Amino acid dipepetide frequency for Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.408AlaAla: 23.408 ± 0.196	0.852AlaCys: 0.852 ± 0.028	9.75AlaAsp: 9.75 ± 0.102	8.614AlaGlu: 8.614 ± 0.094	4.024AlaPhe: 4.024 ± 0.054	14.093AlaGly: 14.093 ± 0.121	2.794AlaHis: 2.794 ± 0.046	4.649AlaIle: 4.649 ± 0.065	1.51AlaLys: 1.51 ± 0.039	14.93AlaLeu: 14.93 ± 0.144	2.689AlaMet: 2.689 ± 0.045	1.918AlaAsn: 1.918 ± 0.039	7.854AlaPro: 7.854 ± 0.097	3.833AlaGln: 3.833 ± 0.059	11.377AlaArg: 11.377 ± 0.101	7.294AlaSer: 7.294 ± 0.077	8.231AlaThr: 8.231 ± 0.121	13.631AlaVal: 13.631 ± 0.118	2.465AlaTrp: 2.465 ± 0.048	2.52AlaTyr: 2.52 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.738CysAla: 0.738 ± 0.023	0.053CysCys: 0.053 ± 0.006	0.333CysAsp: 0.333 ± 0.017	0.272CysGlu: 0.272 ± 0.014	0.152CysPhe: 0.152 ± 0.009	0.632CysGly: 0.632 ± 0.02	0.126CysHis: 0.126 ± 0.01	0.116CysIle: 0.116 ± 0.01	0.041CysLys: 0.041 ± 0.005	0.496CysLeu: 0.496 ± 0.019	0.054CysMet: 0.054 ± 0.006	0.074CysAsn: 0.074 ± 0.006	0.303CysPro: 0.303 ± 0.018	0.105CysGln: 0.105 ± 0.009	0.333CysArg: 0.333 ± 0.016	0.327CysSer: 0.327 ± 0.015	0.335CysThr: 0.335 ± 0.018	0.515CysVal: 0.515 ± 0.021	0.082CysTrp: 0.082 ± 0.007	0.117CysTyr: 0.117 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	10.697AspAla: 10.697 ± 0.114	0.231AspCys: 0.231 ± 0.015	5.654AspAsp: 5.654 ± 0.077	3.87AspGlu: 3.87 ± 0.063	1.335AspPhe: 1.335 ± 0.031	7.851AspGly: 7.851 ± 0.102	1.231AspHis: 1.231 ± 0.033	1.456AspIle: 1.456 ± 0.036	0.505AspLys: 0.505 ± 0.024	6.932AspLeu: 6.932 ± 0.072	0.695AspMet: 0.695 ± 0.024	0.733AspAsn: 0.733 ± 0.03	4.888AspPro: 4.888 ± 0.066	1.236AspGln: 1.236 ± 0.031	4.191AspArg: 4.191 ± 0.057	2.181AspSer: 2.181 ± 0.037	2.547AspThr: 2.547 ± 0.047	8.019AspVal: 8.019 ± 0.077	0.982AspTrp: 0.982 ± 0.028	1.112AspTyr: 1.112 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.382GluAla: 7.382 ± 0.098	0.249GluCys: 0.249 ± 0.014	2.846GluAsp: 2.846 ± 0.048	2.895GluGlu: 2.895 ± 0.052	1.416GluPhe: 1.416 ± 0.031	3.752GluGly: 3.752 ± 0.05	1.603GluHis: 1.603 ± 0.036	2.434GluIle: 2.434 ± 0.043	0.739GluLys: 0.739 ± 0.025	6.81GluLeu: 6.81 ± 0.078	0.84GluMet: 0.84 ± 0.027	0.989GluAsn: 0.989 ± 0.029	3.682GluPro: 3.682 ± 0.069	1.919GluGln: 1.919 ± 0.035	5.623GluArg: 5.623 ± 0.07	2.383GluSer: 2.383 ± 0.044	2.637GluThr: 2.637 ± 0.047	4.846GluVal: 4.846 ± 0.062	0.816GluTrp: 0.816 ± 0.022	1.021GluTyr: 1.021 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.086PheAla: 4.086 ± 0.059	0.187PheCys: 0.187 ± 0.013	2.103PheAsp: 2.103 ± 0.037	1.319PheGlu: 1.319 ± 0.031	0.934PhePhe: 0.934 ± 0.03	2.92PheGly: 2.92 ± 0.044	0.559PheHis: 0.559 ± 0.018	0.682PheIle: 0.682 ± 0.024	0.265PheLys: 0.265 ± 0.015	2.673PheLeu: 2.673 ± 0.051	0.379PheMet: 0.379 ± 0.016	0.504PheAsn: 0.504 ± 0.018	1.287PhePro: 1.287 ± 0.03	0.632PheGln: 0.632 ± 0.022	1.681PheArg: 1.681 ± 0.036	1.525PheSer: 1.525 ± 0.033	2.033PheThr: 2.033 ± 0.037	2.708PheVal: 2.708 ± 0.055	0.521PheTrp: 0.521 ± 0.021	0.612PheTyr: 0.612 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	12.856GlyAla: 12.856 ± 0.112	0.529GlyCys: 0.529 ± 0.021	5.687GlyAsp: 5.687 ± 0.071	5.344GlyGlu: 5.344 ± 0.06	2.766GlyPhe: 2.766 ± 0.047	8.959GlyGly: 8.959 ± 0.099	1.897GlyHis: 1.897 ± 0.044	3.576GlyIle: 3.576 ± 0.058	1.327GlyLys: 1.327 ± 0.036	9.16GlyLeu: 9.16 ± 0.09	1.849GlyMet: 1.849 ± 0.038	1.476GlyAsn: 1.476 ± 0.042	4.925GlyPro: 4.925 ± 0.059	2.245GlyGln: 2.245 ± 0.044	7.184GlyArg: 7.184 ± 0.086	5.237GlySer: 5.237 ± 0.059	6.169GlyThr: 6.169 ± 0.109	9.074GlyVal: 9.074 ± 0.08	1.887GlyTrp: 1.887 ± 0.042	2.275GlyTyr: 2.275 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.816HisAla: 2.816 ± 0.05	0.112HisCys: 0.112 ± 0.009	1.498HisAsp: 1.498 ± 0.032	1.174HisGlu: 1.174 ± 0.029	0.439HisPhe: 0.439 ± 0.017	2.062HisGly: 2.062 ± 0.041	0.58HisHis: 0.58 ± 0.024	0.46HisIle: 0.46 ± 0.018	0.176HisLys: 0.176 ± 0.01	2.301HisLeu: 2.301 ± 0.047	0.229HisMet: 0.229 ± 0.012	0.264HisAsn: 0.264 ± 0.013	1.548HisPro: 1.548 ± 0.037	0.456HisGln: 0.456 ± 0.02	1.644HisArg: 1.644 ± 0.04	0.725HisSer: 0.725 ± 0.022	1.008HisThr: 1.008 ± 0.029	2.139HisVal: 2.139 ± 0.046	0.31HisTrp: 0.31 ± 0.016	0.374HisTyr: 0.374 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.275IleAla: 5.275 ± 0.069	0.194IleCys: 0.194 ± 0.012	2.579IleAsp: 2.579 ± 0.044	1.905IleGlu: 1.905 ± 0.041	0.806IlePhe: 0.806 ± 0.029	3.563IleGly: 3.563 ± 0.061	0.511IleHis: 0.511 ± 0.018	0.911IleIle: 0.911 ± 0.031	0.379IleLys: 0.379 ± 0.018	2.614IleLeu: 2.614 ± 0.055	0.411IleMet: 0.411 ± 0.019	0.571IleAsn: 0.571 ± 0.018	1.808IlePro: 1.808 ± 0.04	0.627IleGln: 0.627 ± 0.024	2.047IleArg: 2.047 ± 0.036	1.577IleSer: 1.577 ± 0.034	2.068IleThr: 2.068 ± 0.052	3.361IleVal: 3.361 ± 0.056	0.421IleTrp: 0.421 ± 0.014	0.532IleTyr: 0.532 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	1.321LysAla: 1.321 ± 0.038	0.045LysCys: 0.045 ± 0.006	0.614LysAsp: 0.614 ± 0.023	0.562LysGlu: 0.562 ± 0.025	0.285LysPhe: 0.285 ± 0.013	0.892LysGly: 0.892 ± 0.028	0.285LysHis: 0.285 ± 0.015	0.45LysIle: 0.45 ± 0.021	0.317LysLys: 0.317 ± 0.018	1.027LysLeu: 1.027 ± 0.031	0.179LysMet: 0.179 ± 0.01	0.271LysAsn: 0.271 ± 0.016	0.682LysPro: 0.682 ± 0.024	0.346LysGln: 0.346 ± 0.017	0.87LysArg: 0.87 ± 0.028	0.6LysSer: 0.6 ± 0.023	0.687LysThr: 0.687 ± 0.021	1.062LysVal: 1.062 ± 0.032	0.132LysTrp: 0.132 ± 0.011	0.253LysTyr: 0.253 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	17.393LeuAla: 17.393 ± 0.139	0.506LeuCys: 0.506 ± 0.017	7.41LeuAsp: 7.41 ± 0.084	5.39LeuGlu: 5.39 ± 0.073	2.462LeuPhe: 2.462 ± 0.047	9.877LeuGly: 9.877 ± 0.101	1.817LeuHis: 1.817 ± 0.037	2.573LeuIle: 2.573 ± 0.05	0.955LeuLys: 0.955 ± 0.027	10.561LeuLeu: 10.561 ± 0.115	1.361LeuMet: 1.361 ± 0.033	1.318LeuAsn: 1.318 ± 0.027	5.851LeuPro: 5.851 ± 0.06	2.045LeuGln: 2.045 ± 0.037	8.038LeuArg: 8.038 ± 0.08	4.462LeuSer: 4.462 ± 0.05	6.613LeuThr: 6.613 ± 0.067	10.886LeuVal: 10.886 ± 0.103	1.269LeuTrp: 1.269 ± 0.034	1.654LeuTyr: 1.654 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.094MetAla: 2.094 ± 0.04	0.096MetCys: 0.096 ± 0.008	0.748MetAsp: 0.748 ± 0.022	0.529MetGlu: 0.529 ± 0.023	0.494MetPhe: 0.494 ± 0.019	1.107MetGly: 1.107 ± 0.029	0.321MetHis: 0.321 ± 0.015	0.584MetIle: 0.584 ± 0.019	0.226MetLys: 0.226 ± 0.013	1.673MetLeu: 1.673 ± 0.035	0.225MetMet: 0.225 ± 0.012	0.313MetAsn: 0.313 ± 0.013	1.063MetPro: 1.063 ± 0.03	0.368MetGln: 0.368 ± 0.016	1.379MetArg: 1.379 ± 0.029	1.371MetSer: 1.371 ± 0.033	1.617MetThr: 1.617 ± 0.03	1.222MetVal: 1.222 ± 0.03	0.232MetTrp: 0.232 ± 0.012	0.305MetTyr: 0.305 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	1.942AsnAla: 1.942 ± 0.045	0.076AsnCys: 0.076 ± 0.007	0.879AsnAsp: 0.879 ± 0.027	0.674AsnGlu: 0.674 ± 0.024	0.498AsnPhe: 0.498 ± 0.019	1.518AsnGly: 1.518 ± 0.06	0.298AsnHis: 0.298 ± 0.014	0.502AsnIle: 0.502 ± 0.021	0.196AsnLys: 0.196 ± 0.013	1.533AsnLeu: 1.533 ± 0.035	0.225AsnMet: 0.225 ± 0.014	0.306AsnAsn: 0.306 ± 0.017	1.242AsnPro: 1.242 ± 0.033	0.393AsnGln: 0.393 ± 0.018	0.994AsnArg: 0.994 ± 0.026	0.737AsnSer: 0.737 ± 0.029	0.903AsnThr: 0.903 ± 0.027	1.495AsnVal: 1.495 ± 0.034	0.257AsnTrp: 0.257 ± 0.013	0.398AsnTyr: 0.398 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	8.714ProAla: 8.714 ± 0.085	0.197ProCys: 0.197 ± 0.012	4.955ProAsp: 4.955 ± 0.078	4.136ProGlu: 4.136 ± 0.06	1.713ProPhe: 1.713 ± 0.035	6.393ProGly: 6.393 ± 0.092	1.211ProHis: 1.211 ± 0.036	1.607ProIle: 1.607 ± 0.034	0.553ProLys: 0.553 ± 0.021	5.046ProLeu: 5.046 ± 0.063	0.959ProMet: 0.959 ± 0.026	0.876ProAsn: 0.876 ± 0.028	3.687ProPro: 3.687 ± 0.073	1.422ProGln: 1.422 ± 0.033	3.977ProArg: 3.977 ± 0.055	3.388ProSer: 3.388 ± 0.045	3.818ProThr: 3.818 ± 0.061	5.183ProVal: 5.183 ± 0.072	1.016ProTrp: 1.016 ± 0.029	1.144ProTyr: 1.144 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.192GlnAla: 3.192 ± 0.05	0.115GlnCys: 0.115 ± 0.008	1.226GlnAsp: 1.226 ± 0.03	1.255GlnGlu: 1.255 ± 0.031	0.69GlnPhe: 0.69 ± 0.021	1.853GlnGly: 1.853 ± 0.035	0.553GlnHis: 0.553 ± 0.019	1.051GlnIle: 1.051 ± 0.029	0.309GlnLys: 0.309 ± 0.014	2.771GlnLeu: 2.771 ± 0.054	0.426GlnMet: 0.426 ± 0.02	0.416GlnAsn: 0.416 ± 0.018	1.371GlnPro: 1.371 ± 0.04	0.913GlnGln: 0.913 ± 0.038	2.197GlnArg: 2.197 ± 0.04	1.045GlnSer: 1.045 ± 0.028	1.162GlnThr: 1.162 ± 0.034	2.573GlnVal: 2.573 ± 0.04	0.406GlnTrp: 0.406 ± 0.017	0.507GlnTyr: 0.507 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.573ArgAla: 10.573 ± 0.1	0.372ArgCys: 0.372 ± 0.016	4.68ArgAsp: 4.68 ± 0.057	4.471ArgGlu: 4.471 ± 0.062	2.192ArgPhe: 2.192 ± 0.04	6.067ArgGly: 6.067 ± 0.078	1.794ArgHis: 1.794 ± 0.041	3.031ArgIle: 3.031 ± 0.042	0.846ArgLys: 0.846 ± 0.028	8.213ArgLeu: 8.213 ± 0.09	1.574ArgMet: 1.574 ± 0.037	1.005ArgAsn: 1.005 ± 0.033	4.471ArgPro: 4.471 ± 0.07	1.845ArgGln: 1.845 ± 0.04	8.198ArgArg: 8.198 ± 0.099	4.204ArgSer: 4.204 ± 0.055	5.042ArgThr: 5.042 ± 0.06	6.709ArgVal: 6.709 ± 0.08	1.43ArgTrp: 1.43 ± 0.037	1.644ArgTyr: 1.644 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.975SerAla: 6.975 ± 0.07	0.25SerCys: 0.25 ± 0.013	3.029SerAsp: 3.029 ± 0.047	2.415SerGlu: 2.415 ± 0.037	1.614SerPhe: 1.614 ± 0.036	5.764SerGly: 5.764 ± 0.071	0.907SerHis: 0.907 ± 0.026	1.709SerIle: 1.709 ± 0.037	0.535SerLys: 0.535 ± 0.018	4.653SerLeu: 4.653 ± 0.061	1.023SerMet: 1.023 ± 0.028	0.786SerAsn: 0.786 ± 0.026	3.15SerPro: 3.15 ± 0.055	1.144SerGln: 1.144 ± 0.028	3.766SerArg: 3.766 ± 0.048	3.13SerSer: 3.13 ± 0.059	3.326SerThr: 3.326 ± 0.082	4.327SerVal: 4.327 ± 0.057	0.979SerTrp: 0.979 ± 0.027	1.085SerTyr: 1.085 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	8.155ThrAla: 8.155 ± 0.124	0.324ThrCys: 0.324 ± 0.014	3.706ThrAsp: 3.706 ± 0.059	2.868ThrGlu: 2.868 ± 0.052	2.129ThrPhe: 2.129 ± 0.04	5.78ThrGly: 5.78 ± 0.072	1.22ThrHis: 1.22 ± 0.029	2.374ThrIle: 2.374 ± 0.059	0.72ThrLys: 0.72 ± 0.025	6.082ThrLeu: 6.082 ± 0.087	0.994ThrMet: 0.994 ± 0.026	1.031ThrAsn: 1.031 ± 0.029	4.215ThrPro: 4.215 ± 0.054	1.509ThrGln: 1.509 ± 0.034	4.03ThrArg: 4.03 ± 0.058	3.785ThrSer: 3.785 ± 0.095	4.427ThrThr: 4.427 ± 0.07	5.335ThrVal: 5.335 ± 0.105	1.204ThrTrp: 1.204 ± 0.035	1.425ThrTyr: 1.425 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	14.218ValAla: 14.218 ± 0.104	0.568ValCys: 0.568 ± 0.024	6.34ValAsp: 6.34 ± 0.073	5.422ValGlu: 5.422 ± 0.066	2.469ValPhe: 2.469 ± 0.043	8.264ValGly: 8.264 ± 0.078	1.892ValHis: 1.892 ± 0.04	2.968ValIle: 2.968 ± 0.058	0.916ValLys: 0.916 ± 0.03	11.013ValLeu: 11.013 ± 0.125	1.348ValMet: 1.348 ± 0.034	1.434ValAsn: 1.434 ± 0.034	5.978ValPro: 5.978 ± 0.066	2.003ValGln: 2.003 ± 0.037	7.632ValArg: 7.632 ± 0.081	4.582ValSer: 4.582 ± 0.064	6.454ValThr: 6.454 ± 0.106	11.801ValVal: 11.801 ± 0.115	1.313ValTrp: 1.313 ± 0.029	1.524ValTyr: 1.524 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.888TrpAla: 1.888 ± 0.042	0.13TrpCys: 0.13 ± 0.01	0.985TrpAsp: 0.985 ± 0.028	0.755TrpGlu: 0.755 ± 0.026	0.592TrpPhe: 0.592 ± 0.022	1.2TrpGly: 1.2 ± 0.033	0.388TrpHis: 0.388 ± 0.015	0.579TrpIle: 0.579 ± 0.021	0.192TrpLys: 0.192 ± 0.013	1.804TrpLeu: 1.804 ± 0.04	0.308TrpMet: 0.308 ± 0.016	0.427TrpAsn: 0.427 ± 0.019	0.93TrpPro: 0.93 ± 0.027	0.533TrpGln: 0.533 ± 0.021	1.526TrpArg: 1.526 ± 0.036	1.056TrpSer: 1.056 ± 0.027	1.096TrpThr: 1.096 ± 0.029	1.363TrpVal: 1.363 ± 0.036	0.457TrpTrp: 0.457 ± 0.019	0.336TrpTyr: 0.336 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.713TyrAla: 2.713 ± 0.047	0.119TyrCys: 0.119 ± 0.01	1.324TyrAsp: 1.324 ± 0.033	1.013TyrGlu: 1.013 ± 0.027	0.601TyrPhe: 0.601 ± 0.022	1.872TyrGly: 1.872 ± 0.034	0.326TyrHis: 0.326 ± 0.015	0.447TyrIle: 0.447 ± 0.017	0.176TyrLys: 0.176 ± 0.01	2.149TyrLeu: 2.149 ± 0.045	0.199TyrMet: 0.199 ± 0.013	0.354TyrAsn: 0.354 ± 0.015	1.059TyrPro: 1.059 ± 0.027	0.457TyrGln: 0.457 ± 0.02	1.676TyrArg: 1.676 ± 0.037	0.957TyrSer: 0.957 ± 0.026	1.138TyrThr: 1.138 ± 0.037	1.888TyrVal: 1.888 ± 0.033	0.368TyrTrp: 0.368 ± 0.019	0.484TyrTyr: 0.484 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4195 proteins (1434007 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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