Amino acid dipepetide frequency for Aspergillus terreus (strain NIH 2624 / FGSC A1156)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.285AlaAla: 9.285 ± 0.078	1.141AlaCys: 1.141 ± 0.018	4.524AlaAsp: 4.524 ± 0.032	5.218AlaGlu: 5.218 ± 0.046	3.225AlaPhe: 3.225 ± 0.03	5.988AlaGly: 5.988 ± 0.036	1.913AlaHis: 1.913 ± 0.02	4.213AlaIle: 4.213 ± 0.033	3.725AlaLys: 3.725 ± 0.025	8.031AlaLeu: 8.031 ± 0.046	2.052AlaMet: 2.052 ± 0.022	2.875AlaAsn: 2.875 ± 0.028	4.891AlaPro: 4.891 ± 0.047	3.428AlaGln: 3.428 ± 0.03	5.18AlaArg: 5.18 ± 0.035	7.232AlaSer: 7.232 ± 0.037	5.219AlaThr: 5.219 ± 0.035	5.73AlaVal: 5.73 ± 0.041	1.189AlaTrp: 1.189 ± 0.017	2.323AlaTyr: 2.323 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.031CysAla: 1.031 ± 0.014	0.267CysCys: 0.267 ± 0.008	0.699CysAsp: 0.699 ± 0.013	0.61CysGlu: 0.61 ± 0.011	0.551CysPhe: 0.551 ± 0.012	0.987CysGly: 0.987 ± 0.014	0.365CysHis: 0.365 ± 0.008	0.717CysIle: 0.717 ± 0.012	0.464CysLys: 0.464 ± 0.01	1.391CysLeu: 1.391 ± 0.021	0.284CysMet: 0.284 ± 0.008	0.423CysAsn: 0.423 ± 0.008	0.697CysPro: 0.697 ± 0.012	0.465CysGln: 0.465 ± 0.01	0.817CysArg: 0.817 ± 0.014	0.954CysSer: 0.954 ± 0.015	0.715CysThr: 0.715 ± 0.012	0.886CysVal: 0.886 ± 0.014	0.217CysTrp: 0.217 ± 0.007	0.381CysTyr: 0.381 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.977AspAla: 4.977 ± 0.036	0.664AspCys: 0.664 ± 0.011	4.053AspAsp: 4.053 ± 0.038	4.29AspGlu: 4.29 ± 0.042	2.149AspPhe: 2.149 ± 0.021	4.131AspGly: 4.131 ± 0.034	1.315AspHis: 1.315 ± 0.017	3.073AspIle: 3.073 ± 0.025	2.144AspLys: 2.144 ± 0.021	5.232AspLeu: 5.232 ± 0.036	1.278AspMet: 1.278 ± 0.017	1.823AspAsn: 1.823 ± 0.02	3.557AspPro: 3.557 ± 0.025	1.959AspGln: 1.959 ± 0.02	3.218AspArg: 3.218 ± 0.029	4.067AspSer: 4.067 ± 0.034	2.992AspThr: 2.992 ± 0.026	3.77AspVal: 3.77 ± 0.03	0.898AspTrp: 0.898 ± 0.014	1.676AspTyr: 1.676 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.227GluAla: 5.227 ± 0.042	0.628GluCys: 0.628 ± 0.011	3.986GluAsp: 3.986 ± 0.034	5.167GluGlu: 5.167 ± 0.052	1.932GluPhe: 1.932 ± 0.018	3.617GluGly: 3.617 ± 0.029	1.419GluHis: 1.419 ± 0.017	2.963GluIle: 2.963 ± 0.024	3.468GluLys: 3.468 ± 0.033	5.145GluLeu: 5.145 ± 0.04	1.449GluMet: 1.449 ± 0.017	2.175GluAsn: 2.175 ± 0.021	2.829GluPro: 2.829 ± 0.034	2.42GluGln: 2.42 ± 0.025	3.983GluArg: 3.983 ± 0.036	4.27GluSer: 4.27 ± 0.037	3.508GluThr: 3.508 ± 0.03	3.443GluVal: 3.443 ± 0.03	0.873GluTrp: 0.873 ± 0.013	1.737GluTyr: 1.737 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.098PheAla: 3.098 ± 0.028	0.6PheCys: 0.6 ± 0.01	2.296PheAsp: 2.296 ± 0.021	2.024PheGlu: 2.024 ± 0.021	1.676PhePhe: 1.676 ± 0.024	2.885PheGly: 2.885 ± 0.028	0.976PheHis: 0.976 ± 0.015	1.796PheIle: 1.796 ± 0.023	1.34PheLys: 1.34 ± 0.02	3.648PheLeu: 3.648 ± 0.033	0.788PheMet: 0.788 ± 0.012	1.38PheAsn: 1.38 ± 0.019	2.028PhePro: 2.028 ± 0.02	1.421PheGln: 1.421 ± 0.018	2.069PheArg: 2.069 ± 0.02	2.931PheSer: 2.931 ± 0.023	2.13PheThr: 2.13 ± 0.022	2.476PheVal: 2.476 ± 0.023	0.658PheTrp: 0.658 ± 0.012	1.195PheTyr: 1.195 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.543GlyAla: 5.543 ± 0.038	0.949GlyCys: 0.949 ± 0.015	3.676GlyAsp: 3.676 ± 0.029	3.577GlyGlu: 3.577 ± 0.03	2.85GlyPhe: 2.85 ± 0.026	5.555GlyGly: 5.555 ± 0.053	1.743GlyHis: 1.743 ± 0.02	3.485GlyIle: 3.485 ± 0.032	3.149GlyLys: 3.149 ± 0.029	6.262GlyLeu: 6.262 ± 0.046	1.602GlyMet: 1.602 ± 0.019	2.351GlyAsn: 2.351 ± 0.021	3.516GlyPro: 3.516 ± 0.027	2.538GlyGln: 2.538 ± 0.024	4.201GlyArg: 4.201 ± 0.028	5.626GlySer: 5.626 ± 0.047	3.915GlyThr: 3.915 ± 0.034	4.616GlyVal: 4.616 ± 0.04	1.196GlyTrp: 1.196 ± 0.017	2.197GlyTyr: 2.197 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	2.035HisAla: 2.035 ± 0.023	0.345HisCys: 0.345 ± 0.009	1.376HisAsp: 1.376 ± 0.017	1.333HisGlu: 1.333 ± 0.017	0.925HisPhe: 0.925 ± 0.013	1.833HisGly: 1.833 ± 0.021	0.912HisHis: 0.912 ± 0.018	1.245HisIle: 1.245 ± 0.016	0.839HisLys: 0.839 ± 0.013	2.379HisLeu: 2.379 ± 0.026	0.52HisMet: 0.52 ± 0.01	0.792HisAsn: 0.792 ± 0.014	1.826HisPro: 1.826 ± 0.022	0.997HisGln: 0.997 ± 0.015	1.671HisArg: 1.671 ± 0.022	1.851HisSer: 1.851 ± 0.019	1.287HisThr: 1.287 ± 0.018	1.509HisVal: 1.509 ± 0.02	0.378HisTrp: 0.378 ± 0.008	0.713HisTyr: 0.713 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.207IleAla: 4.207 ± 0.032	0.791IleCys: 0.791 ± 0.014	2.799IleAsp: 2.799 ± 0.022	2.712IleGlu: 2.712 ± 0.026	1.994IlePhe: 1.994 ± 0.026	3.188IleGly: 3.188 ± 0.031	1.251IleHis: 1.251 ± 0.016	2.417IleIle: 2.417 ± 0.029	1.905IleLys: 1.905 ± 0.021	4.58IleLeu: 4.58 ± 0.033	1.001IleMet: 1.001 ± 0.013	1.687IleAsn: 1.687 ± 0.02	3.133IlePro: 3.133 ± 0.021	1.923IleGln: 1.923 ± 0.021	2.844IleArg: 2.844 ± 0.026	3.67IleSer: 3.67 ± 0.031	2.697IleThr: 2.697 ± 0.027	3.225IleVal: 3.225 ± 0.03	0.705IleTrp: 0.705 ± 0.012	1.48IleTyr: 1.48 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.873LysAla: 3.873 ± 0.034	0.464LysCys: 0.464 ± 0.01	2.557LysAsp: 2.557 ± 0.025	3.062LysGlu: 3.062 ± 0.033	1.323LysPhe: 1.323 ± 0.015	2.714LysGly: 2.714 ± 0.027	1.051LysHis: 1.051 ± 0.015	2.08LysIle: 2.08 ± 0.022	2.885LysLys: 2.885 ± 0.041	3.755LysLeu: 3.755 ± 0.031	0.913LysMet: 0.913 ± 0.011	1.588LysAsn: 1.588 ± 0.019	2.559LysPro: 2.559 ± 0.031	1.736LysGln: 1.736 ± 0.02	3.205LysArg: 3.205 ± 0.035	3.157LysSer: 3.157 ± 0.03	2.651LysThr: 2.651 ± 0.026	2.586LysVal: 2.586 ± 0.025	0.627LysTrp: 0.627 ± 0.011	1.356LysTyr: 1.356 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	8.053LeuAla: 8.053 ± 0.051	1.303LeuCys: 1.303 ± 0.018	5.314LeuAsp: 5.314 ± 0.033	5.454LeuGlu: 5.454 ± 0.04	3.462LeuPhe: 3.462 ± 0.028	6.11LeuGly: 6.11 ± 0.038	2.403LeuHis: 2.403 ± 0.028	3.936LeuIle: 3.936 ± 0.032	3.868LeuLys: 3.868 ± 0.031	8.786LeuLeu: 8.786 ± 0.072	1.857LeuMet: 1.857 ± 0.02	3.125LeuAsn: 3.125 ± 0.025	5.606LeuPro: 5.606 ± 0.038	3.941LeuGln: 3.941 ± 0.028	6.096LeuArg: 6.096 ± 0.036	7.511LeuSer: 7.511 ± 0.048	4.86LeuThr: 4.86 ± 0.036	5.701LeuVal: 5.701 ± 0.041	1.256LeuTrp: 1.256 ± 0.018	2.544LeuTyr: 2.544 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.22MetAla: 2.22 ± 0.022	0.263MetCys: 0.263 ± 0.008	1.322MetAsp: 1.322 ± 0.016	1.321MetGlu: 1.321 ± 0.014	0.754MetPhe: 0.754 ± 0.012	1.52MetGly: 1.52 ± 0.02	0.503MetHis: 0.503 ± 0.01	0.986MetIle: 0.986 ± 0.015	0.973MetLys: 0.973 ± 0.015	1.875MetLeu: 1.875 ± 0.02	0.549MetMet: 0.549 ± 0.011	0.783MetAsn: 0.783 ± 0.013	1.217MetPro: 1.217 ± 0.018	0.857MetGln: 0.857 ± 0.013	1.296MetArg: 1.296 ± 0.016	1.821MetSer: 1.821 ± 0.02	1.318MetThr: 1.318 ± 0.017	1.433MetVal: 1.433 ± 0.016	0.269MetTrp: 0.269 ± 0.007	0.547MetTyr: 0.547 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.126AsnAla: 3.126 ± 0.025	0.434AsnCys: 0.434 ± 0.009	1.839AsnAsp: 1.839 ± 0.019	1.917AsnGlu: 1.917 ± 0.02	1.288AsnPhe: 1.288 ± 0.017	2.745AsnGly: 2.745 ± 0.025	0.804AsnHis: 0.804 ± 0.012	1.946AsnIle: 1.946 ± 0.018	1.397AsnLys: 1.397 ± 0.019	3.18AsnLeu: 3.18 ± 0.026	0.794AsnMet: 0.794 ± 0.011	1.336AsnAsn: 1.336 ± 0.02	2.492AsnPro: 2.492 ± 0.024	1.253AsnGln: 1.253 ± 0.016	1.923AsnArg: 1.923 ± 0.02	2.446AsnSer: 2.446 ± 0.024	2.04AsnThr: 2.04 ± 0.019	2.309AsnVal: 2.309 ± 0.024	0.537AsnTrp: 0.537 ± 0.01	1.051AsnTyr: 1.051 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.438ProAla: 5.438 ± 0.047	0.588ProCys: 0.588 ± 0.012	3.468ProAsp: 3.468 ± 0.027	3.879ProGlu: 3.879 ± 0.035	2.143ProPhe: 2.143 ± 0.021	4.057ProGly: 4.057 ± 0.034	1.409ProHis: 1.409 ± 0.016	2.457ProIle: 2.457 ± 0.022	2.466ProLys: 2.466 ± 0.027	4.856ProLeu: 4.856 ± 0.037	1.115ProMet: 1.115 ± 0.015	2.149ProAsn: 2.149 ± 0.025	5.063ProPro: 5.063 ± 0.07	2.448ProGln: 2.448 ± 0.027	3.637ProArg: 3.637 ± 0.031	6.166ProSer: 6.166 ± 0.05	3.959ProThr: 3.959 ± 0.035	3.853ProVal: 3.853 ± 0.029	0.825ProTrp: 0.825 ± 0.012	1.604ProTyr: 1.604 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.378GlnAla: 3.378 ± 0.029	0.466GlnCys: 0.466 ± 0.011	2.058GlnAsp: 2.058 ± 0.02	2.342GlnGlu: 2.342 ± 0.022	1.305GlnPhe: 1.305 ± 0.018	2.386GlnGly: 2.386 ± 0.022	1.076GlnHis: 1.076 ± 0.016	1.871GlnIle: 1.871 ± 0.018	1.916GlnLys: 1.916 ± 0.021	3.521GlnLeu: 3.521 ± 0.031	0.938GlnMet: 0.938 ± 0.014	1.479GlnAsn: 1.479 ± 0.017	2.541GlnPro: 2.541 ± 0.031	2.188GlnGln: 2.188 ± 0.038	2.737GlnArg: 2.737 ± 0.027	3.122GlnSer: 3.122 ± 0.029	2.361GlnThr: 2.361 ± 0.023	2.189GlnVal: 2.189 ± 0.02	0.622GlnTrp: 0.622 ± 0.01	1.194GlnTyr: 1.194 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.958ArgAla: 4.958 ± 0.035	0.772ArgCys: 0.772 ± 0.014	3.484ArgAsp: 3.484 ± 0.03	3.917ArgGlu: 3.917 ± 0.036	2.276ArgPhe: 2.276 ± 0.022	3.803ArgGly: 3.803 ± 0.029	1.646ArgHis: 1.646 ± 0.019	2.932ArgIle: 2.932 ± 0.027	3.28ArgLys: 3.28 ± 0.032	5.871ArgLeu: 5.871 ± 0.038	1.384ArgMet: 1.384 ± 0.018	2.214ArgAsn: 2.214 ± 0.021	3.701ArgPro: 3.701 ± 0.034	2.659ArgGln: 2.659 ± 0.026	5.399ArgArg: 5.399 ± 0.047	4.827ArgSer: 4.827 ± 0.043	3.394ArgThr: 3.394 ± 0.027	3.657ArgVal: 3.657 ± 0.028	1.002ArgTrp: 1.002 ± 0.015	1.771ArgTyr: 1.771 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.696SerAla: 6.696 ± 0.04	0.92SerCys: 0.92 ± 0.013	4.272SerAsp: 4.272 ± 0.03	4.049SerGlu: 4.049 ± 0.037	2.997SerPhe: 2.997 ± 0.024	5.525SerGly: 5.525 ± 0.042	1.977SerHis: 1.977 ± 0.021	3.842SerIle: 3.842 ± 0.032	3.415SerLys: 3.415 ± 0.033	7.347SerLeu: 7.347 ± 0.042	1.716SerMet: 1.716 ± 0.018	2.768SerAsn: 2.768 ± 0.026	5.51SerPro: 5.51 ± 0.05	3.239SerGln: 3.239 ± 0.03	5.054SerArg: 5.054 ± 0.045	8.328SerSer: 8.328 ± 0.066	5.396SerThr: 5.396 ± 0.038	4.726SerVal: 4.726 ± 0.035	1.173SerTrp: 1.173 ± 0.017	2.097SerTyr: 2.097 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.317ThrAla: 5.317 ± 0.037	0.769ThrCys: 0.769 ± 0.013	2.967ThrAsp: 2.967 ± 0.028	3.079ThrGlu: 3.079 ± 0.028	2.19ThrPhe: 2.19 ± 0.023	4.272ThrGly: 4.272 ± 0.032	1.302ThrHis: 1.302 ± 0.018	2.982ThrIle: 2.982 ± 0.023	2.371ThrLys: 2.371 ± 0.021	5.236ThrLeu: 5.236 ± 0.036	1.191ThrMet: 1.191 ± 0.014	1.939ThrAsn: 1.939 ± 0.021	4.391ThrPro: 4.391 ± 0.038	2.025ThrGln: 2.025 ± 0.021	3.142ThrArg: 3.142 ± 0.025	5.04ThrSer: 5.04 ± 0.04	4.215ThrThr: 4.215 ± 0.041	3.951ThrVal: 3.951 ± 0.033	0.882ThrTrp: 0.882 ± 0.014	1.625ThrTyr: 1.625 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.402ValAla: 5.402 ± 0.043	0.902ValCys: 0.902 ± 0.016	3.984ValAsp: 3.984 ± 0.028	3.835ValGlu: 3.835 ± 0.032	2.585ValPhe: 2.585 ± 0.027	4.152ValGly: 4.152 ± 0.039	1.558ValHis: 1.558 ± 0.015	3.015ValIle: 3.015 ± 0.03	2.678ValLys: 2.678 ± 0.027	5.887ValLeu: 5.887 ± 0.039	1.352ValMet: 1.352 ± 0.013	2.214ValAsn: 2.214 ± 0.023	3.788ValPro: 3.788 ± 0.031	2.492ValGln: 2.492 ± 0.02	3.7ValArg: 3.7 ± 0.025	4.868ValSer: 4.868 ± 0.032	3.534ValThr: 3.534 ± 0.032	4.49ValVal: 4.49 ± 0.036	0.916ValTrp: 0.916 ± 0.016	1.904ValTyr: 1.904 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.203TrpAla: 1.203 ± 0.017	0.209TrpCys: 0.209 ± 0.006	0.916TrpAsp: 0.916 ± 0.015	0.876TrpGlu: 0.876 ± 0.015	0.551TrpPhe: 0.551 ± 0.011	0.945TrpGly: 0.945 ± 0.015	0.362TrpHis: 0.362 ± 0.009	0.789TrpIle: 0.789 ± 0.015	0.797TrpLys: 0.797 ± 0.012	1.365TrpLeu: 1.365 ± 0.019	0.395TrpMet: 0.395 ± 0.009	0.638TrpAsn: 0.638 ± 0.011	0.62TrpPro: 0.62 ± 0.013	0.567TrpGln: 0.567 ± 0.011	1.015TrpArg: 1.015 ± 0.014	1.079TrpSer: 1.079 ± 0.015	0.981TrpThr: 0.981 ± 0.014	0.938TrpVal: 0.938 ± 0.014	0.283TrpTrp: 0.283 ± 0.007	0.456TrpTyr: 0.456 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.314TyrAla: 2.314 ± 0.021	0.446TyrCys: 0.446 ± 0.011	1.676TyrAsp: 1.676 ± 0.019	1.576TyrGlu: 1.576 ± 0.02	1.237TyrPhe: 1.237 ± 0.016	2.132TyrGly: 2.132 ± 0.023	0.779TyrHis: 0.779 ± 0.013	1.467TyrIle: 1.467 ± 0.016	1.062TyrLys: 1.062 ± 0.015	2.839TyrLeu: 2.839 ± 0.03	0.646TyrMet: 0.646 ± 0.011	1.119TyrAsn: 1.119 ± 0.014	1.617TyrPro: 1.617 ± 0.021	1.136TyrGln: 1.136 ± 0.017	1.761TyrArg: 1.761 ± 0.021	2.083TyrSer: 2.083 ± 0.022	1.712TyrThr: 1.712 ± 0.019	1.767TyrVal: 1.767 ± 0.019	0.479TyrTrp: 0.479 ± 0.01	0.994TyrTyr: 0.994 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.007

Statistics based on 10417 proteins (5198365 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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