Amino acid dipepetide frequency for Solirubrobacter pauli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.044AlaAla: 22.044 ± 0.191	1.043AlaCys: 1.043 ± 0.025	8.059AlaAsp: 8.059 ± 0.08	8.103AlaGlu: 8.103 ± 0.089	4.33AlaPhe: 4.33 ± 0.057	13.105AlaGly: 13.105 ± 0.104	2.605AlaHis: 2.605 ± 0.038	5.309AlaIle: 5.309 ± 0.048	3.126AlaLys: 3.126 ± 0.048	15.96AlaLeu: 15.96 ± 0.141	2.569AlaMet: 2.569 ± 0.039	2.589AlaAsn: 2.589 ± 0.047	7.522AlaPro: 7.522 ± 0.086	3.968AlaGln: 3.968 ± 0.047	10.569AlaArg: 10.569 ± 0.114	6.534AlaSer: 6.534 ± 0.066	8.427AlaThr: 8.427 ± 0.1	11.358AlaVal: 11.358 ± 0.091	1.877AlaTrp: 1.877 ± 0.03	2.604AlaTyr: 2.604 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.026CysAla: 1.026 ± 0.022	0.086CysCys: 0.086 ± 0.006	0.445CysAsp: 0.445 ± 0.015	0.418CysGlu: 0.418 ± 0.015	0.219CysPhe: 0.219 ± 0.01	0.918CysGly: 0.918 ± 0.026	0.166CysHis: 0.166 ± 0.009	0.196CysIle: 0.196 ± 0.009	0.134CysLys: 0.134 ± 0.008	0.591CysLeu: 0.591 ± 0.017	0.105CysMet: 0.105 ± 0.006	0.136CysAsn: 0.136 ± 0.008	0.442CysPro: 0.442 ± 0.017	0.145CysGln: 0.145 ± 0.007	0.505CysArg: 0.505 ± 0.02	0.443CysSer: 0.443 ± 0.017	0.455CysThr: 0.455 ± 0.016	0.633CysVal: 0.633 ± 0.02	0.093CysTrp: 0.093 ± 0.007	0.112CysTyr: 0.112 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	8.789AspAla: 8.789 ± 0.08	0.416AspCys: 0.416 ± 0.015	3.951AspAsp: 3.951 ± 0.058	4.286AspGlu: 4.286 ± 0.054	1.746AspPhe: 1.746 ± 0.031	6.752AspGly: 6.752 ± 0.084	1.263AspHis: 1.263 ± 0.025	1.773AspIle: 1.773 ± 0.031	1.094AspLys: 1.094 ± 0.025	5.857AspLeu: 5.857 ± 0.061	0.744AspMet: 0.744 ± 0.02	0.972AspAsn: 0.972 ± 0.029	4.26AspPro: 4.26 ± 0.047	1.51AspGln: 1.51 ± 0.026	4.613AspArg: 4.613 ± 0.057	2.167AspSer: 2.167 ± 0.036	2.825AspThr: 2.825 ± 0.042	5.502AspVal: 5.502 ± 0.054	0.836AspTrp: 0.836 ± 0.021	1.207AspTyr: 1.207 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.978GluAla: 7.978 ± 0.085	0.318GluCys: 0.318 ± 0.015	3.14GluAsp: 3.14 ± 0.039	3.14GluGlu: 3.14 ± 0.056	1.353GluPhe: 1.353 ± 0.026	4.099GluGly: 4.099 ± 0.053	1.682GluHis: 1.682 ± 0.026	2.538GluIle: 2.538 ± 0.041	1.164GluLys: 1.164 ± 0.027	7.37GluLeu: 7.37 ± 0.087	0.765GluMet: 0.765 ± 0.021	0.907GluAsn: 0.907 ± 0.024	3.584GluPro: 3.584 ± 0.051	2.228GluGln: 2.228 ± 0.034	6.383GluArg: 6.383 ± 0.077	2.316GluSer: 2.316 ± 0.035	3.03GluThr: 3.03 ± 0.041	4.408GluVal: 4.408 ± 0.054	0.779GluTrp: 0.779 ± 0.021	0.976GluTyr: 0.976 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.291PheAla: 4.291 ± 0.056	0.247PheCys: 0.247 ± 0.012	2.159PheAsp: 2.159 ± 0.028	1.844PheGlu: 1.844 ± 0.032	0.934PhePhe: 0.934 ± 0.024	3.204PheGly: 3.204 ± 0.051	0.562PheHis: 0.562 ± 0.018	0.95PheIle: 0.95 ± 0.025	0.786PheLys: 0.786 ± 0.022	2.486PheLeu: 2.486 ± 0.043	0.433PheMet: 0.433 ± 0.017	0.743PheAsn: 0.743 ± 0.02	1.39PhePro: 1.39 ± 0.028	0.737PheGln: 0.737 ± 0.018	1.83PheArg: 1.83 ± 0.029	1.617PheSer: 1.617 ± 0.032	2.127PheThr: 2.127 ± 0.037	2.539PheVal: 2.539 ± 0.038	0.389PheTrp: 0.389 ± 0.013	0.601PheTyr: 0.601 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	11.762GlyAla: 11.762 ± 0.108	0.783GlyCys: 0.783 ± 0.019	5.49GlyAsp: 5.49 ± 0.072	5.285GlyGlu: 5.285 ± 0.062	3.078GlyPhe: 3.078 ± 0.036	8.789GlyGly: 8.789 ± 0.118	1.926GlyHis: 1.926 ± 0.03	3.53GlyIle: 3.53 ± 0.042	2.448GlyLys: 2.448 ± 0.036	8.726GlyLeu: 8.726 ± 0.079	1.752GlyMet: 1.752 ± 0.03	2.016GlyAsn: 2.016 ± 0.051	4.628GlyPro: 4.628 ± 0.052	2.363GlyGln: 2.363 ± 0.041	6.925GlyArg: 6.925 ± 0.066	4.98GlySer: 4.98 ± 0.075	6.434GlyThr: 6.434 ± 0.114	7.539GlyVal: 7.539 ± 0.064	1.479GlyTrp: 1.479 ± 0.031	2.139GlyTyr: 2.139 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.824HisAla: 2.824 ± 0.044	0.162HisCys: 0.162 ± 0.009	1.311HisAsp: 1.311 ± 0.027	1.299HisGlu: 1.299 ± 0.023	0.645HisPhe: 0.645 ± 0.017	2.127HisGly: 2.127 ± 0.035	0.527HisHis: 0.527 ± 0.018	0.609HisIle: 0.609 ± 0.019	0.327HisLys: 0.327 ± 0.013	1.891HisLeu: 1.891 ± 0.036	0.293HisMet: 0.293 ± 0.014	0.354HisAsn: 0.354 ± 0.016	1.386HisPro: 1.386 ± 0.024	0.503HisGln: 0.503 ± 0.016	1.527HisArg: 1.527 ± 0.031	0.802HisSer: 0.802 ± 0.019	1.007HisThr: 1.007 ± 0.022	1.873HisVal: 1.873 ± 0.029	0.311HisTrp: 0.311 ± 0.014	0.424HisTyr: 0.424 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.99IleAla: 5.99 ± 0.054	0.28IleCys: 0.28 ± 0.012	2.784IleAsp: 2.784 ± 0.038	2.568IleGlu: 2.568 ± 0.038	0.916IlePhe: 0.916 ± 0.028	3.796IleGly: 3.796 ± 0.043	0.643IleHis: 0.643 ± 0.019	1.111IleIle: 1.111 ± 0.031	0.912IleLys: 0.912 ± 0.026	2.82IleLeu: 2.82 ± 0.042	0.411IleMet: 0.411 ± 0.015	0.876IleAsn: 0.876 ± 0.027	1.869IlePro: 1.869 ± 0.032	0.883IleGln: 0.883 ± 0.021	2.299IleArg: 2.299 ± 0.035	1.825IleSer: 1.825 ± 0.032	2.411IleThr: 2.411 ± 0.038	3.586IleVal: 3.586 ± 0.049	0.371IleTrp: 0.371 ± 0.014	0.693IleTyr: 0.693 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.021LysAla: 3.021 ± 0.048	0.112LysCys: 0.112 ± 0.008	1.22LysAsp: 1.22 ± 0.024	0.91LysGlu: 0.91 ± 0.025	0.506LysPhe: 0.506 ± 0.016	1.773LysGly: 1.773 ± 0.035	0.445LysHis: 0.445 ± 0.013	0.913LysIle: 0.913 ± 0.027	0.727LysLys: 0.727 ± 0.028	2.529LysLeu: 2.529 ± 0.039	0.319LysMet: 0.319 ± 0.013	0.444LysAsn: 0.444 ± 0.016	1.584LysPro: 1.584 ± 0.034	0.748LysGln: 0.748 ± 0.02	1.939LysArg: 1.939 ± 0.031	1.021LysSer: 1.021 ± 0.027	1.635LysThr: 1.635 ± 0.034	2.016LysVal: 2.016 ± 0.038	0.275LysTrp: 0.275 ± 0.012	0.41LysTyr: 0.41 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.633LeuAla: 15.633 ± 0.118	0.723LeuCys: 0.723 ± 0.018	6.786LeuAsp: 6.786 ± 0.066	6.103LeuGlu: 6.103 ± 0.072	2.553LeuPhe: 2.553 ± 0.042	9.119LeuGly: 9.119 ± 0.08	2.034LeuHis: 2.034 ± 0.035	3.698LeuIle: 3.698 ± 0.047	2.258LeuLys: 2.258 ± 0.038	10.246LeuLeu: 10.246 ± 0.123	1.518LeuMet: 1.518 ± 0.028	1.851LeuAsn: 1.851 ± 0.036	5.564LeuPro: 5.564 ± 0.057	2.604LeuGln: 2.604 ± 0.034	8.328LeuArg: 8.328 ± 0.071	5.274LeuSer: 5.274 ± 0.048	6.318LeuThr: 6.318 ± 0.067	8.858LeuVal: 8.858 ± 0.086	1.116LeuTrp: 1.116 ± 0.025	1.652LeuTyr: 1.652 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.024MetAla: 2.024 ± 0.035	0.106MetCys: 0.106 ± 0.006	0.806MetAsp: 0.806 ± 0.018	0.718MetGlu: 0.718 ± 0.018	0.405MetPhe: 0.405 ± 0.013	1.22MetGly: 1.22 ± 0.025	0.348MetHis: 0.348 ± 0.011	0.724MetIle: 0.724 ± 0.018	0.428MetLys: 0.428 ± 0.014	1.714MetLeu: 1.714 ± 0.031	0.227MetMet: 0.227 ± 0.011	0.385MetAsn: 0.385 ± 0.012	1.039MetPro: 1.039 ± 0.022	0.471MetGln: 0.471 ± 0.016	1.479MetArg: 1.479 ± 0.025	1.151MetSer: 1.151 ± 0.023	1.244MetThr: 1.244 ± 0.026	1.117MetVal: 1.117 ± 0.025	0.151MetTrp: 0.151 ± 0.008	0.23MetTyr: 0.23 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.706AsnAla: 2.706 ± 0.041	0.155AsnCys: 0.155 ± 0.009	1.197AsnAsp: 1.197 ± 0.038	0.971AsnGlu: 0.971 ± 0.024	0.548AsnPhe: 0.548 ± 0.017	2.239AsnGly: 2.239 ± 0.053	0.385AsnHis: 0.385 ± 0.014	0.586AsnIle: 0.586 ± 0.017	0.385AsnLys: 0.385 ± 0.016	1.894AsnLeu: 1.894 ± 0.031	0.251AsnMet: 0.251 ± 0.012	0.471AsnAsn: 0.471 ± 0.019	1.536AsnPro: 1.536 ± 0.032	0.555AsnGln: 0.555 ± 0.018	1.355AsnArg: 1.355 ± 0.023	0.81AsnSer: 0.81 ± 0.022	1.157AsnThr: 1.157 ± 0.034	1.798AsnVal: 1.798 ± 0.032	0.261AsnTrp: 0.261 ± 0.011	0.452AsnTyr: 0.452 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	8.05ProAla: 8.05 ± 0.091	0.332ProCys: 0.332 ± 0.013	4.069ProAsp: 4.069 ± 0.046	3.943ProGlu: 3.943 ± 0.046	1.742ProPhe: 1.742 ± 0.027	5.655ProGly: 5.655 ± 0.059	1.035ProHis: 1.035 ± 0.026	1.947ProIle: 1.947 ± 0.032	1.355ProLys: 1.355 ± 0.026	5.179ProLeu: 5.179 ± 0.049	0.874ProMet: 0.874 ± 0.021	1.144ProAsn: 1.144 ± 0.028	3.473ProPro: 3.473 ± 0.062	1.531ProGln: 1.531 ± 0.028	3.728ProArg: 3.728 ± 0.051	3.198ProSer: 3.198 ± 0.048	3.688ProThr: 3.688 ± 0.069	4.853ProVal: 4.853 ± 0.06	0.798ProTrp: 0.798 ± 0.022	1.12ProTyr: 1.12 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.827GlnAla: 3.827 ± 0.046	0.156GlnCys: 0.156 ± 0.009	1.325GlnAsp: 1.325 ± 0.029	1.277GlnGlu: 1.277 ± 0.028	0.735GlnPhe: 0.735 ± 0.019	2.046GlnGly: 2.046 ± 0.029	0.588GlnHis: 0.588 ± 0.018	1.145GlnIle: 1.145 ± 0.022	0.52GlnLys: 0.52 ± 0.016	3.143GlnLeu: 3.143 ± 0.043	0.439GlnMet: 0.439 ± 0.015	0.519GlnAsn: 0.519 ± 0.017	1.718GlnPro: 1.718 ± 0.032	1.022GlnGln: 1.022 ± 0.024	2.557GlnArg: 2.557 ± 0.037	1.248GlnSer: 1.248 ± 0.025	1.542GlnThr: 1.542 ± 0.03	2.192GlnVal: 2.192 ± 0.03	0.419GlnTrp: 0.419 ± 0.015	0.51GlnTyr: 0.51 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	10.618ArgAla: 10.618 ± 0.109	0.568ArgCys: 0.568 ± 0.019	4.418ArgAsp: 4.418 ± 0.058	5.065ArgGlu: 5.065 ± 0.067	2.693ArgPhe: 2.693 ± 0.035	5.937ArgGly: 5.937 ± 0.062	1.682ArgHis: 1.682 ± 0.032	3.138ArgIle: 3.138 ± 0.039	1.567ArgLys: 1.567 ± 0.032	8.309ArgLeu: 8.309 ± 0.082	1.653ArgMet: 1.653 ± 0.028	1.341ArgAsn: 1.341 ± 0.022	4.109ArgPro: 4.109 ± 0.053	1.913ArgGln: 1.913 ± 0.031	7.337ArgArg: 7.337 ± 0.103	3.841ArgSer: 3.841 ± 0.044	4.482ArgThr: 4.482 ± 0.053	6.535ArgVal: 6.535 ± 0.063	1.321ArgTrp: 1.321 ± 0.027	1.71ArgTyr: 1.71 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.708SerAla: 6.708 ± 0.067	0.39SerCys: 0.39 ± 0.016	2.7SerAsp: 2.7 ± 0.035	2.498SerGlu: 2.498 ± 0.036	1.671SerPhe: 1.671 ± 0.036	5.372SerGly: 5.372 ± 0.069	0.891SerHis: 0.891 ± 0.021	1.857SerIle: 1.857 ± 0.031	1.152SerLys: 1.152 ± 0.027	4.653SerLeu: 4.653 ± 0.05	0.964SerMet: 0.964 ± 0.02	1.025SerAsn: 1.025 ± 0.028	2.903SerPro: 2.903 ± 0.04	1.224SerGln: 1.224 ± 0.024	3.4SerArg: 3.4 ± 0.044	2.889SerSer: 2.889 ± 0.043	3.292SerThr: 3.292 ± 0.05	4.066SerVal: 4.066 ± 0.049	0.736SerTrp: 0.736 ± 0.02	1.055SerTyr: 1.055 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	8.247ThrAla: 8.247 ± 0.108	0.438ThrCys: 0.438 ± 0.017	3.236ThrAsp: 3.236 ± 0.052	2.69ThrGlu: 2.69 ± 0.041	2.268ThrPhe: 2.268 ± 0.052	6.04ThrGly: 6.04 ± 0.095	1.065ThrHis: 1.065 ± 0.022	2.573ThrIle: 2.573 ± 0.048	1.324ThrLys: 1.324 ± 0.027	6.525ThrLeu: 6.525 ± 0.08	0.901ThrMet: 0.901 ± 0.02	1.319ThrAsn: 1.319 ± 0.034	4.41ThrPro: 4.41 ± 0.073	1.474ThrGln: 1.474 ± 0.026	4.095ThrArg: 4.095 ± 0.048	3.213ThrSer: 3.213 ± 0.052	3.997ThrThr: 3.997 ± 0.081	5.823ThrVal: 5.823 ± 0.07	0.878ThrTrp: 0.878 ± 0.025	1.38ThrTyr: 1.38 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	12.084ValAla: 12.084 ± 0.088	0.665ValCys: 0.665 ± 0.016	5.302ValAsp: 5.302 ± 0.053	5.164ValGlu: 5.164 ± 0.054	2.425ValPhe: 2.425 ± 0.039	6.989ValGly: 6.989 ± 0.069	1.677ValHis: 1.677 ± 0.03	3.334ValIle: 3.334 ± 0.046	2.053ValLys: 2.053 ± 0.039	8.917ValLeu: 8.917 ± 0.086	1.255ValMet: 1.255 ± 0.026	1.856ValAsn: 1.856 ± 0.036	4.68ValPro: 4.68 ± 0.054	2.086ValGln: 2.086 ± 0.024	6.488ValArg: 6.488 ± 0.066	4.331ValSer: 4.331 ± 0.052	5.568ValThr: 5.568 ± 0.076	7.78ValVal: 7.78 ± 0.076	1.0ValTrp: 1.0 ± 0.024	1.539ValTyr: 1.539 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.498TrpAla: 1.498 ± 0.029	0.13TrpCys: 0.13 ± 0.008	0.779TrpAsp: 0.779 ± 0.019	0.645TrpGlu: 0.645 ± 0.016	0.468TrpPhe: 0.468 ± 0.016	0.943TrpGly: 0.943 ± 0.023	0.326TrpHis: 0.326 ± 0.013	0.589TrpIle: 0.589 ± 0.017	0.313TrpLys: 0.313 ± 0.014	1.637TrpLeu: 1.637 ± 0.031	0.271TrpMet: 0.271 ± 0.011	0.342TrpAsn: 0.342 ± 0.014	0.7TrpPro: 0.7 ± 0.02	0.461TrpGln: 0.461 ± 0.021	1.189TrpArg: 1.189 ± 0.023	0.793TrpSer: 0.793 ± 0.019	0.988TrpThr: 0.988 ± 0.027	1.032TrpVal: 1.032 ± 0.02	0.287TrpTrp: 0.287 ± 0.012	0.294TrpTyr: 0.294 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.582TyrAla: 2.582 ± 0.035	0.158TyrCys: 0.158 ± 0.008	1.387TyrAsp: 1.387 ± 0.03	1.229TyrGlu: 1.229 ± 0.02	0.634TyrPhe: 0.634 ± 0.019	1.95TyrGly: 1.95 ± 0.032	0.353TyrHis: 0.353 ± 0.013	0.52TyrIle: 0.52 ± 0.016	0.475TyrLys: 0.475 ± 0.018	1.789TyrLeu: 1.789 ± 0.033	0.247TyrMet: 0.247 ± 0.01	0.425TyrAsn: 0.425 ± 0.017	0.917TyrPro: 0.917 ± 0.022	0.499TyrGln: 0.499 ± 0.016	1.69TyrArg: 1.69 ± 0.031	0.993TyrSer: 0.993 ± 0.027	1.268TyrThr: 1.268 ± 0.033	1.683TyrVal: 1.683 ± 0.028	0.31TyrTrp: 0.31 ± 0.013	0.435TyrTyr: 0.435 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6590 proteins (2231201 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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