Amino acid dipepetide frequency for Polyporus brumalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.274AlaAla: 10.274 ± 0.057	1.342AlaCys: 1.342 ± 0.014	4.732AlaAsp: 4.732 ± 0.027	5.182AlaGlu: 5.182 ± 0.032	3.384AlaPhe: 3.384 ± 0.024	5.928AlaGly: 5.928 ± 0.036	2.479AlaHis: 2.479 ± 0.022	3.978AlaIle: 3.978 ± 0.027	3.586AlaLys: 3.586 ± 0.027	9.0AlaLeu: 9.0 ± 0.042	1.993AlaMet: 1.993 ± 0.017	2.661AlaAsn: 2.661 ± 0.021	6.025AlaPro: 6.025 ± 0.04	3.581AlaGln: 3.581 ± 0.03	6.483AlaArg: 6.483 ± 0.036	8.149AlaSer: 8.149 ± 0.039	5.535AlaThr: 5.535 ± 0.031	6.096AlaVal: 6.096 ± 0.033	1.318AlaTrp: 1.318 ± 0.016	2.341AlaTyr: 2.341 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.327CysAla: 1.327 ± 0.013	0.351CysCys: 0.351 ± 0.007	0.727CysAsp: 0.727 ± 0.011	0.668CysGlu: 0.668 ± 0.01	0.522CysPhe: 0.522 ± 0.009	1.076CysGly: 1.076 ± 0.014	0.4CysHis: 0.4 ± 0.007	0.716CysIle: 0.716 ± 0.01	0.539CysLys: 0.539 ± 0.009	1.331CysLeu: 1.331 ± 0.014	0.326CysMet: 0.326 ± 0.007	0.411CysAsn: 0.411 ± 0.009	0.993CysPro: 0.993 ± 0.014	0.467CysGln: 0.467 ± 0.009	1.089CysArg: 1.089 ± 0.014	1.199CysSer: 1.199 ± 0.015	0.896CysThr: 0.896 ± 0.011	0.95CysVal: 0.95 ± 0.013	0.223CysTrp: 0.223 ± 0.006	0.375CysTyr: 0.375 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	5.482AspAla: 5.482 ± 0.032	0.706AspCys: 0.706 ± 0.01	4.296AspAsp: 4.296 ± 0.038	4.27AspGlu: 4.27 ± 0.038	2.002AspPhe: 2.002 ± 0.019	4.161AspGly: 4.161 ± 0.028	1.281AspHis: 1.281 ± 0.013	2.809AspIle: 2.809 ± 0.021	1.916AspLys: 1.916 ± 0.019	4.851AspLeu: 4.851 ± 0.025	1.252AspMet: 1.252 ± 0.012	1.43AspAsn: 1.43 ± 0.013	3.662AspPro: 3.662 ± 0.026	1.472AspGln: 1.472 ± 0.015	3.139AspArg: 3.139 ± 0.026	3.875AspSer: 3.875 ± 0.027	2.972AspThr: 2.972 ± 0.019	4.283AspVal: 4.283 ± 0.023	0.934AspTrp: 0.934 ± 0.011	1.468AspTyr: 1.468 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	5.084GluAla: 5.084 ± 0.036	0.726GluCys: 0.726 ± 0.011	4.199GluAsp: 4.199 ± 0.033	5.032GluGlu: 5.032 ± 0.049	1.789GluPhe: 1.789 ± 0.018	3.614GluGly: 3.614 ± 0.025	1.608GluHis: 1.608 ± 0.017	2.353GluIle: 2.353 ± 0.02	2.669GluLys: 2.669 ± 0.024	5.474GluLeu: 5.474 ± 0.036	1.236GluMet: 1.236 ± 0.014	1.573GluAsn: 1.573 ± 0.015	2.836GluPro: 2.836 ± 0.023	2.181GluGln: 2.181 ± 0.02	4.244GluArg: 4.244 ± 0.035	3.659GluSer: 3.659 ± 0.026	2.898GluThr: 2.898 ± 0.022	3.698GluVal: 3.698 ± 0.023	0.93GluTrp: 0.93 ± 0.011	1.512GluTyr: 1.512 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.344PheAla: 3.344 ± 0.025	0.569PheCys: 0.569 ± 0.01	2.178PheAsp: 2.178 ± 0.02	1.885PheGlu: 1.885 ± 0.018	1.421PhePhe: 1.421 ± 0.016	2.523PheGly: 2.523 ± 0.025	0.876PheHis: 0.876 ± 0.011	1.532PheIle: 1.532 ± 0.015	1.3PheLys: 1.3 ± 0.014	3.338PheLeu: 3.338 ± 0.024	0.733PheMet: 0.733 ± 0.011	1.14PheAsn: 1.14 ± 0.015	2.211PhePro: 2.211 ± 0.021	1.13PheGln: 1.13 ± 0.013	2.087PheArg: 2.087 ± 0.017	2.841PheSer: 2.841 ± 0.018	2.059PheThr: 2.059 ± 0.019	2.581PheVal: 2.581 ± 0.022	0.59PheTrp: 0.59 ± 0.01	0.96PheTyr: 0.96 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	5.529GlyAla: 5.529 ± 0.035	1.001GlyCys: 1.001 ± 0.013	3.52GlyAsp: 3.52 ± 0.023	3.472GlyGlu: 3.472 ± 0.025	2.372GlyPhe: 2.372 ± 0.024	5.281GlyGly: 5.281 ± 0.041	1.773GlyHis: 1.773 ± 0.016	2.843GlyIle: 2.843 ± 0.023	2.948GlyLys: 2.948 ± 0.024	5.583GlyLeu: 5.583 ± 0.032	1.494GlyMet: 1.494 ± 0.017	1.916GlyAsn: 1.916 ± 0.02	3.733GlyPro: 3.733 ± 0.026	2.264GlyGln: 2.264 ± 0.022	4.64GlyArg: 4.64 ± 0.034	5.507GlySer: 5.507 ± 0.036	4.074GlyThr: 4.074 ± 0.027	4.272GlyVal: 4.272 ± 0.029	1.145GlyTrp: 1.145 ± 0.012	1.806GlyTyr: 1.806 ± 0.018	0.0GlyXaa: 0.0 ± 0.0
His	2.588HisAla: 2.588 ± 0.02	0.442HisCys: 0.442 ± 0.008	1.475HisAsp: 1.475 ± 0.016	1.358HisGlu: 1.358 ± 0.015	0.937HisPhe: 0.937 ± 0.012	1.847HisGly: 1.847 ± 0.018	0.886HisHis: 0.886 ± 0.014	1.321HisIle: 1.321 ± 0.015	0.859HisLys: 0.859 ± 0.011	2.698HisLeu: 2.698 ± 0.023	0.531HisMet: 0.531 ± 0.009	0.752HisAsn: 0.752 ± 0.011	2.124HisPro: 2.124 ± 0.018	0.815HisGln: 0.815 ± 0.011	1.914HisArg: 1.914 ± 0.018	2.058HisSer: 2.058 ± 0.019	1.579HisThr: 1.579 ± 0.014	1.85HisVal: 1.85 ± 0.017	0.393HisTrp: 0.393 ± 0.009	0.7HisTyr: 0.7 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.03IleAla: 4.03 ± 0.029	0.714IleCys: 0.714 ± 0.011	2.423IleAsp: 2.423 ± 0.018	2.31IleGlu: 2.31 ± 0.017	1.594IlePhe: 1.594 ± 0.016	2.586IleGly: 2.586 ± 0.023	1.153IleHis: 1.153 ± 0.013	1.958IleIle: 1.958 ± 0.019	1.543IleLys: 1.543 ± 0.018	4.105IleLeu: 4.105 ± 0.025	0.863IleMet: 0.863 ± 0.012	1.235IleAsn: 1.235 ± 0.013	3.119IlePro: 3.119 ± 0.022	1.478IleGln: 1.478 ± 0.015	2.79IleArg: 2.79 ± 0.018	3.266IleSer: 3.266 ± 0.022	2.455IleThr: 2.455 ± 0.019	3.051IleVal: 3.051 ± 0.023	0.659IleTrp: 0.659 ± 0.011	1.191IleTyr: 1.191 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.805LysAla: 3.805 ± 0.026	0.453LysCys: 0.453 ± 0.008	2.194LysAsp: 2.194 ± 0.022	2.565LysGlu: 2.565 ± 0.026	1.191LysPhe: 1.191 ± 0.015	2.457LysGly: 2.457 ± 0.021	1.054LysHis: 1.054 ± 0.013	1.599LysIle: 1.599 ± 0.018	2.421LysLys: 2.421 ± 0.028	3.551LysLeu: 3.551 ± 0.022	0.789LysMet: 0.789 ± 0.012	1.178LysAsn: 1.178 ± 0.014	2.324LysPro: 2.324 ± 0.02	1.424LysGln: 1.424 ± 0.014	3.107LysArg: 3.107 ± 0.023	2.636LysSer: 2.636 ± 0.024	2.276LysThr: 2.276 ± 0.018	2.443LysVal: 2.443 ± 0.023	0.613LysTrp: 0.613 ± 0.009	1.142LysTyr: 1.142 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.62LeuAla: 8.62 ± 0.038	1.428LeuCys: 1.428 ± 0.015	5.151LeuAsp: 5.151 ± 0.028	5.325LeuGlu: 5.325 ± 0.035	3.268LeuPhe: 3.268 ± 0.027	5.533LeuGly: 5.533 ± 0.03	2.727LeuHis: 2.727 ± 0.024	3.416LeuIle: 3.416 ± 0.024	3.572LeuLys: 3.572 ± 0.025	8.831LeuLeu: 8.831 ± 0.046	1.667LeuMet: 1.667 ± 0.015	2.714LeuAsn: 2.714 ± 0.02	6.654LeuPro: 6.654 ± 0.036	3.708LeuGln: 3.708 ± 0.029	7.113LeuArg: 7.113 ± 0.042	7.799LeuSer: 7.799 ± 0.036	5.181LeuThr: 5.181 ± 0.027	5.999LeuVal: 5.999 ± 0.033	1.298LeuTrp: 1.298 ± 0.014	2.413LeuTyr: 2.413 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	1.856MetAla: 1.856 ± 0.015	0.288MetCys: 0.288 ± 0.006	1.176MetAsp: 1.176 ± 0.014	1.066MetGlu: 1.066 ± 0.013	0.766MetPhe: 0.766 ± 0.011	1.179MetGly: 1.179 ± 0.016	0.605MetHis: 0.605 ± 0.009	0.792MetIle: 0.792 ± 0.011	0.797MetLys: 0.797 ± 0.011	1.912MetLeu: 1.912 ± 0.016	0.475MetMet: 0.475 ± 0.009	0.656MetAsn: 0.656 ± 0.01	1.397MetPro: 1.397 ± 0.014	0.831MetGln: 0.831 ± 0.012	1.489MetArg: 1.489 ± 0.017	2.071MetSer: 2.071 ± 0.017	1.197MetThr: 1.197 ± 0.013	1.212MetVal: 1.212 ± 0.014	0.28MetTrp: 0.28 ± 0.007	0.552MetTyr: 0.552 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.964AsnAla: 2.964 ± 0.022	0.377AsnCys: 0.377 ± 0.008	1.499AsnAsp: 1.499 ± 0.015	1.437AsnGlu: 1.437 ± 0.015	1.069AsnPhe: 1.069 ± 0.012	2.262AsnGly: 2.262 ± 0.022	0.713AsnHis: 0.713 ± 0.01	1.541AsnIle: 1.541 ± 0.017	1.039AsnLys: 1.039 ± 0.012	2.668AsnLeu: 2.668 ± 0.023	0.656AsnMet: 0.656 ± 0.009	0.92AsnAsn: 0.92 ± 0.013	2.055AsnPro: 2.055 ± 0.02	0.858AsnGln: 0.858 ± 0.011	1.577AsnArg: 1.577 ± 0.015	2.019AsnSer: 2.019 ± 0.016	1.732AsnThr: 1.732 ± 0.016	2.208AsnVal: 2.208 ± 0.018	0.449AsnTrp: 0.449 ± 0.008	0.766AsnTyr: 0.766 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	6.729ProAla: 6.729 ± 0.044	0.768ProCys: 0.768 ± 0.013	3.579ProAsp: 3.579 ± 0.023	3.921ProGlu: 3.921 ± 0.024	2.198ProPhe: 2.198 ± 0.019	4.298ProGly: 4.298 ± 0.03	1.821ProHis: 1.821 ± 0.017	2.503ProIle: 2.503 ± 0.02	2.233ProLys: 2.233 ± 0.018	5.576ProLeu: 5.576 ± 0.036	1.173ProMet: 1.173 ± 0.015	1.925ProAsn: 1.925 ± 0.017	7.108ProPro: 7.108 ± 0.064	2.512ProGln: 2.512 ± 0.022	4.562ProArg: 4.562 ± 0.036	7.344ProSer: 7.344 ± 0.051	4.534ProThr: 4.534 ± 0.03	4.251ProVal: 4.251 ± 0.029	0.83ProTrp: 0.83 ± 0.011	1.595ProTyr: 1.595 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.407GlnAla: 3.407 ± 0.023	0.515GlnCys: 0.515 ± 0.01	1.869GlnAsp: 1.869 ± 0.018	2.129GlnGlu: 2.129 ± 0.018	1.173GlnPhe: 1.173 ± 0.013	2.107GlnGly: 2.107 ± 0.017	1.057GlnHis: 1.057 ± 0.015	1.406GlnIle: 1.406 ± 0.015	1.403GlnLys: 1.403 ± 0.016	3.327GlnLeu: 3.327 ± 0.022	0.761GlnMet: 0.761 ± 0.011	1.063GlnAsn: 1.063 ± 0.013	2.447GlnPro: 2.447 ± 0.025	1.774GlnGln: 1.774 ± 0.026	2.63GlnArg: 2.63 ± 0.019	2.76GlnSer: 2.76 ± 0.02	2.041GlnThr: 2.041 ± 0.019	2.105GlnVal: 2.105 ± 0.016	0.574GlnTrp: 0.574 ± 0.01	1.09GlnTyr: 1.09 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	6.352ArgAla: 6.352 ± 0.037	1.114ArgCys: 1.114 ± 0.014	3.674ArgAsp: 3.674 ± 0.027	4.055ArgGlu: 4.055 ± 0.03	2.25ArgPhe: 2.25 ± 0.018	4.235ArgGly: 4.235 ± 0.035	1.94ArgHis: 1.94 ± 0.018	2.943ArgIle: 2.943 ± 0.022	3.182ArgLys: 3.182 ± 0.024	6.376ArgLeu: 6.376 ± 0.037	1.54ArgMet: 1.54 ± 0.016	1.975ArgAsn: 1.975 ± 0.017	4.49ArgPro: 4.49 ± 0.033	2.418ArgGln: 2.418 ± 0.019	6.508ArgArg: 6.508 ± 0.038	5.669ArgSer: 5.669 ± 0.04	4.33ArgThr: 4.33 ± 0.025	4.237ArgVal: 4.237 ± 0.031	1.15ArgTrp: 1.15 ± 0.012	1.846ArgTyr: 1.846 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	7.688SerAla: 7.688 ± 0.042	1.133SerCys: 1.133 ± 0.014	4.276SerAsp: 4.276 ± 0.029	3.838SerGlu: 3.838 ± 0.027	2.917SerPhe: 2.917 ± 0.02	5.558SerGly: 5.558 ± 0.032	2.138SerHis: 2.138 ± 0.022	3.388SerIle: 3.388 ± 0.022	2.935SerLys: 2.935 ± 0.025	7.59SerLeu: 7.59 ± 0.04	1.689SerMet: 1.689 ± 0.018	2.222SerAsn: 2.222 ± 0.019	6.505SerPro: 6.505 ± 0.053	2.872SerGln: 2.872 ± 0.024	5.738SerArg: 5.738 ± 0.038	9.557SerSer: 9.557 ± 0.076	5.741SerThr: 5.741 ± 0.034	5.079SerVal: 5.079 ± 0.026	1.152SerTrp: 1.152 ± 0.013	1.946SerTyr: 1.946 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.435ThrAla: 5.435 ± 0.028	0.89ThrCys: 0.89 ± 0.014	2.806ThrAsp: 2.806 ± 0.02	2.714ThrGlu: 2.714 ± 0.02	2.355ThrPhe: 2.355 ± 0.02	3.838ThrGly: 3.838 ± 0.024	1.614ThrHis: 1.614 ± 0.015	2.737ThrIle: 2.737 ± 0.02	2.002ThrLys: 2.002 ± 0.017	5.841ThrLeu: 5.841 ± 0.029	1.168ThrMet: 1.168 ± 0.014	1.647ThrAsn: 1.647 ± 0.016	4.814ThrPro: 4.814 ± 0.035	1.937ThrGln: 1.937 ± 0.017	3.822ThrArg: 3.822 ± 0.024	5.53ThrSer: 5.53 ± 0.036	4.031ThrThr: 4.031 ± 0.034	4.078ThrVal: 4.078 ± 0.023	0.859ThrTrp: 0.859 ± 0.01	1.608ThrTyr: 1.608 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	5.947ValAla: 5.947 ± 0.031	1.074ValCys: 1.074 ± 0.012	3.906ValAsp: 3.906 ± 0.026	3.819ValGlu: 3.819 ± 0.027	2.48ValPhe: 2.48 ± 0.022	3.95ValGly: 3.95 ± 0.028	1.842ValHis: 1.842 ± 0.016	2.746ValIle: 2.746 ± 0.02	2.575ValLys: 2.575 ± 0.022	6.503ValLeu: 6.503 ± 0.032	1.306ValMet: 1.306 ± 0.014	1.945ValAsn: 1.945 ± 0.018	4.607ValPro: 4.607 ± 0.029	2.47ValGln: 2.47 ± 0.017	4.448ValArg: 4.448 ± 0.025	5.035ValSer: 5.035 ± 0.027	3.636ValThr: 3.636 ± 0.021	4.848ValVal: 4.848 ± 0.027	1.026ValTrp: 1.026 ± 0.013	1.825ValTyr: 1.825 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.183TrpAla: 1.183 ± 0.013	0.242TrpCys: 0.242 ± 0.006	0.93TrpAsp: 0.93 ± 0.011	0.869TrpGlu: 0.869 ± 0.01	0.569TrpPhe: 0.569 ± 0.01	0.863TrpGly: 0.863 ± 0.012	0.402TrpHis: 0.402 ± 0.008	0.684TrpIle: 0.684 ± 0.011	0.745TrpLys: 0.745 ± 0.01	1.39TrpLeu: 1.39 ± 0.015	0.37TrpMet: 0.37 ± 0.007	0.552TrpAsn: 0.552 ± 0.008	0.758TrpPro: 0.758 ± 0.011	0.57TrpGln: 0.57 ± 0.009	1.21TrpArg: 1.21 ± 0.014	1.137TrpSer: 1.137 ± 0.013	1.002TrpThr: 1.002 ± 0.013	0.901TrpVal: 0.901 ± 0.011	0.302TrpTrp: 0.302 ± 0.008	0.441TrpTyr: 0.441 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.419TyrAla: 2.419 ± 0.019	0.455TyrCys: 0.455 ± 0.009	1.65TyrAsp: 1.65 ± 0.018	1.403TyrGlu: 1.403 ± 0.016	1.044TyrPhe: 1.044 ± 0.013	1.878TyrGly: 1.878 ± 0.017	0.76TyrHis: 0.76 ± 0.012	1.259TyrIle: 1.259 ± 0.013	0.957TyrLys: 0.957 ± 0.013	2.47TyrLeu: 2.47 ± 0.019	0.572TyrMet: 0.572 ± 0.009	0.895TyrAsn: 0.895 ± 0.011	1.596TyrPro: 1.596 ± 0.02	0.877TyrGln: 0.877 ± 0.012	1.692TyrArg: 1.692 ± 0.017	1.853TyrSer: 1.853 ± 0.018	1.555TyrThr: 1.555 ± 0.017	1.846TyrVal: 1.846 ± 0.019	0.397TyrTrp: 0.397 ± 0.009	0.837TyrTyr: 0.837 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 18174 proteins (7177947 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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