Amino acid dipepetide frequency for Streptococcus phage phiARI0746

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.992AlaAla: 2.992 ± 0.951
0.359AlaCys: 0.359 ± 0.216
5.865AlaAsp: 5.865 ± 0.809
5.506AlaGlu: 5.506 ± 0.89
2.873AlaPhe: 2.873 ± 0.947
4.788AlaGly: 4.788 ± 1.255
0.479AlaHis: 0.479 ± 0.216
6.463AlaIle: 6.463 ± 1.15
6.583AlaLys: 6.583 ± 0.99
6.344AlaLeu: 6.344 ± 1.127
2.035AlaMet: 2.035 ± 0.519
4.309AlaAsn: 4.309 ± 0.577
1.915AlaPro: 1.915 ± 0.443
2.035AlaGln: 2.035 ± 0.535
2.873AlaArg: 2.873 ± 0.672
2.633AlaSer: 2.633 ± 0.636
4.788AlaThr: 4.788 ± 0.695
4.907AlaVal: 4.907 ± 1.011
1.077AlaTrp: 1.077 ± 0.545
2.274AlaTyr: 2.274 ± 0.45
0.0AlaXaa: 0.0 ± 0.0
Cys
0.239CysAla: 0.239 ± 0.198
0.12CysCys: 0.12 ± 0.12
0.359CysAsp: 0.359 ± 0.18
0.838CysGlu: 0.838 ± 0.331
0.598CysPhe: 0.598 ± 0.338
0.239CysGly: 0.239 ± 0.155
0.0CysHis: 0.0 ± 0.0
0.359CysIle: 0.359 ± 0.247
0.479CysLys: 0.479 ± 0.217
0.12CysLeu: 0.12 ± 0.105
0.12CysMet: 0.12 ± 0.113
0.239CysAsn: 0.239 ± 0.241
0.239CysPro: 0.239 ± 0.177
0.479CysGln: 0.479 ± 0.183
0.239CysArg: 0.239 ± 0.156
0.479CysSer: 0.479 ± 0.251
0.12CysThr: 0.12 ± 0.144
0.359CysVal: 0.359 ± 0.198
0.239CysTrp: 0.239 ± 0.149
0.12CysTyr: 0.12 ± 0.12
0.0CysXaa: 0.0 ± 0.0
Asp
5.386AspAla: 5.386 ± 0.957
0.479AspCys: 0.479 ± 0.265
3.112AspAsp: 3.112 ± 0.547
5.386AspGlu: 5.386 ± 1.225
3.232AspPhe: 3.232 ± 0.659
4.428AspGly: 4.428 ± 0.695
0.359AspHis: 0.359 ± 0.225
5.147AspIle: 5.147 ± 0.921
6.463AspLys: 6.463 ± 1.051
5.147AspLeu: 5.147 ± 1.039
2.274AspMet: 2.274 ± 0.455
3.112AspAsn: 3.112 ± 0.556
1.795AspPro: 1.795 ± 0.401
1.436AspGln: 1.436 ± 0.303
2.154AspArg: 2.154 ± 0.584
3.232AspSer: 3.232 ± 0.556
3.591AspThr: 3.591 ± 0.646
4.189AspVal: 4.189 ± 0.708
0.838AspTrp: 0.838 ± 0.319
2.753AspTyr: 2.753 ± 0.654
0.0AspXaa: 0.0 ± 0.0
Glu
5.147GluAla: 5.147 ± 0.911
0.239GluCys: 0.239 ± 0.22
5.027GluAsp: 5.027 ± 1.104
5.984GluGlu: 5.984 ± 1.358
3.591GluPhe: 3.591 ± 0.666
2.992GluGly: 2.992 ± 0.713
1.676GluHis: 1.676 ± 0.416
8.139GluIle: 8.139 ± 1.069
6.583GluLys: 6.583 ± 1.295
8.259GluLeu: 8.259 ± 1.226
1.436GluMet: 1.436 ± 0.463
5.027GluAsn: 5.027 ± 0.632
1.676GluPro: 1.676 ± 0.606
3.591GluGln: 3.591 ± 0.837
3.83GluArg: 3.83 ± 0.693
4.309GluSer: 4.309 ± 0.823
3.351GluThr: 3.351 ± 0.876
5.266GluVal: 5.266 ± 0.703
0.958GluTrp: 0.958 ± 0.305
3.471GluTyr: 3.471 ± 0.815
0.0GluXaa: 0.0 ± 0.0
Phe
2.992PheAla: 2.992 ± 0.726
0.239PheCys: 0.239 ± 0.159
3.95PheAsp: 3.95 ± 0.664
4.189PheGlu: 4.189 ± 0.906
1.676PhePhe: 1.676 ± 0.432
3.351PheGly: 3.351 ± 0.891
0.479PheHis: 0.479 ± 0.303
2.035PheIle: 2.035 ± 0.472
2.633PheLys: 2.633 ± 0.642
2.274PheLeu: 2.274 ± 0.531
0.958PheMet: 0.958 ± 0.372
2.873PheAsn: 2.873 ± 0.54
0.718PhePro: 0.718 ± 0.37
1.556PheGln: 1.556 ± 0.451
1.795PheArg: 1.795 ± 0.344
3.71PheSer: 3.71 ± 0.873
2.753PheThr: 2.753 ± 0.568
1.556PheVal: 1.556 ± 0.381
0.12PheTrp: 0.12 ± 0.12
1.676PheTyr: 1.676 ± 0.401
0.0PheXaa: 0.0 ± 0.0
Gly
2.992GlyAla: 2.992 ± 0.622
0.12GlyCys: 0.12 ± 0.121
4.189GlyAsp: 4.189 ± 0.835
5.386GlyGlu: 5.386 ± 0.821
2.873GlyPhe: 2.873 ± 0.955
5.266GlyGly: 5.266 ± 1.62
1.197GlyHis: 1.197 ± 0.425
3.83GlyIle: 3.83 ± 0.82
4.668GlyLys: 4.668 ± 0.71
6.583GlyLeu: 6.583 ± 1.189
1.795GlyMet: 1.795 ± 0.388
3.232GlyAsn: 3.232 ± 0.835
0.598GlyPro: 0.598 ± 0.296
3.95GlyGln: 3.95 ± 0.691
3.232GlyArg: 3.232 ± 0.607
4.309GlySer: 4.309 ± 0.88
2.513GlyThr: 2.513 ± 0.626
5.147GlyVal: 5.147 ± 0.93
0.359GlyTrp: 0.359 ± 0.259
2.394GlyTyr: 2.394 ± 0.544
0.0GlyXaa: 0.0 ± 0.0
His
0.958HisAla: 0.958 ± 0.334
0.0HisCys: 0.0 ± 0.0
0.718HisAsp: 0.718 ± 0.381
1.197HisGlu: 1.197 ± 0.34
0.359HisPhe: 0.359 ± 0.19
0.718HisGly: 0.718 ± 0.296
0.239HisHis: 0.239 ± 0.193
1.077HisIle: 1.077 ± 0.432
0.598HisLys: 0.598 ± 0.291
1.317HisLeu: 1.317 ± 0.441
0.12HisMet: 0.12 ± 0.121
0.838HisAsn: 0.838 ± 0.258
0.479HisPro: 0.479 ± 0.218
0.479HisGln: 0.479 ± 0.21
0.479HisArg: 0.479 ± 0.278
1.317HisSer: 1.317 ± 0.414
0.958HisThr: 0.958 ± 0.313
0.479HisVal: 0.479 ± 0.185
0.12HisTrp: 0.12 ± 0.12
0.838HisTyr: 0.838 ± 0.392
0.0HisXaa: 0.0 ± 0.0
Ile
6.344IleAla: 6.344 ± 0.933
0.598IleCys: 0.598 ± 0.226
4.189IleAsp: 4.189 ± 0.866
7.301IleGlu: 7.301 ± 1.203
3.95IlePhe: 3.95 ± 0.753
5.027IleGly: 5.027 ± 1.179
0.718IleHis: 0.718 ± 0.357
2.992IleIle: 2.992 ± 0.488
7.421IleLys: 7.421 ± 0.993
4.309IleLeu: 4.309 ± 0.673
1.197IleMet: 1.197 ± 0.382
3.351IleAsn: 3.351 ± 0.623
1.077IlePro: 1.077 ± 0.466
2.633IleGln: 2.633 ± 0.614
2.154IleArg: 2.154 ± 0.629
4.189IleSer: 4.189 ± 0.705
4.788IleThr: 4.788 ± 0.685
3.83IleVal: 3.83 ± 0.6
0.479IleTrp: 0.479 ± 0.225
3.351IleTyr: 3.351 ± 0.91
0.0IleXaa: 0.0 ± 0.0
Lys
5.625LysAla: 5.625 ± 0.8
0.838LysCys: 0.838 ± 0.351
4.907LysAsp: 4.907 ± 0.796
6.822LysGlu: 6.822 ± 0.731
3.83LysPhe: 3.83 ± 0.648
5.027LysGly: 5.027 ± 0.853
0.838LysHis: 0.838 ± 0.292
7.181LysIle: 7.181 ± 1.421
7.54LysLys: 7.54 ± 1.295
7.421LysLeu: 7.421 ± 0.839
3.112LysMet: 3.112 ± 0.642
4.788LysAsn: 4.788 ± 0.666
1.915LysPro: 1.915 ± 0.465
3.83LysGln: 3.83 ± 0.978
3.232LysArg: 3.232 ± 0.573
4.548LysSer: 4.548 ± 0.884
5.506LysThr: 5.506 ± 0.731
6.583LysVal: 6.583 ± 0.946
1.197LysTrp: 1.197 ± 0.334
3.591LysTyr: 3.591 ± 0.633
0.0LysXaa: 0.0 ± 0.0
Leu
6.703LeuAla: 6.703 ± 1.182
0.838LeuCys: 0.838 ± 0.371
5.386LeuAsp: 5.386 ± 0.691
7.301LeuGlu: 7.301 ± 1.392
3.112LeuPhe: 3.112 ± 0.607
5.625LeuGly: 5.625 ± 1.775
0.958LeuHis: 0.958 ± 0.296
4.069LeuIle: 4.069 ± 0.591
9.216LeuLys: 9.216 ± 1.217
6.703LeuLeu: 6.703 ± 0.933
2.154LeuMet: 2.154 ± 0.437
2.873LeuAsn: 2.873 ± 0.345
2.633LeuPro: 2.633 ± 0.545
3.232LeuGln: 3.232 ± 0.53
3.232LeuArg: 3.232 ± 0.67
6.224LeuSer: 6.224 ± 0.873
4.788LeuThr: 4.788 ± 0.739
3.591LeuVal: 3.591 ± 0.643
0.239LeuTrp: 0.239 ± 0.189
2.274LeuTyr: 2.274 ± 0.427
0.0LeuXaa: 0.0 ± 0.0
Met
1.795MetAla: 1.795 ± 0.436
0.12MetCys: 0.12 ± 0.136
1.795MetAsp: 1.795 ± 0.415
1.676MetGlu: 1.676 ± 0.467
0.598MetPhe: 0.598 ± 0.258
1.197MetGly: 1.197 ± 0.54
0.239MetHis: 0.239 ± 0.159
2.035MetIle: 2.035 ± 0.504
2.873MetLys: 2.873 ± 0.531
1.676MetLeu: 1.676 ± 0.544
0.359MetMet: 0.359 ± 0.198
1.197MetAsn: 1.197 ± 0.406
1.077MetPro: 1.077 ± 0.369
1.077MetGln: 1.077 ± 0.372
1.197MetArg: 1.197 ± 0.362
0.958MetSer: 0.958 ± 0.396
1.915MetThr: 1.915 ± 0.502
2.154MetVal: 2.154 ± 0.603
0.12MetTrp: 0.12 ± 0.135
0.598MetTyr: 0.598 ± 0.266
0.0MetXaa: 0.0 ± 0.0
Asn
3.83AsnAla: 3.83 ± 1.093
0.359AsnCys: 0.359 ± 0.198
2.873AsnAsp: 2.873 ± 0.486
3.232AsnGlu: 3.232 ± 0.794
1.436AsnPhe: 1.436 ± 0.394
3.71AsnGly: 3.71 ± 0.677
0.958AsnHis: 0.958 ± 0.344
4.069AsnIle: 4.069 ± 0.533
4.907AsnLys: 4.907 ± 0.668
4.428AsnLeu: 4.428 ± 0.944
1.795AsnMet: 1.795 ± 0.491
2.513AsnAsn: 2.513 ± 0.71
2.035AsnPro: 2.035 ± 0.555
2.274AsnGln: 2.274 ± 0.61
1.556AsnArg: 1.556 ± 0.405
3.71AsnSer: 3.71 ± 0.84
2.992AsnThr: 2.992 ± 0.706
3.471AsnVal: 3.471 ± 0.558
0.598AsnTrp: 0.598 ± 0.206
2.035AsnTyr: 2.035 ± 0.442
0.0AsnXaa: 0.0 ± 0.0
Pro
1.795ProAla: 1.795 ± 0.477
0.479ProCys: 0.479 ± 0.22
1.676ProAsp: 1.676 ± 0.507
2.633ProGlu: 2.633 ± 0.476
1.197ProPhe: 1.197 ± 0.456
0.718ProGly: 0.718 ± 0.239
0.12ProHis: 0.12 ± 0.121
2.035ProIle: 2.035 ± 0.426
2.633ProLys: 2.633 ± 0.42
1.795ProLeu: 1.795 ± 0.489
0.479ProMet: 0.479 ± 0.233
1.676ProAsn: 1.676 ± 0.506
0.479ProPro: 0.479 ± 0.217
1.197ProGln: 1.197 ± 0.349
1.197ProArg: 1.197 ± 0.37
1.317ProSer: 1.317 ± 0.429
1.676ProThr: 1.676 ± 0.444
1.795ProVal: 1.795 ± 0.5
0.838ProTrp: 0.838 ± 0.342
0.838ProTyr: 0.838 ± 0.405
0.0ProXaa: 0.0 ± 0.0
Gln
3.591GlnAla: 3.591 ± 0.512
0.239GlnCys: 0.239 ± 0.181
1.077GlnAsp: 1.077 ± 0.31
3.83GlnGlu: 3.83 ± 0.933
1.077GlnPhe: 1.077 ± 0.328
3.232GlnGly: 3.232 ± 1.019
0.718GlnHis: 0.718 ± 0.308
3.591GlnIle: 3.591 ± 0.703
3.591GlnLys: 3.591 ± 0.772
2.394GlnLeu: 2.394 ± 0.472
0.718GlnMet: 0.718 ± 0.223
2.154GlnAsn: 2.154 ± 0.475
1.676GlnPro: 1.676 ± 0.419
2.154GlnGln: 2.154 ± 0.645
2.274GlnArg: 2.274 ± 0.495
2.274GlnSer: 2.274 ± 0.439
2.513GlnThr: 2.513 ± 0.544
3.112GlnVal: 3.112 ± 0.54
0.479GlnTrp: 0.479 ± 0.185
1.556GlnTyr: 1.556 ± 0.43
0.0GlnXaa: 0.0 ± 0.0
Arg
2.513ArgAla: 2.513 ± 0.503
0.239ArgCys: 0.239 ± 0.188
2.394ArgAsp: 2.394 ± 0.668
2.873ArgGlu: 2.873 ± 0.603
1.436ArgPhe: 1.436 ± 0.426
2.274ArgGly: 2.274 ± 0.685
0.958ArgHis: 0.958 ± 0.402
2.753ArgIle: 2.753 ± 0.671
3.112ArgLys: 3.112 ± 0.637
3.83ArgLeu: 3.83 ± 0.594
1.915ArgMet: 1.915 ± 0.527
1.795ArgAsn: 1.795 ± 0.506
0.958ArgPro: 0.958 ± 0.339
1.676ArgGln: 1.676 ± 0.36
2.513ArgArg: 2.513 ± 0.734
1.436ArgSer: 1.436 ± 0.467
2.154ArgThr: 2.154 ± 0.472
2.992ArgVal: 2.992 ± 0.52
0.359ArgTrp: 0.359 ± 0.216
1.795ArgTyr: 1.795 ± 0.55
0.0ArgXaa: 0.0 ± 0.0
Ser
4.668SerAla: 4.668 ± 1.095
0.0SerCys: 0.0 ± 0.0
3.83SerAsp: 3.83 ± 0.751
3.71SerGlu: 3.71 ± 0.718
1.676SerPhe: 1.676 ± 0.419
4.788SerGly: 4.788 ± 0.922
1.197SerHis: 1.197 ± 0.496
3.83SerIle: 3.83 ± 0.762
5.027SerLys: 5.027 ± 0.872
6.104SerLeu: 6.104 ± 0.778
0.838SerMet: 0.838 ± 0.274
3.71SerAsn: 3.71 ± 0.757
1.556SerPro: 1.556 ± 0.429
2.753SerGln: 2.753 ± 0.478
2.394SerArg: 2.394 ± 0.851
3.232SerSer: 3.232 ± 0.856
3.83SerThr: 3.83 ± 0.536
2.753SerVal: 2.753 ± 0.744
1.317SerTrp: 1.317 ± 0.538
2.274SerTyr: 2.274 ± 0.566
0.0SerXaa: 0.0 ± 0.0
Thr
4.428ThrAla: 4.428 ± 0.781
0.12ThrCys: 0.12 ± 0.11
4.069ThrAsp: 4.069 ± 0.768
4.189ThrGlu: 4.189 ± 0.786
2.992ThrPhe: 2.992 ± 0.445
3.591ThrGly: 3.591 ± 0.54
0.479ThrHis: 0.479 ± 0.29
3.95ThrIle: 3.95 ± 0.709
4.189ThrLys: 4.189 ± 0.905
4.668ThrLeu: 4.668 ± 1.003
1.676ThrMet: 1.676 ± 0.575
2.992ThrAsn: 2.992 ± 0.5
1.795ThrPro: 1.795 ± 0.484
2.633ThrGln: 2.633 ± 0.602
1.795ThrArg: 1.795 ± 0.546
3.591ThrSer: 3.591 ± 0.716
4.668ThrThr: 4.668 ± 0.783
5.147ThrVal: 5.147 ± 0.85
0.718ThrTrp: 0.718 ± 0.289
2.035ThrTyr: 2.035 ± 0.656
0.0ThrXaa: 0.0 ± 0.0
Val
5.865ValAla: 5.865 ± 0.955
0.239ValCys: 0.239 ± 0.165
5.745ValAsp: 5.745 ± 1.058
4.428ValGlu: 4.428 ± 0.604
2.513ValPhe: 2.513 ± 0.552
4.668ValGly: 4.668 ± 0.806
0.718ValHis: 0.718 ± 0.368
3.232ValIle: 3.232 ± 0.601
5.027ValLys: 5.027 ± 0.799
4.309ValLeu: 4.309 ± 0.556
1.197ValMet: 1.197 ± 0.375
4.428ValAsn: 4.428 ± 0.924
2.394ValPro: 2.394 ± 0.49
1.915ValGln: 1.915 ± 0.634
2.394ValArg: 2.394 ± 0.426
4.788ValSer: 4.788 ± 0.825
3.95ValThr: 3.95 ± 0.627
5.147ValVal: 5.147 ± 1.085
0.359ValTrp: 0.359 ± 0.191
2.154ValTyr: 2.154 ± 0.457
0.0ValXaa: 0.0 ± 0.0
Trp
1.556TrpAla: 1.556 ± 0.439
0.239TrpCys: 0.239 ± 0.13
0.598TrpAsp: 0.598 ± 0.373
0.838TrpGlu: 0.838 ± 0.367
1.317TrpPhe: 1.317 ± 0.541
0.239TrpGly: 0.239 ± 0.164
0.12TrpHis: 0.12 ± 0.118
0.479TrpIle: 0.479 ± 0.381
0.479TrpLys: 0.479 ± 0.202
0.598TrpLeu: 0.598 ± 0.378
0.239TrpMet: 0.239 ± 0.168
0.598TrpAsn: 0.598 ± 0.233
0.0TrpPro: 0.0 ± 0.0
0.598TrpGln: 0.598 ± 0.39
0.359TrpArg: 0.359 ± 0.187
0.359TrpSer: 0.359 ± 0.231
0.718TrpThr: 0.718 ± 0.299
0.838TrpVal: 0.838 ± 0.285
0.0TrpTrp: 0.0 ± 0.0
0.359TrpTyr: 0.359 ± 0.21
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.676TyrAla: 1.676 ± 0.524
0.12TyrCys: 0.12 ± 0.12
2.753TyrAsp: 2.753 ± 0.48
3.232TyrGlu: 3.232 ± 0.788
1.317TyrPhe: 1.317 ± 0.479
2.753TyrGly: 2.753 ± 0.571
0.838TyrHis: 0.838 ± 0.324
2.633TyrIle: 2.633 ± 0.699
4.309TyrLys: 4.309 ± 0.923
2.873TyrLeu: 2.873 ± 0.709
0.12TyrMet: 0.12 ± 0.144
1.077TyrAsn: 1.077 ± 0.329
1.556TyrPro: 1.556 ± 0.539
2.753TyrGln: 2.753 ± 0.655
1.077TyrArg: 1.077 ± 0.297
2.873TyrSer: 2.873 ± 0.624
2.154TyrThr: 2.154 ± 0.469
2.154TyrVal: 2.154 ± 0.693
0.12TyrTrp: 0.12 ± 0.118
1.197TyrTyr: 1.197 ± 0.524
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 42 proteins (8356 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski