Amino acid dipepetide frequency for Lachnoclostridium sp. An169

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.415AlaAla: 8.415 ± 0.114
1.149AlaCys: 1.149 ± 0.029
5.024AlaAsp: 5.024 ± 0.067
6.446AlaGlu: 6.446 ± 0.087
3.115AlaPhe: 3.115 ± 0.054
7.081AlaGly: 7.081 ± 0.083
1.074AlaHis: 1.074 ± 0.03
3.75AlaIle: 3.75 ± 0.054
3.8AlaLys: 3.8 ± 0.057
7.051AlaLeu: 7.051 ± 0.076
2.244AlaMet: 2.244 ± 0.047
2.061AlaAsn: 2.061 ± 0.036
2.212AlaPro: 2.212 ± 0.041
2.378AlaGln: 2.378 ± 0.041
3.419AlaArg: 3.419 ± 0.05
3.871AlaSer: 3.871 ± 0.06
2.649AlaThr: 2.649 ± 0.054
7.445AlaVal: 7.445 ± 0.078
0.741AlaTrp: 0.741 ± 0.023
2.769AlaTyr: 2.769 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
1.134CysAla: 1.134 ± 0.03
0.306CysCys: 0.306 ± 0.017
0.804CysAsp: 0.804 ± 0.025
0.914CysGlu: 0.914 ± 0.025
0.649CysPhe: 0.649 ± 0.019
1.639CysGly: 1.639 ± 0.043
0.3CysHis: 0.3 ± 0.015
1.119CysIle: 1.119 ± 0.028
0.532CysLys: 0.532 ± 0.022
1.25CysLeu: 1.25 ± 0.032
0.5CysMet: 0.5 ± 0.018
0.471CysAsn: 0.471 ± 0.02
0.727CysPro: 0.727 ± 0.027
0.386CysGln: 0.386 ± 0.015
1.112CysArg: 1.112 ± 0.029
1.002CysSer: 1.002 ± 0.026
0.803CysThr: 0.803 ± 0.025
1.073CysVal: 1.073 ± 0.028
0.124CysTrp: 0.124 ± 0.009
0.579CysTyr: 0.579 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.246AspAla: 4.246 ± 0.066
0.815AspCys: 0.815 ± 0.026
2.961AspAsp: 2.961 ± 0.054
4.838AspGlu: 4.838 ± 0.062
2.657AspPhe: 2.657 ± 0.039
4.868AspGly: 4.868 ± 0.076
0.934AspHis: 0.934 ± 0.029
4.1AspIle: 4.1 ± 0.059
2.599AspLys: 2.599 ± 0.046
4.689AspLeu: 4.689 ± 0.059
1.865AspMet: 1.865 ± 0.039
1.957AspAsn: 1.957 ± 0.038
2.176AspPro: 2.176 ± 0.046
1.463AspGln: 1.463 ± 0.034
3.142AspArg: 3.142 ± 0.062
3.219AspSer: 3.219 ± 0.051
3.211AspThr: 3.211 ± 0.053
3.793AspVal: 3.793 ± 0.055
0.698AspTrp: 0.698 ± 0.023
2.864AspTyr: 2.864 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.777GluAla: 5.777 ± 0.076
0.93GluCys: 0.93 ± 0.025
4.476GluAsp: 4.476 ± 0.06
8.169GluGlu: 8.169 ± 0.091
2.607GluPhe: 2.607 ± 0.047
4.774GluGly: 4.774 ± 0.066
1.425GluHis: 1.425 ± 0.034
5.618GluIle: 5.618 ± 0.07
7.015GluLys: 7.015 ± 0.084
6.685GluLeu: 6.685 ± 0.069
2.587GluMet: 2.587 ± 0.041
4.562GluAsn: 4.562 ± 0.051
2.18GluPro: 2.18 ± 0.045
3.078GluGln: 3.078 ± 0.053
4.018GluArg: 4.018 ± 0.054
3.514GluSer: 3.514 ± 0.057
4.114GluThr: 4.114 ± 0.059
4.335GluVal: 4.335 ± 0.064
0.865GluTrp: 0.865 ± 0.028
3.475GluTyr: 3.475 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.069PheAla: 3.069 ± 0.046
0.814PheCys: 0.814 ± 0.024
2.452PheAsp: 2.452 ± 0.039
2.661PheGlu: 2.661 ± 0.041
1.894PhePhe: 1.894 ± 0.041
3.078PheGly: 3.078 ± 0.052
0.907PheHis: 0.907 ± 0.025
2.637PheIle: 2.637 ± 0.049
1.533PheLys: 1.533 ± 0.035
4.153PheLeu: 4.153 ± 0.063
1.092PheMet: 1.092 ± 0.026
1.366PheAsn: 1.366 ± 0.032
1.616PhePro: 1.616 ± 0.036
1.298PheGln: 1.298 ± 0.032
2.323PheArg: 2.323 ± 0.043
2.974PheSer: 2.974 ± 0.054
2.464PheThr: 2.464 ± 0.04
2.732PheVal: 2.732 ± 0.046
0.463PheTrp: 0.463 ± 0.021
1.859PheTyr: 1.859 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
5.226GlyAla: 5.226 ± 0.075
1.316GlyCys: 1.316 ± 0.031
3.849GlyAsp: 3.849 ± 0.053
5.633GlyGlu: 5.633 ± 0.073
3.129GlyPhe: 3.129 ± 0.051
5.318GlyGly: 5.318 ± 0.084
1.261GlyHis: 1.261 ± 0.035
6.091GlyIle: 6.091 ± 0.072
5.45GlyLys: 5.45 ± 0.058
5.867GlyLeu: 5.867 ± 0.082
2.64GlyMet: 2.64 ± 0.048
3.222GlyAsn: 3.222 ± 0.055
1.411GlyPro: 1.411 ± 0.038
2.149GlyGln: 2.149 ± 0.042
3.838GlyArg: 3.838 ± 0.059
4.421GlySer: 4.421 ± 0.07
4.609GlyThr: 4.609 ± 0.068
4.816GlyVal: 4.816 ± 0.064
0.842GlyTrp: 0.842 ± 0.029
3.475GlyTyr: 3.475 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.159HisAla: 1.159 ± 0.03
0.31HisCys: 0.31 ± 0.014
0.948HisAsp: 0.948 ± 0.029
1.052HisGlu: 1.052 ± 0.026
0.904HisPhe: 0.904 ± 0.027
1.323HisGly: 1.323 ± 0.034
0.374HisHis: 0.374 ± 0.02
1.37HisIle: 1.37 ± 0.033
0.698HisLys: 0.698 ± 0.019
1.557HisLeu: 1.557 ± 0.033
0.563HisMet: 0.563 ± 0.021
0.644HisAsn: 0.644 ± 0.024
0.924HisPro: 0.924 ± 0.028
0.469HisGln: 0.469 ± 0.018
0.957HisArg: 0.957 ± 0.026
0.965HisSer: 0.965 ± 0.023
1.025HisThr: 1.025 ± 0.028
1.123HisVal: 1.123 ± 0.027
0.187HisTrp: 0.187 ± 0.011
0.798HisTyr: 0.798 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.126IleAla: 5.126 ± 0.071
1.314IleCys: 1.314 ± 0.032
3.682IleAsp: 3.682 ± 0.049
4.212IleGlu: 4.212 ± 0.059
2.975IlePhe: 2.975 ± 0.055
4.637IleGly: 4.637 ± 0.067
1.274IleHis: 1.274 ± 0.03
4.139IleIle: 4.139 ± 0.064
2.702IleLys: 2.702 ± 0.047
6.863IleLeu: 6.863 ± 0.082
1.775IleMet: 1.775 ± 0.04
2.338IleAsn: 2.338 ± 0.043
3.265IlePro: 3.265 ± 0.048
2.03IleGln: 2.03 ± 0.035
4.823IleArg: 4.823 ± 0.062
4.582IleSer: 4.582 ± 0.058
3.814IleThr: 3.814 ± 0.052
4.368IleVal: 4.368 ± 0.063
0.703IleTrp: 0.703 ± 0.023
2.647IleTyr: 2.647 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.323LysAla: 4.323 ± 0.06
0.652LysCys: 0.652 ± 0.024
3.308LysAsp: 3.308 ± 0.051
5.731LysGlu: 5.731 ± 0.067
1.638LysPhe: 1.638 ± 0.035
3.732LysGly: 3.732 ± 0.055
0.918LysHis: 0.918 ± 0.028
4.12LysIle: 4.12 ± 0.052
5.216LysLys: 5.216 ± 0.068
4.431LysLeu: 4.431 ± 0.061
1.97LysMet: 1.97 ± 0.045
3.008LysAsn: 3.008 ± 0.052
1.782LysPro: 1.782 ± 0.034
1.868LysGln: 1.868 ± 0.043
2.999LysArg: 2.999 ± 0.053
2.803LysSer: 2.803 ± 0.049
3.289LysThr: 3.289 ± 0.054
3.608LysVal: 3.608 ± 0.063
0.61LysTrp: 0.61 ± 0.021
2.63LysTyr: 2.63 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
6.967LeuAla: 6.967 ± 0.074
1.611LeuCys: 1.611 ± 0.033
5.063LeuAsp: 5.063 ± 0.062
6.449LeuGlu: 6.449 ± 0.073
3.818LeuPhe: 3.818 ± 0.068
5.791LeuGly: 5.791 ± 0.082
1.542LeuHis: 1.542 ± 0.034
5.824LeuIle: 5.824 ± 0.076
5.488LeuLys: 5.488 ± 0.055
8.594LeuLeu: 8.594 ± 0.119
2.585LeuMet: 2.585 ± 0.046
3.507LeuAsn: 3.507 ± 0.051
3.892LeuPro: 3.892 ± 0.064
2.697LeuGln: 2.697 ± 0.053
4.436LeuArg: 4.436 ± 0.068
6.001LeuSer: 6.001 ± 0.07
5.218LeuThr: 5.218 ± 0.068
5.185LeuVal: 5.185 ± 0.075
0.871LeuTrp: 0.871 ± 0.023
3.477LeuTyr: 3.477 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.42MetAla: 2.42 ± 0.046
0.368MetCys: 0.368 ± 0.016
1.814MetAsp: 1.814 ± 0.034
2.792MetGlu: 2.792 ± 0.048
1.048MetPhe: 1.048 ± 0.028
1.96MetGly: 1.96 ± 0.039
0.462MetHis: 0.462 ± 0.019
2.069MetIle: 2.069 ± 0.041
2.549MetLys: 2.549 ± 0.04
2.641MetLeu: 2.641 ± 0.051
0.905MetMet: 0.905 ± 0.027
1.445MetAsn: 1.445 ± 0.03
1.202MetPro: 1.202 ± 0.029
0.994MetGln: 0.994 ± 0.023
1.456MetArg: 1.456 ± 0.032
1.731MetSer: 1.731 ± 0.034
1.82MetThr: 1.82 ± 0.031
1.75MetVal: 1.75 ± 0.037
0.269MetTrp: 0.269 ± 0.013
0.96MetTyr: 0.96 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
2.995AsnAla: 2.995 ± 0.053
0.594AsnCys: 0.594 ± 0.023
1.849AsnAsp: 1.849 ± 0.038
2.611AsnGlu: 2.611 ± 0.041
1.516AsnPhe: 1.516 ± 0.032
3.462AsnGly: 3.462 ± 0.051
0.766AsnHis: 0.766 ± 0.023
2.995AsnIle: 2.995 ± 0.051
1.625AsnLys: 1.625 ± 0.038
3.41AsnLeu: 3.41 ± 0.044
1.335AsnMet: 1.335 ± 0.028
1.479AsnAsn: 1.479 ± 0.034
1.956AsnPro: 1.956 ± 0.041
1.231AsnGln: 1.231 ± 0.033
2.348AsnArg: 2.348 ± 0.041
2.216AsnSer: 2.216 ± 0.038
2.314AsnThr: 2.314 ± 0.045
2.59AsnVal: 2.59 ± 0.042
0.446AsnTrp: 0.446 ± 0.017
1.736AsnTyr: 1.736 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
2.979ProAla: 2.979 ± 0.044
0.509ProCys: 0.509 ± 0.02
2.767ProAsp: 2.767 ± 0.049
4.058ProGlu: 4.058 ± 0.06
1.641ProPhe: 1.641 ± 0.04
3.009ProGly: 3.009 ± 0.057
0.632ProHis: 0.632 ± 0.022
1.562ProIle: 1.562 ± 0.032
1.582ProLys: 1.582 ± 0.039
2.985ProLeu: 2.985 ± 0.045
0.83ProMet: 0.83 ± 0.024
1.065ProAsn: 1.065 ± 0.03
0.824ProPro: 0.824 ± 0.026
1.13ProGln: 1.13 ± 0.029
1.268ProArg: 1.268 ± 0.027
1.839ProSer: 1.839 ± 0.047
1.428ProThr: 1.428 ± 0.04
3.458ProVal: 3.458 ± 0.056
0.408ProTrp: 0.408 ± 0.016
1.575ProTyr: 1.575 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
2.392GlnAla: 2.392 ± 0.042
0.36GlnCys: 0.36 ± 0.016
1.524GlnAsp: 1.524 ± 0.033
2.722GlnGlu: 2.722 ± 0.052
1.184GlnPhe: 1.184 ± 0.032
1.941GlnGly: 1.941 ± 0.038
0.417GlnHis: 0.417 ± 0.015
2.6GlnIle: 2.6 ± 0.047
2.375GlnLys: 2.375 ± 0.044
2.468GlnLeu: 2.468 ± 0.046
1.186GlnMet: 1.186 ± 0.027
1.515GlnAsn: 1.515 ± 0.035
0.926GlnPro: 0.926 ± 0.024
1.11GlnGln: 1.11 ± 0.037
1.52GlnArg: 1.52 ± 0.034
1.616GlnSer: 1.616 ± 0.039
1.818GlnThr: 1.818 ± 0.039
1.94GlnVal: 1.94 ± 0.035
0.366GlnTrp: 0.366 ± 0.016
1.355GlnTyr: 1.355 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
3.372ArgAla: 3.372 ± 0.046
0.72ArgCys: 0.72 ± 0.023
2.719ArgAsp: 2.719 ± 0.046
5.174ArgGlu: 5.174 ± 0.071
2.254ArgPhe: 2.254 ± 0.045
2.983ArgGly: 2.983 ± 0.05
0.958ArgHis: 0.958 ± 0.024
4.109ArgIle: 4.109 ± 0.055
4.17ArgLys: 4.17 ± 0.056
4.591ArgLeu: 4.591 ± 0.055
1.843ArgMet: 1.843 ± 0.036
2.338ArgAsn: 2.338 ± 0.037
1.554ArgPro: 1.554 ± 0.036
2.042ArgGln: 2.042 ± 0.042
3.342ArgArg: 3.342 ± 0.06
2.598ArgSer: 2.598 ± 0.043
2.828ArgThr: 2.828 ± 0.042
2.884ArgVal: 2.884 ± 0.048
0.53ArgTrp: 0.53 ± 0.019
2.306ArgTyr: 2.306 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
4.569SerAla: 4.569 ± 0.064
0.806SerCys: 0.806 ± 0.025
3.455SerAsp: 3.455 ± 0.054
3.957SerGlu: 3.957 ± 0.059
2.579SerPhe: 2.579 ± 0.051
5.705SerGly: 5.705 ± 0.08
0.998SerHis: 0.998 ± 0.026
3.442SerIle: 3.442 ± 0.054
2.324SerLys: 2.324 ± 0.045
5.22SerLeu: 5.22 ± 0.061
1.774SerMet: 1.774 ± 0.039
1.778SerAsn: 1.778 ± 0.038
2.005SerPro: 2.005 ± 0.042
1.711SerGln: 1.711 ± 0.041
3.401SerArg: 3.401 ± 0.05
3.471SerSer: 3.471 ± 0.059
2.634SerThr: 2.634 ± 0.049
4.385SerVal: 4.385 ± 0.058
0.608SerTrp: 0.608 ± 0.02
2.419SerTyr: 2.419 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
4.896ThrAla: 4.896 ± 0.069
0.697ThrCys: 0.697 ± 0.024
3.635ThrAsp: 3.635 ± 0.054
4.224ThrGlu: 4.224 ± 0.055
2.252ThrPhe: 2.252 ± 0.038
5.19ThrGly: 5.19 ± 0.075
0.876ThrHis: 0.876 ± 0.029
3.216ThrIle: 3.216 ± 0.044
2.414ThrLys: 2.414 ± 0.041
4.75ThrLeu: 4.75 ± 0.063
1.368ThrMet: 1.368 ± 0.03
1.695ThrAsn: 1.695 ± 0.039
2.296ThrPro: 2.296 ± 0.045
1.384ThrGln: 1.384 ± 0.036
2.178ThrArg: 2.178 ± 0.038
2.687ThrSer: 2.687 ± 0.043
2.473ThrThr: 2.473 ± 0.045
4.778ThrVal: 4.778 ± 0.078
0.559ThrTrp: 0.559 ± 0.021
2.126ThrTyr: 2.126 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
4.13ValAla: 4.13 ± 0.059
1.309ValCys: 1.309 ± 0.034
3.453ValAsp: 3.453 ± 0.053
4.625ValGlu: 4.625 ± 0.064
3.165ValPhe: 3.165 ± 0.054
4.028ValGly: 4.028 ± 0.059
1.126ValHis: 1.126 ± 0.028
4.997ValIle: 4.997 ± 0.068
3.989ValLys: 3.989 ± 0.054
6.919ValLeu: 6.919 ± 0.072
2.054ValMet: 2.054 ± 0.042
2.705ValAsn: 2.705 ± 0.043
2.741ValPro: 2.741 ± 0.05
2.032ValGln: 2.032 ± 0.036
3.639ValArg: 3.639 ± 0.052
4.637ValSer: 4.637 ± 0.064
4.218ValThr: 4.218 ± 0.061
4.406ValVal: 4.406 ± 0.068
0.813ValTrp: 0.813 ± 0.025
2.902ValTyr: 2.902 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.623TrpAla: 0.623 ± 0.022
0.171TrpCys: 0.171 ± 0.01
0.672TrpAsp: 0.672 ± 0.025
0.783TrpGlu: 0.783 ± 0.023
0.428TrpPhe: 0.428 ± 0.02
0.765TrpGly: 0.765 ± 0.025
0.211TrpHis: 0.211 ± 0.013
0.761TrpIle: 0.761 ± 0.024
0.849TrpLys: 0.849 ± 0.029
0.971TrpLeu: 0.971 ± 0.029
0.381TrpMet: 0.381 ± 0.017
0.613TrpAsn: 0.613 ± 0.024
0.235TrpPro: 0.235 ± 0.013
0.424TrpGln: 0.424 ± 0.017
0.451TrpArg: 0.451 ± 0.017
0.628TrpSer: 0.628 ± 0.02
0.545TrpThr: 0.545 ± 0.021
0.534TrpVal: 0.534 ± 0.017
0.142TrpTrp: 0.142 ± 0.011
0.508TrpTyr: 0.508 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.874TyrAla: 2.874 ± 0.049
0.673TyrCys: 0.673 ± 0.019
2.64TyrAsp: 2.64 ± 0.05
3.153TyrGlu: 3.153 ± 0.046
1.929TyrPhe: 1.929 ± 0.038
3.28TyrGly: 3.28 ± 0.045
0.895TyrHis: 0.895 ± 0.023
2.754TyrIle: 2.754 ± 0.042
1.722TyrLys: 1.722 ± 0.041
3.921TyrLeu: 3.921 ± 0.058
1.156TyrMet: 1.156 ± 0.03
1.703TyrAsn: 1.703 ± 0.032
1.624TyrPro: 1.624 ± 0.036
1.462TyrGln: 1.462 ± 0.038
2.646TyrArg: 2.646 ± 0.044
2.468TyrSer: 2.468 ± 0.046
2.421TyrThr: 2.421 ± 0.044
2.688TyrVal: 2.688 ± 0.041
0.45TyrTrp: 0.45 ± 0.019
2.057TyrTyr: 2.057 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4280 proteins (1444677 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski