Amino acid dipepetide frequency for Aotine betaherpesvirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.298AlaAla: 9.298 ± 1.225
1.775AlaCys: 1.775 ± 0.203
3.462AlaAsp: 3.462 ± 0.285
4.13AlaGlu: 4.13 ± 0.338
2.847AlaPhe: 2.847 ± 0.236
4.57AlaGly: 4.57 ± 0.531
1.459AlaHis: 1.459 ± 0.224
3.656AlaIle: 3.656 ± 0.306
2.285AlaLys: 2.285 ± 0.206
7.786AlaLeu: 7.786 ± 0.497
1.81AlaMet: 1.81 ± 0.195
2.373AlaAsn: 2.373 ± 0.196
4.288AlaPro: 4.288 ± 0.357
2.074AlaGln: 2.074 ± 0.202
4.745AlaArg: 4.745 ± 0.466
5.185AlaSer: 5.185 ± 0.388
5.642AlaThr: 5.642 ± 0.365
6.521AlaVal: 6.521 ± 0.425
1.142AlaTrp: 1.142 ± 0.172
2.197AlaTyr: 2.197 ± 0.189
0.0AlaXaa: 0.0 ± 0.0
Cys
1.81CysAla: 1.81 ± 0.195
0.773CysCys: 0.773 ± 0.124
1.178CysAsp: 1.178 ± 0.161
1.318CysGlu: 1.318 ± 0.173
1.23CysPhe: 1.23 ± 0.164
1.107CysGly: 1.107 ± 0.129
0.685CysHis: 0.685 ± 0.112
0.967CysIle: 0.967 ± 0.141
0.791CysLys: 0.791 ± 0.103
2.9CysLeu: 2.9 ± 0.204
0.703CysMet: 0.703 ± 0.128
0.808CysAsn: 0.808 ± 0.119
1.142CysPro: 1.142 ± 0.174
0.967CysGln: 0.967 ± 0.119
1.775CysArg: 1.775 ± 0.236
1.828CysSer: 1.828 ± 0.18
1.599CysThr: 1.599 ± 0.22
2.496CysVal: 2.496 ± 0.212
0.246CysTrp: 0.246 ± 0.063
1.055CysTyr: 1.055 ± 0.137
0.0CysXaa: 0.0 ± 0.0
Asp
4.411AspAla: 4.411 ± 0.298
0.914AspCys: 0.914 ± 0.136
3.55AspAsp: 3.55 ± 0.338
4.042AspGlu: 4.042 ± 0.336
1.898AspPhe: 1.898 ± 0.188
2.812AspGly: 2.812 ± 0.231
1.142AspHis: 1.142 ± 0.148
2.478AspIle: 2.478 ± 0.23
1.652AspLys: 1.652 ± 0.21
5.29AspLeu: 5.29 ± 0.366
0.896AspMet: 0.896 ± 0.108
1.986AspAsn: 1.986 ± 0.17
2.777AspPro: 2.777 ± 0.235
1.23AspGln: 1.23 ± 0.184
2.619AspArg: 2.619 ± 0.215
3.093AspSer: 3.093 ± 0.259
2.847AspThr: 2.847 ± 0.183
3.849AspVal: 3.849 ± 0.28
0.721AspTrp: 0.721 ± 0.126
1.599AspTyr: 1.599 ± 0.215
0.0AspXaa: 0.0 ± 0.0
Glu
4.253GluAla: 4.253 ± 0.328
1.441GluCys: 1.441 ± 0.177
3.708GluAsp: 3.708 ± 0.348
4.253GluGlu: 4.253 ± 0.351
1.617GluPhe: 1.617 ± 0.16
2.513GluGly: 2.513 ± 0.225
1.81GluHis: 1.81 ± 0.189
2.285GluIle: 2.285 ± 0.157
2.443GluLys: 2.443 ± 0.296
4.886GluLeu: 4.886 ± 0.414
1.248GluMet: 1.248 ± 0.164
2.179GluAsn: 2.179 ± 0.184
2.584GluPro: 2.584 ± 0.248
1.968GluGln: 1.968 ± 0.224
3.339GluArg: 3.339 ± 0.288
3.603GluSer: 3.603 ± 0.262
3.427GluThr: 3.427 ± 0.266
3.199GluVal: 3.199 ± 0.267
0.685GluTrp: 0.685 ± 0.123
1.933GluTyr: 1.933 ± 0.2
0.0GluXaa: 0.0 ± 0.0
Phe
2.267PheAla: 2.267 ± 0.209
1.265PheCys: 1.265 ± 0.164
1.916PheAsp: 1.916 ± 0.216
2.021PheGlu: 2.021 ± 0.209
2.162PhePhe: 2.162 ± 0.221
2.091PheGly: 2.091 ± 0.14
1.055PheHis: 1.055 ± 0.12
2.197PheIle: 2.197 ± 0.23
1.441PheLys: 1.441 ± 0.165
4.605PheLeu: 4.605 ± 0.309
1.09PheMet: 1.09 ± 0.148
1.881PheAsn: 1.881 ± 0.216
2.127PhePro: 2.127 ± 0.18
1.494PheGln: 1.494 ± 0.179
2.408PheArg: 2.408 ± 0.201
3.076PheSer: 3.076 ± 0.296
2.636PheThr: 2.636 ± 0.247
3.515PheVal: 3.515 ± 0.25
0.51PheTrp: 0.51 ± 0.095
1.476PheTyr: 1.476 ± 0.185
0.0PheXaa: 0.0 ± 0.0
Gly
4.429GlyAla: 4.429 ± 0.408
1.019GlyCys: 1.019 ± 0.14
2.759GlyAsp: 2.759 ± 0.282
2.988GlyGlu: 2.988 ± 0.233
1.898GlyPhe: 1.898 ± 0.213
3.849GlyGly: 3.849 ± 0.419
1.353GlyHis: 1.353 ± 0.146
2.109GlyIle: 2.109 ± 0.174
1.898GlyLys: 1.898 ± 0.202
5.255GlyLeu: 5.255 ± 0.335
1.019GlyMet: 1.019 ± 0.126
2.197GlyAsn: 2.197 ± 0.227
2.742GlyPro: 2.742 ± 0.29
1.775GlyGln: 1.775 ± 0.161
4.288GlyArg: 4.288 ± 0.383
4.201GlySer: 4.201 ± 0.373
3.902GlyThr: 3.902 ± 0.253
3.955GlyVal: 3.955 ± 0.234
0.615GlyTrp: 0.615 ± 0.101
2.144GlyTyr: 2.144 ± 0.195
0.0GlyXaa: 0.0 ± 0.0
His
2.215HisAla: 2.215 ± 0.201
0.58HisCys: 0.58 ± 0.101
1.81HisAsp: 1.81 ± 0.215
1.283HisGlu: 1.283 ± 0.16
1.16HisPhe: 1.16 ± 0.162
1.74HisGly: 1.74 ± 0.178
1.301HisHis: 1.301 ± 0.189
1.002HisIle: 1.002 ± 0.132
0.703HisLys: 0.703 ± 0.091
2.707HisLeu: 2.707 ± 0.237
0.439HisMet: 0.439 ± 0.097
1.318HisAsn: 1.318 ± 0.15
1.547HisPro: 1.547 ± 0.169
1.125HisGln: 1.125 ± 0.114
2.671HisArg: 2.671 ± 0.227
1.283HisSer: 1.283 ± 0.144
1.705HisThr: 1.705 ± 0.196
2.355HisVal: 2.355 ± 0.209
0.246HisTrp: 0.246 ± 0.068
0.861HisTyr: 0.861 ± 0.116
0.0HisXaa: 0.0 ± 0.0
Ile
2.953IleAla: 2.953 ± 0.279
1.178IleCys: 1.178 ± 0.132
1.828IleAsp: 1.828 ± 0.216
1.81IleGlu: 1.81 ± 0.181
1.881IlePhe: 1.881 ± 0.217
2.25IleGly: 2.25 ± 0.23
1.178IleHis: 1.178 ± 0.151
2.847IleIle: 2.847 ± 0.279
1.635IleLys: 1.635 ± 0.191
4.341IleLeu: 4.341 ± 0.306
1.248IleMet: 1.248 ± 0.14
1.722IleAsn: 1.722 ± 0.202
2.355IlePro: 2.355 ± 0.212
1.687IleGln: 1.687 ± 0.191
2.443IleArg: 2.443 ± 0.222
3.234IleSer: 3.234 ± 0.275
3.041IleThr: 3.041 ± 0.295
4.007IleVal: 4.007 ± 0.263
0.545IleTrp: 0.545 ± 0.098
2.074IleTyr: 2.074 ± 0.185
0.0IleXaa: 0.0 ± 0.0
Lys
2.461LysAla: 2.461 ± 0.219
0.914LysCys: 0.914 ± 0.142
1.722LysAsp: 1.722 ± 0.215
1.81LysGlu: 1.81 ± 0.196
1.23LysPhe: 1.23 ± 0.185
1.441LysGly: 1.441 ± 0.177
1.318LysHis: 1.318 ± 0.147
2.162LysIle: 2.162 ± 0.215
2.39LysLys: 2.39 ± 0.279
3.445LysLeu: 3.445 ± 0.227
0.791LysMet: 0.791 ± 0.113
2.074LysAsn: 2.074 ± 0.196
1.986LysPro: 1.986 ± 0.238
1.494LysGln: 1.494 ± 0.206
2.795LysArg: 2.795 ± 0.225
2.25LysSer: 2.25 ± 0.223
3.199LysThr: 3.199 ± 0.234
1.898LysVal: 1.898 ± 0.22
0.334LysTrp: 0.334 ± 0.064
1.388LysTyr: 1.388 ± 0.192
0.0LysXaa: 0.0 ± 0.0
Leu
6.89LeuAla: 6.89 ± 0.42
3.638LeuCys: 3.638 ± 0.22
4.201LeuAsp: 4.201 ± 0.349
4.781LeuGlu: 4.781 ± 0.354
4.763LeuPhe: 4.763 ± 0.317
5.73LeuGly: 5.73 ± 0.406
2.742LeuHis: 2.742 ± 0.195
4.71LeuIle: 4.71 ± 0.322
3.972LeuLys: 3.972 ± 0.311
10.844LeuLeu: 10.844 ± 0.605
2.742LeuMet: 2.742 ± 0.262
3.673LeuAsn: 3.673 ± 0.336
5.132LeuPro: 5.132 ± 0.362
4.183LeuGln: 4.183 ± 0.434
6.819LeuArg: 6.819 ± 0.445
7.645LeuSer: 7.645 ± 0.44
6.064LeuThr: 6.064 ± 0.392
6.38LeuVal: 6.38 ± 0.343
1.107LeuTrp: 1.107 ± 0.148
3.972LeuTyr: 3.972 ± 0.297
0.0LeuXaa: 0.0 ± 0.0
Met
2.25MetAla: 2.25 ± 0.169
0.562MetCys: 0.562 ± 0.108
1.265MetAsp: 1.265 ± 0.156
1.353MetGlu: 1.353 ± 0.171
1.055MetPhe: 1.055 ± 0.129
1.055MetGly: 1.055 ± 0.128
0.633MetHis: 0.633 ± 0.104
1.09MetIle: 1.09 ± 0.151
1.16MetLys: 1.16 ± 0.161
2.425MetLeu: 2.425 ± 0.232
0.598MetMet: 0.598 ± 0.085
0.756MetAsn: 0.756 ± 0.137
1.142MetPro: 1.142 ± 0.14
0.633MetGln: 0.633 ± 0.103
1.336MetArg: 1.336 ± 0.154
2.109MetSer: 2.109 ± 0.167
1.019MetThr: 1.019 ± 0.129
1.494MetVal: 1.494 ± 0.162
0.492MetTrp: 0.492 ± 0.097
0.896MetTyr: 0.896 ± 0.116
0.0MetXaa: 0.0 ± 0.0
Asn
3.058AsnAla: 3.058 ± 0.243
0.844AsnCys: 0.844 ± 0.121
1.512AsnAsp: 1.512 ± 0.164
2.39AsnGlu: 2.39 ± 0.204
1.371AsnPhe: 1.371 ± 0.177
2.461AsnGly: 2.461 ± 0.205
0.967AsnHis: 0.967 ± 0.112
2.144AsnIle: 2.144 ± 0.247
1.494AsnLys: 1.494 ± 0.162
2.97AsnLeu: 2.97 ± 0.248
0.756AsnMet: 0.756 ± 0.097
1.74AsnAsn: 1.74 ± 0.196
1.81AsnPro: 1.81 ± 0.171
1.301AsnGln: 1.301 ± 0.156
2.091AsnArg: 2.091 ± 0.186
2.83AsnSer: 2.83 ± 0.303
3.093AsnThr: 3.093 ± 0.335
4.394AsnVal: 4.394 ± 0.284
0.387AsnTrp: 0.387 ± 0.082
1.09AsnTyr: 1.09 ± 0.152
0.0AsnXaa: 0.0 ± 0.0
Pro
4.64ProAla: 4.64 ± 0.538
1.283ProCys: 1.283 ± 0.177
2.566ProAsp: 2.566 ± 0.216
3.111ProGlu: 3.111 ± 0.252
1.758ProPhe: 1.758 ± 0.159
3.462ProGly: 3.462 ± 0.362
1.283ProHis: 1.283 ± 0.128
1.67ProIle: 1.67 ± 0.166
2.144ProLys: 2.144 ± 0.246
4.71ProLeu: 4.71 ± 0.348
1.178ProMet: 1.178 ± 0.159
1.635ProAsn: 1.635 ± 0.183
4.078ProPro: 4.078 ± 0.44
2.584ProGln: 2.584 ± 0.233
4.394ProArg: 4.394 ± 0.426
4.851ProSer: 4.851 ± 0.417
3.287ProThr: 3.287 ± 0.33
4.042ProVal: 4.042 ± 0.276
0.738ProTrp: 0.738 ± 0.097
1.74ProTyr: 1.74 ± 0.19
0.0ProXaa: 0.0 ± 0.0
Gln
2.548GlnAla: 2.548 ± 0.288
0.896GlnCys: 0.896 ± 0.134
1.687GlnAsp: 1.687 ± 0.176
2.004GlnGlu: 2.004 ± 0.24
1.512GlnPhe: 1.512 ± 0.158
1.512GlnGly: 1.512 ± 0.181
1.388GlnHis: 1.388 ± 0.148
1.81GlnIle: 1.81 ± 0.175
1.582GlnLys: 1.582 ± 0.166
3.638GlnLeu: 3.638 ± 0.29
0.896GlnMet: 0.896 ± 0.134
1.564GlnAsn: 1.564 ± 0.169
1.863GlnPro: 1.863 ± 0.17
1.705GlnGln: 1.705 ± 0.212
3.234GlnArg: 3.234 ± 0.266
2.25GlnSer: 2.25 ± 0.21
2.531GlnThr: 2.531 ± 0.182
1.74GlnVal: 1.74 ± 0.154
0.281GlnTrp: 0.281 ± 0.071
1.09GlnTyr: 1.09 ± 0.151
0.0GlnXaa: 0.0 ± 0.0
Arg
4.658ArgAla: 4.658 ± 0.485
1.547ArgCys: 1.547 ± 0.185
3.937ArgAsp: 3.937 ± 0.284
3.234ArgGlu: 3.234 ± 0.194
3.251ArgPhe: 3.251 ± 0.253
3.392ArgGly: 3.392 ± 0.257
2.759ArgHis: 2.759 ± 0.24
2.355ArgIle: 2.355 ± 0.231
2.267ArgLys: 2.267 ± 0.248
6.907ArgLeu: 6.907 ± 0.359
1.142ArgMet: 1.142 ± 0.151
2.636ArgAsn: 2.636 ± 0.197
3.621ArgPro: 3.621 ± 0.397
3.076ArgGln: 3.076 ± 0.261
6.749ArgArg: 6.749 ± 0.526
4.429ArgSer: 4.429 ± 0.257
3.48ArgThr: 3.48 ± 0.218
4.745ArgVal: 4.745 ± 0.249
0.844ArgTrp: 0.844 ± 0.182
2.935ArgTyr: 2.935 ± 0.293
0.0ArgXaa: 0.0 ± 0.0
Ser
5.325SerAla: 5.325 ± 0.303
1.968SerCys: 1.968 ± 0.215
3.427SerAsp: 3.427 ± 0.267
4.06SerGlu: 4.06 ± 0.29
3.041SerPhe: 3.041 ± 0.211
4.288SerGly: 4.288 ± 0.327
1.599SerHis: 1.599 ± 0.142
2.671SerIle: 2.671 ± 0.242
2.601SerLys: 2.601 ± 0.254
7.065SerLeu: 7.065 ± 0.309
1.74SerMet: 1.74 ± 0.191
2.724SerAsn: 2.724 ± 0.242
4.693SerPro: 4.693 ± 0.357
2.566SerGln: 2.566 ± 0.223
4.411SerArg: 4.411 ± 0.315
8.612SerSer: 8.612 ± 0.68
5.554SerThr: 5.554 ± 0.565
5.765SerVal: 5.765 ± 0.312
0.861SerTrp: 0.861 ± 0.137
2.267SerTyr: 2.267 ± 0.188
0.0SerXaa: 0.0 ± 0.0
Thr
5.589ThrAla: 5.589 ± 0.368
1.775ThrCys: 1.775 ± 0.196
2.584ThrAsp: 2.584 ± 0.215
2.935ThrGlu: 2.935 ± 0.254
3.058ThrPhe: 3.058 ± 0.259
3.568ThrGly: 3.568 ± 0.267
1.968ThrHis: 1.968 ± 0.179
2.408ThrIle: 2.408 ± 0.236
1.968ThrLys: 1.968 ± 0.193
7.101ThrLeu: 7.101 ± 0.42
1.547ThrMet: 1.547 ± 0.188
2.373ThrAsn: 2.373 ± 0.324
4.605ThrPro: 4.605 ± 0.392
2.091ThrGln: 2.091 ± 0.21
3.867ThrArg: 3.867 ± 0.245
5.536ThrSer: 5.536 ± 0.576
5.923ThrThr: 5.923 ± 0.734
6.45ThrVal: 6.45 ± 0.402
1.019ThrTrp: 1.019 ± 0.153
2.039ThrTyr: 2.039 ± 0.219
0.0ThrXaa: 0.0 ± 0.0
Val
5.22ValAla: 5.22 ± 0.358
1.951ValCys: 1.951 ± 0.18
4.025ValAsp: 4.025 ± 0.366
3.41ValGlu: 3.41 ± 0.293
3.533ValPhe: 3.533 ± 0.25
3.761ValGly: 3.761 ± 0.301
1.916ValHis: 1.916 ± 0.187
3.603ValIle: 3.603 ± 0.265
3.023ValLys: 3.023 ± 0.29
7.874ValLeu: 7.874 ± 0.429
1.933ValMet: 1.933 ± 0.194
2.9ValAsn: 2.9 ± 0.285
4.078ValPro: 4.078 ± 0.289
2.566ValGln: 2.566 ± 0.225
4.57ValArg: 4.57 ± 0.306
5.905ValSer: 5.905 ± 0.409
6.415ValThr: 6.415 ± 0.471
4.851ValVal: 4.851 ± 0.324
1.213ValTrp: 1.213 ± 0.166
3.146ValTyr: 3.146 ± 0.216
0.0ValXaa: 0.0 ± 0.0
Trp
0.65TrpAla: 0.65 ± 0.147
0.264TrpCys: 0.264 ± 0.066
0.562TrpAsp: 0.562 ± 0.094
0.58TrpGlu: 0.58 ± 0.095
0.545TrpPhe: 0.545 ± 0.108
0.457TrpGly: 0.457 ± 0.078
0.264TrpHis: 0.264 ± 0.064
0.65TrpIle: 0.65 ± 0.131
0.51TrpLys: 0.51 ± 0.095
1.599TrpLeu: 1.599 ± 0.206
0.562TrpMet: 0.562 ± 0.09
0.51TrpAsn: 0.51 ± 0.093
0.861TrpPro: 0.861 ± 0.124
0.369TrpGln: 0.369 ± 0.076
0.791TrpArg: 0.791 ± 0.149
0.879TrpSer: 0.879 ± 0.132
0.685TrpThr: 0.685 ± 0.108
0.808TrpVal: 0.808 ± 0.14
0.176TrpTrp: 0.176 ± 0.052
0.773TrpTyr: 0.773 ± 0.141
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.32TyrAla: 2.32 ± 0.164
0.808TyrCys: 0.808 ± 0.122
2.109TyrAsp: 2.109 ± 0.213
1.863TyrGlu: 1.863 ± 0.17
1.424TyrPhe: 1.424 ± 0.168
2.338TyrGly: 2.338 ± 0.27
1.23TyrHis: 1.23 ± 0.135
1.441TyrIle: 1.441 ± 0.155
1.142TyrLys: 1.142 ± 0.164
3.638TyrLeu: 3.638 ± 0.24
0.967TyrMet: 0.967 ± 0.116
1.652TyrAsn: 1.652 ± 0.224
1.722TyrPro: 1.722 ± 0.18
0.844TyrGln: 0.844 ± 0.122
2.619TyrArg: 2.619 ± 0.245
2.443TyrSer: 2.443 ± 0.194
2.355TyrThr: 2.355 ± 0.212
3.427TyrVal: 3.427 ± 0.227
0.334TyrTrp: 0.334 ± 0.069
1.582TyrTyr: 1.582 ± 0.176
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 146 proteins (56898 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski