Amino acid dipepetide frequency for Sulfolobus spindle-shaped virus Lassen

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.0AlaCys: 0.0 ± 0.0
1.685AlaAsp: 1.685 ± 0.598
3.557AlaGlu: 3.557 ± 0.955
2.434AlaPhe: 2.434 ± 0.716
2.434AlaGly: 2.434 ± 0.83
0.187AlaHis: 0.187 ± 0.175
3.557AlaIle: 3.557 ± 0.853
5.991AlaLys: 5.991 ± 1.331
6.366AlaLeu: 6.366 ± 1.151
1.498AlaMet: 1.498 ± 0.732
2.434AlaAsn: 2.434 ± 0.78
1.311AlaPro: 1.311 ± 0.639
1.685AlaGln: 1.685 ± 0.601
0.749AlaArg: 0.749 ± 0.341
3.183AlaSer: 3.183 ± 1.004
2.247AlaThr: 2.247 ± 0.651
3.932AlaVal: 3.932 ± 0.899
1.311AlaTrp: 1.311 ± 0.395
2.996AlaTyr: 2.996 ± 0.656
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.374CysGlu: 0.374 ± 0.326
0.374CysPhe: 0.374 ± 0.291
0.374CysGly: 0.374 ± 0.262
0.0CysHis: 0.0 ± 0.0
0.749CysIle: 0.749 ± 0.451
0.374CysLys: 0.374 ± 0.302
0.749CysLeu: 0.749 ± 0.397
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.936CysPro: 0.936 ± 0.632
0.187CysGln: 0.187 ± 0.228
0.0CysArg: 0.0 ± 0.0
0.749CysSer: 0.749 ± 0.541
0.0CysThr: 0.0 ± 0.0
0.374CysVal: 0.374 ± 0.322
0.187CysTrp: 0.187 ± 0.21
0.187CysTyr: 0.187 ± 0.218
0.0CysXaa: 0.0 ± 0.0
Asp
2.06AspAla: 2.06 ± 0.704
0.0AspCys: 0.0 ± 0.0
2.247AspAsp: 2.247 ± 0.736
3.745AspGlu: 3.745 ± 1.06
1.872AspPhe: 1.872 ± 0.555
2.996AspGly: 2.996 ± 0.68
0.187AspHis: 0.187 ± 0.234
3.37AspIle: 3.37 ± 0.818
2.808AspLys: 2.808 ± 0.593
3.557AspLeu: 3.557 ± 1.029
0.749AspMet: 0.749 ± 0.34
1.311AspAsn: 1.311 ± 0.543
1.123AspPro: 1.123 ± 0.408
0.562AspGln: 0.562 ± 0.401
1.498AspArg: 1.498 ± 0.466
1.685AspSer: 1.685 ± 0.557
1.685AspThr: 1.685 ± 0.619
1.872AspVal: 1.872 ± 0.737
0.562AspTrp: 0.562 ± 0.311
1.872AspTyr: 1.872 ± 0.665
0.0AspXaa: 0.0 ± 0.0
Glu
3.37GluAla: 3.37 ± 0.976
0.749GluCys: 0.749 ± 0.505
2.247GluAsp: 2.247 ± 0.827
7.676GluGlu: 7.676 ± 2.427
1.498GluPhe: 1.498 ± 0.666
2.621GluGly: 2.621 ± 0.723
0.936GluHis: 0.936 ± 0.426
6.366GluIle: 6.366 ± 1.511
5.055GluLys: 5.055 ± 1.176
7.302GluLeu: 7.302 ± 1.422
2.434GluMet: 2.434 ± 0.673
2.808GluAsn: 2.808 ± 0.98
0.936GluPro: 0.936 ± 0.386
0.562GluGln: 0.562 ± 0.359
1.872GluArg: 1.872 ± 0.739
2.621GluSer: 2.621 ± 0.796
3.183GluThr: 3.183 ± 0.971
4.119GluVal: 4.119 ± 1.316
1.311GluTrp: 1.311 ± 0.569
1.872GluTyr: 1.872 ± 0.504
0.0GluXaa: 0.0 ± 0.0
Phe
2.434PheAla: 2.434 ± 0.66
0.374PheCys: 0.374 ± 0.275
2.06PheAsp: 2.06 ± 0.593
2.247PheGlu: 2.247 ± 0.65
2.808PhePhe: 2.808 ± 0.593
2.247PheGly: 2.247 ± 0.659
0.562PheHis: 0.562 ± 0.316
3.932PheIle: 3.932 ± 0.91
1.498PheLys: 1.498 ± 0.434
3.932PheLeu: 3.932 ± 0.978
0.936PheMet: 0.936 ± 0.471
2.247PheAsn: 2.247 ± 0.719
1.685PhePro: 1.685 ± 0.597
2.434PheGln: 2.434 ± 0.623
1.123PheArg: 1.123 ± 0.417
3.37PheSer: 3.37 ± 0.829
3.183PheThr: 3.183 ± 0.921
3.557PheVal: 3.557 ± 0.919
0.562PheTrp: 0.562 ± 0.283
4.119PheTyr: 4.119 ± 0.796
0.0PheXaa: 0.0 ± 0.0
Gly
2.434GlyAla: 2.434 ± 0.936
0.187GlyCys: 0.187 ± 0.173
1.872GlyAsp: 1.872 ± 0.601
1.685GlyGlu: 1.685 ± 0.692
4.119GlyPhe: 4.119 ± 1.212
4.306GlyGly: 4.306 ± 1.23
0.374GlyHis: 0.374 ± 0.314
5.804GlyIle: 5.804 ± 0.88
3.37GlyLys: 3.37 ± 0.861
6.366GlyLeu: 6.366 ± 1.053
1.685GlyMet: 1.685 ± 0.647
2.808GlyAsn: 2.808 ± 0.772
1.685GlyPro: 1.685 ± 0.751
2.06GlyGln: 2.06 ± 0.978
1.498GlyArg: 1.498 ± 0.609
5.804GlySer: 5.804 ± 0.979
3.183GlyThr: 3.183 ± 0.831
5.055GlyVal: 5.055 ± 0.828
1.311GlyTrp: 1.311 ± 0.434
3.37GlyTyr: 3.37 ± 0.905
0.0GlyXaa: 0.0 ± 0.0
His
0.562HisAla: 0.562 ± 0.31
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.936HisGlu: 0.936 ± 0.5
0.562HisPhe: 0.562 ± 0.301
1.123HisGly: 1.123 ± 0.397
0.187HisHis: 0.187 ± 0.162
0.936HisIle: 0.936 ± 0.376
1.311HisLys: 1.311 ± 0.517
1.498HisLeu: 1.498 ± 0.646
0.749HisMet: 0.749 ± 0.446
0.562HisAsn: 0.562 ± 0.344
0.187HisPro: 0.187 ± 0.156
0.187HisGln: 0.187 ± 0.162
0.0HisArg: 0.0 ± 0.0
0.562HisSer: 0.562 ± 0.337
1.123HisThr: 1.123 ± 0.435
1.311HisVal: 1.311 ± 0.596
0.0HisTrp: 0.0 ± 0.0
0.936HisTyr: 0.936 ± 0.439
0.0HisXaa: 0.0 ± 0.0
Ile
5.991IleAla: 5.991 ± 1.326
0.374IleCys: 0.374 ± 0.302
1.872IleAsp: 1.872 ± 0.577
3.932IleGlu: 3.932 ± 1.006
4.868IlePhe: 4.868 ± 1.056
4.494IleGly: 4.494 ± 0.987
0.749IleHis: 0.749 ± 0.429
5.804IleIle: 5.804 ± 1.497
5.242IleLys: 5.242 ± 1.175
8.8IleLeu: 8.8 ± 1.477
1.311IleMet: 1.311 ± 0.489
3.557IleAsn: 3.557 ± 0.786
4.868IlePro: 4.868 ± 0.983
3.37IleGln: 3.37 ± 0.72
4.681IleArg: 4.681 ± 1.226
7.489IleSer: 7.489 ± 1.444
6.179IleThr: 6.179 ± 1.138
8.051IleVal: 8.051 ± 1.047
0.562IleTrp: 0.562 ± 0.354
5.43IleTyr: 5.43 ± 1.075
0.0IleXaa: 0.0 ± 0.0
Lys
4.494LysAla: 4.494 ± 1.376
0.374LysCys: 0.374 ± 0.274
4.681LysAsp: 4.681 ± 0.908
4.868LysGlu: 4.868 ± 1.41
2.247LysPhe: 2.247 ± 0.66
4.868LysGly: 4.868 ± 0.866
1.311LysHis: 1.311 ± 0.465
7.864LysIle: 7.864 ± 2.253
8.425LysLys: 8.425 ± 2.03
8.987LysLeu: 8.987 ± 1.844
1.872LysMet: 1.872 ± 0.703
2.996LysAsn: 2.996 ± 0.716
1.498LysPro: 1.498 ± 0.542
3.745LysGln: 3.745 ± 0.956
3.183LysArg: 3.183 ± 0.834
3.183LysSer: 3.183 ± 0.932
3.557LysThr: 3.557 ± 0.796
5.43LysVal: 5.43 ± 1.125
0.936LysTrp: 0.936 ± 0.466
4.306LysTyr: 4.306 ± 0.877
0.0LysXaa: 0.0 ± 0.0
Leu
5.43LeuAla: 5.43 ± 1.025
0.562LeuCys: 0.562 ± 0.337
4.119LeuAsp: 4.119 ± 1.4
5.617LeuGlu: 5.617 ± 1.099
5.242LeuPhe: 5.242 ± 1.233
7.489LeuGly: 7.489 ± 1.319
1.123LeuHis: 1.123 ± 0.413
9.174LeuIle: 9.174 ± 1.555
8.425LeuLys: 8.425 ± 1.505
13.855LeuLeu: 13.855 ± 1.575
3.183LeuMet: 3.183 ± 0.89
9.549LeuAsn: 9.549 ± 1.556
4.494LeuPro: 4.494 ± 0.896
3.745LeuGln: 3.745 ± 0.674
4.119LeuArg: 4.119 ± 1.329
7.676LeuSer: 7.676 ± 1.415
8.238LeuThr: 8.238 ± 1.434
6.366LeuVal: 6.366 ± 1.029
1.498LeuTrp: 1.498 ± 0.588
4.681LeuTyr: 4.681 ± 1.052
0.0LeuXaa: 0.0 ± 0.0
Met
1.123MetAla: 1.123 ± 0.439
0.0MetCys: 0.0 ± 0.0
1.123MetAsp: 1.123 ± 0.5
1.123MetGlu: 1.123 ± 0.657
1.123MetPhe: 1.123 ± 0.509
1.872MetGly: 1.872 ± 0.487
0.374MetHis: 0.374 ± 0.293
1.123MetIle: 1.123 ± 0.452
2.808MetLys: 2.808 ± 0.986
2.06MetLeu: 2.06 ± 0.632
0.562MetMet: 0.562 ± 0.309
0.936MetAsn: 0.936 ± 0.432
0.374MetPro: 0.374 ± 0.302
0.374MetGln: 0.374 ± 0.275
1.498MetArg: 1.498 ± 0.635
0.936MetSer: 0.936 ± 0.381
1.311MetThr: 1.311 ± 0.651
1.498MetVal: 1.498 ± 0.5
0.0MetTrp: 0.0 ± 0.0
1.123MetTyr: 1.123 ± 0.595
0.0MetXaa: 0.0 ± 0.0
Asn
2.808AsnAla: 2.808 ± 0.776
0.562AsnCys: 0.562 ± 0.321
2.434AsnAsp: 2.434 ± 0.841
4.681AsnGlu: 4.681 ± 1.169
2.808AsnPhe: 2.808 ± 0.638
4.119AsnGly: 4.119 ± 1.343
0.936AsnHis: 0.936 ± 0.421
5.242AsnIle: 5.242 ± 0.879
3.183AsnLys: 3.183 ± 1.008
3.37AsnLeu: 3.37 ± 0.829
0.749AsnMet: 0.749 ± 0.341
4.119AsnAsn: 4.119 ± 1.155
2.996AsnPro: 2.996 ± 0.82
1.872AsnGln: 1.872 ± 0.61
0.749AsnArg: 0.749 ± 0.424
3.37AsnSer: 3.37 ± 1.036
3.183AsnThr: 3.183 ± 1.169
3.932AsnVal: 3.932 ± 1.469
0.749AsnTrp: 0.749 ± 0.342
3.37AsnTyr: 3.37 ± 1.056
0.0AsnXaa: 0.0 ± 0.0
Pro
2.247ProAla: 2.247 ± 0.608
0.0ProCys: 0.0 ± 0.0
1.685ProAsp: 1.685 ± 0.615
1.498ProGlu: 1.498 ± 0.49
2.434ProPhe: 2.434 ± 0.617
1.685ProGly: 1.685 ± 0.644
0.749ProHis: 0.749 ± 0.27
2.808ProIle: 2.808 ± 0.827
2.434ProLys: 2.434 ± 0.772
2.247ProLeu: 2.247 ± 0.589
0.374ProMet: 0.374 ± 0.299
1.311ProAsn: 1.311 ± 0.419
2.808ProPro: 2.808 ± 0.973
1.123ProGln: 1.123 ± 0.396
0.749ProArg: 0.749 ± 0.408
3.37ProSer: 3.37 ± 0.775
2.808ProThr: 2.808 ± 0.956
2.247ProVal: 2.247 ± 0.6
0.749ProTrp: 0.749 ± 0.503
2.247ProTyr: 2.247 ± 0.695
0.0ProXaa: 0.0 ± 0.0
Gln
0.749GlnAla: 0.749 ± 0.355
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
0.936GlnGlu: 0.936 ± 0.395
1.872GlnPhe: 1.872 ± 0.724
1.311GlnGly: 1.311 ± 0.368
1.498GlnHis: 1.498 ± 0.67
4.494GlnIle: 4.494 ± 1.038
2.808GlnLys: 2.808 ± 0.858
3.745GlnLeu: 3.745 ± 0.649
0.749GlnMet: 0.749 ± 0.431
2.247GlnAsn: 2.247 ± 0.711
0.936GlnPro: 0.936 ± 0.352
1.123GlnGln: 1.123 ± 0.483
1.123GlnArg: 1.123 ± 0.556
2.434GlnSer: 2.434 ± 0.539
2.434GlnThr: 2.434 ± 0.594
2.06GlnVal: 2.06 ± 0.706
0.187GlnTrp: 0.187 ± 0.156
1.685GlnTyr: 1.685 ± 0.618
0.0GlnXaa: 0.0 ± 0.0
Arg
0.562ArgAla: 0.562 ± 0.34
0.374ArgCys: 0.374 ± 0.318
1.498ArgAsp: 1.498 ± 0.566
2.808ArgGlu: 2.808 ± 0.867
1.311ArgPhe: 1.311 ± 0.758
1.311ArgGly: 1.311 ± 0.499
0.562ArgHis: 0.562 ± 0.362
2.06ArgIle: 2.06 ± 0.56
4.868ArgLys: 4.868 ± 1.227
4.868ArgLeu: 4.868 ± 1.136
1.498ArgMet: 1.498 ± 0.64
1.123ArgAsn: 1.123 ± 0.568
0.374ArgPro: 0.374 ± 0.258
1.498ArgGln: 1.498 ± 0.603
2.247ArgArg: 2.247 ± 0.708
1.123ArgSer: 1.123 ± 0.425
1.311ArgThr: 1.311 ± 0.4
2.434ArgVal: 2.434 ± 0.859
0.562ArgTrp: 0.562 ± 0.343
1.311ArgTyr: 1.311 ± 0.675
0.0ArgXaa: 0.0 ± 0.0
Ser
3.37SerAla: 3.37 ± 0.711
0.187SerCys: 0.187 ± 0.179
2.247SerAsp: 2.247 ± 0.587
2.996SerGlu: 2.996 ± 0.791
2.621SerPhe: 2.621 ± 0.648
4.306SerGly: 4.306 ± 0.898
0.749SerHis: 0.749 ± 0.441
5.055SerIle: 5.055 ± 1.325
5.43SerLys: 5.43 ± 1.173
7.676SerLeu: 7.676 ± 1.409
0.374SerMet: 0.374 ± 0.262
4.868SerAsn: 4.868 ± 1.481
2.808SerPro: 2.808 ± 0.721
2.434SerGln: 2.434 ± 0.692
1.872SerArg: 1.872 ± 0.623
5.055SerSer: 5.055 ± 1.907
4.306SerThr: 4.306 ± 1.28
4.681SerVal: 4.681 ± 1.499
0.562SerTrp: 0.562 ± 0.276
4.494SerTyr: 4.494 ± 0.976
0.0SerXaa: 0.0 ± 0.0
Thr
2.434ThrAla: 2.434 ± 0.555
0.187ThrCys: 0.187 ± 0.17
1.498ThrAsp: 1.498 ± 0.571
3.745ThrGlu: 3.745 ± 1.086
3.37ThrPhe: 3.37 ± 0.904
3.183ThrGly: 3.183 ± 0.941
0.749ThrHis: 0.749 ± 0.407
7.489ThrIle: 7.489 ± 1.546
4.119ThrLys: 4.119 ± 0.838
11.983ThrLeu: 11.983 ± 1.765
0.374ThrMet: 0.374 ± 0.225
3.932ThrAsn: 3.932 ± 0.879
2.247ThrPro: 2.247 ± 0.725
2.247ThrGln: 2.247 ± 0.674
1.123ThrArg: 1.123 ± 0.498
3.37ThrSer: 3.37 ± 0.934
6.928ThrThr: 6.928 ± 1.901
3.557ThrVal: 3.557 ± 0.908
0.749ThrTrp: 0.749 ± 0.393
3.932ThrTyr: 3.932 ± 1.064
0.0ThrXaa: 0.0 ± 0.0
Val
2.621ValAla: 2.621 ± 0.781
1.123ValCys: 1.123 ± 0.967
2.247ValAsp: 2.247 ± 0.522
3.557ValGlu: 3.557 ± 0.857
1.311ValPhe: 1.311 ± 0.51
4.119ValGly: 4.119 ± 0.886
0.749ValHis: 0.749 ± 0.375
5.617ValIle: 5.617 ± 1.12
5.617ValLys: 5.617 ± 1.065
7.676ValLeu: 7.676 ± 1.044
1.498ValMet: 1.498 ± 0.53
4.119ValAsn: 4.119 ± 0.923
2.247ValPro: 2.247 ± 0.669
1.311ValGln: 1.311 ± 0.461
3.557ValArg: 3.557 ± 0.961
6.366ValSer: 6.366 ± 1.847
7.302ValThr: 7.302 ± 1.515
5.055ValVal: 5.055 ± 1.009
1.123ValTrp: 1.123 ± 0.469
4.306ValTyr: 4.306 ± 0.798
0.0ValXaa: 0.0 ± 0.0
Trp
0.749TrpAla: 0.749 ± 0.295
0.374TrpCys: 0.374 ± 0.274
0.187TrpAsp: 0.187 ± 0.178
0.749TrpGlu: 0.749 ± 0.36
0.562TrpPhe: 0.562 ± 0.372
1.498TrpGly: 1.498 ± 0.446
0.0TrpHis: 0.0 ± 0.0
0.749TrpIle: 0.749 ± 0.393
1.123TrpLys: 1.123 ± 0.547
2.434TrpLeu: 2.434 ± 0.796
0.374TrpMet: 0.374 ± 0.285
0.374TrpAsn: 0.374 ± 0.22
0.374TrpPro: 0.374 ± 0.248
0.374TrpGln: 0.374 ± 0.382
0.562TrpArg: 0.562 ± 0.271
0.562TrpSer: 0.562 ± 0.243
1.123TrpThr: 1.123 ± 0.384
0.749TrpVal: 0.749 ± 0.299
0.0TrpTrp: 0.0 ± 0.0
0.749TrpTyr: 0.749 ± 0.477
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.119TyrAla: 4.119 ± 0.834
0.187TyrCys: 0.187 ± 0.218
2.06TyrAsp: 2.06 ± 0.617
2.808TyrGlu: 2.808 ± 0.824
1.872TyrPhe: 1.872 ± 0.53
2.621TyrGly: 2.621 ± 0.878
0.749TyrHis: 0.749 ± 0.474
5.43TyrIle: 5.43 ± 1.073
3.932TyrLys: 3.932 ± 0.964
7.302TyrLeu: 7.302 ± 1.316
0.187TyrMet: 0.187 ± 0.204
3.932TyrAsn: 3.932 ± 0.94
1.685TyrPro: 1.685 ± 0.807
1.498TyrGln: 1.498 ± 0.618
1.498TyrArg: 1.498 ± 0.485
3.183TyrSer: 3.183 ± 1.172
3.932TyrThr: 3.932 ± 1.123
5.242TyrVal: 5.242 ± 0.896
0.749TyrTrp: 0.749 ± 0.388
3.745TyrTyr: 3.745 ± 0.975
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 38 proteins (5342 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski