Amino acid dipepetide frequency for Klebsiella phage vB_KpnS_IME279

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.327AlaAla: 14.327 ± 2.038
0.985AlaCys: 0.985 ± 0.266
6.974AlaAsp: 6.974 ± 0.738
7.126AlaGlu: 7.126 ± 0.946
3.639AlaPhe: 3.639 ± 0.61
10.385AlaGly: 10.385 ± 1.902
1.516AlaHis: 1.516 ± 0.301
5.306AlaIle: 5.306 ± 0.723
5.23AlaLys: 5.23 ± 0.721
10.385AlaLeu: 10.385 ± 1.322
2.881AlaMet: 2.881 ± 0.444
4.472AlaAsn: 4.472 ± 0.611
3.714AlaPro: 3.714 ± 0.623
6.064AlaGln: 6.064 ± 1.357
7.277AlaArg: 7.277 ± 1.046
4.927AlaSer: 4.927 ± 0.667
5.306AlaThr: 5.306 ± 0.957
4.397AlaVal: 4.397 ± 0.631
1.516AlaTrp: 1.516 ± 0.385
3.184AlaTyr: 3.184 ± 0.514
0.0AlaXaa: 0.0 ± 0.0
Cys
0.985CysAla: 0.985 ± 0.311
0.152CysCys: 0.152 ± 0.11
0.985CysAsp: 0.985 ± 0.268
0.531CysGlu: 0.531 ± 0.265
0.303CysPhe: 0.303 ± 0.137
0.985CysGly: 0.985 ± 0.388
0.303CysHis: 0.303 ± 0.136
0.303CysIle: 0.303 ± 0.145
0.606CysLys: 0.606 ± 0.239
0.682CysLeu: 0.682 ± 0.234
0.303CysMet: 0.303 ± 0.162
0.455CysAsn: 0.455 ± 0.156
0.682CysPro: 0.682 ± 0.212
0.227CysGln: 0.227 ± 0.125
1.137CysArg: 1.137 ± 0.372
0.152CysSer: 0.152 ± 0.097
0.531CysThr: 0.531 ± 0.211
0.606CysVal: 0.606 ± 0.201
0.227CysTrp: 0.227 ± 0.118
0.379CysTyr: 0.379 ± 0.148
0.0CysXaa: 0.0 ± 0.0
Asp
7.126AspAla: 7.126 ± 0.82
0.682AspCys: 0.682 ± 0.254
4.624AspAsp: 4.624 ± 0.615
4.927AspGlu: 4.927 ± 0.661
1.668AspPhe: 1.668 ± 0.26
5.609AspGly: 5.609 ± 0.729
1.289AspHis: 1.289 ± 0.39
2.729AspIle: 2.729 ± 0.432
2.653AspLys: 2.653 ± 0.384
6.747AspLeu: 6.747 ± 0.676
1.592AspMet: 1.592 ± 0.238
2.426AspAsn: 2.426 ± 0.519
4.245AspPro: 4.245 ± 0.665
3.639AspGln: 3.639 ± 0.716
3.639AspArg: 3.639 ± 0.548
3.108AspSer: 3.108 ± 0.547
2.198AspThr: 2.198 ± 0.341
3.563AspVal: 3.563 ± 0.414
2.122AspTrp: 2.122 ± 0.434
2.047AspTyr: 2.047 ± 0.369
0.0AspXaa: 0.0 ± 0.0
Glu
6.671GluAla: 6.671 ± 0.704
0.758GluCys: 0.758 ± 0.225
4.321GluAsp: 4.321 ± 0.506
4.093GluGlu: 4.093 ± 0.649
1.516GluPhe: 1.516 ± 0.319
3.487GluGly: 3.487 ± 0.534
1.061GluHis: 1.061 ± 0.276
4.548GluIle: 4.548 ± 0.757
3.411GluLys: 3.411 ± 0.62
6.064GluLeu: 6.064 ± 0.991
1.061GluMet: 1.061 ± 0.273
2.35GluAsn: 2.35 ± 0.451
2.956GluPro: 2.956 ± 0.507
4.093GluGln: 4.093 ± 0.675
4.169GluArg: 4.169 ± 0.57
2.426GluSer: 2.426 ± 0.412
3.032GluThr: 3.032 ± 0.485
3.108GluVal: 3.108 ± 0.571
1.516GluTrp: 1.516 ± 0.336
1.895GluTyr: 1.895 ± 0.411
0.0GluXaa: 0.0 ± 0.0
Phe
2.577PheAla: 2.577 ± 0.398
0.152PheCys: 0.152 ± 0.103
2.426PheAsp: 2.426 ± 0.355
1.668PheGlu: 1.668 ± 0.31
1.061PhePhe: 1.061 ± 0.307
2.805PheGly: 2.805 ± 0.508
0.606PheHis: 0.606 ± 0.237
1.213PheIle: 1.213 ± 0.322
1.743PheLys: 1.743 ± 0.343
1.971PheLeu: 1.971 ± 0.402
1.44PheMet: 1.44 ± 0.363
1.364PheAsn: 1.364 ± 0.272
0.985PhePro: 0.985 ± 0.343
0.834PheGln: 0.834 ± 0.361
1.971PheArg: 1.971 ± 0.354
1.44PheSer: 1.44 ± 0.27
1.971PheThr: 1.971 ± 0.381
2.653PheVal: 2.653 ± 0.399
0.834PheTrp: 0.834 ± 0.334
0.606PheTyr: 0.606 ± 0.231
0.0PheXaa: 0.0 ± 0.0
Gly
8.717GlyAla: 8.717 ± 1.304
0.606GlyCys: 0.606 ± 0.271
4.776GlyAsp: 4.776 ± 0.801
5.155GlyGlu: 5.155 ± 0.706
2.35GlyPhe: 2.35 ± 0.412
7.884GlyGly: 7.884 ± 1.012
1.819GlyHis: 1.819 ± 0.351
5.003GlyIle: 5.003 ± 0.748
4.548GlyLys: 4.548 ± 0.686
4.624GlyLeu: 4.624 ± 0.596
1.895GlyMet: 1.895 ± 0.452
4.472GlyAsn: 4.472 ± 0.662
2.577GlyPro: 2.577 ± 0.378
3.942GlyGln: 3.942 ± 0.647
5.382GlyArg: 5.382 ± 0.707
5.003GlySer: 5.003 ± 0.597
4.397GlyThr: 4.397 ± 0.561
4.776GlyVal: 4.776 ± 0.599
1.213GlyTrp: 1.213 ± 0.253
3.108GlyTyr: 3.108 ± 0.483
0.0GlyXaa: 0.0 ± 0.0
His
1.516HisAla: 1.516 ± 0.379
0.227HisCys: 0.227 ± 0.123
1.137HisAsp: 1.137 ± 0.354
1.668HisGlu: 1.668 ± 0.394
0.834HisPhe: 0.834 ± 0.244
1.364HisGly: 1.364 ± 0.282
0.531HisHis: 0.531 ± 0.257
0.91HisIle: 0.91 ± 0.229
0.91HisLys: 0.91 ± 0.231
1.592HisLeu: 1.592 ± 0.454
0.455HisMet: 0.455 ± 0.192
0.91HisAsn: 0.91 ± 0.324
1.364HisPro: 1.364 ± 0.376
0.758HisGln: 0.758 ± 0.23
1.213HisArg: 1.213 ± 0.302
0.682HisSer: 0.682 ± 0.201
0.985HisThr: 0.985 ± 0.226
1.137HisVal: 1.137 ± 0.337
0.152HisTrp: 0.152 ± 0.103
0.303HisTyr: 0.303 ± 0.193
0.0HisXaa: 0.0 ± 0.0
Ile
4.7IleAla: 4.7 ± 0.481
0.455IleCys: 0.455 ± 0.157
4.472IleAsp: 4.472 ± 0.506
3.563IleGlu: 3.563 ± 0.517
1.895IlePhe: 1.895 ± 0.398
3.714IleGly: 3.714 ± 0.462
1.213IleHis: 1.213 ± 0.316
3.26IleIle: 3.26 ± 0.612
1.819IleLys: 1.819 ± 0.444
2.956IleLeu: 2.956 ± 0.536
1.516IleMet: 1.516 ± 0.299
2.122IleAsn: 2.122 ± 0.358
2.577IlePro: 2.577 ± 0.451
2.35IleGln: 2.35 ± 0.435
3.184IleArg: 3.184 ± 0.6
1.971IleSer: 1.971 ± 0.385
2.577IleThr: 2.577 ± 0.502
3.563IleVal: 3.563 ± 0.451
0.834IleTrp: 0.834 ± 0.268
1.895IleTyr: 1.895 ± 0.366
0.0IleXaa: 0.0 ± 0.0
Lys
5.458LysAla: 5.458 ± 0.593
0.379LysCys: 0.379 ± 0.149
4.093LysAsp: 4.093 ± 0.63
4.169LysGlu: 4.169 ± 0.824
1.743LysPhe: 1.743 ± 0.396
3.866LysGly: 3.866 ± 0.476
0.682LysHis: 0.682 ± 0.217
2.653LysIle: 2.653 ± 0.556
3.335LysLys: 3.335 ± 0.59
4.018LysLeu: 4.018 ± 0.484
1.819LysMet: 1.819 ± 0.366
1.971LysAsn: 1.971 ± 0.413
3.032LysPro: 3.032 ± 0.498
2.653LysGln: 2.653 ± 0.381
3.411LysArg: 3.411 ± 0.532
2.35LysSer: 2.35 ± 0.365
2.881LysThr: 2.881 ± 0.451
3.714LysVal: 3.714 ± 0.557
0.682LysTrp: 0.682 ± 0.196
1.44LysTyr: 1.44 ± 0.31
0.0LysXaa: 0.0 ± 0.0
Leu
9.551LeuAla: 9.551 ± 0.83
1.061LeuCys: 1.061 ± 0.28
5.23LeuAsp: 5.23 ± 0.609
4.7LeuGlu: 4.7 ± 0.638
2.047LeuPhe: 2.047 ± 0.384
4.548LeuGly: 4.548 ± 0.667
1.592LeuHis: 1.592 ± 0.333
3.866LeuIle: 3.866 ± 0.508
4.776LeuLys: 4.776 ± 0.649
5.685LeuLeu: 5.685 ± 0.631
2.35LeuMet: 2.35 ± 0.452
2.881LeuAsn: 2.881 ± 0.509
3.942LeuPro: 3.942 ± 0.535
2.426LeuGln: 2.426 ± 0.57
5.003LeuArg: 5.003 ± 0.818
4.472LeuSer: 4.472 ± 0.454
5.685LeuThr: 5.685 ± 0.564
5.003LeuVal: 5.003 ± 0.631
0.91LeuTrp: 0.91 ± 0.267
1.895LeuTyr: 1.895 ± 0.423
0.0LeuXaa: 0.0 ± 0.0
Met
4.472MetAla: 4.472 ± 0.574
0.227MetCys: 0.227 ± 0.137
1.44MetAsp: 1.44 ± 0.495
1.44MetGlu: 1.44 ± 0.383
1.137MetPhe: 1.137 ± 0.309
1.668MetGly: 1.668 ± 0.386
0.152MetHis: 0.152 ± 0.102
1.592MetIle: 1.592 ± 0.378
1.516MetLys: 1.516 ± 0.307
1.895MetLeu: 1.895 ± 0.44
1.137MetMet: 1.137 ± 0.266
1.061MetAsn: 1.061 ± 0.272
1.971MetPro: 1.971 ± 0.43
1.364MetGln: 1.364 ± 0.294
1.895MetArg: 1.895 ± 0.477
1.819MetSer: 1.819 ± 0.253
1.364MetThr: 1.364 ± 0.286
0.985MetVal: 0.985 ± 0.279
0.834MetTrp: 0.834 ± 0.246
1.289MetTyr: 1.289 ± 0.269
0.0MetXaa: 0.0 ± 0.0
Asn
4.624AsnAla: 4.624 ± 0.614
0.379AsnCys: 0.379 ± 0.225
3.108AsnAsp: 3.108 ± 0.481
2.502AsnGlu: 2.502 ± 0.374
1.061AsnPhe: 1.061 ± 0.373
4.927AsnGly: 4.927 ± 0.823
0.606AsnHis: 0.606 ± 0.205
1.971AsnIle: 1.971 ± 0.46
2.122AsnLys: 2.122 ± 0.354
3.411AsnLeu: 3.411 ± 0.49
1.137AsnMet: 1.137 ± 0.28
2.122AsnAsn: 2.122 ± 0.472
2.35AsnPro: 2.35 ± 0.491
2.35AsnGln: 2.35 ± 0.442
1.971AsnArg: 1.971 ± 0.314
1.743AsnSer: 1.743 ± 0.333
1.819AsnThr: 1.819 ± 0.401
3.108AsnVal: 3.108 ± 0.663
0.682AsnTrp: 0.682 ± 0.164
0.682AsnTyr: 0.682 ± 0.201
0.0AsnXaa: 0.0 ± 0.0
Pro
4.397ProAla: 4.397 ± 0.704
0.606ProCys: 0.606 ± 0.254
4.245ProAsp: 4.245 ± 0.47
4.093ProGlu: 4.093 ± 0.567
1.971ProPhe: 1.971 ± 0.394
4.7ProGly: 4.7 ± 0.631
0.606ProHis: 0.606 ± 0.217
2.198ProIle: 2.198 ± 0.343
1.971ProLys: 1.971 ± 0.344
3.411ProLeu: 3.411 ± 0.522
1.061ProMet: 1.061 ± 0.29
1.895ProAsn: 1.895 ± 0.437
1.743ProPro: 1.743 ± 0.362
2.198ProGln: 2.198 ± 0.353
2.198ProArg: 2.198 ± 0.379
2.047ProSer: 2.047 ± 0.36
3.032ProThr: 3.032 ± 0.47
3.487ProVal: 3.487 ± 0.494
0.682ProTrp: 0.682 ± 0.258
1.364ProTyr: 1.364 ± 0.382
0.0ProXaa: 0.0 ± 0.0
Gln
6.519GlnAla: 6.519 ± 1.356
0.531GlnCys: 0.531 ± 0.222
2.047GlnAsp: 2.047 ± 0.517
2.274GlnGlu: 2.274 ± 0.433
1.289GlnPhe: 1.289 ± 0.327
3.639GlnGly: 3.639 ± 0.638
0.758GlnHis: 0.758 ± 0.38
1.971GlnIle: 1.971 ± 0.295
3.411GlnLys: 3.411 ± 0.606
4.018GlnLeu: 4.018 ± 0.676
2.047GlnMet: 2.047 ± 0.333
1.971GlnAsn: 1.971 ± 0.532
2.502GlnPro: 2.502 ± 0.357
4.093GlnGln: 4.093 ± 1.209
2.881GlnArg: 2.881 ± 0.413
1.516GlnSer: 1.516 ± 0.341
2.956GlnThr: 2.956 ± 0.514
3.032GlnVal: 3.032 ± 0.501
0.834GlnTrp: 0.834 ± 0.287
0.985GlnTyr: 0.985 ± 0.272
0.0GlnXaa: 0.0 ± 0.0
Arg
6.519ArgAla: 6.519 ± 0.76
0.758ArgCys: 0.758 ± 0.43
3.942ArgAsp: 3.942 ± 0.524
3.563ArgGlu: 3.563 ± 0.525
2.274ArgPhe: 2.274 ± 0.489
4.624ArgGly: 4.624 ± 0.661
1.668ArgHis: 1.668 ± 0.386
2.956ArgIle: 2.956 ± 0.493
4.472ArgLys: 4.472 ± 0.75
4.776ArgLeu: 4.776 ± 0.7
2.047ArgMet: 2.047 ± 0.425
2.502ArgAsn: 2.502 ± 0.551
2.122ArgPro: 2.122 ± 0.413
2.881ArgGln: 2.881 ± 0.355
3.714ArgArg: 3.714 ± 0.535
2.198ArgSer: 2.198 ± 0.286
2.729ArgThr: 2.729 ± 0.467
3.942ArgVal: 3.942 ± 0.535
0.834ArgTrp: 0.834 ± 0.22
2.426ArgTyr: 2.426 ± 0.314
0.0ArgXaa: 0.0 ± 0.0
Ser
4.7SerAla: 4.7 ± 0.804
0.227SerCys: 0.227 ± 0.136
3.184SerAsp: 3.184 ± 0.472
2.047SerGlu: 2.047 ± 0.417
0.985SerPhe: 0.985 ± 0.267
4.397SerGly: 4.397 ± 0.609
1.061SerHis: 1.061 ± 0.297
1.819SerIle: 1.819 ± 0.376
3.184SerLys: 3.184 ± 0.515
3.184SerLeu: 3.184 ± 0.411
1.516SerMet: 1.516 ± 0.346
2.198SerAsn: 2.198 ± 0.476
2.577SerPro: 2.577 ± 0.4
2.653SerGln: 2.653 ± 0.465
2.426SerArg: 2.426 ± 0.528
2.198SerSer: 2.198 ± 0.389
2.881SerThr: 2.881 ± 0.559
3.032SerVal: 3.032 ± 0.474
0.455SerTrp: 0.455 ± 0.212
1.516SerTyr: 1.516 ± 0.386
0.0SerXaa: 0.0 ± 0.0
Thr
5.458ThrAla: 5.458 ± 0.785
0.682ThrCys: 0.682 ± 0.243
2.805ThrAsp: 2.805 ± 0.346
3.184ThrGlu: 3.184 ± 0.453
1.364ThrPhe: 1.364 ± 0.278
5.079ThrGly: 5.079 ± 0.502
0.303ThrHis: 0.303 ± 0.132
2.653ThrIle: 2.653 ± 0.347
2.577ThrLys: 2.577 ± 0.519
5.155ThrLeu: 5.155 ± 0.739
1.819ThrMet: 1.819 ± 0.402
2.047ThrAsn: 2.047 ± 0.352
4.397ThrPro: 4.397 ± 0.576
2.35ThrGln: 2.35 ± 0.362
3.335ThrArg: 3.335 ± 0.459
3.184ThrSer: 3.184 ± 0.537
3.487ThrThr: 3.487 ± 0.522
2.881ThrVal: 2.881 ± 0.71
0.455ThrTrp: 0.455 ± 0.155
1.516ThrTyr: 1.516 ± 0.31
0.0ThrXaa: 0.0 ± 0.0
Val
7.277ValAla: 7.277 ± 0.892
0.758ValCys: 0.758 ± 0.225
3.411ValAsp: 3.411 ± 0.645
3.487ValGlu: 3.487 ± 0.617
1.516ValPhe: 1.516 ± 0.372
4.776ValGly: 4.776 ± 0.656
1.213ValHis: 1.213 ± 0.253
3.411ValIle: 3.411 ± 0.589
3.866ValLys: 3.866 ± 0.552
2.653ValLeu: 2.653 ± 0.478
1.895ValMet: 1.895 ± 0.411
3.184ValAsn: 3.184 ± 0.718
2.729ValPro: 2.729 ± 0.517
2.426ValGln: 2.426 ± 0.43
3.032ValArg: 3.032 ± 0.456
2.956ValSer: 2.956 ± 0.415
3.866ValThr: 3.866 ± 0.628
3.411ValVal: 3.411 ± 0.649
1.137ValTrp: 1.137 ± 0.281
1.971ValTyr: 1.971 ± 0.413
0.0ValXaa: 0.0 ± 0.0
Trp
0.985TrpAla: 0.985 ± 0.285
0.379TrpCys: 0.379 ± 0.167
1.289TrpAsp: 1.289 ± 0.269
0.91TrpGlu: 0.91 ± 0.223
0.606TrpPhe: 0.606 ± 0.242
1.668TrpGly: 1.668 ± 0.349
0.606TrpHis: 0.606 ± 0.192
0.91TrpIle: 0.91 ± 0.325
0.682TrpLys: 0.682 ± 0.226
1.743TrpLeu: 1.743 ± 0.327
0.531TrpMet: 0.531 ± 0.223
0.834TrpAsn: 0.834 ± 0.305
0.606TrpPro: 0.606 ± 0.196
0.682TrpGln: 0.682 ± 0.259
1.364TrpArg: 1.364 ± 0.302
0.682TrpSer: 0.682 ± 0.208
1.061TrpThr: 1.061 ± 0.292
0.455TrpVal: 0.455 ± 0.192
0.152TrpTrp: 0.152 ± 0.096
0.606TrpTyr: 0.606 ± 0.181
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.108TyrAla: 3.108 ± 0.433
0.531TyrCys: 0.531 ± 0.227
2.122TyrAsp: 2.122 ± 0.43
1.44TyrGlu: 1.44 ± 0.426
1.061TyrPhe: 1.061 ± 0.247
2.122TyrGly: 2.122 ± 0.356
1.061TyrHis: 1.061 ± 0.288
1.364TyrIle: 1.364 ± 0.359
1.516TyrLys: 1.516 ± 0.394
2.653TyrLeu: 2.653 ± 0.457
0.682TyrMet: 0.682 ± 0.208
1.44TyrAsn: 1.44 ± 0.397
0.834TyrPro: 0.834 ± 0.367
1.289TyrGln: 1.289 ± 0.367
1.743TyrArg: 1.743 ± 0.365
1.364TyrSer: 1.364 ± 0.279
1.971TyrThr: 1.971 ± 0.508
2.122TyrVal: 2.122 ± 0.331
0.682TyrTrp: 0.682 ± 0.227
0.985TyrTyr: 0.985 ± 0.308
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 59 proteins (13193 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski