Amino acid dipepetide frequency for Pseudodesulfovibrio sp. JC047

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.564AlaAla: 8.564 ± 0.112	1.291AlaCys: 1.291 ± 0.037	5.015AlaAsp: 5.015 ± 0.083	5.68AlaGlu: 5.68 ± 0.075	3.678AlaPhe: 3.678 ± 0.06	7.065AlaGly: 7.065 ± 0.099	1.896AlaHis: 1.896 ± 0.041	5.318AlaIle: 5.318 ± 0.08	4.406AlaLys: 4.406 ± 0.072	9.541AlaLeu: 9.541 ± 0.102	3.169AlaMet: 3.169 ± 0.058	2.619AlaAsn: 2.619 ± 0.064	3.34AlaPro: 3.34 ± 0.062	3.091AlaGln: 3.091 ± 0.055	4.793AlaArg: 4.793 ± 0.071	4.913AlaSer: 4.913 ± 0.081	4.657AlaThr: 4.657 ± 0.077	6.973AlaVal: 6.973 ± 0.089	1.113AlaTrp: 1.113 ± 0.035	2.35AlaTyr: 2.35 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.232CysAla: 1.232 ± 0.042	0.254CysCys: 0.254 ± 0.016	0.703CysAsp: 0.703 ± 0.027	0.712CysGlu: 0.712 ± 0.026	0.512CysPhe: 0.512 ± 0.026	1.363CysGly: 1.363 ± 0.041	0.509CysHis: 0.509 ± 0.037	0.729CysIle: 0.729 ± 0.03	0.526CysLys: 0.526 ± 0.025	1.344CysLeu: 1.344 ± 0.037	0.371CysMet: 0.371 ± 0.018	0.365CysAsn: 0.365 ± 0.018	0.883CysPro: 0.883 ± 0.035	0.38CysGln: 0.38 ± 0.019	0.744CysArg: 0.744 ± 0.026	0.847CysSer: 0.847 ± 0.03	0.687CysThr: 0.687 ± 0.027	0.997CysVal: 0.997 ± 0.033	0.154CysTrp: 0.154 ± 0.012	0.335CysTyr: 0.335 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.257AspAla: 5.257 ± 0.08	0.716AspCys: 0.716 ± 0.026	3.16AspAsp: 3.16 ± 0.068	3.952AspGlu: 3.952 ± 0.072	2.701AspPhe: 2.701 ± 0.052	4.583AspGly: 4.583 ± 0.12	1.238AspHis: 1.238 ± 0.036	4.01AspIle: 4.01 ± 0.066	2.659AspLys: 2.659 ± 0.053	5.531AspLeu: 5.531 ± 0.07	1.842AspMet: 1.842 ± 0.043	1.726AspAsn: 1.726 ± 0.045	2.853AspPro: 2.853 ± 0.066	1.726AspGln: 1.726 ± 0.045	3.155AspArg: 3.155 ± 0.052	2.971AspSer: 2.971 ± 0.058	3.365AspThr: 3.365 ± 0.074	4.375AspVal: 4.375 ± 0.072	0.813AspTrp: 0.813 ± 0.029	1.6AspTyr: 1.6 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.067GluAla: 6.067 ± 0.069	0.738GluCys: 0.738 ± 0.025	3.328GluAsp: 3.328 ± 0.057	4.124GluGlu: 4.124 ± 0.069	2.476GluPhe: 2.476 ± 0.049	3.918GluGly: 3.918 ± 0.07	1.355GluHis: 1.355 ± 0.037	4.074GluIle: 4.074 ± 0.073	4.253GluLys: 4.253 ± 0.076	6.277GluLeu: 6.277 ± 0.085	1.974GluMet: 1.974 ± 0.047	2.456GluAsn: 2.456 ± 0.047	2.312GluPro: 2.312 ± 0.044	2.414GluGln: 2.414 ± 0.051	3.579GluArg: 3.579 ± 0.073	3.365GluSer: 3.365 ± 0.058	3.994GluThr: 3.994 ± 0.067	4.076GluVal: 4.076 ± 0.074	0.687GluTrp: 0.687 ± 0.031	1.898GluTyr: 1.898 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.382PheAla: 3.382 ± 0.061	0.615PheCys: 0.615 ± 0.024	2.696PheAsp: 2.696 ± 0.063	2.618PheGlu: 2.618 ± 0.052	2.06PhePhe: 2.06 ± 0.056	3.467PheGly: 3.467 ± 0.064	0.842PheHis: 0.842 ± 0.03	2.524PheIle: 2.524 ± 0.058	2.043PheLys: 2.043 ± 0.05	4.072PheLeu: 4.072 ± 0.084	1.312PheMet: 1.312 ± 0.035	1.502PheAsn: 1.502 ± 0.042	1.796PhePro: 1.796 ± 0.041	1.192PheGln: 1.192 ± 0.032	1.971PheArg: 1.971 ± 0.041	2.878PheSer: 2.878 ± 0.054	2.483PheThr: 2.483 ± 0.053	2.924PheVal: 2.924 ± 0.054	0.575PheTrp: 0.575 ± 0.026	1.217PheTyr: 1.217 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.068GlyAla: 6.068 ± 0.086	1.309GlyCys: 1.309 ± 0.04	4.038GlyAsp: 4.038 ± 0.079	4.54GlyGlu: 4.54 ± 0.077	3.551GlyPhe: 3.551 ± 0.067	5.811GlyGly: 5.811 ± 0.101	1.859GlyHis: 1.859 ± 0.043	4.984GlyIle: 4.984 ± 0.076	4.297GlyLys: 4.297 ± 0.073	8.293GlyLeu: 8.293 ± 0.097	2.69GlyMet: 2.69 ± 0.061	2.412GlyAsn: 2.412 ± 0.055	2.671GlyPro: 2.671 ± 0.059	2.777GlyGln: 2.777 ± 0.056	4.036GlyArg: 4.036 ± 0.071	4.044GlySer: 4.044 ± 0.074	4.807GlyThr: 4.807 ± 0.089	6.061GlyVal: 6.061 ± 0.088	1.037GlyTrp: 1.037 ± 0.035	2.48GlyTyr: 2.48 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.777HisAla: 1.777 ± 0.043	0.356HisCys: 0.356 ± 0.019	1.33HisAsp: 1.33 ± 0.036	1.35HisGlu: 1.35 ± 0.042	1.033HisPhe: 1.033 ± 0.03	1.88HisGly: 1.88 ± 0.051	0.623HisHis: 0.623 ± 0.026	1.329HisIle: 1.329 ± 0.036	0.883HisLys: 0.883 ± 0.032	2.16HisLeu: 2.16 ± 0.05	0.59HisMet: 0.59 ± 0.023	0.642HisAsn: 0.642 ± 0.023	1.343HisPro: 1.343 ± 0.04	0.727HisGln: 0.727 ± 0.026	1.159HisArg: 1.159 ± 0.032	1.162HisSer: 1.162 ± 0.033	1.335HisThr: 1.335 ± 0.039	1.477HisVal: 1.477 ± 0.034	0.314HisTrp: 0.314 ± 0.018	0.599HisTyr: 0.599 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.265IleAla: 5.265 ± 0.084	0.821IleCys: 0.821 ± 0.031	3.359IleAsp: 3.359 ± 0.061	3.817IleGlu: 3.817 ± 0.065	2.527IlePhe: 2.527 ± 0.056	4.664IleGly: 4.664 ± 0.074	1.372IleHis: 1.372 ± 0.041	3.498IleIle: 3.498 ± 0.07	2.83IleLys: 2.83 ± 0.057	6.124IleLeu: 6.124 ± 0.087	1.645IleMet: 1.645 ± 0.042	2.045IleAsn: 2.045 ± 0.04	3.151IlePro: 3.151 ± 0.064	2.032IleGln: 2.032 ± 0.042	3.414IleArg: 3.414 ± 0.054	3.699IleSer: 3.699 ± 0.068	3.181IleThr: 3.181 ± 0.062	4.254IleVal: 4.254 ± 0.072	0.65IleTrp: 0.65 ± 0.026	1.484IleTyr: 1.484 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.986LysAla: 4.986 ± 0.081	0.512LysCys: 0.512 ± 0.024	3.131LysAsp: 3.131 ± 0.07	3.502LysGlu: 3.502 ± 0.07	1.604LysPhe: 1.604 ± 0.039	3.928LysGly: 3.928 ± 0.068	1.039LysHis: 1.039 ± 0.037	3.018LysIle: 3.018 ± 0.061	3.943LysLys: 3.943 ± 0.08	4.193LysLeu: 4.193 ± 0.067	1.533LysMet: 1.533 ± 0.047	2.13LysAsn: 2.13 ± 0.052	2.262LysPro: 2.262 ± 0.051	1.873LysGln: 1.873 ± 0.046	3.168LysArg: 3.168 ± 0.071	2.662LysSer: 2.662 ± 0.054	3.256LysThr: 3.256 ± 0.056	3.374LysVal: 3.374 ± 0.065	0.532LysTrp: 0.532 ± 0.023	1.497LysTyr: 1.497 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	9.675LeuAla: 9.675 ± 0.105	1.35LeuCys: 1.35 ± 0.037	6.297LeuAsp: 6.297 ± 0.085	6.116LeuGlu: 6.116 ± 0.095	4.252LeuPhe: 4.252 ± 0.073	7.927LeuGly: 7.927 ± 0.115	2.074LeuHis: 2.074 ± 0.043	5.404LeuIle: 5.404 ± 0.081	5.493LeuLys: 5.493 ± 0.085	9.118LeuLeu: 9.118 ± 0.122	2.555LeuMet: 2.555 ± 0.054	3.483LeuAsn: 3.483 ± 0.059	4.721LeuPro: 4.721 ± 0.072	2.789LeuGln: 2.789 ± 0.053	4.911LeuArg: 4.911 ± 0.075	6.287LeuSer: 6.287 ± 0.077	5.967LeuThr: 5.967 ± 0.085	7.112LeuVal: 7.112 ± 0.081	1.043LeuTrp: 1.043 ± 0.034	2.389LeuTyr: 2.389 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.217MetAla: 3.217 ± 0.053	0.334MetCys: 0.334 ± 0.019	2.051MetAsp: 2.051 ± 0.054	1.766MetGlu: 1.766 ± 0.038	0.964MetPhe: 0.964 ± 0.035	2.302MetGly: 2.302 ± 0.043	0.626MetHis: 0.626 ± 0.03	1.482MetIle: 1.482 ± 0.043	1.652MetLys: 1.652 ± 0.038	2.656MetLeu: 2.656 ± 0.045	0.709MetMet: 0.709 ± 0.027	1.153MetAsn: 1.153 ± 0.031	1.422MetPro: 1.422 ± 0.034	1.043MetGln: 1.043 ± 0.034	1.559MetArg: 1.559 ± 0.04	1.842MetSer: 1.842 ± 0.042	2.038MetThr: 2.038 ± 0.047	2.214MetVal: 2.214 ± 0.047	0.234MetTrp: 0.234 ± 0.015	0.601MetTyr: 0.601 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.015AsnAla: 3.015 ± 0.057	0.494AsnCys: 0.494 ± 0.025	1.856AsnAsp: 1.856 ± 0.062	2.011AsnGlu: 2.011 ± 0.044	1.388AsnPhe: 1.388 ± 0.033	2.641AsnGly: 2.641 ± 0.067	0.69AsnHis: 0.69 ± 0.029	2.117AsnIle: 2.117 ± 0.048	1.529AsnLys: 1.529 ± 0.04	3.108AsnLeu: 3.108 ± 0.055	1.024AsnMet: 1.024 ± 0.03	1.036AsnAsn: 1.036 ± 0.033	2.073AsnPro: 2.073 ± 0.047	1.085AsnGln: 1.085 ± 0.035	1.873AsnArg: 1.873 ± 0.044	1.726AsnSer: 1.726 ± 0.041	1.92AsnThr: 1.92 ± 0.045	2.347AsnVal: 2.347 ± 0.044	0.506AsnTrp: 0.506 ± 0.021	0.927AsnTyr: 0.927 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.62ProAla: 3.62 ± 0.063	0.565ProCys: 0.565 ± 0.026	3.282ProAsp: 3.282 ± 0.068	3.854ProGlu: 3.854 ± 0.067	1.96ProPhe: 1.96 ± 0.048	3.752ProGly: 3.752 ± 0.074	1.039ProHis: 1.039 ± 0.033	2.423ProIle: 2.423 ± 0.051	2.307ProLys: 2.307 ± 0.05	4.188ProLeu: 4.188 ± 0.063	1.241ProMet: 1.241 ± 0.035	1.436ProAsn: 1.436 ± 0.039	1.711ProPro: 1.711 ± 0.044	1.414ProGln: 1.414 ± 0.037	1.889ProArg: 1.889 ± 0.042	2.51ProSer: 2.51 ± 0.053	2.383ProThr: 2.383 ± 0.057	3.802ProVal: 3.802 ± 0.075	0.606ProTrp: 0.606 ± 0.022	1.241ProTyr: 1.241 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.431GlnAla: 3.431 ± 0.056	0.447GlnCys: 0.447 ± 0.022	1.79GlnAsp: 1.79 ± 0.047	2.133GlnGlu: 2.133 ± 0.045	1.282GlnPhe: 1.282 ± 0.036	2.544GlnGly: 2.544 ± 0.052	0.707GlnHis: 0.707 ± 0.029	1.831GlnIle: 1.831 ± 0.043	1.893GlnLys: 1.893 ± 0.049	3.107GlnLeu: 3.107 ± 0.067	0.961GlnMet: 0.961 ± 0.028	1.067GlnAsn: 1.067 ± 0.031	1.316GlnPro: 1.316 ± 0.032	1.252GlnGln: 1.252 ± 0.04	1.899GlnArg: 1.899 ± 0.044	1.905GlnSer: 1.905 ± 0.041	1.978GlnThr: 1.978 ± 0.041	2.29GlnVal: 2.29 ± 0.046	0.436GlnTrp: 0.436 ± 0.022	0.944GlnTyr: 0.944 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	4.149ArgAla: 4.149 ± 0.064	0.716ArgCys: 0.716 ± 0.027	3.019ArgAsp: 3.019 ± 0.059	3.785ArgGlu: 3.785 ± 0.064	2.413ArgPhe: 2.413 ± 0.05	3.296ArgGly: 3.296 ± 0.065	1.346ArgHis: 1.346 ± 0.036	3.567ArgIle: 3.567 ± 0.053	3.032ArgLys: 3.032 ± 0.065	5.71ArgLeu: 5.71 ± 0.094	1.657ArgMet: 1.657 ± 0.043	1.871ArgAsn: 1.871 ± 0.042	2.286ArgPro: 2.286 ± 0.054	2.078ArgGln: 2.078 ± 0.045	2.938ArgArg: 2.938 ± 0.061	2.829ArgSer: 2.829 ± 0.055	2.905ArgThr: 2.905 ± 0.057	3.536ArgVal: 3.536 ± 0.059	0.572ArgTrp: 0.572 ± 0.024	1.562ArgTyr: 1.562 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.55SerAla: 4.55 ± 0.076	0.731SerCys: 0.731 ± 0.029	3.072SerAsp: 3.072 ± 0.071	3.239SerGlu: 3.239 ± 0.06	2.513SerPhe: 2.513 ± 0.044	5.294SerGly: 5.294 ± 0.078	1.243SerHis: 1.243 ± 0.033	3.599SerIle: 3.599 ± 0.057	2.688SerLys: 2.688 ± 0.056	6.078SerLeu: 6.078 ± 0.084	1.877SerMet: 1.877 ± 0.043	1.658SerAsn: 1.658 ± 0.046	2.538SerPro: 2.538 ± 0.057	1.905SerGln: 1.905 ± 0.047	3.102SerArg: 3.102 ± 0.056	3.358SerSer: 3.358 ± 0.072	3.059SerThr: 3.059 ± 0.059	4.264SerVal: 4.264 ± 0.075	0.737SerTrp: 0.737 ± 0.031	1.472SerTyr: 1.472 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.251ThrAla: 5.251 ± 0.066	0.723ThrCys: 0.723 ± 0.029	3.264ThrAsp: 3.264 ± 0.067	3.133ThrGlu: 3.133 ± 0.06	2.323ThrPhe: 2.323 ± 0.05	4.976ThrGly: 4.976 ± 0.075	1.304ThrHis: 1.304 ± 0.041	3.621ThrIle: 3.621 ± 0.07	2.391ThrLys: 2.391 ± 0.049	6.18ThrLeu: 6.18 ± 0.077	1.667ThrMet: 1.667 ± 0.038	1.785ThrAsn: 1.785 ± 0.036	3.368ThrPro: 3.368 ± 0.061	1.76ThrGln: 1.76 ± 0.042	2.913ThrArg: 2.913 ± 0.061	3.191ThrSer: 3.191 ± 0.053	3.244ThrThr: 3.244 ± 0.069	4.733ThrVal: 4.733 ± 0.088	0.643ThrTrp: 0.643 ± 0.025	1.511ThrTyr: 1.511 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	6.614ValAla: 6.614 ± 0.089	1.095ValCys: 1.095 ± 0.043	4.46ValAsp: 4.46 ± 0.066	4.728ValGlu: 4.728 ± 0.074	3.131ValPhe: 3.131 ± 0.055	5.195ValGly: 5.195 ± 0.079	1.5ValHis: 1.5 ± 0.042	4.204ValIle: 4.204 ± 0.071	3.447ValLys: 3.447 ± 0.066	7.351ValLeu: 7.351 ± 0.102	1.964ValMet: 1.964 ± 0.049	2.631ValAsn: 2.631 ± 0.054	3.261ValPro: 3.261 ± 0.065	2.327ValGln: 2.327 ± 0.047	3.927ValArg: 3.927 ± 0.058	4.56ValSer: 4.56 ± 0.078	4.311ValThr: 4.311 ± 0.095	5.846ValVal: 5.846 ± 0.093	0.833ValTrp: 0.833 ± 0.028	1.815ValTyr: 1.815 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.015TrpAla: 1.015 ± 0.03	0.158TrpCys: 0.158 ± 0.011	0.709TrpAsp: 0.709 ± 0.028	0.738TrpGlu: 0.738 ± 0.028	0.561TrpPhe: 0.561 ± 0.026	0.928TrpGly: 0.928 ± 0.032	0.251TrpHis: 0.251 ± 0.017	0.648TrpIle: 0.648 ± 0.03	0.648TrpLys: 0.648 ± 0.026	1.265TrpLeu: 1.265 ± 0.045	0.366TrpMet: 0.366 ± 0.017	0.463TrpAsn: 0.463 ± 0.022	0.587TrpPro: 0.587 ± 0.025	0.46TrpGln: 0.46 ± 0.022	0.667TrpArg: 0.667 ± 0.025	0.592TrpSer: 0.592 ± 0.026	0.77TrpThr: 0.77 ± 0.028	0.75TrpVal: 0.75 ± 0.028	0.21TrpTrp: 0.21 ± 0.015	0.309TrpTyr: 0.309 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.337TyrAla: 2.337 ± 0.043	0.418TyrCys: 0.418 ± 0.022	1.675TyrAsp: 1.675 ± 0.043	1.568TyrGlu: 1.568 ± 0.045	1.246TyrPhe: 1.246 ± 0.037	2.227TyrGly: 2.227 ± 0.049	0.555TyrHis: 0.555 ± 0.021	1.452TyrIle: 1.452 ± 0.035	1.222TyrLys: 1.222 ± 0.035	2.666TyrLeu: 2.666 ± 0.053	0.715TyrMet: 0.715 ± 0.027	0.886TyrAsn: 0.886 ± 0.032	1.329TyrPro: 1.329 ± 0.035	0.889TyrGln: 0.889 ± 0.028	1.57TyrArg: 1.57 ± 0.048	1.636TyrSer: 1.636 ± 0.039	1.643TyrThr: 1.643 ± 0.041	1.796TyrVal: 1.796 ± 0.045	0.401TyrTrp: 0.401 ± 0.02	0.932TyrTyr: 0.932 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3293 proteins (1039952 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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