Amino acid dipepetide frequency for Wenyingzhuangia fucanilytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.017AlaAla: 4.017 ± 0.088	0.567AlaCys: 0.567 ± 0.028	3.243AlaAsp: 3.243 ± 0.054	3.737AlaGlu: 3.737 ± 0.073	3.097AlaPhe: 3.097 ± 0.058	3.946AlaGly: 3.946 ± 0.067	1.108AlaHis: 1.108 ± 0.036	5.217AlaIle: 5.217 ± 0.092	4.928AlaLys: 4.928 ± 0.088	5.729AlaLeu: 5.729 ± 0.08	1.416AlaMet: 1.416 ± 0.04	3.734AlaAsn: 3.734 ± 0.065	1.969AlaPro: 1.969 ± 0.05	2.316AlaGln: 2.316 ± 0.055	1.739AlaArg: 1.739 ± 0.046	4.045AlaSer: 4.045 ± 0.073	3.81AlaThr: 3.81 ± 0.075	3.965AlaVal: 3.965 ± 0.069	0.662AlaTrp: 0.662 ± 0.025	2.526AlaTyr: 2.526 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.454CysAla: 0.454 ± 0.022	0.086CysCys: 0.086 ± 0.009	0.455CysAsp: 0.455 ± 0.022	0.513CysGlu: 0.513 ± 0.021	0.395CysPhe: 0.395 ± 0.021	0.584CysGly: 0.584 ± 0.024	0.218CysHis: 0.218 ± 0.019	0.546CysIle: 0.546 ± 0.024	0.535CysLys: 0.535 ± 0.023	0.628CysLeu: 0.628 ± 0.028	0.17CysMet: 0.17 ± 0.013	0.443CysAsn: 0.443 ± 0.022	0.271CysPro: 0.271 ± 0.017	0.208CysGln: 0.208 ± 0.014	0.181CysArg: 0.181 ± 0.012	0.53CysSer: 0.53 ± 0.027	0.422CysThr: 0.422 ± 0.023	0.501CysVal: 0.501 ± 0.025	0.064CysTrp: 0.064 ± 0.007	0.358CysTyr: 0.358 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.541AspAla: 3.541 ± 0.065	0.428AspCys: 0.428 ± 0.019	3.021AspAsp: 3.021 ± 0.059	3.887AspGlu: 3.887 ± 0.065	3.601AspPhe: 3.601 ± 0.068	3.852AspGly: 3.852 ± 0.066	0.93AspHis: 0.93 ± 0.03	4.431AspIle: 4.431 ± 0.075	4.239AspLys: 4.239 ± 0.07	5.474AspLeu: 5.474 ± 0.099	1.081AspMet: 1.081 ± 0.038	3.058AspAsn: 3.058 ± 0.065	1.557AspPro: 1.557 ± 0.044	1.472AspGln: 1.472 ± 0.036	1.709AspArg: 1.709 ± 0.044	2.618AspSer: 2.618 ± 0.061	2.684AspThr: 2.684 ± 0.054	3.943AspVal: 3.943 ± 0.065	0.824AspTrp: 0.824 ± 0.031	2.841AspTyr: 2.841 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	4.112GluAla: 4.112 ± 0.074	0.345GluCys: 0.345 ± 0.02	3.349GluAsp: 3.349 ± 0.059	4.572GluGlu: 4.572 ± 0.081	2.952GluPhe: 2.952 ± 0.058	3.613GluGly: 3.613 ± 0.059	1.2GluHis: 1.2 ± 0.036	5.515GluIle: 5.515 ± 0.072	5.72GluLys: 5.72 ± 0.075	6.205GluLeu: 6.205 ± 0.088	1.515GluMet: 1.515 ± 0.044	5.081GluAsn: 5.081 ± 0.079	1.538GluPro: 1.538 ± 0.037	2.322GluGln: 2.322 ± 0.059	2.069GluArg: 2.069 ± 0.046	3.18GluSer: 3.18 ± 0.055	3.499GluThr: 3.499 ± 0.06	4.718GluVal: 4.718 ± 0.069	0.716GluTrp: 0.716 ± 0.031	2.642GluTyr: 2.642 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.707PheAla: 2.707 ± 0.063	0.467PheCys: 0.467 ± 0.024	3.126PheAsp: 3.126 ± 0.052	3.067PheGlu: 3.067 ± 0.053	2.555PhePhe: 2.555 ± 0.057	3.349PheGly: 3.349 ± 0.061	0.788PheHis: 0.788 ± 0.024	3.882PheIle: 3.882 ± 0.075	4.11PheLys: 4.11 ± 0.072	4.406PheLeu: 4.406 ± 0.072	1.161PheMet: 1.161 ± 0.034	3.445PheAsn: 3.445 ± 0.069	1.641PhePro: 1.641 ± 0.038	1.351PheGln: 1.351 ± 0.041	1.379PheArg: 1.379 ± 0.039	3.772PheSer: 3.772 ± 0.072	3.178PheThr: 3.178 ± 0.066	3.064PheVal: 3.064 ± 0.054	0.604PheTrp: 0.604 ± 0.028	2.202PheTyr: 2.202 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.352GlyAla: 4.352 ± 0.081	0.538GlyCys: 0.538 ± 0.028	3.532GlyAsp: 3.532 ± 0.072	3.753GlyGlu: 3.753 ± 0.068	3.55GlyPhe: 3.55 ± 0.059	4.542GlyGly: 4.542 ± 0.09	1.121GlyHis: 1.121 ± 0.033	5.238GlyIle: 5.238 ± 0.079	5.106GlyLys: 5.106 ± 0.078	5.716GlyLeu: 5.716 ± 0.097	1.554GlyMet: 1.554 ± 0.037	3.714GlyAsn: 3.714 ± 0.078	1.333GlyPro: 1.333 ± 0.036	1.822GlyGln: 1.822 ± 0.041	2.041GlyArg: 2.041 ± 0.052	3.818GlySer: 3.818 ± 0.073	4.17GlyThr: 4.17 ± 0.074	4.91GlyVal: 4.91 ± 0.074	0.822GlyTrp: 0.822 ± 0.031	2.979GlyTyr: 2.979 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.022HisAla: 1.022 ± 0.033	0.164HisCys: 0.164 ± 0.013	0.908HisAsp: 0.908 ± 0.029	0.955HisGlu: 0.955 ± 0.03	1.092HisPhe: 1.092 ± 0.031	1.188HisGly: 1.188 ± 0.036	0.615HisHis: 0.615 ± 0.032	1.375HisIle: 1.375 ± 0.037	1.391HisLys: 1.391 ± 0.038	1.761HisLeu: 1.761 ± 0.046	0.355HisMet: 0.355 ± 0.019	1.12HisAsn: 1.12 ± 0.036	0.99HisPro: 0.99 ± 0.032	0.91HisGln: 0.91 ± 0.033	0.615HisArg: 0.615 ± 0.023	1.045HisSer: 1.045 ± 0.029	1.028HisThr: 1.028 ± 0.032	1.013HisVal: 1.013 ± 0.034	0.267HisTrp: 0.267 ± 0.018	0.94HisTyr: 0.94 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.287IleAla: 5.287 ± 0.081	0.634IleCys: 0.634 ± 0.026	5.075IleAsp: 5.075 ± 0.061	5.454IleGlu: 5.454 ± 0.083	3.168IlePhe: 3.168 ± 0.061	4.997IleGly: 4.997 ± 0.083	1.517IleHis: 1.517 ± 0.041	5.856IleIle: 5.856 ± 0.086	6.535IleLys: 6.535 ± 0.092	6.616IleLeu: 6.616 ± 0.106	1.356IleMet: 1.356 ± 0.039	5.266IleAsn: 5.266 ± 0.089	3.208IlePro: 3.208 ± 0.059	2.584IleGln: 2.584 ± 0.057	2.303IleArg: 2.303 ± 0.053	5.616IleSer: 5.616 ± 0.083	5.007IleThr: 5.007 ± 0.076	4.843IleVal: 4.843 ± 0.071	0.673IleTrp: 0.673 ± 0.029	2.834IleTyr: 2.834 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	4.92LysAla: 4.92 ± 0.08	0.389LysCys: 0.389 ± 0.02	4.762LysAsp: 4.762 ± 0.07	7.066LysGlu: 7.066 ± 0.107	2.949LysPhe: 2.949 ± 0.056	5.123LysGly: 5.123 ± 0.077	1.58LysHis: 1.58 ± 0.044	6.442LysIle: 6.442 ± 0.086	7.343LysLys: 7.343 ± 0.094	6.579LysLeu: 6.579 ± 0.09	1.909LysMet: 1.909 ± 0.043	6.041LysAsn: 6.041 ± 0.087	2.639LysPro: 2.639 ± 0.06	2.924LysGln: 2.924 ± 0.064	2.612LysArg: 2.612 ± 0.051	4.654LysSer: 4.654 ± 0.063	5.152LysThr: 5.152 ± 0.071	5.18LysVal: 5.18 ± 0.076	0.85LysTrp: 0.85 ± 0.029	3.382LysTyr: 3.382 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	5.573LeuAla: 5.573 ± 0.084	0.681LeuCys: 0.681 ± 0.029	4.855LeuAsp: 4.855 ± 0.089	5.998LeuGlu: 5.998 ± 0.083	4.605LeuPhe: 4.605 ± 0.084	5.941LeuGly: 5.941 ± 0.084	1.504LeuHis: 1.504 ± 0.04	6.742LeuIle: 6.742 ± 0.102	8.025LeuLys: 8.025 ± 0.101	8.144LeuLeu: 8.144 ± 0.118	1.948LeuMet: 1.948 ± 0.053	5.705LeuAsn: 5.705 ± 0.093	3.431LeuPro: 3.431 ± 0.057	2.899LeuGln: 2.899 ± 0.057	2.835LeuArg: 2.835 ± 0.058	6.602LeuSer: 6.602 ± 0.094	5.332LeuThr: 5.332 ± 0.09	5.186LeuVal: 5.186 ± 0.073	0.858LeuTrp: 0.858 ± 0.035	3.217LeuTyr: 3.217 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.469MetAla: 1.469 ± 0.042	0.174MetCys: 0.174 ± 0.014	1.117MetAsp: 1.117 ± 0.033	1.246MetGlu: 1.246 ± 0.039	0.942MetPhe: 0.942 ± 0.034	1.365MetGly: 1.365 ± 0.039	0.372MetHis: 0.372 ± 0.018	1.61MetIle: 1.61 ± 0.04	1.985MetLys: 1.985 ± 0.041	1.922MetLeu: 1.922 ± 0.044	0.588MetMet: 0.588 ± 0.025	1.245MetAsn: 1.245 ± 0.032	0.832MetPro: 0.832 ± 0.029	0.717MetGln: 0.717 ± 0.027	0.723MetArg: 0.723 ± 0.026	1.403MetSer: 1.403 ± 0.038	1.021MetThr: 1.021 ± 0.031	1.355MetVal: 1.355 ± 0.032	0.204MetTrp: 0.204 ± 0.013	0.74MetTyr: 0.74 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.844AsnAla: 3.844 ± 0.06	0.46AsnCys: 0.46 ± 0.022	3.209AsnAsp: 3.209 ± 0.062	3.513AsnGlu: 3.513 ± 0.048	3.065AsnPhe: 3.065 ± 0.051	4.311AsnGly: 4.311 ± 0.095	1.34AsnHis: 1.34 ± 0.042	5.822AsnIle: 5.822 ± 0.085	5.395AsnLys: 5.395 ± 0.094	5.498AsnLeu: 5.498 ± 0.08	1.177AsnMet: 1.177 ± 0.037	4.86AsnAsn: 4.86 ± 0.106	2.857AsnPro: 2.857 ± 0.068	2.68AsnGln: 2.68 ± 0.056	2.037AsnArg: 2.037 ± 0.052	4.066AsnSer: 4.066 ± 0.077	4.362AsnThr: 4.362 ± 0.083	3.632AsnVal: 3.632 ± 0.06	0.77AsnTrp: 0.77 ± 0.029	3.066AsnTyr: 3.066 ± 0.066	0.0AsnXaa: 0.0 ± 0.0
Pro	1.804ProAla: 1.804 ± 0.042	0.207ProCys: 0.207 ± 0.014	1.783ProAsp: 1.783 ± 0.046	2.596ProGlu: 2.596 ± 0.049	1.93ProPhe: 1.93 ± 0.043	1.881ProGly: 1.881 ± 0.047	0.714ProHis: 0.714 ± 0.027	2.59ProIle: 2.59 ± 0.051	2.898ProLys: 2.898 ± 0.055	2.973ProLeu: 2.973 ± 0.055	0.686ProMet: 0.686 ± 0.026	2.66ProAsn: 2.66 ± 0.056	0.762ProPro: 0.762 ± 0.032	1.024ProGln: 1.024 ± 0.034	0.874ProArg: 0.874 ± 0.028	2.206ProSer: 2.206 ± 0.046	2.178ProThr: 2.178 ± 0.052	2.342ProVal: 2.342 ± 0.048	0.398ProTrp: 0.398 ± 0.021	1.467ProTyr: 1.467 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.965GlnAla: 1.965 ± 0.042	0.191GlnCys: 0.191 ± 0.014	1.544GlnAsp: 1.544 ± 0.041	2.475GlnGlu: 2.475 ± 0.045	1.585GlnPhe: 1.585 ± 0.042	1.935GlnGly: 1.935 ± 0.049	0.662GlnHis: 0.662 ± 0.026	2.682GlnIle: 2.682 ± 0.056	3.032GlnLys: 3.032 ± 0.067	3.161GlnLeu: 3.161 ± 0.062	0.756GlnMet: 0.756 ± 0.024	2.324GlnAsn: 2.324 ± 0.054	1.11GlnPro: 1.11 ± 0.03	1.486GlnGln: 1.486 ± 0.041	1.084GlnArg: 1.084 ± 0.034	1.841GlnSer: 1.841 ± 0.042	1.897GlnThr: 1.897 ± 0.043	1.985GlnVal: 1.985 ± 0.047	0.372GlnTrp: 0.372 ± 0.019	1.447GlnTyr: 1.447 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.011ArgAla: 2.011 ± 0.052	0.195ArgCys: 0.195 ± 0.014	1.623ArgAsp: 1.623 ± 0.044	1.902ArgGlu: 1.902 ± 0.054	1.697ArgPhe: 1.697 ± 0.043	1.915ArgGly: 1.915 ± 0.046	0.533ArgHis: 0.533 ± 0.023	2.52ArgIle: 2.52 ± 0.052	2.406ArgLys: 2.406 ± 0.052	2.876ArgLeu: 2.876 ± 0.055	0.76ArgMet: 0.76 ± 0.026	1.922ArgAsn: 1.922 ± 0.049	1.059ArgPro: 1.059 ± 0.037	0.86ArgGln: 0.86 ± 0.027	1.127ArgArg: 1.127 ± 0.036	1.641ArgSer: 1.641 ± 0.048	1.832ArgThr: 1.832 ± 0.043	2.027ArgVal: 2.027 ± 0.042	0.368ArgTrp: 0.368 ± 0.02	1.387ArgTyr: 1.387 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.582SerAla: 3.582 ± 0.065	0.596SerCys: 0.596 ± 0.025	3.379SerAsp: 3.379 ± 0.059	3.723SerGlu: 3.723 ± 0.054	3.63SerPhe: 3.63 ± 0.062	4.329SerGly: 4.329 ± 0.078	1.098SerHis: 1.098 ± 0.032	5.123SerIle: 5.123 ± 0.076	5.273SerLys: 5.273 ± 0.083	5.903SerLeu: 5.903 ± 0.085	1.232SerMet: 1.232 ± 0.034	4.003SerAsn: 4.003 ± 0.08	2.035SerPro: 2.035 ± 0.043	2.04SerGln: 2.04 ± 0.046	1.963SerArg: 1.963 ± 0.05	4.206SerSer: 4.206 ± 0.082	3.59SerThr: 3.59 ± 0.072	4.094SerVal: 4.094 ± 0.068	0.711SerTrp: 0.711 ± 0.027	2.806SerTyr: 2.806 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.798ThrAla: 3.798 ± 0.086	0.411ThrCys: 0.411 ± 0.021	3.346ThrAsp: 3.346 ± 0.063	3.535ThrGlu: 3.535 ± 0.073	3.027ThrPhe: 3.027 ± 0.056	4.147ThrGly: 4.147 ± 0.075	1.121ThrHis: 1.121 ± 0.041	4.839ThrIle: 4.839 ± 0.073	4.237ThrLys: 4.237 ± 0.057	5.402ThrLeu: 5.402 ± 0.079	0.94ThrMet: 0.94 ± 0.027	3.721ThrAsn: 3.721 ± 0.072	2.722ThrPro: 2.722 ± 0.052	1.984ThrGln: 1.984 ± 0.041	1.568ThrArg: 1.568 ± 0.041	4.177ThrSer: 4.177 ± 0.06	3.867ThrThr: 3.867 ± 0.089	3.836ThrVal: 3.836 ± 0.072	0.642ThrTrp: 0.642 ± 0.03	2.507ThrTyr: 2.507 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.138ValAla: 4.138 ± 0.089	0.577ValCys: 0.577 ± 0.026	3.826ValAsp: 3.826 ± 0.062	3.89ValGlu: 3.89 ± 0.062	3.546ValPhe: 3.546 ± 0.06	3.961ValGly: 3.961 ± 0.081	1.06ValHis: 1.06 ± 0.031	4.717ValIle: 4.717 ± 0.07	4.98ValLys: 4.98 ± 0.068	6.216ValLeu: 6.216 ± 0.088	1.312ValMet: 1.312 ± 0.036	3.928ValAsn: 3.928 ± 0.068	2.072ValPro: 2.072 ± 0.046	1.73ValGln: 1.73 ± 0.047	1.961ValArg: 1.961 ± 0.052	4.632ValSer: 4.632 ± 0.082	3.703ValThr: 3.703 ± 0.061	4.417ValVal: 4.417 ± 0.07	0.684ValTrp: 0.684 ± 0.029	2.586ValTyr: 2.586 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.615TrpAla: 0.615 ± 0.027	0.105TrpCys: 0.105 ± 0.01	0.671TrpAsp: 0.671 ± 0.029	0.688TrpGlu: 0.688 ± 0.025	0.545TrpPhe: 0.545 ± 0.025	0.799TrpGly: 0.799 ± 0.028	0.298TrpHis: 0.298 ± 0.018	0.749TrpIle: 0.749 ± 0.028	0.926TrpLys: 0.926 ± 0.03	0.969TrpLeu: 0.969 ± 0.032	0.327TrpMet: 0.327 ± 0.018	0.751TrpAsn: 0.751 ± 0.027	0.322TrpPro: 0.322 ± 0.018	0.404TrpGln: 0.404 ± 0.024	0.383TrpArg: 0.383 ± 0.02	0.693TrpSer: 0.693 ± 0.028	0.615TrpThr: 0.615 ± 0.027	0.662TrpVal: 0.662 ± 0.031	0.151TrpTrp: 0.151 ± 0.013	0.481TrpTyr: 0.481 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.559TyrAla: 2.559 ± 0.055	0.346TyrCys: 0.346 ± 0.019	2.365TyrAsp: 2.365 ± 0.051	2.292TyrGlu: 2.292 ± 0.048	2.323TyrPhe: 2.323 ± 0.052	2.832TyrGly: 2.832 ± 0.056	0.974TyrHis: 0.974 ± 0.035	2.934TyrIle: 2.934 ± 0.054	3.432TyrLys: 3.432 ± 0.069	3.902TyrLeu: 3.902 ± 0.071	0.79TyrMet: 0.79 ± 0.029	2.943TyrAsn: 2.943 ± 0.064	1.627TyrPro: 1.627 ± 0.039	1.801TyrGln: 1.801 ± 0.049	1.46TyrArg: 1.46 ± 0.04	2.571TyrSer: 2.571 ± 0.054	2.483TyrThr: 2.483 ± 0.056	2.263TyrVal: 2.263 ± 0.053	0.512TyrTrp: 0.512 ± 0.026	1.776TyrTyr: 1.776 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2747 proteins (1031829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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