Amino acid dipepetide frequency for Diaminobutyricibacter tongyongensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.677AlaAla: 18.677 ± 0.174	0.671AlaCys: 0.671 ± 0.029	7.701AlaAsp: 7.701 ± 0.09	7.417AlaGlu: 7.417 ± 0.114	4.133AlaPhe: 4.133 ± 0.061	11.702AlaGly: 11.702 ± 0.163	2.405AlaHis: 2.405 ± 0.043	6.47AlaIle: 6.47 ± 0.085	2.903AlaLys: 2.903 ± 0.061	13.246AlaLeu: 13.246 ± 0.14	2.523AlaMet: 2.523 ± 0.05	2.767AlaAsn: 2.767 ± 0.074	5.944AlaPro: 5.944 ± 0.09	3.776AlaGln: 3.776 ± 0.062	8.505AlaArg: 8.505 ± 0.107	8.019AlaSer: 8.019 ± 0.171	7.826AlaThr: 7.826 ± 0.194	11.116AlaVal: 11.116 ± 0.118	1.742AlaTrp: 1.742 ± 0.042	2.464AlaTyr: 2.464 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.6CysAla: 0.6 ± 0.024	0.046CysCys: 0.046 ± 0.007	0.341CysAsp: 0.341 ± 0.016	0.256CysGlu: 0.256 ± 0.015	0.167CysPhe: 0.167 ± 0.013	0.541CysGly: 0.541 ± 0.024	0.103CysHis: 0.103 ± 0.009	0.188CysIle: 0.188 ± 0.013	0.073CysLys: 0.073 ± 0.008	0.42CysLeu: 0.42 ± 0.021	0.082CysMet: 0.082 ± 0.008	0.113CysAsn: 0.113 ± 0.01	0.298CysPro: 0.298 ± 0.019	0.113CysGln: 0.113 ± 0.01	0.289CysArg: 0.289 ± 0.016	0.355CysSer: 0.355 ± 0.016	0.354CysThr: 0.354 ± 0.018	0.412CysVal: 0.412 ± 0.022	0.081CysTrp: 0.081 ± 0.007	0.103CysTyr: 0.103 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.234AspAla: 8.234 ± 0.095	0.224AspCys: 0.224 ± 0.015	3.951AspAsp: 3.951 ± 0.076	4.063AspGlu: 4.063 ± 0.079	1.869AspPhe: 1.869 ± 0.043	5.692AspGly: 5.692 ± 0.072	1.189AspHis: 1.189 ± 0.032	2.516AspIle: 2.516 ± 0.043	1.147AspLys: 1.147 ± 0.038	6.212AspLeu: 6.212 ± 0.076	0.724AspMet: 0.724 ± 0.021	1.109AspAsn: 1.109 ± 0.032	3.977AspPro: 3.977 ± 0.062	1.645AspGln: 1.645 ± 0.039	4.299AspArg: 4.299 ± 0.077	2.865AspSer: 2.865 ± 0.051	2.899AspThr: 2.899 ± 0.052	5.108AspVal: 5.108 ± 0.077	0.988AspTrp: 0.988 ± 0.032	1.363AspTyr: 1.363 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.425GluAla: 6.425 ± 0.101	0.226GluCys: 0.226 ± 0.014	2.336GluAsp: 2.336 ± 0.049	2.727GluGlu: 2.727 ± 0.06	1.827GluPhe: 1.827 ± 0.041	3.615GluGly: 3.615 ± 0.057	1.418GluHis: 1.418 ± 0.041	2.606GluIle: 2.606 ± 0.047	1.346GluLys: 1.346 ± 0.046	6.712GluLeu: 6.712 ± 0.11	0.814GluMet: 0.814 ± 0.025	1.249GluAsn: 1.249 ± 0.03	2.91GluPro: 2.91 ± 0.061	2.017GluGln: 2.017 ± 0.051	5.007GluArg: 5.007 ± 0.086	3.107GluSer: 3.107 ± 0.06	3.106GluThr: 3.106 ± 0.057	4.126GluVal: 4.126 ± 0.077	0.867GluTrp: 0.867 ± 0.03	1.155GluTyr: 1.155 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.42PheAla: 4.42 ± 0.068	0.186PheCys: 0.186 ± 0.013	2.473PheAsp: 2.473 ± 0.048	1.863PheGlu: 1.863 ± 0.05	1.173PhePhe: 1.173 ± 0.032	3.583PheGly: 3.583 ± 0.057	0.572PheHis: 0.572 ± 0.024	1.437PheIle: 1.437 ± 0.043	0.528PheLys: 0.528 ± 0.025	2.912PheLeu: 2.912 ± 0.046	0.475PheMet: 0.475 ± 0.019	0.766PheAsn: 0.766 ± 0.03	1.489PhePro: 1.489 ± 0.037	0.814PheGln: 0.814 ± 0.028	1.947PheArg: 1.947 ± 0.044	1.942PheSer: 1.942 ± 0.038	2.259PheThr: 2.259 ± 0.048	3.05PheVal: 3.05 ± 0.054	0.535PheTrp: 0.535 ± 0.022	0.783PheTyr: 0.783 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.318GlyAla: 10.318 ± 0.193	0.579GlyCys: 0.579 ± 0.025	4.838GlyAsp: 4.838 ± 0.068	4.393GlyGlu: 4.393 ± 0.077	3.373GlyPhe: 3.373 ± 0.058	7.445GlyGly: 7.445 ± 0.185	1.879GlyHis: 1.879 ± 0.043	4.936GlyIle: 4.936 ± 0.064	2.333GlyLys: 2.333 ± 0.052	8.766GlyLeu: 8.766 ± 0.088	1.823GlyMet: 1.823 ± 0.047	1.938GlyAsn: 1.938 ± 0.045	3.857GlyPro: 3.857 ± 0.062	2.488GlyGln: 2.488 ± 0.049	6.044GlyArg: 6.044 ± 0.082	5.886GlySer: 5.886 ± 0.108	5.573GlyThr: 5.573 ± 0.103	7.562GlyVal: 7.562 ± 0.095	1.693GlyTrp: 1.693 ± 0.04	2.286GlyTyr: 2.286 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.25HisAla: 2.25 ± 0.049	0.11HisCys: 0.11 ± 0.01	1.348HisAsp: 1.348 ± 0.037	1.105HisGlu: 1.105 ± 0.031	0.627HisPhe: 0.627 ± 0.024	1.861HisGly: 1.861 ± 0.042	0.531HisHis: 0.531 ± 0.022	0.795HisIle: 0.795 ± 0.029	0.312HisLys: 0.312 ± 0.017	1.982HisLeu: 1.982 ± 0.049	0.306HisMet: 0.306 ± 0.017	0.443HisAsn: 0.443 ± 0.02	1.573HisPro: 1.573 ± 0.036	0.541HisGln: 0.541 ± 0.021	1.442HisArg: 1.442 ± 0.038	1.022HisSer: 1.022 ± 0.032	1.112HisThr: 1.112 ± 0.033	1.597HisVal: 1.597 ± 0.033	0.329HisTrp: 0.329 ± 0.017	0.476HisTyr: 0.476 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.259IleAla: 7.259 ± 0.077	0.241IleCys: 0.241 ± 0.013	3.462IleAsp: 3.462 ± 0.058	2.797IleGlu: 2.797 ± 0.056	1.395IlePhe: 1.395 ± 0.043	4.852IleGly: 4.852 ± 0.069	0.847IleHis: 0.847 ± 0.026	2.005IleIle: 2.005 ± 0.044	0.856IleLys: 0.856 ± 0.029	4.153IleLeu: 4.153 ± 0.072	0.64IleMet: 0.64 ± 0.021	1.067IleAsn: 1.067 ± 0.034	2.686IlePro: 2.686 ± 0.054	1.162IleGln: 1.162 ± 0.032	3.023IleArg: 3.023 ± 0.058	2.586IleSer: 2.586 ± 0.047	3.056IleThr: 3.056 ± 0.071	5.155IleVal: 5.155 ± 0.068	0.575IleTrp: 0.575 ± 0.022	0.887IleTyr: 0.887 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.835LysAla: 2.835 ± 0.057	0.06LysCys: 0.06 ± 0.008	1.191LysAsp: 1.191 ± 0.031	0.946LysGlu: 0.946 ± 0.032	0.545LysPhe: 0.545 ± 0.024	1.725LysGly: 1.725 ± 0.041	0.48LysHis: 0.48 ± 0.022	0.979LysIle: 0.979 ± 0.034	0.773LysLys: 0.773 ± 0.031	2.104LysLeu: 2.104 ± 0.051	0.421LysMet: 0.421 ± 0.021	0.639LysAsn: 0.639 ± 0.028	1.379LysPro: 1.379 ± 0.039	0.773LysGln: 0.773 ± 0.025	1.667LysArg: 1.667 ± 0.042	1.305LysSer: 1.305 ± 0.041	1.527LysThr: 1.527 ± 0.042	1.819LysVal: 1.819 ± 0.042	0.295LysTrp: 0.295 ± 0.017	0.531LysTyr: 0.531 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.195LeuAla: 14.195 ± 0.142	0.52LeuCys: 0.52 ± 0.021	6.539LeuAsp: 6.539 ± 0.106	5.165LeuGlu: 5.165 ± 0.084	3.041LeuPhe: 3.041 ± 0.065	9.016LeuGly: 9.016 ± 0.101	1.87LeuHis: 1.87 ± 0.042	4.833LeuIle: 4.833 ± 0.085	2.061LeuLys: 2.061 ± 0.049	9.776LeuLeu: 9.776 ± 0.127	1.515LeuMet: 1.515 ± 0.039	2.256LeuAsn: 2.256 ± 0.046	5.321LeuPro: 5.321 ± 0.069	2.516LeuGln: 2.516 ± 0.046	6.901LeuArg: 6.901 ± 0.1	6.071LeuSer: 6.071 ± 0.06	6.515LeuThr: 6.515 ± 0.085	9.03LeuVal: 9.03 ± 0.105	1.268LeuTrp: 1.268 ± 0.041	1.909LeuTyr: 1.909 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.02MetAla: 2.02 ± 0.046	0.091MetCys: 0.091 ± 0.009	0.781MetAsp: 0.781 ± 0.024	0.659MetGlu: 0.659 ± 0.023	0.543MetPhe: 0.543 ± 0.021	1.208MetGly: 1.208 ± 0.03	0.318MetHis: 0.318 ± 0.016	0.876MetIle: 0.876 ± 0.029	0.503MetLys: 0.503 ± 0.021	1.816MetLeu: 1.816 ± 0.042	0.314MetMet: 0.314 ± 0.018	0.551MetAsn: 0.551 ± 0.017	1.035MetPro: 1.035 ± 0.028	0.52MetGln: 0.52 ± 0.021	1.301MetArg: 1.301 ± 0.035	1.401MetSer: 1.401 ± 0.032	1.613MetThr: 1.613 ± 0.04	1.308MetVal: 1.308 ± 0.038	0.211MetTrp: 0.211 ± 0.015	0.291MetTyr: 0.291 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.908AsnAla: 2.908 ± 0.066	0.141AsnCys: 0.141 ± 0.012	1.329AsnAsp: 1.329 ± 0.034	1.121AsnGlu: 1.121 ± 0.03	0.743AsnPhe: 0.743 ± 0.027	2.388AsnGly: 2.388 ± 0.07	0.447AsnHis: 0.447 ± 0.02	0.978AsnIle: 0.978 ± 0.029	0.504AsnLys: 0.504 ± 0.025	2.231AsnLeu: 2.231 ± 0.047	0.363AsnMet: 0.363 ± 0.02	0.606AsnAsn: 0.606 ± 0.026	1.769AsnPro: 1.769 ± 0.04	0.679AsnGln: 0.679 ± 0.031	1.44AsnArg: 1.44 ± 0.032	1.325AsnSer: 1.325 ± 0.038	1.411AsnThr: 1.411 ± 0.052	1.965AsnVal: 1.965 ± 0.066	0.383AsnTrp: 0.383 ± 0.018	0.544AsnTyr: 0.544 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.948ProAla: 6.948 ± 0.105	0.183ProCys: 0.183 ± 0.012	3.772ProAsp: 3.772 ± 0.067	3.441ProGlu: 3.441 ± 0.063	1.804ProPhe: 1.804 ± 0.044	4.966ProGly: 4.966 ± 0.075	1.105ProHis: 1.105 ± 0.028	2.373ProIle: 2.373 ± 0.04	1.161ProLys: 1.161 ± 0.037	4.751ProLeu: 4.751 ± 0.075	0.86ProMet: 0.86 ± 0.029	1.298ProAsn: 1.298 ± 0.032	2.405ProPro: 2.405 ± 0.053	1.522ProGln: 1.522 ± 0.034	3.05ProArg: 3.05 ± 0.056	3.465ProSer: 3.465 ± 0.055	3.526ProThr: 3.526 ± 0.072	4.761ProVal: 4.761 ± 0.067	0.87ProTrp: 0.87 ± 0.03	1.108ProTyr: 1.108 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.534GlnAla: 3.534 ± 0.057	0.097GlnCys: 0.097 ± 0.008	1.211GlnAsp: 1.211 ± 0.031	1.209GlnGlu: 1.209 ± 0.032	0.94GlnPhe: 0.94 ± 0.027	2.016GlnGly: 2.016 ± 0.043	0.608GlnHis: 0.608 ± 0.024	1.362GlnIle: 1.362 ± 0.04	0.775GlnLys: 0.775 ± 0.03	3.514GlnLeu: 3.514 ± 0.061	0.485GlnMet: 0.485 ± 0.022	0.814GlnAsn: 0.814 ± 0.027	1.589GlnPro: 1.589 ± 0.04	1.142GlnGln: 1.142 ± 0.038	2.24GlnArg: 2.24 ± 0.051	1.635GlnSer: 1.635 ± 0.042	1.628GlnThr: 1.628 ± 0.043	2.518GlnVal: 2.518 ± 0.047	0.475GlnTrp: 0.475 ± 0.021	0.672GlnTyr: 0.672 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.227ArgAla: 8.227 ± 0.108	0.298ArgCys: 0.298 ± 0.017	3.996ArgAsp: 3.996 ± 0.06	4.118ArgGlu: 4.118 ± 0.077	2.457ArgPhe: 2.457 ± 0.054	4.92ArgGly: 4.92 ± 0.07	1.436ArgHis: 1.436 ± 0.036	3.78ArgIle: 3.78 ± 0.052	1.432ArgLys: 1.432 ± 0.044	7.13ArgLeu: 7.13 ± 0.102	1.676ArgMet: 1.676 ± 0.039	1.604ArgAsn: 1.604 ± 0.038	3.505ArgPro: 3.505 ± 0.077	1.995ArgGln: 1.995 ± 0.048	5.896ArgArg: 5.896 ± 0.097	4.369ArgSer: 4.369 ± 0.067	3.999ArgThr: 3.999 ± 0.061	5.669ArgVal: 5.669 ± 0.072	1.076ArgTrp: 1.076 ± 0.028	1.614ArgTyr: 1.614 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.728SerAla: 7.728 ± 0.171	0.263SerCys: 0.263 ± 0.015	3.416SerAsp: 3.416 ± 0.056	2.888SerGlu: 2.888 ± 0.056	2.065SerPhe: 2.065 ± 0.043	6.18SerGly: 6.18 ± 0.111	1.093SerHis: 1.093 ± 0.033	3.033SerIle: 3.033 ± 0.056	1.34SerLys: 1.34 ± 0.035	5.615SerLeu: 5.615 ± 0.065	1.234SerMet: 1.234 ± 0.034	1.409SerAsn: 1.409 ± 0.043	3.245SerPro: 3.245 ± 0.052	1.683SerGln: 1.683 ± 0.038	3.988SerArg: 3.988 ± 0.068	3.893SerSer: 3.893 ± 0.084	4.032SerThr: 4.032 ± 0.114	5.231SerVal: 5.231 ± 0.087	0.966SerTrp: 0.966 ± 0.029	1.3SerTyr: 1.3 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	7.807ThrAla: 7.807 ± 0.179	0.297ThrCys: 0.297 ± 0.019	3.604ThrAsp: 3.604 ± 0.051	2.973ThrGlu: 2.973 ± 0.055	2.131ThrPhe: 2.131 ± 0.047	5.993ThrGly: 5.993 ± 0.113	1.128ThrHis: 1.128 ± 0.032	3.392ThrIle: 3.392 ± 0.072	1.391ThrLys: 1.391 ± 0.045	6.005ThrLeu: 6.005 ± 0.083	1.082ThrMet: 1.082 ± 0.026	1.456ThrAsn: 1.456 ± 0.045	3.902ThrPro: 3.902 ± 0.07	1.606ThrGln: 1.606 ± 0.045	3.768ThrArg: 3.768 ± 0.061	3.781ThrSer: 3.781 ± 0.118	4.221ThrThr: 4.221 ± 0.135	5.976ThrVal: 5.976 ± 0.098	0.892ThrTrp: 0.892 ± 0.033	1.272ThrTyr: 1.272 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	11.603ValAla: 11.603 ± 0.119	0.466ValCys: 0.466 ± 0.019	5.644ValAsp: 5.644 ± 0.068	4.652ValGlu: 4.652 ± 0.08	2.952ValPhe: 2.952 ± 0.052	7.232ValGly: 7.232 ± 0.106	1.631ValHis: 1.631 ± 0.038	4.578ValIle: 4.578 ± 0.066	1.803ValLys: 1.803 ± 0.038	8.785ValLeu: 8.785 ± 0.109	1.428ValMet: 1.428 ± 0.034	2.095ValAsn: 2.095 ± 0.055	4.645ValPro: 4.645 ± 0.065	2.222ValGln: 2.222 ± 0.041	5.566ValArg: 5.566 ± 0.073	5.325ValSer: 5.325 ± 0.089	5.911ValThr: 5.911 ± 0.128	8.862ValVal: 8.862 ± 0.123	1.096ValTrp: 1.096 ± 0.03	1.632ValTyr: 1.632 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.564TrpAla: 1.564 ± 0.036	0.096TrpCys: 0.096 ± 0.008	0.768TrpAsp: 0.768 ± 0.027	0.64TrpGlu: 0.64 ± 0.024	0.61TrpPhe: 0.61 ± 0.024	1.061TrpGly: 1.061 ± 0.034	0.337TrpHis: 0.337 ± 0.016	0.761TrpIle: 0.761 ± 0.027	0.359TrpLys: 0.359 ± 0.019	1.798TrpLeu: 1.798 ± 0.044	0.342TrpMet: 0.342 ± 0.018	0.528TrpAsn: 0.528 ± 0.023	0.729TrpPro: 0.729 ± 0.027	0.561TrpGln: 0.561 ± 0.022	1.142TrpArg: 1.142 ± 0.041	1.015TrpSer: 1.015 ± 0.032	0.922TrpThr: 0.922 ± 0.034	1.14TrpVal: 1.14 ± 0.034	0.392TrpTrp: 0.392 ± 0.019	0.34TrpTyr: 0.34 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.452TyrAla: 2.452 ± 0.043	0.14TyrCys: 0.14 ± 0.012	1.376TyrAsp: 1.376 ± 0.034	1.162TyrGlu: 1.162 ± 0.034	0.811TyrPhe: 0.811 ± 0.024	2.014TyrGly: 2.014 ± 0.046	0.364TyrHis: 0.364 ± 0.018	0.804TyrIle: 0.804 ± 0.029	0.393TyrLys: 0.393 ± 0.02	2.393TyrLeu: 2.393 ± 0.051	0.255TyrMet: 0.255 ± 0.014	0.569TyrAsn: 0.569 ± 0.025	1.112TyrPro: 1.112 ± 0.032	0.689TyrGln: 0.689 ± 0.028	1.681TyrArg: 1.681 ± 0.043	1.235TyrSer: 1.235 ± 0.032	1.186TyrThr: 1.186 ± 0.036	1.724TyrVal: 1.724 ± 0.036	0.37TyrTrp: 0.37 ± 0.018	0.494TyrTyr: 0.494 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3799 proteins (1213229 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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