Amino acid dipepetide frequency for Winogradskyella sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.042AlaAla: 4.042 ± 0.087	0.561AlaCys: 0.561 ± 0.024	3.487AlaAsp: 3.487 ± 0.059	4.113AlaGlu: 4.113 ± 0.067	3.422AlaPhe: 3.422 ± 0.056	3.792AlaGly: 3.792 ± 0.074	1.166AlaHis: 1.166 ± 0.032	5.745AlaIle: 5.745 ± 0.09	4.709AlaLys: 4.709 ± 0.082	6.609AlaLeu: 6.609 ± 0.096	1.549AlaMet: 1.549 ± 0.044	3.599AlaAsn: 3.599 ± 0.07	1.793AlaPro: 1.793 ± 0.052	2.481AlaGln: 2.481 ± 0.052	1.866AlaArg: 1.866 ± 0.047	4.313AlaSer: 4.313 ± 0.066	3.973AlaThr: 3.973 ± 0.092	3.993AlaVal: 3.993 ± 0.065	0.575AlaTrp: 0.575 ± 0.028	2.612AlaTyr: 2.612 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.477CysAla: 0.477 ± 0.024	0.087CysCys: 0.087 ± 0.009	0.505CysAsp: 0.505 ± 0.032	0.445CysGlu: 0.445 ± 0.024	0.385CysPhe: 0.385 ± 0.021	0.599CysGly: 0.599 ± 0.029	0.177CysHis: 0.177 ± 0.015	0.622CysIle: 0.622 ± 0.026	0.483CysLys: 0.483 ± 0.021	0.62CysLeu: 0.62 ± 0.026	0.135CysMet: 0.135 ± 0.012	0.453CysAsn: 0.453 ± 0.022	0.32CysPro: 0.32 ± 0.022	0.214CysGln: 0.214 ± 0.014	0.174CysArg: 0.174 ± 0.013	0.575CysSer: 0.575 ± 0.031	0.416CysThr: 0.416 ± 0.026	0.473CysVal: 0.473 ± 0.019	0.057CysTrp: 0.057 ± 0.01	0.325CysTyr: 0.325 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.109AspAla: 4.109 ± 0.081	0.463AspCys: 0.463 ± 0.024	3.634AspAsp: 3.634 ± 0.079	3.755AspGlu: 3.755 ± 0.055	3.662AspPhe: 3.662 ± 0.059	3.708AspGly: 3.708 ± 0.08	0.928AspHis: 0.928 ± 0.035	4.901AspIle: 4.901 ± 0.07	3.892AspLys: 3.892 ± 0.074	5.551AspLeu: 5.551 ± 0.084	1.226AspMet: 1.226 ± 0.034	3.557AspAsn: 3.557 ± 0.065	1.605AspPro: 1.605 ± 0.047	1.528AspGln: 1.528 ± 0.04	1.799AspArg: 1.799 ± 0.036	3.436AspSer: 3.436 ± 0.067	3.266AspThr: 3.266 ± 0.067	3.935AspVal: 3.935 ± 0.064	0.702AspTrp: 0.702 ± 0.029	3.093AspTyr: 3.093 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	4.83GluAla: 4.83 ± 0.08	0.346GluCys: 0.346 ± 0.021	4.151GluAsp: 4.151 ± 0.076	4.391GluGlu: 4.391 ± 0.084	2.993GluPhe: 2.993 ± 0.057	3.727GluGly: 3.727 ± 0.061	1.309GluHis: 1.309 ± 0.04	5.246GluIle: 5.246 ± 0.087	4.872GluLys: 4.872 ± 0.088	6.011GluLeu: 6.011 ± 0.074	1.369GluMet: 1.369 ± 0.036	4.442GluAsn: 4.442 ± 0.071	1.605GluPro: 1.605 ± 0.04	2.255GluGln: 2.255 ± 0.053	2.436GluArg: 2.436 ± 0.057	3.591GluSer: 3.591 ± 0.066	4.189GluThr: 4.189 ± 0.064	4.197GluVal: 4.197 ± 0.073	0.574GluTrp: 0.574 ± 0.024	2.184GluTyr: 2.184 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	2.856PheAla: 2.856 ± 0.052	0.382PheCys: 0.382 ± 0.019	3.199PheAsp: 3.199 ± 0.06	3.538PheGlu: 3.538 ± 0.059	2.502PhePhe: 2.502 ± 0.062	3.614PheGly: 3.614 ± 0.063	0.802PheHis: 0.802 ± 0.03	3.993PheIle: 3.993 ± 0.066	3.997PheLys: 3.997 ± 0.075	4.344PheLeu: 4.344 ± 0.07	1.097PheMet: 1.097 ± 0.032	3.671PheAsn: 3.671 ± 0.066	1.601PhePro: 1.601 ± 0.045	1.584PheGln: 1.584 ± 0.04	1.423PheArg: 1.423 ± 0.039	3.924PheSer: 3.924 ± 0.067	3.234PheThr: 3.234 ± 0.065	2.997PheVal: 2.997 ± 0.051	0.552PheTrp: 0.552 ± 0.029	2.085PheTyr: 2.085 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	3.902GlyAla: 3.902 ± 0.074	0.607GlyCys: 0.607 ± 0.033	3.545GlyAsp: 3.545 ± 0.067	3.618GlyGlu: 3.618 ± 0.066	3.609GlyPhe: 3.609 ± 0.061	4.21GlyGly: 4.21 ± 0.081	1.134GlyHis: 1.134 ± 0.032	5.086GlyIle: 5.086 ± 0.071	4.384GlyLys: 4.384 ± 0.081	5.64GlyLeu: 5.64 ± 0.074	1.459GlyMet: 1.459 ± 0.035	3.518GlyAsn: 3.518 ± 0.074	1.342GlyPro: 1.342 ± 0.053	1.867GlyGln: 1.867 ± 0.046	1.919GlyArg: 1.919 ± 0.044	3.993GlySer: 3.993 ± 0.08	4.119GlyThr: 4.119 ± 0.103	4.174GlyVal: 4.174 ± 0.074	0.684GlyTrp: 0.684 ± 0.025	2.775GlyTyr: 2.775 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	0.909HisAla: 0.909 ± 0.035	0.182HisCys: 0.182 ± 0.014	0.802HisAsp: 0.802 ± 0.028	0.924HisGlu: 0.924 ± 0.028	1.137HisPhe: 1.137 ± 0.034	1.033HisGly: 1.033 ± 0.03	0.521HisHis: 0.521 ± 0.024	1.631HisIle: 1.631 ± 0.042	1.32HisLys: 1.32 ± 0.04	1.876HisLeu: 1.876 ± 0.048	0.352HisMet: 0.352 ± 0.018	1.163HisAsn: 1.163 ± 0.036	0.863HisPro: 0.863 ± 0.034	0.772HisGln: 0.772 ± 0.027	0.657HisArg: 0.657 ± 0.024	1.102HisSer: 1.102 ± 0.031	0.986HisThr: 0.986 ± 0.032	0.972HisVal: 0.972 ± 0.032	0.25HisTrp: 0.25 ± 0.015	0.896HisTyr: 0.896 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.809IleAla: 5.809 ± 0.085	0.616IleCys: 0.616 ± 0.023	5.339IleAsp: 5.339 ± 0.077	5.812IleGlu: 5.812 ± 0.087	3.407IlePhe: 3.407 ± 0.057	5.149IleGly: 5.149 ± 0.076	1.311IleHis: 1.311 ± 0.034	6.282IleIle: 6.282 ± 0.096	5.908IleLys: 5.908 ± 0.093	6.95IleLeu: 6.95 ± 0.1	1.396IleMet: 1.396 ± 0.033	4.961IleAsn: 4.961 ± 0.079	3.131IlePro: 3.131 ± 0.054	2.429IleGln: 2.429 ± 0.053	2.287IleArg: 2.287 ± 0.048	5.977IleSer: 5.977 ± 0.069	5.204IleThr: 5.204 ± 0.096	5.046IleVal: 5.046 ± 0.076	0.624IleTrp: 0.624 ± 0.025	2.971IleTyr: 2.971 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	5.286LysAla: 5.286 ± 0.088	0.33LysCys: 0.33 ± 0.019	4.606LysAsp: 4.606 ± 0.084	5.089LysGlu: 5.089 ± 0.097	2.907LysPhe: 2.907 ± 0.056	4.174LysGly: 4.174 ± 0.067	1.637LysHis: 1.637 ± 0.038	5.619LysIle: 5.619 ± 0.079	5.809LysLys: 5.809 ± 0.107	6.469LysLeu: 6.469 ± 0.093	1.829LysMet: 1.829 ± 0.046	4.657LysAsn: 4.657 ± 0.079	2.378LysPro: 2.378 ± 0.049	2.813LysGln: 2.813 ± 0.054	2.914LysArg: 2.914 ± 0.06	4.732LysSer: 4.732 ± 0.084	4.953LysThr: 4.953 ± 0.075	4.443LysVal: 4.443 ± 0.075	0.672LysTrp: 0.672 ± 0.029	2.848LysTyr: 2.848 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	5.601LeuAla: 5.601 ± 0.086	0.713LeuCys: 0.713 ± 0.029	5.216LeuAsp: 5.216 ± 0.071	6.249LeuGlu: 6.249 ± 0.076	4.72LeuPhe: 4.72 ± 0.086	5.603LeuGly: 5.603 ± 0.083	1.608LeuHis: 1.608 ± 0.041	7.113LeuIle: 7.113 ± 0.103	7.965LeuLys: 7.965 ± 0.103	8.443LeuLeu: 8.443 ± 0.118	2.08LeuMet: 2.08 ± 0.045	6.071LeuAsn: 6.071 ± 0.089	3.406LeuPro: 3.406 ± 0.054	3.177LeuGln: 3.177 ± 0.06	3.107LeuArg: 3.107 ± 0.059	6.744LeuSer: 6.744 ± 0.086	5.311LeuThr: 5.311 ± 0.079	5.361LeuVal: 5.361 ± 0.08	0.812LeuTrp: 0.812 ± 0.025	3.231LeuTyr: 3.231 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.607MetAla: 1.607 ± 0.045	0.139MetCys: 0.139 ± 0.012	1.166MetAsp: 1.166 ± 0.031	1.124MetGlu: 1.124 ± 0.036	0.871MetPhe: 0.871 ± 0.03	1.159MetGly: 1.159 ± 0.036	0.415MetHis: 0.415 ± 0.02	1.485MetIle: 1.485 ± 0.036	2.003MetLys: 2.003 ± 0.047	1.938MetLeu: 1.938 ± 0.052	0.561MetMet: 0.561 ± 0.024	1.228MetAsn: 1.228 ± 0.035	0.869MetPro: 0.869 ± 0.031	0.789MetGln: 0.789 ± 0.026	0.82MetArg: 0.82 ± 0.033	1.537MetSer: 1.537 ± 0.04	1.207MetThr: 1.207 ± 0.032	1.375MetVal: 1.375 ± 0.039	0.138MetTrp: 0.138 ± 0.011	0.737MetTyr: 0.737 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	4.21AsnAla: 4.21 ± 0.075	0.483AsnCys: 0.483 ± 0.027	3.587AsnAsp: 3.587 ± 0.066	3.774AsnGlu: 3.774 ± 0.056	3.151AsnPhe: 3.151 ± 0.063	4.059AsnGly: 4.059 ± 0.083	1.163AsnHis: 1.163 ± 0.033	4.979AsnIle: 4.979 ± 0.069	4.125AsnLys: 4.125 ± 0.061	5.684AsnLeu: 5.684 ± 0.072	1.244AsnMet: 1.244 ± 0.035	3.913AsnAsn: 3.913 ± 0.077	2.789AsnPro: 2.789 ± 0.069	2.162AsnGln: 2.162 ± 0.047	2.118AsnArg: 2.118 ± 0.039	4.124AsnSer: 4.124 ± 0.068	4.191AsnThr: 4.191 ± 0.08	3.787AsnVal: 3.787 ± 0.066	0.708AsnTrp: 0.708 ± 0.028	3.127AsnTyr: 3.127 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	1.692ProAla: 1.692 ± 0.047	0.211ProCys: 0.211 ± 0.015	1.942ProAsp: 1.942 ± 0.047	2.727ProGlu: 2.727 ± 0.054	1.759ProPhe: 1.759 ± 0.035	1.682ProGly: 1.682 ± 0.053	0.597ProHis: 0.597 ± 0.026	2.758ProIle: 2.758 ± 0.051	2.493ProLys: 2.493 ± 0.056	2.933ProLeu: 2.933 ± 0.06	0.696ProMet: 0.696 ± 0.026	2.402ProAsn: 2.402 ± 0.054	0.769ProPro: 0.769 ± 0.034	1.106ProGln: 1.106 ± 0.028	0.843ProArg: 0.843 ± 0.032	2.2ProSer: 2.2 ± 0.05	2.138ProThr: 2.138 ± 0.057	2.097ProVal: 2.097 ± 0.05	0.312ProTrp: 0.312 ± 0.016	1.43ProTyr: 1.43 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.921GlnAla: 1.921 ± 0.048	0.196GlnCys: 0.196 ± 0.014	1.685GlnAsp: 1.685 ± 0.043	2.014GlnGlu: 2.014 ± 0.042	1.731GlnPhe: 1.731 ± 0.044	1.762GlnGly: 1.762 ± 0.048	0.667GlnHis: 0.667 ± 0.023	2.597GlnIle: 2.597 ± 0.05	2.51GlnLys: 2.51 ± 0.053	3.66GlnLeu: 3.66 ± 0.063	0.769GlnMet: 0.769 ± 0.026	2.212GlnAsn: 2.212 ± 0.047	1.247GlnPro: 1.247 ± 0.032	1.438GlnGln: 1.438 ± 0.043	1.245GlnArg: 1.245 ± 0.037	1.97GlnSer: 1.97 ± 0.045	2.087GlnThr: 2.087 ± 0.05	1.878GlnVal: 1.878 ± 0.04	0.41GlnTrp: 0.41 ± 0.023	1.326GlnTyr: 1.326 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.059ArgAla: 2.059 ± 0.051	0.185ArgCys: 0.185 ± 0.014	1.722ArgAsp: 1.722 ± 0.046	1.856ArgGlu: 1.856 ± 0.044	1.804ArgPhe: 1.804 ± 0.044	1.752ArgGly: 1.752 ± 0.044	0.634ArgHis: 0.634 ± 0.025	2.724ArgIle: 2.724 ± 0.048	2.44ArgLys: 2.44 ± 0.051	3.273ArgLeu: 3.273 ± 0.066	0.792ArgMet: 0.792 ± 0.025	1.861ArgAsn: 1.861 ± 0.041	1.047ArgPro: 1.047 ± 0.033	1.175ArgGln: 1.175 ± 0.034	1.287ArgArg: 1.287 ± 0.048	1.828ArgSer: 1.828 ± 0.052	1.876ArgThr: 1.876 ± 0.049	2.056ArgVal: 2.056 ± 0.044	0.34ArgTrp: 0.34 ± 0.018	1.483ArgTyr: 1.483 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.933SerAla: 3.933 ± 0.065	0.666SerCys: 0.666 ± 0.028	3.838SerAsp: 3.838 ± 0.068	4.441SerGlu: 4.441 ± 0.067	3.691SerPhe: 3.691 ± 0.07	4.56SerGly: 4.56 ± 0.093	1.186SerHis: 1.186 ± 0.036	5.52SerIle: 5.52 ± 0.074	5.029SerLys: 5.029 ± 0.072	5.87SerLeu: 5.87 ± 0.078	1.228SerMet: 1.228 ± 0.034	4.355SerAsn: 4.355 ± 0.079	1.998SerPro: 1.998 ± 0.053	2.205SerGln: 2.205 ± 0.046	2.046SerArg: 2.046 ± 0.045	4.435SerSer: 4.435 ± 0.089	3.917SerThr: 3.917 ± 0.088	4.175SerVal: 4.175 ± 0.073	0.642SerTrp: 0.642 ± 0.026	2.938SerTyr: 2.938 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.993ThrAla: 3.993 ± 0.09	0.416ThrCys: 0.416 ± 0.023	3.552ThrAsp: 3.552 ± 0.066	3.854ThrGlu: 3.854 ± 0.06	3.32ThrPhe: 3.32 ± 0.062	4.089ThrGly: 4.089 ± 0.095	1.092ThrHis: 1.092 ± 0.039	5.534ThrIle: 5.534 ± 0.096	3.968ThrLys: 3.968 ± 0.065	5.912ThrLeu: 5.912 ± 0.092	1.048ThrMet: 1.048 ± 0.03	3.693ThrAsn: 3.693 ± 0.085	2.365ThrPro: 2.365 ± 0.058	1.888ThrGln: 1.888 ± 0.051	1.583ThrArg: 1.583 ± 0.036	4.322ThrSer: 4.322 ± 0.086	4.144ThrThr: 4.144 ± 0.096	4.28ThrVal: 4.28 ± 0.093	0.626ThrTrp: 0.626 ± 0.028	2.816ThrTyr: 2.816 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	4.115ValAla: 4.115 ± 0.067	0.539ValCys: 0.539 ± 0.024	3.688ValAsp: 3.688 ± 0.055	4.108ValGlu: 4.108 ± 0.068	3.375ValPhe: 3.375 ± 0.067	3.853ValGly: 3.853 ± 0.061	0.959ValHis: 0.959 ± 0.032	5.066ValIle: 5.066 ± 0.059	4.342ValLys: 4.342 ± 0.074	5.96ValLeu: 5.96 ± 0.083	1.306ValMet: 1.306 ± 0.04	3.845ValAsn: 3.845 ± 0.07	2.046ValPro: 2.046 ± 0.05	1.587ValGln: 1.587 ± 0.039	1.816ValArg: 1.816 ± 0.048	4.534ValSer: 4.534 ± 0.078	3.992ValThr: 3.992 ± 0.104	4.324ValVal: 4.324 ± 0.075	0.564ValTrp: 0.564 ± 0.024	2.41ValTyr: 2.41 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.522TrpAla: 0.522 ± 0.028	0.088TrpCys: 0.088 ± 0.009	0.593TrpAsp: 0.593 ± 0.027	0.645TrpGlu: 0.645 ± 0.03	0.579TrpPhe: 0.579 ± 0.025	0.506TrpGly: 0.506 ± 0.021	0.218TrpHis: 0.218 ± 0.016	0.681TrpIle: 0.681 ± 0.027	0.699TrpLys: 0.699 ± 0.029	0.998TrpLeu: 0.998 ± 0.031	0.262TrpMet: 0.262 ± 0.013	0.69TrpAsn: 0.69 ± 0.033	0.212TrpPro: 0.212 ± 0.016	0.392TrpGln: 0.392 ± 0.02	0.351TrpArg: 0.351 ± 0.02	0.695TrpSer: 0.695 ± 0.027	0.592TrpThr: 0.592 ± 0.026	0.57TrpVal: 0.57 ± 0.024	0.134TrpTrp: 0.134 ± 0.012	0.422TrpTyr: 0.422 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.529TyrAla: 2.529 ± 0.056	0.33TyrCys: 0.33 ± 0.017	2.492TyrAsp: 2.492 ± 0.051	2.239TyrGlu: 2.239 ± 0.049	2.369TyrPhe: 2.369 ± 0.049	2.551TyrGly: 2.551 ± 0.056	0.825TyrHis: 0.825 ± 0.026	3.03TyrIle: 3.03 ± 0.054	3.216TyrLys: 3.216 ± 0.055	3.791TyrLeu: 3.791 ± 0.063	0.769TyrMet: 0.769 ± 0.026	3.089TyrAsn: 3.089 ± 0.061	1.4TyrPro: 1.4 ± 0.036	1.465TyrGln: 1.465 ± 0.041	1.502TyrArg: 1.502 ± 0.041	2.642TyrSer: 2.642 ± 0.056	2.702TyrThr: 2.702 ± 0.06	2.296TyrVal: 2.296 ± 0.045	0.472TyrTrp: 0.472 ± 0.023	1.954TyrTyr: 1.954 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3162 proteins (1098209 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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