Amino acid dipepetide frequency for Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.59AlaAla: 20.59 ± 0.152	0.897AlaCys: 0.897 ± 0.021	8.407AlaAsp: 8.407 ± 0.068	8.534AlaGlu: 8.534 ± 0.094	3.496AlaPhe: 3.496 ± 0.042	13.361AlaGly: 13.361 ± 0.101	2.22AlaHis: 2.22 ± 0.033	4.466AlaIle: 4.466 ± 0.042	3.058AlaLys: 3.058 ± 0.046	13.276AlaLeu: 13.276 ± 0.106	2.351AlaMet: 2.351 ± 0.033	2.277AlaAsn: 2.277 ± 0.039	6.09AlaPro: 6.09 ± 0.063	3.869AlaGln: 3.869 ± 0.045	8.713AlaArg: 8.713 ± 0.089	5.863AlaSer: 5.863 ± 0.057	7.803AlaThr: 7.803 ± 0.063	12.156AlaVal: 12.156 ± 0.097	1.888AlaTrp: 1.888 ± 0.033	2.717AlaTyr: 2.717 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.819CysAla: 0.819 ± 0.018	0.091CysCys: 0.091 ± 0.006	0.433CysAsp: 0.433 ± 0.013	0.342CysGlu: 0.342 ± 0.011	0.208CysPhe: 0.208 ± 0.011	0.836CysGly: 0.836 ± 0.018	0.174CysHis: 0.174 ± 0.008	0.171CysIle: 0.171 ± 0.008	0.103CysLys: 0.103 ± 0.007	0.661CysLeu: 0.661 ± 0.016	0.098CysMet: 0.098 ± 0.007	0.145CysAsn: 0.145 ± 0.008	0.41CysPro: 0.41 ± 0.015	0.181CysGln: 0.181 ± 0.01	0.483CysArg: 0.483 ± 0.014	0.421CysSer: 0.421 ± 0.015	0.441CysThr: 0.441 ± 0.014	0.573CysVal: 0.573 ± 0.015	0.115CysTrp: 0.115 ± 0.007	0.148CysTyr: 0.148 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.336AspAla: 7.336 ± 0.073	0.364AspCys: 0.364 ± 0.013	3.854AspAsp: 3.854 ± 0.046	4.025AspGlu: 4.025 ± 0.049	1.601AspPhe: 1.601 ± 0.029	6.238AspGly: 6.238 ± 0.062	1.424AspHis: 1.424 ± 0.026	1.611AspIle: 1.611 ± 0.027	1.214AspLys: 1.214 ± 0.03	6.888AspLeu: 6.888 ± 0.057	0.647AspMet: 0.647 ± 0.016	1.109AspAsn: 1.109 ± 0.024	4.494AspPro: 4.494 ± 0.048	2.111AspGln: 2.111 ± 0.026	4.947AspArg: 4.947 ± 0.055	2.505AspSer: 2.505 ± 0.035	2.78AspThr: 2.78 ± 0.038	5.143AspVal: 5.143 ± 0.059	1.041AspTrp: 1.041 ± 0.021	1.187AspTyr: 1.187 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.488GluAla: 6.488 ± 0.084	0.283GluCys: 0.283 ± 0.01	2.474GluAsp: 2.474 ± 0.035	2.383GluGlu: 2.383 ± 0.043	1.508GluPhe: 1.508 ± 0.025	3.374GluGly: 3.374 ± 0.04	1.464GluHis: 1.464 ± 0.026	2.253GluIle: 2.253 ± 0.034	1.203GluLys: 1.203 ± 0.028	7.398GluLeu: 7.398 ± 0.069	0.819GluMet: 0.819 ± 0.02	1.054GluAsn: 1.054 ± 0.024	3.306GluPro: 3.306 ± 0.042	2.881GluGln: 2.881 ± 0.04	4.654GluArg: 4.654 ± 0.054	2.555GluSer: 2.555 ± 0.039	2.734GluThr: 2.734 ± 0.036	4.677GluVal: 4.677 ± 0.054	0.791GluTrp: 0.791 ± 0.02	1.133GluTyr: 1.133 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.791PheAla: 3.791 ± 0.04	0.264PheCys: 0.264 ± 0.011	2.049PheAsp: 2.049 ± 0.036	1.511PheGlu: 1.511 ± 0.023	0.918PhePhe: 0.918 ± 0.023	3.2PheGly: 3.2 ± 0.036	0.611PheHis: 0.611 ± 0.016	0.704PheIle: 0.704 ± 0.019	0.527PheLys: 0.527 ± 0.016	2.578PheLeu: 2.578 ± 0.037	0.337PheMet: 0.337 ± 0.011	0.583PheAsn: 0.583 ± 0.016	1.305PhePro: 1.305 ± 0.023	0.733PheGln: 0.733 ± 0.02	1.894PheArg: 1.894 ± 0.03	1.53PheSer: 1.53 ± 0.027	1.974PheThr: 1.974 ± 0.032	2.652PheVal: 2.652 ± 0.036	0.467PheTrp: 0.467 ± 0.015	0.657PheTyr: 0.657 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	9.976GlyAla: 9.976 ± 0.08	0.754GlyCys: 0.754 ± 0.016	5.05GlyAsp: 5.05 ± 0.052	4.568GlyGlu: 4.568 ± 0.044	2.965GlyPhe: 2.965 ± 0.036	7.915GlyGly: 7.915 ± 0.089	1.958GlyHis: 1.958 ± 0.033	3.585GlyIle: 3.585 ± 0.044	2.439GlyLys: 2.439 ± 0.038	9.534GlyLeu: 9.534 ± 0.08	1.733GlyMet: 1.733 ± 0.032	1.983GlyAsn: 1.983 ± 0.034	4.833GlyPro: 4.833 ± 0.058	3.024GlyGln: 3.024 ± 0.049	7.077GlyArg: 7.077 ± 0.062	5.396GlySer: 5.396 ± 0.053	5.999GlyThr: 5.999 ± 0.063	7.79GlyVal: 7.79 ± 0.059	1.876GlyTrp: 1.876 ± 0.027	2.364GlyTyr: 2.364 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.31HisAla: 2.31 ± 0.033	0.179HisCys: 0.179 ± 0.009	1.269HisAsp: 1.269 ± 0.027	1.056HisGlu: 1.056 ± 0.022	0.598HisPhe: 0.598 ± 0.018	2.018HisGly: 2.018 ± 0.026	0.619HisHis: 0.619 ± 0.018	0.483HisIle: 0.483 ± 0.017	0.325HisLys: 0.325 ± 0.013	2.392HisLeu: 2.392 ± 0.036	0.237HisMet: 0.237 ± 0.011	0.391HisAsn: 0.391 ± 0.015	1.581HisPro: 1.581 ± 0.033	0.742HisGln: 0.742 ± 0.017	1.938HisArg: 1.938 ± 0.03	0.95HisSer: 0.95 ± 0.02	1.086HisThr: 1.086 ± 0.022	1.644HisVal: 1.644 ± 0.029	0.394HisTrp: 0.394 ± 0.012	0.43HisTyr: 0.43 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.25IleAla: 5.25 ± 0.055	0.298IleCys: 0.298 ± 0.011	2.518IleAsp: 2.518 ± 0.036	2.127IleGlu: 2.127 ± 0.036	0.851IlePhe: 0.851 ± 0.023	3.925IleGly: 3.925 ± 0.051	0.576IleHis: 0.576 ± 0.017	0.851IleIle: 0.851 ± 0.022	0.709IleLys: 0.709 ± 0.019	2.627IleLeu: 2.627 ± 0.037	0.378IleMet: 0.378 ± 0.013	0.703IleAsn: 0.703 ± 0.019	1.811IlePro: 1.811 ± 0.029	0.851IleGln: 0.851 ± 0.019	2.382IleArg: 2.382 ± 0.036	1.97IleSer: 1.97 ± 0.034	2.463IleThr: 2.463 ± 0.032	3.074IleVal: 3.074 ± 0.038	0.478IleTrp: 0.478 ± 0.017	0.662IleTyr: 0.662 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.959LysAla: 2.959 ± 0.051	0.097LysCys: 0.097 ± 0.007	1.169LysAsp: 1.169 ± 0.027	0.911LysGlu: 0.911 ± 0.024	0.568LysPhe: 0.568 ± 0.017	1.481LysGly: 1.481 ± 0.031	0.468LysHis: 0.468 ± 0.015	0.843LysIle: 0.843 ± 0.022	0.7LysLys: 0.7 ± 0.028	2.42LysLeu: 2.42 ± 0.032	0.364LysMet: 0.364 ± 0.013	0.552LysAsn: 0.552 ± 0.019	1.548LysPro: 1.548 ± 0.03	0.775LysGln: 0.775 ± 0.019	1.322LysArg: 1.322 ± 0.024	1.167LysSer: 1.167 ± 0.029	1.338LysThr: 1.338 ± 0.031	2.13LysVal: 2.13 ± 0.032	0.267LysTrp: 0.267 ± 0.013	0.534LysTyr: 0.534 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	15.227LeuAla: 15.227 ± 0.114	0.679LeuCys: 0.679 ± 0.018	6.923LeuAsp: 6.923 ± 0.06	4.87LeuGlu: 4.87 ± 0.054	2.635LeuPhe: 2.635 ± 0.039	9.368LeuGly: 9.368 ± 0.07	2.156LeuHis: 2.156 ± 0.034	3.762LeuIle: 3.762 ± 0.048	1.957LeuLys: 1.957 ± 0.032	11.313LeuLeu: 11.313 ± 0.109	1.57LeuMet: 1.57 ± 0.028	1.907LeuAsn: 1.907 ± 0.028	6.361LeuPro: 6.361 ± 0.051	2.847LeuGln: 2.847 ± 0.038	8.332LeuArg: 8.332 ± 0.071	5.561LeuSer: 5.561 ± 0.05	7.242LeuThr: 7.242 ± 0.059	9.751LeuVal: 9.751 ± 0.075	1.343LeuTrp: 1.343 ± 0.029	1.848LeuTyr: 1.848 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	1.987MetAla: 1.987 ± 0.028	0.086MetCys: 0.086 ± 0.006	0.76MetAsp: 0.76 ± 0.019	0.634MetGlu: 0.634 ± 0.019	0.458MetPhe: 0.458 ± 0.013	1.057MetGly: 1.057 ± 0.023	0.307MetHis: 0.307 ± 0.012	0.68MetIle: 0.68 ± 0.017	0.413MetLys: 0.413 ± 0.013	1.793MetLeu: 1.793 ± 0.033	0.288MetMet: 0.288 ± 0.012	0.404MetAsn: 0.404 ± 0.014	1.101MetPro: 1.101 ± 0.021	0.431MetGln: 0.431 ± 0.014	1.226MetArg: 1.226 ± 0.022	1.26MetSer: 1.26 ± 0.025	1.572MetThr: 1.572 ± 0.029	1.35MetVal: 1.35 ± 0.028	0.161MetTrp: 0.161 ± 0.008	0.269MetTyr: 0.269 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.393AsnAla: 2.393 ± 0.031	0.177AsnCys: 0.177 ± 0.01	1.175AsnAsp: 1.175 ± 0.025	0.92AsnGlu: 0.92 ± 0.019	0.581AsnPhe: 0.581 ± 0.018	2.125AsnGly: 2.125 ± 0.035	0.45AsnHis: 0.45 ± 0.013	0.591AsnIle: 0.591 ± 0.014	0.433AsnLys: 0.433 ± 0.015	2.041AsnLeu: 2.041 ± 0.033	0.274AsnMet: 0.274 ± 0.011	0.506AsnAsn: 0.506 ± 0.016	1.529AsnPro: 1.529 ± 0.027	0.709AsnGln: 0.709 ± 0.019	1.429AsnArg: 1.429 ± 0.027	0.991AsnSer: 0.991 ± 0.02	1.148AsnThr: 1.148 ± 0.029	1.534AsnVal: 1.534 ± 0.029	0.381AsnTrp: 0.381 ± 0.014	0.485AsnTyr: 0.485 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.62ProAla: 8.62 ± 0.073	0.29ProCys: 0.29 ± 0.012	4.438ProAsp: 4.438 ± 0.049	3.789ProGlu: 3.789 ± 0.042	1.49ProPhe: 1.49 ± 0.026	6.056ProGly: 6.056 ± 0.065	1.125ProHis: 1.125 ± 0.022	1.705ProIle: 1.705 ± 0.031	1.232ProLys: 1.232 ± 0.025	5.029ProLeu: 5.029 ± 0.057	0.937ProMet: 0.937 ± 0.021	1.184ProAsn: 1.184 ± 0.024	3.355ProPro: 3.355 ± 0.059	1.805ProGln: 1.805 ± 0.038	3.523ProArg: 3.523 ± 0.045	3.262ProSer: 3.262 ± 0.049	3.733ProThr: 3.733 ± 0.063	5.27ProVal: 5.27 ± 0.048	0.951ProTrp: 0.951 ± 0.022	1.342ProTyr: 1.342 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.306GlnAla: 4.306 ± 0.058	0.163GlnCys: 0.163 ± 0.01	1.407GlnAsp: 1.407 ± 0.024	1.353GlnGlu: 1.353 ± 0.028	0.866GlnPhe: 0.866 ± 0.022	2.162GlnGly: 2.162 ± 0.036	0.767GlnHis: 0.767 ± 0.018	1.213GlnIle: 1.213 ± 0.022	0.637GlnLys: 0.637 ± 0.019	4.029GlnLeu: 4.029 ± 0.046	0.457GlnMet: 0.457 ± 0.013	0.626GlnAsn: 0.626 ± 0.015	2.115GlnPro: 2.115 ± 0.042	1.594GlnGln: 1.594 ± 0.035	2.761GlnArg: 2.761 ± 0.036	1.456GlnSer: 1.456 ± 0.027	1.664GlnThr: 1.664 ± 0.023	3.051GlnVal: 3.051 ± 0.038	0.564GlnTrp: 0.564 ± 0.018	0.875GlnTyr: 0.875 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.54ArgAla: 8.54 ± 0.078	0.512ArgCys: 0.512 ± 0.016	4.156ArgAsp: 4.156 ± 0.047	3.982ArgGlu: 3.982 ± 0.056	2.304ArgPhe: 2.304 ± 0.03	5.232ArgGly: 5.232 ± 0.049	1.717ArgHis: 1.717 ± 0.033	3.278ArgIle: 3.278 ± 0.042	1.664ArgLys: 1.664 ± 0.03	8.271ArgLeu: 8.271 ± 0.077	1.713ArgMet: 1.713 ± 0.027	1.423ArgAsn: 1.423 ± 0.025	4.601ArgPro: 4.601 ± 0.055	2.518ArgGln: 2.518 ± 0.037	7.481ArgArg: 7.481 ± 0.087	4.293ArgSer: 4.293 ± 0.042	5.032ArgThr: 5.032 ± 0.054	5.525ArgVal: 5.525 ± 0.061	1.467ArgTrp: 1.467 ± 0.025	1.844ArgTyr: 1.844 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.701SerAla: 6.701 ± 0.067	0.359SerCys: 0.359 ± 0.014	2.695SerAsp: 2.695 ± 0.032	2.422SerGlu: 2.422 ± 0.037	1.614SerPhe: 1.614 ± 0.027	5.641SerGly: 5.641 ± 0.061	0.952SerHis: 0.952 ± 0.021	1.806SerIle: 1.806 ± 0.028	1.109SerLys: 1.109 ± 0.024	4.983SerLeu: 4.983 ± 0.048	1.09SerMet: 1.09 ± 0.022	1.077SerAsn: 1.077 ± 0.023	3.16SerPro: 3.16 ± 0.04	1.413SerGln: 1.413 ± 0.027	3.723SerArg: 3.723 ± 0.04	3.203SerSer: 3.203 ± 0.05	3.806SerThr: 3.806 ± 0.048	4.424SerVal: 4.424 ± 0.044	1.044SerTrp: 1.044 ± 0.024	1.34SerTyr: 1.34 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	8.742ThrAla: 8.742 ± 0.07	0.417ThrCys: 0.417 ± 0.014	3.677ThrAsp: 3.677 ± 0.041	3.3ThrGlu: 3.3 ± 0.04	1.854ThrPhe: 1.854 ± 0.032	6.535ThrGly: 6.535 ± 0.066	1.091ThrHis: 1.091 ± 0.024	2.172ThrIle: 2.172 ± 0.034	1.338ThrLys: 1.338 ± 0.026	5.932ThrLeu: 5.932 ± 0.055	1.005ThrMet: 1.005 ± 0.022	1.194ThrAsn: 1.194 ± 0.028	4.299ThrPro: 4.299 ± 0.07	1.572ThrGln: 1.572 ± 0.026	3.823ThrArg: 3.823 ± 0.046	3.453ThrSer: 3.453 ± 0.048	4.498ThrThr: 4.498 ± 0.069	6.084ThrVal: 6.084 ± 0.058	1.015ThrTrp: 1.015 ± 0.021	1.405ThrTyr: 1.405 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.625ValAla: 11.625 ± 0.074	0.612ValCys: 0.612 ± 0.017	5.542ValAsp: 5.542 ± 0.052	5.014ValGlu: 5.014 ± 0.05	2.483ValPhe: 2.483 ± 0.034	7.032ValGly: 7.032 ± 0.065	1.755ValHis: 1.755 ± 0.03	3.201ValIle: 3.201 ± 0.04	1.817ValLys: 1.817 ± 0.036	10.148ValLeu: 10.148 ± 0.08	1.414ValMet: 1.414 ± 0.03	1.81ValAsn: 1.81 ± 0.034	5.212ValPro: 5.212 ± 0.048	2.508ValGln: 2.508 ± 0.033	6.653ValArg: 6.653 ± 0.055	4.527ValSer: 4.527 ± 0.049	5.782ValThr: 5.782 ± 0.056	9.272ValVal: 9.272 ± 0.088	1.116ValTrp: 1.116 ± 0.024	1.533ValTyr: 1.533 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.628TrpAla: 1.628 ± 0.025	0.137TrpCys: 0.137 ± 0.008	0.819TrpAsp: 0.819 ± 0.023	0.598TrpGlu: 0.598 ± 0.014	0.588TrpPhe: 0.588 ± 0.017	1.05TrpGly: 1.05 ± 0.024	0.39TrpHis: 0.39 ± 0.014	0.67TrpIle: 0.67 ± 0.017	0.377TrpLys: 0.377 ± 0.012	1.984TrpLeu: 1.984 ± 0.033	0.334TrpMet: 0.334 ± 0.013	0.487TrpAsn: 0.487 ± 0.018	0.885TrpPro: 0.885 ± 0.019	0.715TrpGln: 0.715 ± 0.018	1.299TrpArg: 1.299 ± 0.025	1.128TrpSer: 1.128 ± 0.023	1.167TrpThr: 1.167 ± 0.027	1.128TrpVal: 1.128 ± 0.026	0.382TrpTrp: 0.382 ± 0.012	0.364TrpTyr: 0.364 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.743TyrAla: 2.743 ± 0.035	0.193TyrCys: 0.193 ± 0.009	1.705TyrAsp: 1.705 ± 0.031	1.093TyrGlu: 1.093 ± 0.02	0.7TyrPhe: 0.7 ± 0.016	2.212TyrGly: 2.212 ± 0.035	0.419TyrHis: 0.419 ± 0.014	0.459TyrIle: 0.459 ± 0.015	0.357TyrLys: 0.357 ± 0.012	2.357TyrLeu: 2.357 ± 0.031	0.19TyrMet: 0.19 ± 0.008	0.46TyrAsn: 0.46 ± 0.015	1.142TyrPro: 1.142 ± 0.026	0.785TyrGln: 0.785 ± 0.018	1.892TyrArg: 1.892 ± 0.03	1.072TyrSer: 1.072 ± 0.024	1.144TyrThr: 1.144 ± 0.025	1.826TyrVal: 1.826 ± 0.026	0.387TyrTrp: 0.387 ± 0.015	0.505TyrTyr: 0.505 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6940 proteins (2258648 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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