Amino acid dipepetide frequency for Maricaulis maris (strain MCS10)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.064AlaAla: 17.064 ± 0.211	1.147AlaCys: 1.147 ± 0.037	8.256AlaAsp: 8.256 ± 0.1	7.881AlaGlu: 7.881 ± 0.121	4.536AlaPhe: 4.536 ± 0.072	11.492AlaGly: 11.492 ± 0.148	2.213AlaHis: 2.213 ± 0.048	6.275AlaIle: 6.275 ± 0.081	3.068AlaLys: 3.068 ± 0.068	13.555AlaLeu: 13.555 ± 0.16	3.514AlaMet: 3.514 ± 0.065	3.094AlaAsn: 3.094 ± 0.055	5.712AlaPro: 5.712 ± 0.089	3.826AlaGln: 3.826 ± 0.076	9.654AlaArg: 9.654 ± 0.125	7.086AlaSer: 7.086 ± 0.093	5.911AlaThr: 5.911 ± 0.094	8.394AlaVal: 8.394 ± 0.092	1.751AlaTrp: 1.751 ± 0.043	2.578AlaTyr: 2.578 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.975CysAla: 0.975 ± 0.034	0.103CysCys: 0.103 ± 0.011	0.602CysAsp: 0.602 ± 0.027	0.459CysGlu: 0.459 ± 0.024	0.256CysPhe: 0.256 ± 0.015	0.819CysGly: 0.819 ± 0.03	0.214CysHis: 0.214 ± 0.015	0.288CysIle: 0.288 ± 0.016	0.152CysLys: 0.152 ± 0.013	0.762CysLeu: 0.762 ± 0.029	0.101CysMet: 0.101 ± 0.01	0.172CysAsn: 0.172 ± 0.013	0.426CysPro: 0.426 ± 0.022	0.248CysGln: 0.248 ± 0.018	0.56CysArg: 0.56 ± 0.024	0.48CysSer: 0.48 ± 0.024	0.382CysThr: 0.382 ± 0.02	0.598CysVal: 0.598 ± 0.024	0.118CysTrp: 0.118 ± 0.01	0.151CysTyr: 0.151 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.255AspAla: 8.255 ± 0.097	0.521AspCys: 0.521 ± 0.022	4.112AspAsp: 4.112 ± 0.078	4.148AspGlu: 4.148 ± 0.074	2.561AspPhe: 2.561 ± 0.072	6.547AspGly: 6.547 ± 0.119	1.37AspHis: 1.37 ± 0.043	3.197AspIle: 3.197 ± 0.065	1.415AspLys: 1.415 ± 0.046	6.443AspLeu: 6.443 ± 0.09	1.662AspMet: 1.662 ± 0.046	1.541AspAsn: 1.541 ± 0.048	3.844AspPro: 3.844 ± 0.065	2.122AspGln: 2.122 ± 0.044	4.919AspArg: 4.919 ± 0.067	2.883AspSer: 2.883 ± 0.063	3.228AspThr: 3.228 ± 0.075	4.603AspVal: 4.603 ± 0.076	1.274AspTrp: 1.274 ± 0.038	1.58AspTyr: 1.58 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	8.726GluAla: 8.726 ± 0.121	0.347GluCys: 0.347 ± 0.02	3.429GluAsp: 3.429 ± 0.073	3.067GluGlu: 3.067 ± 0.075	1.999GluPhe: 1.999 ± 0.048	4.503GluGly: 4.503 ± 0.066	1.228GluHis: 1.228 ± 0.036	3.625GluIle: 3.625 ± 0.059	1.621GluLys: 1.621 ± 0.05	5.53GluLeu: 5.53 ± 0.083	1.699GluMet: 1.699 ± 0.04	1.688GluAsn: 1.688 ± 0.041	2.835GluPro: 2.835 ± 0.066	2.006GluGln: 2.006 ± 0.049	5.141GluArg: 5.141 ± 0.083	2.648GluSer: 2.648 ± 0.057	4.319GluThr: 4.319 ± 0.071	3.689GluVal: 3.689 ± 0.06	0.759GluTrp: 0.759 ± 0.031	1.022GluTyr: 1.022 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.731PheAla: 4.731 ± 0.066	0.325PheCys: 0.325 ± 0.02	3.062PheAsp: 3.062 ± 0.058	2.456PheGlu: 2.456 ± 0.049	1.436PhePhe: 1.436 ± 0.048	3.703PheGly: 3.703 ± 0.082	0.752PheHis: 0.752 ± 0.026	1.729PheIle: 1.729 ± 0.043	0.862PheLys: 0.862 ± 0.032	3.275PheLeu: 3.275 ± 0.068	0.814PheMet: 0.814 ± 0.029	1.189PheAsn: 1.189 ± 0.037	1.392PhePro: 1.392 ± 0.042	0.998PheGln: 0.998 ± 0.029	2.161PheArg: 2.161 ± 0.047	2.297PheSer: 2.297 ± 0.066	2.099PheThr: 2.099 ± 0.059	2.659PheVal: 2.659 ± 0.06	0.566PheTrp: 0.566 ± 0.029	0.834PheTyr: 0.834 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.778GlyAla: 9.778 ± 0.147	0.73GlyCys: 0.73 ± 0.026	5.443GlyAsp: 5.443 ± 0.138	5.786GlyGlu: 5.786 ± 0.08	3.856GlyPhe: 3.856 ± 0.064	8.194GlyGly: 8.194 ± 0.547	1.863GlyHis: 1.863 ± 0.047	3.987GlyIle: 3.987 ± 0.093	2.304GlyLys: 2.304 ± 0.056	9.311GlyLeu: 9.311 ± 0.109	2.381GlyMet: 2.381 ± 0.053	2.297GlyAsn: 2.297 ± 0.102	3.64GlyPro: 3.64 ± 0.061	3.13GlyGln: 3.13 ± 0.058	6.081GlyArg: 6.081 ± 0.083	4.936GlySer: 4.936 ± 0.13	4.1GlyThr: 4.1 ± 0.089	6.569GlyVal: 6.569 ± 0.105	1.477GlyTrp: 1.477 ± 0.042	2.278GlyTyr: 2.278 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.419HisAla: 2.419 ± 0.049	0.221HisCys: 0.221 ± 0.016	1.289HisAsp: 1.289 ± 0.037	1.083HisGlu: 1.083 ± 0.037	0.789HisPhe: 0.789 ± 0.031	1.78HisGly: 1.78 ± 0.046	0.566HisHis: 0.566 ± 0.027	0.928HisIle: 0.928 ± 0.033	0.45HisLys: 0.45 ± 0.022	1.886HisLeu: 1.886 ± 0.047	0.493HisMet: 0.493 ± 0.02	0.445HisAsn: 0.445 ± 0.019	1.162HisPro: 1.162 ± 0.032	0.599HisGln: 0.599 ± 0.026	1.324HisArg: 1.324 ± 0.037	0.885HisSer: 0.885 ± 0.037	0.867HisThr: 0.867 ± 0.027	1.491HisVal: 1.491 ± 0.04	0.345HisTrp: 0.345 ± 0.02	0.545HisTyr: 0.545 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.994IleAla: 6.994 ± 0.081	0.414IleCys: 0.414 ± 0.02	3.849IleAsp: 3.849 ± 0.062	3.766IleGlu: 3.766 ± 0.061	1.662IlePhe: 1.662 ± 0.046	4.769IleGly: 4.769 ± 0.109	0.907IleHis: 0.907 ± 0.027	2.392IleIle: 2.392 ± 0.057	1.188IleLys: 1.188 ± 0.033	4.388IleLeu: 4.388 ± 0.069	0.943IleMet: 0.943 ± 0.035	1.541IleAsn: 1.541 ± 0.042	2.143IlePro: 2.143 ± 0.048	1.246IleGln: 1.246 ± 0.033	3.191IleArg: 3.191 ± 0.063	2.908IleSer: 2.908 ± 0.062	2.669IleThr: 2.669 ± 0.065	3.606IleVal: 3.606 ± 0.073	0.685IleTrp: 0.685 ± 0.028	1.027IleTyr: 1.027 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.492LysAla: 3.492 ± 0.085	0.128LysCys: 0.128 ± 0.012	1.366LysAsp: 1.366 ± 0.038	1.07LysGlu: 1.07 ± 0.033	0.709LysPhe: 0.709 ± 0.029	1.875LysGly: 1.875 ± 0.043	0.506LysHis: 0.506 ± 0.022	1.237LysIle: 1.237 ± 0.036	0.953LysLys: 0.953 ± 0.04	2.45LysLeu: 2.45 ± 0.061	0.548LysMet: 0.548 ± 0.026	0.551LysAsn: 0.551 ± 0.025	1.66LysPro: 1.66 ± 0.05	0.728LysGln: 0.728 ± 0.03	2.021LysArg: 2.021 ± 0.054	1.63LysSer: 1.63 ± 0.043	1.653LysThr: 1.653 ± 0.053	1.588LysVal: 1.588 ± 0.045	0.293LysTrp: 0.293 ± 0.018	0.441LysTyr: 0.441 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.935LeuAla: 13.935 ± 0.155	0.752LeuCys: 0.752 ± 0.027	7.041LeuAsp: 7.041 ± 0.108	5.654LeuGlu: 5.654 ± 0.082	3.457LeuPhe: 3.457 ± 0.068	8.07LeuGly: 8.07 ± 0.122	1.735LeuHis: 1.735 ± 0.042	5.11LeuIle: 5.11 ± 0.077	2.709LeuLys: 2.709 ± 0.066	8.344LeuLeu: 8.344 ± 0.124	2.28LeuMet: 2.28 ± 0.052	2.613LeuAsn: 2.613 ± 0.054	5.132LeuPro: 5.132 ± 0.081	2.688LeuGln: 2.688 ± 0.058	6.336LeuArg: 6.336 ± 0.085	6.234LeuSer: 6.234 ± 0.092	5.813LeuThr: 5.813 ± 0.087	7.47LeuVal: 7.47 ± 0.108	1.091LeuTrp: 1.091 ± 0.04	1.956LeuTyr: 1.956 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.262MetAla: 3.262 ± 0.064	0.156MetCys: 0.156 ± 0.012	1.386MetAsp: 1.386 ± 0.036	1.147MetGlu: 1.147 ± 0.038	0.72MetPhe: 0.72 ± 0.027	1.863MetGly: 1.863 ± 0.044	0.399MetHis: 0.399 ± 0.021	1.459MetIle: 1.459 ± 0.04	0.931MetLys: 0.931 ± 0.035	2.217MetLeu: 2.217 ± 0.049	0.761MetMet: 0.761 ± 0.028	0.667MetAsn: 0.667 ± 0.024	1.425MetPro: 1.425 ± 0.041	0.747MetGln: 0.747 ± 0.035	1.874MetArg: 1.874 ± 0.045	1.871MetSer: 1.871 ± 0.041	1.999MetThr: 1.999 ± 0.039	1.555MetVal: 1.555 ± 0.044	0.236MetTrp: 0.236 ± 0.014	0.3MetTyr: 0.3 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.235AsnAla: 3.235 ± 0.059	0.22AsnCys: 0.22 ± 0.016	1.537AsnAsp: 1.537 ± 0.051	1.21AsnGlu: 1.21 ± 0.031	0.972AsnPhe: 0.972 ± 0.03	2.485AsnGly: 2.485 ± 0.075	0.478AsnHis: 0.478 ± 0.022	1.238AsnIle: 1.238 ± 0.038	0.535AsnLys: 0.535 ± 0.022	2.628AsnLeu: 2.628 ± 0.057	0.597AsnMet: 0.597 ± 0.025	0.734AsnAsn: 0.734 ± 0.034	1.843AsnPro: 1.843 ± 0.044	0.768AsnGln: 0.768 ± 0.025	1.812AsnArg: 1.812 ± 0.044	1.363AsnSer: 1.363 ± 0.045	1.355AsnThr: 1.355 ± 0.04	1.809AsnVal: 1.809 ± 0.053	0.467AsnTrp: 0.467 ± 0.02	0.662AsnTyr: 0.662 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.137ProAla: 6.137 ± 0.089	0.301ProCys: 0.301 ± 0.02	4.398ProAsp: 4.398 ± 0.086	3.448ProGlu: 3.448 ± 0.07	1.798ProPhe: 1.798 ± 0.047	4.717ProGly: 4.717 ± 0.071	0.967ProHis: 0.967 ± 0.033	2.137ProIle: 2.137 ± 0.048	1.25ProLys: 1.25 ± 0.048	4.194ProLeu: 4.194 ± 0.083	1.167ProMet: 1.167 ± 0.035	1.22ProAsn: 1.22 ± 0.039	2.209ProPro: 2.209 ± 0.067	1.514ProGln: 1.514 ± 0.042	2.718ProArg: 2.718 ± 0.062	2.661ProSer: 2.661 ± 0.062	2.373ProThr: 2.373 ± 0.054	4.468ProVal: 4.468 ± 0.072	0.656ProTrp: 0.656 ± 0.029	1.048ProTyr: 1.048 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.48GlnAla: 4.48 ± 0.072	0.213GlnCys: 0.213 ± 0.014	1.737GlnAsp: 1.737 ± 0.038	1.323GlnGlu: 1.323 ± 0.046	1.05GlnPhe: 1.05 ± 0.037	2.146GlnGly: 2.146 ± 0.047	0.584GlnHis: 0.584 ± 0.025	1.719GlnIle: 1.719 ± 0.043	0.677GlnLys: 0.677 ± 0.031	3.009GlnLeu: 3.009 ± 0.058	0.849GlnMet: 0.849 ± 0.027	0.682GlnAsn: 0.682 ± 0.03	1.651GlnPro: 1.651 ± 0.041	0.943GlnGln: 0.943 ± 0.035	2.337GlnArg: 2.337 ± 0.057	2.097GlnSer: 2.097 ± 0.083	1.929GlnThr: 1.929 ± 0.043	2.217GlnVal: 2.217 ± 0.048	0.359GlnTrp: 0.359 ± 0.018	0.613GlnTyr: 0.613 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.09ArgAla: 8.09 ± 0.101	0.504ArgCys: 0.504 ± 0.026	4.583ArgAsp: 4.583 ± 0.067	4.395ArgGlu: 4.395 ± 0.078	3.072ArgPhe: 3.072 ± 0.059	4.898ArgGly: 4.898 ± 0.078	1.589ArgHis: 1.589 ± 0.041	3.913ArgIle: 3.913 ± 0.067	1.926ArgLys: 1.926 ± 0.049	8.035ArgLeu: 8.035 ± 0.112	1.872ArgMet: 1.872 ± 0.044	1.817ArgAsn: 1.817 ± 0.048	3.452ArgPro: 3.452 ± 0.064	2.519ArgGln: 2.519 ± 0.059	5.536ArgArg: 5.536 ± 0.094	3.866ArgSer: 3.866 ± 0.066	3.458ArgThr: 3.458 ± 0.053	4.879ArgVal: 4.879 ± 0.078	1.04ArgTrp: 1.04 ± 0.032	1.757ArgTyr: 1.757 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.798SerAla: 6.798 ± 0.096	0.385SerCys: 0.385 ± 0.021	3.836SerAsp: 3.836 ± 0.068	3.315SerGlu: 3.315 ± 0.053	2.154SerPhe: 2.154 ± 0.059	6.001SerGly: 6.001 ± 0.122	1.103SerHis: 1.103 ± 0.033	2.756SerIle: 2.756 ± 0.069	1.243SerLys: 1.243 ± 0.035	5.774SerLeu: 5.774 ± 0.076	1.401SerMet: 1.401 ± 0.038	1.475SerAsn: 1.475 ± 0.048	2.768SerPro: 2.768 ± 0.044	1.774SerGln: 1.774 ± 0.045	3.783SerArg: 3.783 ± 0.065	2.888SerSer: 2.888 ± 0.071	2.753SerThr: 2.753 ± 0.058	4.214SerVal: 4.214 ± 0.092	0.883SerTrp: 0.883 ± 0.032	1.201SerTyr: 1.201 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.589ThrAla: 6.589 ± 0.098	0.405ThrCys: 0.405 ± 0.018	3.415ThrAsp: 3.415 ± 0.076	2.844ThrGlu: 2.844 ± 0.054	1.877ThrPhe: 1.877 ± 0.058	5.791ThrGly: 5.791 ± 0.097	0.983ThrHis: 0.983 ± 0.031	2.727ThrIle: 2.727 ± 0.08	1.082ThrLys: 1.082 ± 0.035	5.81ThrLeu: 5.81 ± 0.085	1.08ThrMet: 1.08 ± 0.036	1.355ThrAsn: 1.355 ± 0.04	3.4ThrPro: 3.4 ± 0.073	1.523ThrGln: 1.523 ± 0.04	3.628ThrArg: 3.628 ± 0.064	2.877ThrSer: 2.877 ± 0.056	2.8ThrThr: 2.8 ± 0.06	4.284ThrVal: 4.284 ± 0.1	0.588ThrTrp: 0.588 ± 0.028	1.138ThrTyr: 1.138 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.204ValAla: 8.204 ± 0.106	0.674ValCys: 0.674 ± 0.026	4.584ValAsp: 4.584 ± 0.083	4.883ValGlu: 4.883 ± 0.084	2.968ValPhe: 2.968 ± 0.054	5.574ValGly: 5.574 ± 0.11	1.341ValHis: 1.341 ± 0.038	4.024ValIle: 4.024 ± 0.066	1.713ValLys: 1.713 ± 0.045	6.896ValLeu: 6.896 ± 0.089	1.969ValMet: 1.969 ± 0.043	1.933ValAsn: 1.933 ± 0.051	2.97ValPro: 2.97 ± 0.056	1.914ValGln: 1.914 ± 0.045	5.095ValArg: 5.095 ± 0.071	4.696ValSer: 4.696 ± 0.077	4.555ValThr: 4.555 ± 0.108	5.205ValVal: 5.205 ± 0.085	1.092ValTrp: 1.092 ± 0.033	1.475ValTyr: 1.475 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.367TrpAla: 1.367 ± 0.039	0.102TrpCys: 0.102 ± 0.01	0.766TrpAsp: 0.766 ± 0.03	0.64TrpGlu: 0.64 ± 0.026	0.572TrpPhe: 0.572 ± 0.024	0.934TrpGly: 0.934 ± 0.029	0.332TrpHis: 0.332 ± 0.019	0.686TrpIle: 0.686 ± 0.028	0.341TrpLys: 0.341 ± 0.018	1.735TrpLeu: 1.735 ± 0.044	0.415TrpMet: 0.415 ± 0.021	0.383TrpAsn: 0.383 ± 0.02	0.738TrpPro: 0.738 ± 0.031	0.578TrpGln: 0.578 ± 0.025	1.398TrpArg: 1.398 ± 0.04	1.02TrpSer: 1.02 ± 0.033	0.842TrpThr: 0.842 ± 0.029	0.908TrpVal: 0.908 ± 0.033	0.262TrpTrp: 0.262 ± 0.016	0.289TrpTyr: 0.289 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.477TyrAla: 2.477 ± 0.055	0.221TyrCys: 0.221 ± 0.015	1.533TyrAsp: 1.533 ± 0.048	1.304TyrGlu: 1.304 ± 0.041	0.897TyrPhe: 0.897 ± 0.031	1.978TyrGly: 1.978 ± 0.044	0.438TyrHis: 0.438 ± 0.021	0.862TyrIle: 0.862 ± 0.037	0.475TyrLys: 0.475 ± 0.024	2.179TyrLeu: 2.179 ± 0.044	0.426TyrMet: 0.426 ± 0.025	0.552TyrAsn: 0.552 ± 0.029	0.978TyrPro: 0.978 ± 0.035	0.743TyrGln: 0.743 ± 0.029	1.637TyrArg: 1.637 ± 0.037	1.181TyrSer: 1.181 ± 0.042	1.091TyrThr: 1.091 ± 0.044	1.561TyrVal: 1.561 ± 0.043	0.365TyrTrp: 0.365 ± 0.02	0.573TyrTyr: 0.573 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3060 proteins (1006057 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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