThrLys: 2.351 ± 0.026	5.47ThrLeu: 5.47 ± 0.034	1.196ThrMet: 1.196 ± 0.014	2.046ThrAsn: 2.046 ± 0.019	4.282ThrPro: 4.282 ± 0.037	2.182ThrGln: 2.182 ± 0.022	3.3ThrArg: 3.3 ± 0.028	5.329ThrSer: 5.329 ± 0.047	4.769ThrThr: 4.769 ± 0.05	3.935ThrVal: 3.935 ± 0.032	0.865ThrTrp: 0.865 ± 0.014	1.697ThrTyr: 1.697 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.397ValAla: 5.397 ± 0.038	0.907ValCys: 0.907 ± 0.014	3.682ValAsp: 3.682 ± 0.027	3.852ValGlu: 3.852 ± 0.03	2.502ValPhe: 2.502 ± 0.025	4.053ValGly: 4.053 ± 0.032	1.502ValHis: 1.502 ± 0.016	2.997ValIle: 2.997 ± 0.025	2.626ValLys: 2.626 ± 0.022	5.873ValLeu: 5.873 ± 0.039	1.348ValMet: 1.348 ± 0.016	2.13ValAsn: 2.13 ± 0.02	3.653ValPro: 3.653 ± 0.03	2.473ValGln: 2.473 ± 0.023	3.649ValArg: 3.649 ± 0.03	4.793ValSer: 4.793 ± 0.035	3.646ValThr: 3.646 ± 0.032	4.477ValVal: 4.477 ± 0.034	0.883ValTrp: 0.883 ± 0.013	1.834ValTyr: 1.834 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.187TrpAla: 1.187 ± 0.015	0.202TrpCys: 0.202 ± 0.007	0.907TrpAsp: 0.907 ± 0.013	0.868TrpGlu: 0.868 ± 0.014	0.549TrpPhe: 0.549 ± 0.011	0.937TrpGly: 0.937 ± 0.017	0.367TrpHis: 0.367 ± 0.009	0.745TrpIle: 0.745 ± 0.014	0.755TrpLys: 0.755 ± 0.011	1.406TrpLeu: 1.406 ± 0.016	0.374TrpMet: 0.374 ± 0.009	0.617TrpAsn: 0.617 ± 0.011	0.622TrpPro: 0.622 ± 0.012	0.566TrpGln: 0.566 ± 0.01	0.999TrpArg: 0.999 ± 0.017	1.085TrpSer: 1.085 ± 0.016	0.95TrpThr: 0.95 ± 0.014	0.944TrpVal: 0.944 ± 0.014	0.292TrpTrp: 0.292 ± 0.008	0.436TrpTyr: 0.436 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.264TyrAla: 2.264 ± 0.024	0.434TyrCys: 0.434 ± 0.009	1.626TyrAsp: 1.626 ± 0.018	1.536TyrGlu: 1.536 ± 0.018	1.189TyrPhe: 1.189 ± 0.016	2.063TyrGly: 2.063 ± 0.023	0.808TyrHis: 0.808 ± 0.013	1.443TyrIle: 1.443 ± 0.018	1.006TyrLys: 1.006 ± 0.014	2.833TyrLeu: 2.833 ± 0.027	0.633TyrMet: 0.633 ± 0.011	1.082TyrAsn: 1.082 ± 0.015	1.588TyrPro: 1.588 ± 0.02	1.132TyrGln: 1.132 ± 0.017	1.786TyrArg: 1.786 ± 0.018	2.088TyrSer: 2.088 ± 0.024	1.686TyrThr: 1.686 ± 0.02	1.682TyrVal: 1.682 ± 0.017	0.453TyrTrp: 0.453 ± 0.009	0.992TyrTyr: 0.992 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 11360 proteins (5329795 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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