Amino acid dipepetide frequency for Thiorhodovibrio sp. 970

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.872AlaAla: 13.872 ± 0.132
1.165AlaCys: 1.165 ± 0.031
6.566AlaAsp: 6.566 ± 0.073
8.118AlaGlu: 8.118 ± 0.094
3.663AlaPhe: 3.663 ± 0.051
8.593AlaGly: 8.593 ± 0.087
2.391AlaHis: 2.391 ± 0.041
5.394AlaIle: 5.394 ± 0.056
3.308AlaLys: 3.308 ± 0.05
14.126AlaLeu: 14.126 ± 0.13
2.926AlaMet: 2.926 ± 0.049
2.891AlaAsn: 2.891 ± 0.044
5.308AlaPro: 5.308 ± 0.074
4.512AlaGln: 4.512 ± 0.059
8.828AlaArg: 8.828 ± 0.096
6.193AlaSer: 6.193 ± 0.066
5.373AlaThr: 5.373 ± 0.07
7.05AlaVal: 7.05 ± 0.086
1.598AlaTrp: 1.598 ± 0.038
2.316AlaTyr: 2.316 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
1.047CysAla: 1.047 ± 0.029
0.158CysCys: 0.158 ± 0.01
0.626CysAsp: 0.626 ± 0.021
0.635CysGlu: 0.635 ± 0.022
0.384CysPhe: 0.384 ± 0.017
0.997CysGly: 0.997 ± 0.028
0.393CysHis: 0.393 ± 0.021
0.445CysIle: 0.445 ± 0.018
0.253CysLys: 0.253 ± 0.012
1.083CysLeu: 1.083 ± 0.026
0.185CysMet: 0.185 ± 0.011
0.286CysAsn: 0.286 ± 0.012
0.603CysPro: 0.603 ± 0.022
0.488CysGln: 0.488 ± 0.017
0.862CysArg: 0.862 ± 0.022
0.527CysSer: 0.527 ± 0.02
0.448CysThr: 0.448 ± 0.019
0.62CysVal: 0.62 ± 0.02
0.163CysTrp: 0.163 ± 0.009
0.276CysTyr: 0.276 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.903AspAla: 6.903 ± 0.075
0.672AspCys: 0.672 ± 0.026
3.352AspAsp: 3.352 ± 0.057
3.494AspGlu: 3.494 ± 0.049
2.373AspPhe: 2.373 ± 0.043
4.825AspGly: 4.825 ± 0.064
1.357AspHis: 1.357 ± 0.03
3.034AspIle: 3.034 ± 0.045
1.622AspLys: 1.622 ± 0.035
6.639AspLeu: 6.639 ± 0.074
1.179AspMet: 1.179 ± 0.03
1.489AspAsn: 1.489 ± 0.034
3.524AspPro: 3.524 ± 0.055
2.938AspGln: 2.938 ± 0.049
3.843AspArg: 3.843 ± 0.051
3.107AspSer: 3.107 ± 0.051
2.61AspThr: 2.61 ± 0.047
3.196AspVal: 3.196 ± 0.053
1.316AspTrp: 1.316 ± 0.033
1.789AspTyr: 1.789 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
6.779GluAla: 6.779 ± 0.081
0.478GluCys: 0.478 ± 0.017
3.066GluAsp: 3.066 ± 0.047
3.347GluGlu: 3.347 ± 0.056
1.877GluPhe: 1.877 ± 0.036
3.591GluGly: 3.591 ± 0.056
1.7GluHis: 1.7 ± 0.036
3.322GluIle: 3.322 ± 0.051
1.929GluLys: 1.929 ± 0.044
7.309GluLeu: 7.309 ± 0.081
1.337GluMet: 1.337 ± 0.028
1.571GluAsn: 1.571 ± 0.033
3.369GluPro: 3.369 ± 0.059
4.012GluGln: 4.012 ± 0.06
6.157GluArg: 6.157 ± 0.07
3.147GluSer: 3.147 ± 0.048
3.483GluThr: 3.483 ± 0.054
3.938GluVal: 3.938 ± 0.054
0.695GluTrp: 0.695 ± 0.021
1.167GluTyr: 1.167 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
3.986PheAla: 3.986 ± 0.053
0.423PheCys: 0.423 ± 0.016
2.633PheAsp: 2.633 ± 0.044
2.185PheGlu: 2.185 ± 0.038
1.468PhePhe: 1.468 ± 0.037
3.129PheGly: 3.129 ± 0.051
0.792PheHis: 0.792 ± 0.022
1.612PheIle: 1.612 ± 0.033
1.057PheLys: 1.057 ± 0.029
3.489PheLeu: 3.489 ± 0.052
0.681PheMet: 0.681 ± 0.025
1.107PheAsn: 1.107 ± 0.029
1.501PhePro: 1.501 ± 0.036
1.164PheGln: 1.164 ± 0.027
2.205PheArg: 2.205 ± 0.04
2.447PheSer: 2.447 ± 0.043
1.625PheThr: 1.625 ± 0.035
2.398PheVal: 2.398 ± 0.043
0.55PheTrp: 0.55 ± 0.019
0.963PheTyr: 0.963 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
7.449GlyAla: 7.449 ± 0.082
1.008GlyCys: 1.008 ± 0.028
4.367GlyAsp: 4.367 ± 0.056
4.802GlyGlu: 4.802 ± 0.061
3.126GlyPhe: 3.126 ± 0.051
5.685GlyGly: 5.685 ± 0.079
1.771GlyHis: 1.771 ± 0.032
3.985GlyIle: 3.985 ± 0.058
2.714GlyLys: 2.714 ± 0.038
8.88GlyLeu: 8.88 ± 0.077
1.925GlyMet: 1.925 ± 0.037
2.007GlyAsn: 2.007 ± 0.049
2.804GlyPro: 2.804 ± 0.043
3.536GlyGln: 3.536 ± 0.05
5.507GlyArg: 5.507 ± 0.063
4.136GlySer: 4.136 ± 0.058
3.747GlyThr: 3.747 ± 0.068
4.965GlyVal: 4.965 ± 0.064
1.271GlyTrp: 1.271 ± 0.027
2.223GlyTyr: 2.223 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.342HisAla: 2.342 ± 0.041
0.382HisCys: 0.382 ± 0.017
1.203HisAsp: 1.203 ± 0.025
1.11HisGlu: 1.11 ± 0.028
1.028HisPhe: 1.028 ± 0.028
1.983HisGly: 1.983 ± 0.039
0.747HisHis: 0.747 ± 0.028
0.908HisIle: 0.908 ± 0.023
0.572HisLys: 0.572 ± 0.019
2.77HisLeu: 2.77 ± 0.044
0.413HisMet: 0.413 ± 0.019
0.572HisAsn: 0.572 ± 0.02
1.707HisPro: 1.707 ± 0.036
1.203HisGln: 1.203 ± 0.03
1.799HisArg: 1.799 ± 0.035
1.191HisSer: 1.191 ± 0.028
0.799HisThr: 0.799 ± 0.025
1.138HisVal: 1.138 ± 0.03
0.546HisTrp: 0.546 ± 0.02
0.697HisTyr: 0.697 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.074IleAla: 6.074 ± 0.065
0.494IleCys: 0.494 ± 0.017
3.848IleAsp: 3.848 ± 0.058
3.722IleGlu: 3.722 ± 0.051
1.543IlePhe: 1.543 ± 0.034
4.348IleGly: 4.348 ± 0.054
1.096IleHis: 1.096 ± 0.027
2.003IleIle: 2.003 ± 0.042
1.619IleLys: 1.619 ± 0.034
4.646IleLeu: 4.646 ± 0.062
0.8IleMet: 0.8 ± 0.023
1.592IleAsn: 1.592 ± 0.031
2.458IlePro: 2.458 ± 0.04
1.659IleGln: 1.659 ± 0.03
3.215IleArg: 3.215 ± 0.05
2.817IleSer: 2.817 ± 0.05
2.383IleThr: 2.383 ± 0.042
2.752IleVal: 2.752 ± 0.052
0.507IleTrp: 0.507 ± 0.015
1.069IleTyr: 1.069 ± 0.022
0.0IleXaa: 0.0 ± 0.0
Lys
3.417LysAla: 3.417 ± 0.058
0.213LysCys: 0.213 ± 0.012
1.704LysAsp: 1.704 ± 0.04
1.613LysGlu: 1.613 ± 0.038
0.787LysPhe: 0.787 ± 0.03
2.099LysGly: 2.099 ± 0.038
0.707LysHis: 0.707 ± 0.022
1.448LysIle: 1.448 ± 0.034
1.189LysLys: 1.189 ± 0.037
3.066LysLeu: 3.066 ± 0.053
0.592LysMet: 0.592 ± 0.022
0.925LysAsn: 0.925 ± 0.027
1.979LysPro: 1.979 ± 0.04
1.39LysGln: 1.39 ± 0.032
2.451LysArg: 2.451 ± 0.045
1.691LysSer: 1.691 ± 0.031
1.933LysThr: 1.933 ± 0.039
1.893LysVal: 1.893 ± 0.041
0.303LysTrp: 0.303 ± 0.015
0.595LysTyr: 0.595 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
14.373LeuAla: 14.373 ± 0.121
1.205LeuCys: 1.205 ± 0.029
6.997LeuAsp: 6.997 ± 0.077
7.011LeuGlu: 7.011 ± 0.073
4.159LeuPhe: 4.159 ± 0.059
8.709LeuGly: 8.709 ± 0.078
2.483LeuHis: 2.483 ± 0.046
5.86LeuIle: 5.86 ± 0.065
3.652LeuLys: 3.652 ± 0.058
12.93LeuLeu: 12.93 ± 0.15
2.434LeuMet: 2.434 ± 0.042
3.082LeuAsn: 3.082 ± 0.045
6.174LeuPro: 6.174 ± 0.061
3.714LeuGln: 3.714 ± 0.057
8.637LeuArg: 8.637 ± 0.082
6.967LeuSer: 6.967 ± 0.067
5.772LeuThr: 5.772 ± 0.066
7.713LeuVal: 7.713 ± 0.088
1.426LeuTrp: 1.426 ± 0.036
2.374LeuTyr: 2.374 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
2.514MetAla: 2.514 ± 0.045
0.132MetCys: 0.132 ± 0.009
1.193MetAsp: 1.193 ± 0.028
1.051MetGlu: 1.051 ± 0.022
0.509MetPhe: 0.509 ± 0.017
1.415MetGly: 1.415 ± 0.029
0.51MetHis: 0.51 ± 0.019
1.109MetIle: 1.109 ± 0.03
0.76MetLys: 0.76 ± 0.021
2.455MetLeu: 2.455 ± 0.045
0.487MetMet: 0.487 ± 0.019
0.758MetAsn: 0.758 ± 0.024
1.344MetPro: 1.344 ± 0.031
0.906MetGln: 0.906 ± 0.021
1.639MetArg: 1.639 ± 0.034
1.379MetSer: 1.379 ± 0.031
1.458MetThr: 1.458 ± 0.031
1.407MetVal: 1.407 ± 0.031
0.131MetTrp: 0.131 ± 0.01
0.297MetTyr: 0.297 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.006AsnAla: 3.006 ± 0.047
0.3AsnCys: 0.3 ± 0.015
1.505AsnAsp: 1.505 ± 0.037
1.359AsnGlu: 1.359 ± 0.033
0.904AsnPhe: 0.904 ± 0.025
2.098AsnGly: 2.098 ± 0.041
0.619AsnHis: 0.619 ± 0.02
1.304AsnIle: 1.304 ± 0.031
0.771AsnLys: 0.771 ± 0.028
3.197AsnLeu: 3.197 ± 0.047
0.521AsnMet: 0.521 ± 0.02
0.833AsnAsn: 0.833 ± 0.03
2.003AsnPro: 2.003 ± 0.043
1.331AsnGln: 1.331 ± 0.033
2.081AsnArg: 2.081 ± 0.039
1.391AsnSer: 1.391 ± 0.031
1.229AsnThr: 1.229 ± 0.033
1.356AsnVal: 1.356 ± 0.036
0.399AsnTrp: 0.399 ± 0.018
0.644AsnTyr: 0.644 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
6.111ProAla: 6.111 ± 0.081
0.437ProCys: 0.437 ± 0.019
3.792ProAsp: 3.792 ± 0.055
4.466ProGlu: 4.466 ± 0.056
1.81ProPhe: 1.81 ± 0.038
4.409ProGly: 4.409 ± 0.058
1.01ProHis: 1.01 ± 0.024
2.248ProIle: 2.248 ± 0.04
1.575ProLys: 1.575 ± 0.036
5.46ProLeu: 5.46 ± 0.069
1.145ProMet: 1.145 ± 0.025
1.434ProAsn: 1.434 ± 0.032
3.082ProPro: 3.082 ± 0.057
1.954ProGln: 1.954 ± 0.036
3.043ProArg: 3.043 ± 0.057
3.029ProSer: 3.029 ± 0.046
2.545ProThr: 2.545 ± 0.045
3.885ProVal: 3.885 ± 0.053
0.807ProTrp: 0.807 ± 0.026
1.086ProTyr: 1.086 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
5.851GlnAla: 5.851 ± 0.078
0.396GlnCys: 0.396 ± 0.017
2.086GlnAsp: 2.086 ± 0.037
2.111GlnGlu: 2.111 ± 0.042
1.185GlnPhe: 1.185 ± 0.027
3.195GlnGly: 3.195 ± 0.046
1.022GlnHis: 1.022 ± 0.027
2.092GlnIle: 2.092 ± 0.044
1.011GlnLys: 1.011 ± 0.028
4.604GlnLeu: 4.604 ± 0.062
0.849GlnMet: 0.849 ± 0.024
0.909GlnAsn: 0.909 ± 0.024
2.624GlnPro: 2.624 ± 0.051
2.322GlnGln: 2.322 ± 0.049
3.708GlnArg: 3.708 ± 0.066
2.426GlnSer: 2.426 ± 0.04
2.167GlnThr: 2.167 ± 0.039
3.175GlnVal: 3.175 ± 0.052
0.589GlnTrp: 0.589 ± 0.019
0.749GlnTyr: 0.749 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
7.933ArgAla: 7.933 ± 0.082
0.795ArgCys: 0.795 ± 0.023
4.31ArgAsp: 4.31 ± 0.058
5.048ArgGlu: 5.048 ± 0.065
3.13ArgPhe: 3.13 ± 0.045
4.354ArgGly: 4.354 ± 0.057
2.01ArgHis: 2.01 ± 0.039
4.108ArgIle: 4.108 ± 0.052
2.096ArgLys: 2.096 ± 0.041
10.054ArgLeu: 10.054 ± 0.106
1.671ArgMet: 1.671 ± 0.033
1.843ArgAsn: 1.843 ± 0.036
3.51ArgPro: 3.51 ± 0.054
3.546ArgGln: 3.546 ± 0.058
5.821ArgArg: 5.821 ± 0.076
3.461ArgSer: 3.461 ± 0.047
3.053ArgThr: 3.053 ± 0.043
5.018ArgVal: 5.018 ± 0.071
1.255ArgTrp: 1.255 ± 0.03
2.034ArgTyr: 2.034 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.564SerAla: 6.564 ± 0.066
0.591SerCys: 0.591 ± 0.023
3.279SerAsp: 3.279 ± 0.049
3.345SerGlu: 3.345 ± 0.047
2.005SerPhe: 2.005 ± 0.037
5.171SerGly: 5.171 ± 0.067
1.172SerHis: 1.172 ± 0.027
2.64SerIle: 2.64 ± 0.042
1.541SerLys: 1.541 ± 0.03
6.282SerLeu: 6.282 ± 0.059
1.161SerMet: 1.161 ± 0.029
1.483SerAsn: 1.483 ± 0.031
3.091SerPro: 3.091 ± 0.053
2.157SerGln: 2.157 ± 0.041
3.763SerArg: 3.763 ± 0.049
3.223SerSer: 3.223 ± 0.057
2.567SerThr: 2.567 ± 0.047
3.532SerVal: 3.532 ± 0.051
0.729SerTrp: 0.729 ± 0.02
1.245SerTyr: 1.245 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
5.491ThrAla: 5.491 ± 0.069
0.432ThrCys: 0.432 ± 0.015
2.961ThrAsp: 2.961 ± 0.049
3.044ThrGlu: 3.044 ± 0.042
1.545ThrPhe: 1.545 ± 0.032
4.398ThrGly: 4.398 ± 0.056
1.049ThrHis: 1.049 ± 0.026
2.159ThrIle: 2.159 ± 0.051
1.372ThrLys: 1.372 ± 0.033
6.116ThrLeu: 6.116 ± 0.074
0.941ThrMet: 0.941 ± 0.025
1.277ThrAsn: 1.277 ± 0.036
3.103ThrPro: 3.103 ± 0.044
1.966ThrGln: 1.966 ± 0.037
3.294ThrArg: 3.294 ± 0.046
2.484ThrSer: 2.484 ± 0.043
2.464ThrThr: 2.464 ± 0.051
2.921ThrVal: 2.921 ± 0.054
0.683ThrTrp: 0.683 ± 0.027
0.987ThrTyr: 0.987 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
7.204ValAla: 7.204 ± 0.077
0.688ValCys: 0.688 ± 0.021
3.808ValAsp: 3.808 ± 0.05
3.99ValGlu: 3.99 ± 0.046
2.431ValPhe: 2.431 ± 0.042
4.371ValGly: 4.371 ± 0.052
1.309ValHis: 1.309 ± 0.027
3.483ValIle: 3.483 ± 0.058
1.964ValLys: 1.964 ± 0.042
7.439ValLeu: 7.439 ± 0.085
1.496ValMet: 1.496 ± 0.031
1.739ValAsn: 1.739 ± 0.031
3.124ValPro: 3.124 ± 0.044
2.21ValGln: 2.21 ± 0.037
4.707ValArg: 4.707 ± 0.066
3.749ValSer: 3.749 ± 0.059
3.465ValThr: 3.465 ± 0.053
4.553ValVal: 4.553 ± 0.07
0.737ValTrp: 0.737 ± 0.025
1.358ValTyr: 1.358 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.07TrpAla: 1.07 ± 0.027
0.161TrpCys: 0.161 ± 0.01
0.704TrpAsp: 0.704 ± 0.02
0.704TrpGlu: 0.704 ± 0.021
0.542TrpPhe: 0.542 ± 0.019
0.824TrpGly: 0.824 ± 0.029
0.382TrpHis: 0.382 ± 0.015
0.642TrpIle: 0.642 ± 0.022
0.417TrpLys: 0.417 ± 0.018
2.177TrpLeu: 2.177 ± 0.053
0.374TrpMet: 0.374 ± 0.014
0.409TrpAsn: 0.409 ± 0.021
0.798TrpPro: 0.798 ± 0.022
0.8TrpGln: 0.8 ± 0.025
1.261TrpArg: 1.261 ± 0.033
0.889TrpSer: 0.889 ± 0.027
0.65TrpThr: 0.65 ± 0.02
0.94TrpVal: 0.94 ± 0.026
0.254TrpTrp: 0.254 ± 0.012
0.354TrpTyr: 0.354 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.204TyrAla: 2.204 ± 0.035
0.349TyrCys: 0.349 ± 0.013
1.262TyrAsp: 1.262 ± 0.029
1.122TyrGlu: 1.122 ± 0.03
0.947TyrPhe: 0.947 ± 0.029
1.714TyrGly: 1.714 ± 0.036
0.587TyrHis: 0.587 ± 0.02
0.85TyrIle: 0.85 ± 0.026
0.57TyrLys: 0.57 ± 0.019
2.951TyrLeu: 2.951 ± 0.048
0.338TyrMet: 0.338 ± 0.016
0.645TyrAsn: 0.645 ± 0.023
1.222TyrPro: 1.222 ± 0.027
1.265TyrGln: 1.265 ± 0.033
2.228TyrArg: 2.228 ± 0.042
1.286TyrSer: 1.286 ± 0.033
0.917TyrThr: 0.917 ± 0.026
1.373TyrVal: 1.373 ± 0.027
0.392TyrTrp: 0.392 ± 0.016
0.665TyrTyr: 0.665 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4691 proteins (1526990 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski