Amino acid dipepetide frequency for Helicocarpus griseus UAMH5409

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.648AlaAla: 8.648 ± 0.061	0.996AlaCys: 0.996 ± 0.017	4.113AlaAsp: 4.113 ± 0.032	5.086AlaGlu: 5.086 ± 0.038	2.951AlaPhe: 2.951 ± 0.027	5.748AlaGly: 5.748 ± 0.036	1.705AlaHis: 1.705 ± 0.02	4.152AlaIle: 4.152 ± 0.037	4.084AlaLys: 4.084 ± 0.036	7.27AlaLeu: 7.27 ± 0.044	1.779AlaMet: 1.779 ± 0.02	3.011AlaAsn: 3.011 ± 0.023	4.598AlaPro: 4.598 ± 0.04	3.171AlaGln: 3.171 ± 0.032	4.724AlaArg: 4.724 ± 0.036	6.928AlaSer: 6.928 ± 0.042	4.937AlaThr: 4.937 ± 0.028	5.124AlaVal: 5.124 ± 0.039	1.007AlaTrp: 1.007 ± 0.014	2.063AlaTyr: 2.063 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.888CysAla: 0.888 ± 0.014	0.254CysCys: 0.254 ± 0.01	0.657CysAsp: 0.657 ± 0.012	0.627CysGlu: 0.627 ± 0.012	0.526CysPhe: 0.526 ± 0.011	0.912CysGly: 0.912 ± 0.016	0.336CysHis: 0.336 ± 0.008	0.684CysIle: 0.684 ± 0.012	0.553CysLys: 0.553 ± 0.013	1.226CysLeu: 1.226 ± 0.016	0.267CysMet: 0.267 ± 0.007	0.426CysAsn: 0.426 ± 0.009	0.676CysPro: 0.676 ± 0.014	0.447CysGln: 0.447 ± 0.009	0.753CysArg: 0.753 ± 0.014	0.906CysSer: 0.906 ± 0.015	0.646CysThr: 0.646 ± 0.012	0.763CysVal: 0.763 ± 0.012	0.199CysTrp: 0.199 ± 0.006	0.369CysTyr: 0.369 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.364AspAla: 4.364 ± 0.033	0.63AspCys: 0.63 ± 0.013	4.213AspAsp: 4.213 ± 0.06	4.483AspGlu: 4.483 ± 0.041	2.195AspPhe: 2.195 ± 0.02	4.188AspGly: 4.188 ± 0.034	1.173AspHis: 1.173 ± 0.015	3.301AspIle: 3.301 ± 0.029	2.541AspLys: 2.541 ± 0.031	4.837AspLeu: 4.837 ± 0.037	1.268AspMet: 1.268 ± 0.015	2.072AspAsn: 2.072 ± 0.022	3.373AspPro: 3.373 ± 0.026	1.777AspGln: 1.777 ± 0.019	3.066AspArg: 3.066 ± 0.032	4.191AspSer: 4.191 ± 0.034	2.92AspThr: 2.92 ± 0.025	3.64AspVal: 3.64 ± 0.026	0.837AspTrp: 0.837 ± 0.014	1.66AspTyr: 1.66 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.156GluAla: 5.156 ± 0.037	0.632GluCys: 0.632 ± 0.011	4.213GluAsp: 4.213 ± 0.037	5.73GluGlu: 5.73 ± 0.055	2.022GluPhe: 2.022 ± 0.021	4.152GluGly: 4.152 ± 0.033	1.372GluHis: 1.372 ± 0.016	3.156GluIle: 3.156 ± 0.029	4.022GluLys: 4.022 ± 0.036	5.25GluLeu: 5.25 ± 0.035	1.505GluMet: 1.505 ± 0.021	2.585GluAsn: 2.585 ± 0.024	2.918GluPro: 2.918 ± 0.039	2.487GluGln: 2.487 ± 0.026	4.165GluArg: 4.165 ± 0.037	4.346GluSer: 4.346 ± 0.035	3.429GluThr: 3.429 ± 0.029	3.533GluVal: 3.533 ± 0.029	0.882GluTrp: 0.882 ± 0.013	1.718GluTyr: 1.718 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.914PheAla: 2.914 ± 0.024	0.562PheCys: 0.562 ± 0.011	2.277PheAsp: 2.277 ± 0.023	2.221PheGlu: 2.221 ± 0.022	1.578PhePhe: 1.578 ± 0.024	2.796PheGly: 2.796 ± 0.029	0.922PheHis: 0.922 ± 0.014	1.776PheIle: 1.776 ± 0.019	1.578PheLys: 1.578 ± 0.021	3.455PheLeu: 3.455 ± 0.03	0.739PheMet: 0.739 ± 0.013	1.457PheAsn: 1.457 ± 0.015	2.056PhePro: 2.056 ± 0.024	1.367PheGln: 1.367 ± 0.019	2.057PheArg: 2.057 ± 0.022	3.073PheSer: 3.073 ± 0.025	2.082PheThr: 2.082 ± 0.024	2.319PheVal: 2.319 ± 0.023	0.618PheTrp: 0.618 ± 0.01	1.118PheTyr: 1.118 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.191GlyAla: 5.191 ± 0.037	0.848GlyCys: 0.848 ± 0.012	3.834GlyAsp: 3.834 ± 0.03	4.07GlyGlu: 4.07 ± 0.033	2.708GlyPhe: 2.708 ± 0.027	6.308GlyGly: 6.308 ± 0.065	1.668GlyHis: 1.668 ± 0.02	3.546GlyIle: 3.546 ± 0.033	3.814GlyLys: 3.814 ± 0.03	5.785GlyLeu: 5.785 ± 0.036	1.62GlyMet: 1.62 ± 0.022	2.754GlyAsn: 2.754 ± 0.026	3.264GlyPro: 3.264 ± 0.03	2.541GlyGln: 2.541 ± 0.024	4.21GlyArg: 4.21 ± 0.035	5.712GlySer: 5.712 ± 0.041	3.807GlyThr: 3.807 ± 0.031	4.403GlyVal: 4.403 ± 0.032	1.129GlyTrp: 1.129 ± 0.017	2.179GlyTyr: 2.179 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.766HisAla: 1.766 ± 0.02	0.319HisCys: 0.319 ± 0.008	1.283HisAsp: 1.283 ± 0.016	1.276HisGlu: 1.276 ± 0.017	0.924HisPhe: 0.924 ± 0.014	1.673HisGly: 1.673 ± 0.019	0.907HisHis: 0.907 ± 0.02	1.24HisIle: 1.24 ± 0.017	0.912HisLys: 0.912 ± 0.014	2.218HisLeu: 2.218 ± 0.021	0.468HisMet: 0.468 ± 0.009	0.9HisAsn: 0.9 ± 0.014	1.764HisPro: 1.764 ± 0.022	1.018HisGln: 1.018 ± 0.014	1.556HisArg: 1.556 ± 0.018	1.919HisSer: 1.919 ± 0.022	1.25HisThr: 1.25 ± 0.017	1.366HisVal: 1.366 ± 0.018	0.326HisTrp: 0.326 ± 0.009	0.698HisTyr: 0.698 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.005IleAla: 4.005 ± 0.034	0.766IleCys: 0.766 ± 0.013	2.917IleAsp: 2.917 ± 0.027	2.911IleGlu: 2.911 ± 0.027	2.034IlePhe: 2.034 ± 0.026	3.101IleGly: 3.101 ± 0.032	1.239IleHis: 1.239 ± 0.015	2.556IleIle: 2.556 ± 0.028	2.207IleLys: 2.207 ± 0.022	4.615IleLeu: 4.615 ± 0.041	0.971IleMet: 0.971 ± 0.014	1.876IleAsn: 1.876 ± 0.019	3.311IlePro: 3.311 ± 0.026	1.89IleGln: 1.89 ± 0.023	2.872IleArg: 2.872 ± 0.024	4.126IleSer: 4.126 ± 0.032	2.793IleThr: 2.793 ± 0.027	3.091IleVal: 3.091 ± 0.028	0.675IleTrp: 0.675 ± 0.012	1.473IleTyr: 1.473 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.141LysAla: 4.141 ± 0.035	0.557LysCys: 0.557 ± 0.011	2.942LysAsp: 2.942 ± 0.028	3.725LysGlu: 3.725 ± 0.034	1.576LysPhe: 1.576 ± 0.017	3.261LysGly: 3.261 ± 0.032	1.153LysHis: 1.153 ± 0.016	2.394LysIle: 2.394 ± 0.023	3.634LysLys: 3.634 ± 0.06	4.277LysLeu: 4.277 ± 0.033	1.017LysMet: 1.017 ± 0.016	1.916LysAsn: 1.916 ± 0.024	3.035LysPro: 3.035 ± 0.033	1.97LysGln: 1.97 ± 0.023	3.63LysArg: 3.63 ± 0.034	3.705LysSer: 3.705 ± 0.034	2.799LysThr: 2.799 ± 0.024	2.81LysVal: 2.81 ± 0.029	0.686LysTrp: 0.686 ± 0.013	1.468LysTyr: 1.468 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	7.349LeuAla: 7.349 ± 0.046	1.202LeuCys: 1.202 ± 0.016	5.032LeuAsp: 5.032 ± 0.035	5.552LeuGlu: 5.552 ± 0.042	3.318LeuPhe: 3.318 ± 0.028	5.731LeuGly: 5.731 ± 0.041	2.213LeuHis: 2.213 ± 0.023	3.902LeuIle: 3.902 ± 0.033	4.415LeuLys: 4.415 ± 0.034	8.399LeuLeu: 8.399 ± 0.063	1.696LeuMet: 1.696 ± 0.021	3.241LeuAsn: 3.241 ± 0.025	5.513LeuPro: 5.513 ± 0.043	3.729LeuGln: 3.729 ± 0.037	5.733LeuArg: 5.733 ± 0.039	7.515LeuSer: 7.515 ± 0.044	4.7LeuThr: 4.7 ± 0.031	5.131LeuVal: 5.131 ± 0.037	1.135LeuTrp: 1.135 ± 0.016	2.363LeuTyr: 2.363 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.082MetAla: 2.082 ± 0.021	0.228MetCys: 0.228 ± 0.007	1.23MetAsp: 1.23 ± 0.015	1.349MetGlu: 1.349 ± 0.015	0.734MetPhe: 0.734 ± 0.012	1.462MetGly: 1.462 ± 0.018	0.456MetHis: 0.456 ± 0.01	0.953MetIle: 0.953 ± 0.015	1.087MetLys: 1.087 ± 0.015	1.752MetLeu: 1.752 ± 0.021	0.516MetMet: 0.516 ± 0.011	0.779MetAsn: 0.779 ± 0.012	1.172MetPro: 1.172 ± 0.017	0.801MetGln: 0.801 ± 0.014	1.254MetArg: 1.254 ± 0.014	1.808MetSer: 1.808 ± 0.021	1.213MetThr: 1.213 ± 0.017	1.272MetVal: 1.272 ± 0.016	0.252MetTrp: 0.252 ± 0.007	0.502MetTyr: 0.502 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.115AsnAla: 3.115 ± 0.027	0.492AsnCys: 0.492 ± 0.01	2.131AsnAsp: 2.131 ± 0.021	2.202AsnGlu: 2.202 ± 0.021	1.411AsnPhe: 1.411 ± 0.017	3.166AsnGly: 3.166 ± 0.031	0.917AsnHis: 0.917 ± 0.014	2.225AsnIle: 2.225 ± 0.021	1.723AsnLys: 1.723 ± 0.021	3.329AsnLeu: 3.329 ± 0.025	0.871AsnMet: 0.871 ± 0.014	1.896AsnAsn: 1.896 ± 0.029	2.738AsnPro: 2.738 ± 0.026	1.401AsnGln: 1.401 ± 0.021	2.115AsnArg: 2.115 ± 0.019	2.986AsnSer: 2.986 ± 0.026	2.253AsnThr: 2.253 ± 0.021	2.32AsnVal: 2.32 ± 0.021	0.551AsnTrp: 0.551 ± 0.01	1.08AsnTyr: 1.08 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.208ProAla: 5.208 ± 0.039	0.537ProCys: 0.537 ± 0.012	3.293ProAsp: 3.293 ± 0.028	3.963ProGlu: 3.963 ± 0.037	2.138ProPhe: 2.138 ± 0.021	3.914ProGly: 3.914 ± 0.034	1.382ProHis: 1.382 ± 0.018	2.602ProIle: 2.602 ± 0.024	2.874ProLys: 2.874 ± 0.029	4.969ProLeu: 4.969 ± 0.035	1.014ProMet: 1.014 ± 0.014	2.465ProAsn: 2.465 ± 0.024	5.752ProPro: 5.752 ± 0.08	2.677ProGln: 2.677 ± 0.031	3.486ProArg: 3.486 ± 0.031	6.59ProSer: 6.59 ± 0.057	4.103ProThr: 4.103 ± 0.035	3.515ProVal: 3.515 ± 0.032	0.685ProTrp: 0.685 ± 0.013	1.562ProTyr: 1.562 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.151GlnAla: 3.151 ± 0.031	0.43GlnCys: 0.43 ± 0.011	1.961GlnAsp: 1.961 ± 0.019	2.342GlnGlu: 2.342 ± 0.025	1.295GlnPhe: 1.295 ± 0.018	2.367GlnGly: 2.367 ± 0.025	1.108GlnHis: 1.108 ± 0.019	1.867GlnIle: 1.867 ± 0.022	2.103GlnLys: 2.103 ± 0.022	3.428GlnLeu: 3.428 ± 0.031	0.842GlnMet: 0.842 ± 0.015	1.677GlnAsn: 1.677 ± 0.021	2.751GlnPro: 2.751 ± 0.031	2.713GlnGln: 2.713 ± 0.048	2.644GlnArg: 2.644 ± 0.029	3.177GlnSer: 3.177 ± 0.027	2.304GlnThr: 2.304 ± 0.025	2.011GlnVal: 2.011 ± 0.022	0.53GlnTrp: 0.53 ± 0.011	1.136GlnTyr: 1.136 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.568ArgAla: 4.568 ± 0.033	0.716ArgCys: 0.716 ± 0.013	3.43ArgAsp: 3.43 ± 0.032	4.04ArgGlu: 4.04 ± 0.036	2.185ArgPhe: 2.185 ± 0.02	3.991ArgGly: 3.991 ± 0.04	1.575ArgHis: 1.575 ± 0.019	2.999ArgIle: 2.999 ± 0.026	3.59ArgLys: 3.59 ± 0.029	5.44ArgLeu: 5.44 ± 0.035	1.319ArgMet: 1.319 ± 0.014	2.439ArgAsn: 2.439 ± 0.021	3.554ArgPro: 3.554 ± 0.034	2.656ArgGln: 2.656 ± 0.023	5.312ArgArg: 5.312 ± 0.047	4.864ArgSer: 4.864 ± 0.039	3.273ArgThr: 3.273 ± 0.027	3.343ArgVal: 3.343 ± 0.03	0.904ArgTrp: 0.904 ± 0.015	1.705ArgTyr: 1.705 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.6SerAla: 6.6 ± 0.04	0.848SerCys: 0.848 ± 0.016	4.149SerAsp: 4.149 ± 0.035	4.21SerGlu: 4.21 ± 0.038	3.093SerPhe: 3.093 ± 0.027	5.65SerGly: 5.65 ± 0.036	1.994SerHis: 1.994 ± 0.023	3.983SerIle: 3.983 ± 0.036	4.01SerLys: 4.01 ± 0.034	7.309SerLeu: 7.309 ± 0.053	1.668SerMet: 1.668 ± 0.02	3.293SerAsn: 3.293 ± 0.028	6.072SerPro: 6.072 ± 0.054	3.434SerGln: 3.434 ± 0.032	5.292SerArg: 5.292 ± 0.039	9.491SerSer: 9.491 ± 0.083	5.674SerThr: 5.674 ± 0.042	4.506SerVal: 4.506 ± 0.034	1.047SerTrp: 1.047 ± 0.015	2.099SerTyr: 2.099 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.018ThrAla: 5.018 ± 0.035	0.714ThrCys: 0.714 ± 0.013	2.832ThrAsp: 2.832 ± 0.028	3.113ThrGlu: 3.113 ± 0.026	2.164ThrPhe: 2.164 ± 0.024	4.039ThrGly: 4.039 ± 0.029	1.258ThrHis: 1.258 ± 0.017	2.969ThrIle: 2.969 ± 0.031	2.604ThrLys: 2.604 ± 0.026	5.084ThrLeu: 5.084 ± 0.034	1.112ThrMet: 1.112 ± 0.016	2.135ThrAsn: 2.135 ± 0.02	4.496ThrPro: 4.496 ± 0.044	1.953ThrGln: 1.953 ± 0.022	3.064ThrArg: 3.064 ± 0.029	5.413ThrSer: 5.413 ± 0.042	4.295ThrThr: 4.295 ± 0.036	3.573ThrVal: 3.573 ± 0.031	0.767ThrTrp: 0.767 ± 0.014	1.552ThrTyr: 1.552 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	4.82ValAla: 4.82 ± 0.033	0.794ValCys: 0.794 ± 0.014	3.683ValAsp: 3.683 ± 0.032	3.928ValGlu: 3.928 ± 0.031	2.384ValPhe: 2.384 ± 0.025	3.998ValGly: 3.998 ± 0.03	1.33ValHis: 1.33 ± 0.018	2.911ValIle: 2.911 ± 0.027	3.007ValLys: 3.007 ± 0.027	5.311ValLeu: 5.311 ± 0.039	1.268ValMet: 1.268 ± 0.015	2.273ValAsn: 2.273 ± 0.024	3.521ValPro: 3.521 ± 0.028	2.203ValGln: 2.203 ± 0.024	3.396ValArg: 3.396 ± 0.036	4.585ValSer: 4.585 ± 0.034	3.292ValThr: 3.292 ± 0.033	4.124ValVal: 4.124 ± 0.042	0.825ValTrp: 0.825 ± 0.014	1.644ValTyr: 1.644 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.046TrpAla: 1.046 ± 0.018	0.179TrpCys: 0.179 ± 0.005	0.882TrpAsp: 0.882 ± 0.015	0.875TrpGlu: 0.875 ± 0.013	0.501TrpPhe: 0.501 ± 0.011	0.876TrpGly: 0.876 ± 0.017	0.322TrpHis: 0.322 ± 0.008	0.72TrpIle: 0.72 ± 0.013	0.793TrpLys: 0.793 ± 0.014	1.27TrpLeu: 1.27 ± 0.019	0.358TrpMet: 0.358 ± 0.008	0.602TrpAsn: 0.602 ± 0.012	0.567TrpPro: 0.567 ± 0.011	0.53TrpGln: 0.53 ± 0.009	0.931TrpArg: 0.931 ± 0.014	0.973TrpSer: 0.973 ± 0.014	0.819TrpThr: 0.819 ± 0.014	0.839TrpVal: 0.839 ± 0.012	0.265TrpTrp: 0.265 ± 0.008	0.401TrpTyr: 0.401 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.066TyrAla: 2.066 ± 0.023	0.414TyrCys: 0.414 ± 0.009	1.659TyrAsp: 1.659 ± 0.019	1.571TyrGlu: 1.571 ± 0.019	1.231TyrPhe: 1.231 ± 0.018	2.056TyrGly: 2.056 ± 0.024	0.752TyrHis: 0.752 ± 0.014	1.491TyrIle: 1.491 ± 0.02	1.145TyrLys: 1.145 ± 0.018	2.647TyrLeu: 2.647 ± 0.026	0.605TyrMet: 0.605 ± 0.012	1.124TyrAsn: 1.124 ± 0.016	1.597TyrPro: 1.597 ± 0.019	1.071TyrGln: 1.071 ± 0.015	1.641TyrArg: 1.641 ± 0.019	2.113TyrSer: 2.113 ± 0.025	1.563TyrThr: 1.563 ± 0.02	1.615TyrVal: 1.615 ± 0.018	0.429TyrTrp: 0.429 ± 0.009	0.943TyrTyr: 0.943 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10216 proteins (4942617 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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