Amino acid dipepetide frequency for Streptococcus satellite phage Javan598

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.943AlaAla: 0.943 ± 0.508
0.314AlaCys: 0.314 ± 0.336
4.714AlaAsp: 4.714 ± 1.744
7.542AlaGlu: 7.542 ± 2.234
1.257AlaPhe: 1.257 ± 0.65
1.886AlaGly: 1.886 ± 0.699
0.0AlaHis: 0.0 ± 0.0
6.285AlaIle: 6.285 ± 1.28
5.343AlaLys: 5.343 ± 1.676
8.171AlaLeu: 8.171 ± 1.898
1.571AlaMet: 1.571 ± 0.793
3.143AlaAsn: 3.143 ± 1.208
1.886AlaPro: 1.886 ± 0.655
3.457AlaGln: 3.457 ± 0.899
3.457AlaArg: 3.457 ± 0.865
3.771AlaSer: 3.771 ± 1.407
6.6AlaThr: 6.6 ± 1.757
2.2AlaVal: 2.2 ± 0.77
0.943AlaTrp: 0.943 ± 0.501
3.457AlaTyr: 3.457 ± 1.104
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.314CysAsp: 0.314 ± 0.323
0.629CysGlu: 0.629 ± 0.439
0.0CysPhe: 0.0 ± 0.0
0.629CysGly: 0.629 ± 0.437
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.314CysPro: 0.314 ± 0.281
0.0CysGln: 0.0 ± 0.0
0.629CysArg: 0.629 ± 0.37
0.314CysSer: 0.314 ± 0.336
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.629CysTyr: 0.629 ± 0.671
0.0CysXaa: 0.0 ± 0.0
Asp
1.886AspAla: 1.886 ± 0.777
0.0AspCys: 0.0 ± 0.0
2.2AspAsp: 2.2 ± 0.798
4.714AspGlu: 4.714 ± 1.367
2.828AspPhe: 2.828 ± 0.687
1.571AspGly: 1.571 ± 0.455
0.943AspHis: 0.943 ± 0.512
6.6AspIle: 6.6 ± 0.907
7.542AspLys: 7.542 ± 1.149
4.4AspLeu: 4.4 ± 1.219
0.629AspMet: 0.629 ± 0.533
3.143AspAsn: 3.143 ± 0.617
2.828AspPro: 2.828 ± 0.709
3.143AspGln: 3.143 ± 0.725
2.2AspArg: 2.2 ± 0.718
1.257AspSer: 1.257 ± 0.703
1.571AspThr: 1.571 ± 0.554
3.457AspVal: 3.457 ± 1.001
0.629AspTrp: 0.629 ± 0.501
4.714AspTyr: 4.714 ± 1.021
0.0AspXaa: 0.0 ± 0.0
Glu
5.971GluAla: 5.971 ± 1.618
0.314GluCys: 0.314 ± 0.265
4.4GluAsp: 4.4 ± 1.404
4.714GluGlu: 4.714 ± 1.036
2.514GluPhe: 2.514 ± 0.742
2.514GluGly: 2.514 ± 0.815
2.514GluHis: 2.514 ± 1.2
6.285GluIle: 6.285 ± 1.423
9.428GluLys: 9.428 ± 2.094
11.628GluLeu: 11.628 ± 2.004
3.143GluMet: 3.143 ± 0.944
7.228GluAsn: 7.228 ± 1.946
0.629GluPro: 0.629 ± 0.348
5.028GluGln: 5.028 ± 1.31
4.085GluArg: 4.085 ± 1.464
2.514GluSer: 2.514 ± 1.008
3.457GluThr: 3.457 ± 0.873
3.771GluVal: 3.771 ± 1.059
0.0GluTrp: 0.0 ± 0.0
3.457GluTyr: 3.457 ± 1.244
0.0GluXaa: 0.0 ± 0.0
Phe
1.886PheAla: 1.886 ± 0.719
0.0PheCys: 0.0 ± 0.0
1.257PheAsp: 1.257 ± 0.652
4.4PheGlu: 4.4 ± 1.005
1.257PhePhe: 1.257 ± 0.629
2.2PheGly: 2.2 ± 0.724
0.629PheHis: 0.629 ± 0.35
1.571PheIle: 1.571 ± 0.667
2.514PheLys: 2.514 ± 0.805
4.085PheLeu: 4.085 ± 0.886
0.629PheMet: 0.629 ± 0.418
1.886PheAsn: 1.886 ± 0.823
0.629PhePro: 0.629 ± 0.393
3.143PheGln: 3.143 ± 0.701
1.571PheArg: 1.571 ± 0.583
1.886PheSer: 1.886 ± 0.641
2.828PheThr: 2.828 ± 1.113
2.2PheVal: 2.2 ± 0.815
0.314PheTrp: 0.314 ± 0.265
1.886PheTyr: 1.886 ± 0.787
0.0PheXaa: 0.0 ± 0.0
Gly
3.457GlyAla: 3.457 ± 0.617
0.314GlyCys: 0.314 ± 0.255
1.257GlyAsp: 1.257 ± 0.832
2.828GlyGlu: 2.828 ± 0.929
2.828GlyPhe: 2.828 ± 1.001
1.886GlyGly: 1.886 ± 0.845
1.257GlyHis: 1.257 ± 0.571
2.2GlyIle: 2.2 ± 0.674
4.4GlyLys: 4.4 ± 1.01
6.914GlyLeu: 6.914 ± 1.504
0.629GlyMet: 0.629 ± 0.382
1.571GlyAsn: 1.571 ± 1.037
0.0GlyPro: 0.0 ± 0.0
3.771GlyGln: 3.771 ± 1.249
4.085GlyArg: 4.085 ± 1.023
0.314GlySer: 0.314 ± 0.281
2.514GlyThr: 2.514 ± 0.823
3.457GlyVal: 3.457 ± 0.974
0.314GlyTrp: 0.314 ± 0.265
3.771GlyTyr: 3.771 ± 0.891
0.0GlyXaa: 0.0 ± 0.0
His
1.571HisAla: 1.571 ± 0.697
0.0HisCys: 0.0 ± 0.0
1.571HisAsp: 1.571 ± 0.691
0.314HisGlu: 0.314 ± 0.358
1.257HisPhe: 1.257 ± 0.642
1.886HisGly: 1.886 ± 0.785
0.314HisHis: 0.314 ± 0.265
1.257HisIle: 1.257 ± 0.833
2.2HisLys: 2.2 ± 0.907
1.886HisLeu: 1.886 ± 0.627
0.0HisMet: 0.0 ± 0.0
0.314HisAsn: 0.314 ± 0.314
0.629HisPro: 0.629 ± 0.461
0.314HisGln: 0.314 ± 0.285
0.943HisArg: 0.943 ± 0.452
0.629HisSer: 0.629 ± 0.394
2.2HisThr: 2.2 ± 0.755
0.629HisVal: 0.629 ± 0.37
0.629HisTrp: 0.629 ± 0.348
0.943HisTyr: 0.943 ± 0.43
0.0HisXaa: 0.0 ± 0.0
Ile
4.714IleAla: 4.714 ± 0.966
0.629IleCys: 0.629 ± 0.487
4.714IleAsp: 4.714 ± 0.728
4.714IleGlu: 4.714 ± 1.151
3.143IlePhe: 3.143 ± 0.918
2.514IleGly: 2.514 ± 0.823
1.571IleHis: 1.571 ± 0.673
3.143IleIle: 3.143 ± 0.968
6.6IleLys: 6.6 ± 1.273
5.971IleLeu: 5.971 ± 1.113
0.943IleMet: 0.943 ± 0.605
5.028IleAsn: 5.028 ± 1.076
2.2IlePro: 2.2 ± 0.851
2.514IleGln: 2.514 ± 0.789
3.457IleArg: 3.457 ± 1.119
4.714IleSer: 4.714 ± 1.674
4.4IleThr: 4.4 ± 1.122
1.257IleVal: 1.257 ± 0.631
1.257IleTrp: 1.257 ± 0.614
1.886IleTyr: 1.886 ± 0.679
0.0IleXaa: 0.0 ± 0.0
Lys
9.742LysAla: 9.742 ± 1.74
0.0LysCys: 0.0 ± 0.0
4.085LysAsp: 4.085 ± 1.114
8.485LysGlu: 8.485 ± 1.396
1.886LysPhe: 1.886 ± 0.682
5.028LysGly: 5.028 ± 2.137
1.571LysHis: 1.571 ± 0.813
8.171LysIle: 8.171 ± 1.251
7.542LysLys: 7.542 ± 1.778
8.799LysLeu: 8.799 ± 1.923
3.771LysMet: 3.771 ± 1.227
3.771LysAsn: 3.771 ± 1.488
3.771LysPro: 3.771 ± 0.937
4.714LysGln: 4.714 ± 0.789
6.6LysArg: 6.6 ± 1.209
5.028LysSer: 5.028 ± 1.463
5.657LysThr: 5.657 ± 1.049
4.714LysVal: 4.714 ± 0.879
0.629LysTrp: 0.629 ± 0.432
3.457LysTyr: 3.457 ± 1.174
0.0LysXaa: 0.0 ± 0.0
Leu
7.857LeuAla: 7.857 ± 1.332
0.314LeuCys: 0.314 ± 0.358
6.285LeuAsp: 6.285 ± 1.269
10.057LeuGlu: 10.057 ± 2.565
3.771LeuPhe: 3.771 ± 0.954
6.285LeuGly: 6.285 ± 2.185
1.886LeuHis: 1.886 ± 0.633
5.343LeuIle: 5.343 ± 1.071
9.428LeuLys: 9.428 ± 1.899
8.485LeuLeu: 8.485 ± 1.695
0.943LeuMet: 0.943 ± 0.476
3.457LeuAsn: 3.457 ± 1.416
3.771LeuPro: 3.771 ± 1.73
6.914LeuGln: 6.914 ± 1.261
4.085LeuArg: 4.085 ± 1.266
4.714LeuSer: 4.714 ± 1.484
8.799LeuThr: 8.799 ± 1.968
4.4LeuVal: 4.4 ± 1.4
1.257LeuTrp: 1.257 ± 0.61
3.457LeuTyr: 3.457 ± 1.097
0.0LeuXaa: 0.0 ± 0.0
Met
2.514MetAla: 2.514 ± 1.139
0.0MetCys: 0.0 ± 0.0
1.886MetAsp: 1.886 ± 0.753
0.629MetGlu: 0.629 ± 0.338
1.257MetPhe: 1.257 ± 0.579
0.943MetGly: 0.943 ± 0.44
0.314MetHis: 0.314 ± 0.314
0.629MetIle: 0.629 ± 0.399
1.886MetLys: 1.886 ± 0.657
1.571MetLeu: 1.571 ± 0.642
0.314MetMet: 0.314 ± 0.321
1.571MetAsn: 1.571 ± 0.71
0.0MetPro: 0.0 ± 0.0
0.943MetGln: 0.943 ± 0.475
0.629MetArg: 0.629 ± 0.571
0.943MetSer: 0.943 ± 0.766
3.771MetThr: 3.771 ± 0.805
0.943MetVal: 0.943 ± 0.618
0.314MetTrp: 0.314 ± 0.281
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.2AsnAla: 2.2 ± 1.012
0.0AsnCys: 0.0 ± 0.0
2.828AsnAsp: 2.828 ± 0.924
5.343AsnGlu: 5.343 ± 1.643
2.828AsnPhe: 2.828 ± 0.963
4.085AsnGly: 4.085 ± 1.23
1.257AsnHis: 1.257 ± 0.664
2.2AsnIle: 2.2 ± 0.727
5.657AsnLys: 5.657 ± 1.536
2.828AsnLeu: 2.828 ± 0.788
1.886AsnMet: 1.886 ± 0.607
2.2AsnAsn: 2.2 ± 0.984
2.2AsnPro: 2.2 ± 0.807
1.257AsnGln: 1.257 ± 0.495
1.257AsnArg: 1.257 ± 0.537
4.085AsnSer: 4.085 ± 1.306
3.457AsnThr: 3.457 ± 0.946
2.2AsnVal: 2.2 ± 0.766
0.629AsnTrp: 0.629 ± 0.544
2.2AsnTyr: 2.2 ± 1.117
0.0AsnXaa: 0.0 ± 0.0
Pro
0.943ProAla: 0.943 ± 0.451
0.0ProCys: 0.0 ± 0.0
2.514ProAsp: 2.514 ± 0.846
2.828ProGlu: 2.828 ± 1.309
0.943ProPhe: 0.943 ± 0.605
0.314ProGly: 0.314 ± 0.321
0.0ProHis: 0.0 ± 0.0
0.943ProIle: 0.943 ± 0.626
3.457ProLys: 3.457 ± 1.063
3.143ProLeu: 3.143 ± 0.997
0.629ProMet: 0.629 ± 0.5
2.514ProAsn: 2.514 ± 1.007
0.943ProPro: 0.943 ± 0.569
0.629ProGln: 0.629 ± 0.504
1.257ProArg: 1.257 ± 0.675
1.257ProSer: 1.257 ± 0.509
1.886ProThr: 1.886 ± 0.887
1.571ProVal: 1.571 ± 0.859
0.0ProTrp: 0.0 ± 0.0
1.571ProTyr: 1.571 ± 0.612
0.0ProXaa: 0.0 ± 0.0
Gln
5.343GlnAla: 5.343 ± 1.074
0.314GlnCys: 0.314 ± 0.336
2.828GlnAsp: 2.828 ± 0.86
5.028GlnGlu: 5.028 ± 1.088
1.257GlnPhe: 1.257 ± 0.517
3.771GlnGly: 3.771 ± 1.704
0.943GlnHis: 0.943 ± 0.515
3.143GlnIle: 3.143 ± 1.276
5.028GlnLys: 5.028 ± 0.939
5.343GlnLeu: 5.343 ± 1.456
1.257GlnMet: 1.257 ± 0.63
1.571GlnAsn: 1.571 ± 0.737
0.943GlnPro: 0.943 ± 0.626
3.771GlnGln: 3.771 ± 1.306
2.2GlnArg: 2.2 ± 0.898
4.085GlnSer: 4.085 ± 0.927
2.828GlnThr: 2.828 ± 1.059
2.828GlnVal: 2.828 ± 1.269
0.314GlnTrp: 0.314 ± 0.307
1.886GlnTyr: 1.886 ± 0.943
0.0GlnXaa: 0.0 ± 0.0
Arg
1.886ArgAla: 1.886 ± 0.602
0.314ArgCys: 0.314 ± 0.336
1.886ArgAsp: 1.886 ± 0.869
4.085ArgGlu: 4.085 ± 1.029
2.2ArgPhe: 2.2 ± 1.023
2.514ArgGly: 2.514 ± 0.79
0.943ArgHis: 0.943 ± 0.486
3.457ArgIle: 3.457 ± 0.733
6.285ArgLys: 6.285 ± 1.454
5.971ArgLeu: 5.971 ± 1.362
0.943ArgMet: 0.943 ± 0.695
2.514ArgAsn: 2.514 ± 0.74
0.629ArgPro: 0.629 ± 0.387
3.771ArgGln: 3.771 ± 1.102
3.143ArgArg: 3.143 ± 0.821
1.571ArgSer: 1.571 ± 0.668
4.4ArgThr: 4.4 ± 1.239
2.2ArgVal: 2.2 ± 1.101
0.629ArgTrp: 0.629 ± 0.621
0.943ArgTyr: 0.943 ± 0.747
0.0ArgXaa: 0.0 ± 0.0
Ser
1.886SerAla: 1.886 ± 0.556
0.0SerCys: 0.0 ± 0.0
5.028SerAsp: 5.028 ± 0.861
3.771SerGlu: 3.771 ± 0.963
0.943SerPhe: 0.943 ± 0.435
2.2SerGly: 2.2 ± 0.936
0.943SerHis: 0.943 ± 0.471
4.4SerIle: 4.4 ± 1.431
3.457SerLys: 3.457 ± 0.937
5.343SerLeu: 5.343 ± 1.155
0.943SerMet: 0.943 ± 0.536
1.571SerAsn: 1.571 ± 0.761
0.629SerPro: 0.629 ± 0.35
3.457SerGln: 3.457 ± 1.204
1.886SerArg: 1.886 ± 0.734
1.571SerSer: 1.571 ± 0.603
3.143SerThr: 3.143 ± 0.841
3.457SerVal: 3.457 ± 1.05
0.314SerTrp: 0.314 ± 0.255
2.828SerTyr: 2.828 ± 0.807
0.0SerXaa: 0.0 ± 0.0
Thr
7.228ThrAla: 7.228 ± 1.074
0.314ThrCys: 0.314 ± 0.281
2.828ThrAsp: 2.828 ± 0.831
5.028ThrGlu: 5.028 ± 1.27
3.457ThrPhe: 3.457 ± 1.642
3.143ThrGly: 3.143 ± 1.166
2.828ThrHis: 2.828 ± 1.332
4.714ThrIle: 4.714 ± 0.959
5.343ThrLys: 5.343 ± 1.572
6.6ThrLeu: 6.6 ± 1.383
0.943ThrMet: 0.943 ± 0.531
2.514ThrAsn: 2.514 ± 1.335
3.457ThrPro: 3.457 ± 1.236
3.457ThrGln: 3.457 ± 1.33
2.514ThrArg: 2.514 ± 0.809
2.828ThrSer: 2.828 ± 1.165
4.085ThrThr: 4.085 ± 1.352
3.771ThrVal: 3.771 ± 1.074
0.314ThrTrp: 0.314 ± 0.307
2.2ThrTyr: 2.2 ± 0.942
0.0ThrXaa: 0.0 ± 0.0
Val
3.771ValAla: 3.771 ± 0.983
0.314ValCys: 0.314 ± 0.317
2.2ValAsp: 2.2 ± 1.03
4.714ValGlu: 4.714 ± 1.495
1.257ValPhe: 1.257 ± 0.593
2.514ValGly: 2.514 ± 0.725
0.629ValHis: 0.629 ± 0.478
2.514ValIle: 2.514 ± 0.815
5.657ValLys: 5.657 ± 1.685
5.971ValLeu: 5.971 ± 0.859
0.629ValMet: 0.629 ± 0.516
2.514ValAsn: 2.514 ± 0.951
0.943ValPro: 0.943 ± 0.64
1.257ValGln: 1.257 ± 0.474
1.257ValArg: 1.257 ± 0.584
3.457ValSer: 3.457 ± 0.831
2.828ValThr: 2.828 ± 1.027
3.457ValVal: 3.457 ± 0.906
0.629ValTrp: 0.629 ± 0.348
1.257ValTyr: 1.257 ± 0.634
0.0ValXaa: 0.0 ± 0.0
Trp
1.257TrpAla: 1.257 ± 0.774
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.943TrpGlu: 0.943 ± 0.619
0.629TrpPhe: 0.629 ± 0.429
0.0TrpGly: 0.0 ± 0.0
0.314TrpHis: 0.314 ± 0.446
0.0TrpIle: 0.0 ± 0.0
1.886TrpLys: 1.886 ± 0.599
1.257TrpLeu: 1.257 ± 0.767
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.314TrpPro: 0.314 ± 0.265
0.314TrpGln: 0.314 ± 0.323
0.629TrpArg: 0.629 ± 0.429
0.314TrpSer: 0.314 ± 0.255
0.629TrpThr: 0.629 ± 0.393
0.314TrpVal: 0.314 ± 0.285
0.314TrpTrp: 0.314 ± 0.255
0.314TrpTyr: 0.314 ± 0.314
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.886TyrAla: 1.886 ± 1.093
0.314TyrCys: 0.314 ± 0.281
3.457TyrAsp: 3.457 ± 0.814
2.828TyrGlu: 2.828 ± 0.812
1.257TyrPhe: 1.257 ± 0.594
1.886TyrGly: 1.886 ± 0.635
0.629TyrHis: 0.629 ± 0.387
2.514TyrIle: 2.514 ± 0.751
3.771TyrLys: 3.771 ± 1.031
3.457TyrLeu: 3.457 ± 0.833
0.943TyrMet: 0.943 ± 0.471
4.085TyrAsn: 4.085 ± 1.244
0.629TyrPro: 0.629 ± 0.37
2.828TyrGln: 2.828 ± 0.814
4.4TyrArg: 4.4 ± 1.135
2.514TyrSer: 2.514 ± 0.692
2.514TyrThr: 2.514 ± 0.921
0.943TyrVal: 0.943 ± 0.598
0.0TyrTrp: 0.0 ± 0.0
4.085TyrTyr: 4.085 ± 1.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (3183 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski