Amino acid dipepetide frequency for Streptomyces himastatinicus ATCC 53653

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.898AlaAla: 20.898 ± 0.135	1.13AlaCys: 1.13 ± 0.021	8.454AlaAsp: 8.454 ± 0.06	8.628AlaGlu: 8.628 ± 0.07	3.575AlaPhe: 3.575 ± 0.042	12.695AlaGly: 12.695 ± 0.079	2.961AlaHis: 2.961 ± 0.033	3.665AlaIle: 3.665 ± 0.037	2.677AlaLys: 2.677 ± 0.04	14.412AlaLeu: 14.412 ± 0.082	2.632AlaMet: 2.632 ± 0.029	1.843AlaAsn: 1.843 ± 0.027	7.255AlaPro: 7.255 ± 0.052	3.643AlaGln: 3.643 ± 0.04	10.523AlaArg: 10.523 ± 0.071	5.912AlaSer: 5.912 ± 0.046	7.2AlaThr: 7.2 ± 0.053	11.953AlaVal: 11.953 ± 0.085	1.878AlaTrp: 1.878 ± 0.026	2.721AlaTyr: 2.721 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	1.151CysAla: 1.151 ± 0.022	0.13CysCys: 0.13 ± 0.008	0.525CysAsp: 0.525 ± 0.011	0.415CysGlu: 0.415 ± 0.013	0.218CysPhe: 0.218 ± 0.009	1.017CysGly: 1.017 ± 0.022	0.216CysHis: 0.216 ± 0.01	0.144CysIle: 0.144 ± 0.008	0.12CysLys: 0.12 ± 0.007	0.727CysLeu: 0.727 ± 0.018	0.134CysMet: 0.134 ± 0.007	0.136CysAsn: 0.136 ± 0.007	0.534CysPro: 0.534 ± 0.016	0.186CysGln: 0.186 ± 0.008	0.727CysArg: 0.727 ± 0.016	0.508CysSer: 0.508 ± 0.015	0.498CysThr: 0.498 ± 0.013	0.688CysVal: 0.688 ± 0.017	0.143CysTrp: 0.143 ± 0.007	0.145CysTyr: 0.145 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.968AspAla: 7.968 ± 0.067	0.408AspCys: 0.408 ± 0.012	3.698AspAsp: 3.698 ± 0.043	3.823AspGlu: 3.823 ± 0.04	1.632AspPhe: 1.632 ± 0.022	6.501AspGly: 6.501 ± 0.057	1.542AspHis: 1.542 ± 0.025	1.95AspIle: 1.95 ± 0.027	1.131AspLys: 1.131 ± 0.026	6.004AspLeu: 6.004 ± 0.049	0.834AspMet: 0.834 ± 0.016	0.926AspAsn: 0.926 ± 0.021	4.474AspPro: 4.474 ± 0.039	1.649AspGln: 1.649 ± 0.024	5.067AspArg: 5.067 ± 0.043	2.404AspSer: 2.404 ± 0.033	3.318AspThr: 3.318 ± 0.04	4.466AspVal: 4.466 ± 0.04	1.045AspTrp: 1.045 ± 0.022	1.174AspTyr: 1.174 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	7.227GluAla: 7.227 ± 0.059	0.402GluCys: 0.402 ± 0.013	2.84GluAsp: 2.84 ± 0.032	3.39GluGlu: 3.39 ± 0.045	1.413GluPhe: 1.413 ± 0.02	4.333GluGly: 4.333 ± 0.042	1.53GluHis: 1.53 ± 0.024	2.095GluIle: 2.095 ± 0.03	1.337GluLys: 1.337 ± 0.026	6.638GluLeu: 6.638 ± 0.054	0.856GluMet: 0.856 ± 0.019	0.94GluAsn: 0.94 ± 0.017	3.422GluPro: 3.422 ± 0.034	2.125GluGln: 2.125 ± 0.041	5.631GluArg: 5.631 ± 0.048	2.439GluSer: 2.439 ± 0.03	2.845GluThr: 2.845 ± 0.028	4.395GluVal: 4.395 ± 0.049	0.766GluTrp: 0.766 ± 0.017	1.007GluTyr: 1.007 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.644PheAla: 3.644 ± 0.037	0.247PheCys: 0.247 ± 0.009	1.951PheAsp: 1.951 ± 0.029	1.363PheGlu: 1.363 ± 0.023	0.876PhePhe: 0.876 ± 0.019	3.009PheGly: 3.009 ± 0.031	0.625PheHis: 0.625 ± 0.016	0.788PheIle: 0.788 ± 0.015	0.482PheLys: 0.482 ± 0.013	2.57PheLeu: 2.57 ± 0.034	0.399PheMet: 0.399 ± 0.012	0.544PheAsn: 0.544 ± 0.013	1.434PhePro: 1.434 ± 0.026	0.721PheGln: 0.721 ± 0.017	1.848PheArg: 1.848 ± 0.028	1.505PheSer: 1.505 ± 0.027	2.007PheThr: 2.007 ± 0.028	2.111PheVal: 2.111 ± 0.029	0.417PheTrp: 0.417 ± 0.012	0.551PheTyr: 0.551 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.376GlyAla: 11.376 ± 0.075	0.922GlyCys: 0.922 ± 0.018	5.223GlyAsp: 5.223 ± 0.046	5.145GlyGlu: 5.145 ± 0.039	2.82GlyPhe: 2.82 ± 0.03	9.287GlyGly: 9.287 ± 0.073	2.595GlyHis: 2.595 ± 0.033	3.461GlyIle: 3.461 ± 0.039	2.403GlyLys: 2.403 ± 0.033	9.413GlyLeu: 9.413 ± 0.06	2.161GlyMet: 2.161 ± 0.025	1.702GlyAsn: 1.702 ± 0.029	5.55GlyPro: 5.55 ± 0.048	2.745GlyGln: 2.745 ± 0.035	8.382GlyArg: 8.382 ± 0.07	5.356GlySer: 5.356 ± 0.047	6.279GlyThr: 6.279 ± 0.054	7.554GlyVal: 7.554 ± 0.066	1.721GlyTrp: 1.721 ± 0.026	2.254GlyTyr: 2.254 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	2.763HisAla: 2.763 ± 0.031	0.226HisCys: 0.226 ± 0.009	1.404HisAsp: 1.404 ± 0.021	1.186HisGlu: 1.186 ± 0.022	0.628HisPhe: 0.628 ± 0.019	2.554HisGly: 2.554 ± 0.031	0.805HisHis: 0.805 ± 0.02	0.749HisIle: 0.749 ± 0.017	0.339HisLys: 0.339 ± 0.011	2.456HisLeu: 2.456 ± 0.032	0.348HisMet: 0.348 ± 0.011	0.359HisAsn: 0.359 ± 0.011	2.081HisPro: 2.081 ± 0.027	0.712HisGln: 0.712 ± 0.015	2.436HisArg: 2.436 ± 0.038	1.068HisSer: 1.068 ± 0.018	1.455HisThr: 1.455 ± 0.021	1.661HisVal: 1.661 ± 0.027	0.38HisTrp: 0.38 ± 0.012	0.496HisTyr: 0.496 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.9IleAla: 4.9 ± 0.039	0.316IleCys: 0.316 ± 0.009	2.252IleAsp: 2.252 ± 0.034	1.99IleGlu: 1.99 ± 0.033	0.712IlePhe: 0.712 ± 0.019	3.631IleGly: 3.631 ± 0.035	0.623IleHis: 0.623 ± 0.015	0.86IleIle: 0.86 ± 0.018	0.756IleLys: 0.756 ± 0.021	2.351IleLeu: 2.351 ± 0.032	0.463IleMet: 0.463 ± 0.012	0.695IleAsn: 0.695 ± 0.016	1.797IlePro: 1.797 ± 0.025	0.715IleGln: 0.715 ± 0.016	2.354IleArg: 2.354 ± 0.028	1.733IleSer: 1.733 ± 0.023	2.298IleThr: 2.298 ± 0.029	2.674IleVal: 2.674 ± 0.034	0.377IleTrp: 0.377 ± 0.01	0.541IleTyr: 0.541 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.761LysAla: 2.761 ± 0.045	0.119LysCys: 0.119 ± 0.007	1.242LysAsp: 1.242 ± 0.022	1.098LysGlu: 1.098 ± 0.022	0.42LysPhe: 0.42 ± 0.014	1.807LysGly: 1.807 ± 0.029	0.421LysHis: 0.421 ± 0.013	0.793LysIle: 0.793 ± 0.019	0.865LysLys: 0.865 ± 0.026	1.918LysLeu: 1.918 ± 0.03	0.363LysMet: 0.363 ± 0.011	0.546LysAsn: 0.546 ± 0.017	1.322LysPro: 1.322 ± 0.023	0.634LysGln: 0.634 ± 0.022	1.493LysArg: 1.493 ± 0.025	1.146LysSer: 1.146 ± 0.022	1.269LysThr: 1.269 ± 0.026	1.76LysVal: 1.76 ± 0.027	0.266LysTrp: 0.266 ± 0.011	0.394LysTyr: 0.394 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	14.554LeuAla: 14.554 ± 0.081	0.847LeuCys: 0.847 ± 0.017	6.687LeuAsp: 6.687 ± 0.062	4.603LeuGlu: 4.603 ± 0.049	2.638LeuPhe: 2.638 ± 0.037	9.236LeuGly: 9.236 ± 0.061	2.377LeuHis: 2.377 ± 0.027	3.407LeuIle: 3.407 ± 0.034	1.864LeuLys: 1.864 ± 0.026	10.96LeuLeu: 10.96 ± 0.085	1.73LeuMet: 1.73 ± 0.025	1.602LeuAsn: 1.602 ± 0.024	6.532LeuPro: 6.532 ± 0.059	1.984LeuGln: 1.984 ± 0.028	9.011LeuArg: 9.011 ± 0.063	5.503LeuSer: 5.503 ± 0.049	6.909LeuThr: 6.909 ± 0.052	8.322LeuVal: 8.322 ± 0.064	1.266LeuTrp: 1.266 ± 0.024	1.82LeuTyr: 1.82 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.443MetAla: 2.443 ± 0.029	0.152MetCys: 0.152 ± 0.008	0.956MetAsp: 0.956 ± 0.019	0.774MetGlu: 0.774 ± 0.017	0.446MetPhe: 0.446 ± 0.011	1.428MetGly: 1.428 ± 0.022	0.35MetHis: 0.35 ± 0.01	0.649MetIle: 0.649 ± 0.016	0.412MetLys: 0.412 ± 0.012	1.727MetLeu: 1.727 ± 0.028	0.327MetMet: 0.327 ± 0.011	0.426MetAsn: 0.426 ± 0.012	1.146MetPro: 1.146 ± 0.021	0.428MetGln: 0.428 ± 0.014	1.563MetArg: 1.563 ± 0.025	1.324MetSer: 1.324 ± 0.023	1.518MetThr: 1.518 ± 0.022	1.41MetVal: 1.41 ± 0.022	0.246MetTrp: 0.246 ± 0.008	0.333MetTyr: 0.333 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.181AsnAla: 2.181 ± 0.028	0.157AsnCys: 0.157 ± 0.009	0.921AsnAsp: 0.921 ± 0.021	0.781AsnGlu: 0.781 ± 0.018	0.477AsnPhe: 0.477 ± 0.013	1.909AsnGly: 1.909 ± 0.032	0.389AsnHis: 0.389 ± 0.012	0.639AsnIle: 0.639 ± 0.015	0.391AsnLys: 0.391 ± 0.014	1.622AsnLeu: 1.622 ± 0.028	0.28AsnMet: 0.28 ± 0.01	0.414AsnAsn: 0.414 ± 0.014	1.354AsnPro: 1.354 ± 0.019	0.532AsnGln: 0.532 ± 0.013	1.264AsnArg: 1.264 ± 0.021	0.883AsnSer: 0.883 ± 0.019	1.116AsnThr: 1.116 ± 0.022	1.27AsnVal: 1.27 ± 0.024	0.274AsnTrp: 0.274 ± 0.01	0.425AsnTyr: 0.425 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	8.343ProAla: 8.343 ± 0.061	0.387ProCys: 0.387 ± 0.012	4.686ProAsp: 4.686 ± 0.044	4.332ProGlu: 4.332 ± 0.042	1.497ProPhe: 1.497 ± 0.02	7.122ProGly: 7.122 ± 0.054	1.53ProHis: 1.53 ± 0.024	1.39ProIle: 1.39 ± 0.02	1.178ProLys: 1.178 ± 0.023	5.569ProLeu: 5.569 ± 0.057	1.107ProMet: 1.107 ± 0.018	0.927ProAsn: 0.927 ± 0.02	3.885ProPro: 3.885 ± 0.052	1.74ProGln: 1.74 ± 0.029	4.584ProArg: 4.584 ± 0.046	3.358ProSer: 3.358 ± 0.037	3.27ProThr: 3.27 ± 0.042	5.344ProVal: 5.344 ± 0.046	0.968ProTrp: 0.968 ± 0.018	1.385ProTyr: 1.385 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.674GlnAla: 3.674 ± 0.04	0.171GlnCys: 0.171 ± 0.008	1.401GlnAsp: 1.401 ± 0.025	1.397GlnGlu: 1.397 ± 0.028	0.677GlnPhe: 0.677 ± 0.016	2.353GlnGly: 2.353 ± 0.033	0.677GlnHis: 0.677 ± 0.015	1.051GlnIle: 1.051 ± 0.018	0.582GlnLys: 0.582 ± 0.019	2.996GlnLeu: 2.996 ± 0.034	0.497GlnMet: 0.497 ± 0.015	0.482GlnAsn: 0.482 ± 0.012	1.75GlnPro: 1.75 ± 0.03	1.3GlnGln: 1.3 ± 0.03	2.563GlnArg: 2.563 ± 0.033	1.256GlnSer: 1.256 ± 0.019	1.336GlnThr: 1.336 ± 0.021	2.216GlnVal: 2.216 ± 0.032	0.472GlnTrp: 0.472 ± 0.013	0.532GlnTyr: 0.532 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	10.164ArgAla: 10.164 ± 0.075	0.75ArgCys: 0.75 ± 0.016	4.435ArgAsp: 4.435 ± 0.042	4.776ArgGlu: 4.776 ± 0.041	2.365ArgPhe: 2.365 ± 0.026	6.599ArgGly: 6.599 ± 0.062	2.466ArgHis: 2.466 ± 0.035	3.269ArgIle: 3.269 ± 0.035	1.667ArgLys: 1.667 ± 0.025	9.04ArgLeu: 9.04 ± 0.069	1.856ArgMet: 1.856 ± 0.024	1.405ArgAsn: 1.405 ± 0.021	5.57ArgPro: 5.57 ± 0.053	2.481ArgGln: 2.481 ± 0.029	8.564ArgArg: 8.564 ± 0.08	4.189ArgSer: 4.189 ± 0.038	5.59ArgThr: 5.59 ± 0.045	5.771ArgVal: 5.771 ± 0.047	1.432ArgTrp: 1.432 ± 0.019	1.865ArgTyr: 1.865 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.805SerAla: 6.805 ± 0.055	0.468SerCys: 0.468 ± 0.013	2.696SerAsp: 2.696 ± 0.032	2.324SerGlu: 2.324 ± 0.031	1.548SerPhe: 1.548 ± 0.024	6.241SerGly: 6.241 ± 0.049	1.081SerHis: 1.081 ± 0.019	1.471SerIle: 1.471 ± 0.021	1.004SerLys: 1.004 ± 0.021	4.781SerLeu: 4.781 ± 0.04	1.069SerMet: 1.069 ± 0.021	0.89SerAsn: 0.89 ± 0.019	3.344SerPro: 3.344 ± 0.038	1.269SerGln: 1.269 ± 0.023	3.848SerArg: 3.848 ± 0.036	3.041SerSer: 3.041 ± 0.04	2.944SerThr: 2.944 ± 0.036	4.123SerVal: 4.123 ± 0.042	0.941SerTrp: 0.941 ± 0.019	1.213SerTyr: 1.213 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	8.962ThrAla: 8.962 ± 0.053	0.42ThrCys: 0.42 ± 0.013	3.528ThrAsp: 3.528 ± 0.035	3.154ThrGlu: 3.154 ± 0.03	1.609ThrPhe: 1.609 ± 0.026	6.939ThrGly: 6.939 ± 0.055	1.256ThrHis: 1.256 ± 0.025	1.716ThrIle: 1.716 ± 0.027	1.123ThrLys: 1.123 ± 0.023	5.679ThrLeu: 5.679 ± 0.049	1.005ThrMet: 1.005 ± 0.021	1.012ThrAsn: 1.012 ± 0.02	4.193ThrPro: 4.193 ± 0.042	1.326ThrGln: 1.326 ± 0.02	3.997ThrArg: 3.997 ± 0.042	3.195ThrSer: 3.195 ± 0.034	3.811ThrThr: 3.811 ± 0.042	5.993ThrVal: 5.993 ± 0.052	0.886ThrTrp: 0.886 ± 0.019	1.363ThrTyr: 1.363 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	10.461ValAla: 10.461 ± 0.072	0.769ValCys: 0.769 ± 0.017	4.802ValAsp: 4.802 ± 0.043	4.515ValGlu: 4.515 ± 0.045	2.438ValPhe: 2.438 ± 0.031	6.284ValGly: 6.284 ± 0.051	1.886ValHis: 1.886 ± 0.024	2.937ValIle: 2.937 ± 0.037	1.571ValLys: 1.571 ± 0.022	9.143ValLeu: 9.143 ± 0.068	1.455ValMet: 1.455 ± 0.024	1.623ValAsn: 1.623 ± 0.023	5.03ValPro: 5.03 ± 0.046	1.979ValGln: 1.979 ± 0.026	7.12ValArg: 7.12 ± 0.055	4.394ValSer: 4.394 ± 0.041	5.351ValThr: 5.351 ± 0.05	7.356ValVal: 7.356 ± 0.065	1.125ValTrp: 1.125 ± 0.021	1.435ValTyr: 1.435 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.652TrpAla: 1.652 ± 0.023	0.167TrpCys: 0.167 ± 0.006	0.841TrpAsp: 0.841 ± 0.018	0.741TrpGlu: 0.741 ± 0.016	0.493TrpPhe: 0.493 ± 0.014	1.167TrpGly: 1.167 ± 0.018	0.371TrpHis: 0.371 ± 0.011	0.519TrpIle: 0.519 ± 0.014	0.377TrpLys: 0.377 ± 0.012	1.78TrpLeu: 1.78 ± 0.024	0.294TrpMet: 0.294 ± 0.01	0.4TrpAsn: 0.4 ± 0.01	0.829TrpPro: 0.829 ± 0.017	0.61TrpGln: 0.61 ± 0.017	1.432TrpArg: 1.432 ± 0.024	0.966TrpSer: 0.966 ± 0.018	1.004TrpThr: 1.004 ± 0.02	0.971TrpVal: 0.971 ± 0.018	0.315TrpTrp: 0.315 ± 0.011	0.356TrpTyr: 0.356 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.729TyrAla: 2.729 ± 0.035	0.175TyrCys: 0.175 ± 0.008	1.471TyrAsp: 1.471 ± 0.022	1.196TyrGlu: 1.196 ± 0.021	0.61TyrPhe: 0.61 ± 0.017	2.237TyrGly: 2.237 ± 0.026	0.404TyrHis: 0.404 ± 0.012	0.483TyrIle: 0.483 ± 0.013	0.358TyrLys: 0.358 ± 0.013	2.065TyrLeu: 2.065 ± 0.027	0.247TyrMet: 0.247 ± 0.009	0.409TyrAsn: 0.409 ± 0.015	1.103TyrPro: 1.103 ± 0.018	0.602TyrGln: 0.602 ± 0.016	1.848TyrArg: 1.848 ± 0.033	0.92TyrSer: 0.92 ± 0.019	1.148TyrThr: 1.148 ± 0.021	1.634TyrVal: 1.634 ± 0.026	0.37TyrTrp: 0.37 ± 0.011	0.45TyrTyr: 0.45 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9177 proteins (3045779 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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