Amino acid dipepetide frequency for Lactobacillus saniviri JCM 17471 = DSM 24301

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.424AlaAla: 9.424 ± 0.179
0.23AlaCys: 0.23 ± 0.019
5.863AlaAsp: 5.863 ± 0.109
4.553AlaGlu: 4.553 ± 0.095
3.626AlaPhe: 3.626 ± 0.075
6.779AlaGly: 6.779 ± 0.122
1.873AlaHis: 1.873 ± 0.054
6.611AlaIle: 6.611 ± 0.104
5.621AlaLys: 5.621 ± 0.114
9.499AlaLeu: 9.499 ± 0.146
2.844AlaMet: 2.844 ± 0.075
4.105AlaAsn: 4.105 ± 0.081
3.173AlaPro: 3.173 ± 0.076
4.557AlaGln: 4.557 ± 0.094
3.305AlaArg: 3.305 ± 0.073
5.092AlaSer: 5.092 ± 0.148
6.606AlaThr: 6.606 ± 0.114
6.85AlaVal: 6.85 ± 0.114
0.937AlaTrp: 0.937 ± 0.042
2.82AlaTyr: 2.82 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.192CysAla: 0.192 ± 0.016
0.023CysCys: 0.023 ± 0.005
0.157CysAsp: 0.157 ± 0.015
0.129CysGlu: 0.129 ± 0.014
0.099CysPhe: 0.099 ± 0.011
0.28CysGly: 0.28 ± 0.024
0.067CysHis: 0.067 ± 0.013
0.132CysIle: 0.132 ± 0.015
0.054CysLys: 0.054 ± 0.008
0.256CysLeu: 0.256 ± 0.019
0.057CysMet: 0.057 ± 0.009
0.102CysAsn: 0.102 ± 0.012
0.147CysPro: 0.147 ± 0.019
0.12CysGln: 0.12 ± 0.013
0.097CysArg: 0.097 ± 0.011
0.124CysSer: 0.124 ± 0.013
0.127CysThr: 0.127 ± 0.015
0.153CysVal: 0.153 ± 0.014
0.031CysTrp: 0.031 ± 0.005
0.08CysTyr: 0.08 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
5.708AspAla: 5.708 ± 0.089
0.129AspCys: 0.129 ± 0.014
3.861AspAsp: 3.861 ± 0.088
3.619AspGlu: 3.619 ± 0.081
2.794AspPhe: 2.794 ± 0.068
4.061AspGly: 4.061 ± 0.095
1.469AspHis: 1.469 ± 0.047
3.556AspIle: 3.556 ± 0.084
3.173AspLys: 3.173 ± 0.079
5.68AspLeu: 5.68 ± 0.088
1.66AspMet: 1.66 ± 0.052
2.368AspAsn: 2.368 ± 0.058
2.488AspPro: 2.488 ± 0.063
3.612AspGln: 3.612 ± 0.084
2.561AspArg: 2.561 ± 0.063
2.798AspSer: 2.798 ± 0.073
3.379AspThr: 3.379 ± 0.072
4.224AspVal: 4.224 ± 0.08
0.831AspTrp: 0.831 ± 0.04
2.5AspTyr: 2.5 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
5.209GluAla: 5.209 ± 0.1
0.096GluCys: 0.096 ± 0.012
2.618GluAsp: 2.618 ± 0.073
2.747GluGlu: 2.747 ± 0.066
1.878GluPhe: 1.878 ± 0.058
2.535GluGly: 2.535 ± 0.072
1.141GluHis: 1.141 ± 0.044
3.33GluIle: 3.33 ± 0.084
2.7GluLys: 2.7 ± 0.067
5.275GluLeu: 5.275 ± 0.104
1.656GluMet: 1.656 ± 0.045
2.072GluAsn: 2.072 ± 0.052
1.832GluPro: 1.832 ± 0.055
2.881GluGln: 2.881 ± 0.067
2.524GluArg: 2.524 ± 0.066
2.563GluSer: 2.563 ± 0.061
3.392GluThr: 3.392 ± 0.079
3.566GluVal: 3.566 ± 0.086
0.519GluTrp: 0.519 ± 0.031
1.377GluTyr: 1.377 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.761PheAla: 3.761 ± 0.07
0.12PheCys: 0.12 ± 0.014
3.104PheAsp: 3.104 ± 0.07
2.158PheGlu: 2.158 ± 0.056
1.882PhePhe: 1.882 ± 0.059
3.339PheGly: 3.339 ± 0.08
0.736PheHis: 0.736 ± 0.036
2.648PheIle: 2.648 ± 0.055
2.041PheLys: 2.041 ± 0.056
3.548PheLeu: 3.548 ± 0.088
1.072PheMet: 1.072 ± 0.045
1.975PheAsn: 1.975 ± 0.047
1.387PhePro: 1.387 ± 0.045
1.351PheGln: 1.351 ± 0.04
1.31PheArg: 1.31 ± 0.044
2.573PheSer: 2.573 ± 0.066
2.651PheThr: 2.651 ± 0.064
3.067PheVal: 3.067 ± 0.061
0.546PheTrp: 0.546 ± 0.024
1.413PheTyr: 1.413 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
5.477GlyAla: 5.477 ± 0.118
0.197GlyCys: 0.197 ± 0.017
3.914GlyAsp: 3.914 ± 0.078
3.242GlyGlu: 3.242 ± 0.072
3.213GlyPhe: 3.213 ± 0.074
4.737GlyGly: 4.737 ± 0.117
1.5GlyHis: 1.5 ± 0.046
5.51GlyIle: 5.51 ± 0.108
4.021GlyLys: 4.021 ± 0.094
6.902GlyLeu: 6.902 ± 0.11
2.126GlyMet: 2.126 ± 0.057
2.793GlyAsn: 2.793 ± 0.076
1.712GlyPro: 1.712 ± 0.048
3.398GlyGln: 3.398 ± 0.076
2.708GlyArg: 2.708 ± 0.076
3.875GlySer: 3.875 ± 0.089
4.59GlyThr: 4.59 ± 0.098
5.347GlyVal: 5.347 ± 0.102
0.794GlyTrp: 0.794 ± 0.039
2.817GlyTyr: 2.817 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.686HisAla: 1.686 ± 0.054
0.067HisCys: 0.067 ± 0.01
1.357HisAsp: 1.357 ± 0.047
1.143HisGlu: 1.143 ± 0.043
1.074HisPhe: 1.074 ± 0.04
1.467HisGly: 1.467 ± 0.05
0.661HisHis: 0.661 ± 0.038
1.281HisIle: 1.281 ± 0.04
0.817HisLys: 0.817 ± 0.033
2.179HisLeu: 2.179 ± 0.063
0.522HisMet: 0.522 ± 0.025
0.817HisAsn: 0.817 ± 0.033
1.057HisPro: 1.057 ± 0.043
1.331HisGln: 1.331 ± 0.048
1.014HisArg: 1.014 ± 0.039
1.037HisSer: 1.037 ± 0.04
1.163HisThr: 1.163 ± 0.043
1.533HisVal: 1.533 ± 0.049
0.283HisTrp: 0.283 ± 0.021
0.952HisTyr: 0.952 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.502IleAla: 6.502 ± 0.112
0.229IleCys: 0.229 ± 0.021
4.583IleAsp: 4.583 ± 0.091
3.468IleGlu: 3.468 ± 0.074
2.488IlePhe: 2.488 ± 0.073
5.199IleGly: 5.199 ± 0.104
1.23IleHis: 1.23 ± 0.039
4.127IleIle: 4.127 ± 0.095
3.429IleLys: 3.429 ± 0.076
5.764IleLeu: 5.764 ± 0.106
1.68IleMet: 1.68 ± 0.049
3.073IleAsn: 3.073 ± 0.067
2.754IlePro: 2.754 ± 0.064
2.668IleGln: 2.668 ± 0.066
2.505IleArg: 2.505 ± 0.066
3.867IleSer: 3.867 ± 0.073
4.367IleThr: 4.367 ± 0.086
5.128IleVal: 5.128 ± 0.091
0.602IleTrp: 0.602 ± 0.028
2.006IleTyr: 2.006 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
5.109LysAla: 5.109 ± 0.096
0.049LysCys: 0.049 ± 0.009
2.98LysAsp: 2.98 ± 0.071
2.607LysGlu: 2.607 ± 0.07
1.549LysPhe: 1.549 ± 0.047
2.814LysGly: 2.814 ± 0.067
1.118LysHis: 1.118 ± 0.041
2.986LysIle: 2.986 ± 0.068
3.233LysLys: 3.233 ± 0.085
4.637LysLeu: 4.637 ± 0.083
1.736LysMet: 1.736 ± 0.054
2.398LysAsn: 2.398 ± 0.07
2.302LysPro: 2.302 ± 0.063
3.36LysGln: 3.36 ± 0.075
2.817LysArg: 2.817 ± 0.068
2.833LysSer: 2.833 ± 0.084
3.809LysThr: 3.809 ± 0.085
3.399LysVal: 3.399 ± 0.091
0.542LysTrp: 0.542 ± 0.031
1.636LysTyr: 1.636 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
10.071LeuAla: 10.071 ± 0.12
0.25LeuCys: 0.25 ± 0.019
5.89LeuAsp: 5.89 ± 0.106
4.396LeuGlu: 4.396 ± 0.089
3.871LeuPhe: 3.871 ± 0.086
6.852LeuGly: 6.852 ± 0.116
1.842LeuHis: 1.842 ± 0.052
6.821LeuIle: 6.821 ± 0.123
5.312LeuLys: 5.312 ± 0.099
9.591LeuLeu: 9.591 ± 0.185
2.783LeuMet: 2.783 ± 0.059
4.665LeuAsn: 4.665 ± 0.085
4.656LeuPro: 4.656 ± 0.083
3.944LeuGln: 3.944 ± 0.08
3.797LeuArg: 3.797 ± 0.072
6.167LeuSer: 6.167 ± 0.094
7.36LeuThr: 7.36 ± 0.113
7.027LeuVal: 7.027 ± 0.117
0.954LeuTrp: 0.954 ± 0.045
2.61LeuTyr: 2.61 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
3.072MetAla: 3.072 ± 0.075
0.082MetCys: 0.082 ± 0.011
1.451MetAsp: 1.451 ± 0.047
0.971MetGlu: 0.971 ± 0.043
0.928MetPhe: 0.928 ± 0.04
1.852MetGly: 1.852 ± 0.048
0.539MetHis: 0.539 ± 0.028
1.928MetIle: 1.928 ± 0.053
1.576MetLys: 1.576 ± 0.042
2.678MetLeu: 2.678 ± 0.08
0.939MetMet: 0.939 ± 0.05
1.34MetAsn: 1.34 ± 0.045
1.244MetPro: 1.244 ± 0.042
1.426MetGln: 1.426 ± 0.043
1.251MetArg: 1.251 ± 0.04
1.604MetSer: 1.604 ± 0.047
2.349MetThr: 2.349 ± 0.057
1.899MetVal: 1.899 ± 0.055
0.217MetTrp: 0.217 ± 0.019
0.671MetTyr: 0.671 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.739AsnAla: 3.739 ± 0.074
0.113AsnCys: 0.113 ± 0.013
2.405AsnAsp: 2.405 ± 0.062
2.108AsnGlu: 2.108 ± 0.056
1.679AsnPhe: 1.679 ± 0.056
3.462AsnGly: 3.462 ± 0.084
1.143AsnHis: 1.143 ± 0.045
2.52AsnIle: 2.52 ± 0.056
1.978AsnLys: 1.978 ± 0.055
3.911AsnLeu: 3.911 ± 0.076
1.135AsnMet: 1.135 ± 0.042
1.926AsnAsn: 1.926 ± 0.069
2.255AsnPro: 2.255 ± 0.053
2.886AsnGln: 2.886 ± 0.073
2.092AsnArg: 2.092 ± 0.064
2.194AsnSer: 2.194 ± 0.072
2.573AsnThr: 2.573 ± 0.066
2.889AsnVal: 2.889 ± 0.069
0.601AsnTrp: 0.601 ± 0.031
1.634AsnTyr: 1.634 ± 0.05
0.0AsnXaa: 0.0 ± 0.0
Pro
3.779ProAla: 3.779 ± 0.085
0.079ProCys: 0.079 ± 0.011
3.042ProAsp: 3.042 ± 0.078
3.1ProGlu: 3.1 ± 0.074
1.71ProPhe: 1.71 ± 0.05
2.58ProGly: 2.58 ± 0.057
0.752ProHis: 0.752 ± 0.032
2.643ProIle: 2.643 ± 0.05
2.175ProLys: 2.175 ± 0.061
3.675ProLeu: 3.675 ± 0.074
0.998ProMet: 0.998 ± 0.038
1.863ProAsn: 1.863 ± 0.059
0.824ProPro: 0.824 ± 0.034
1.715ProGln: 1.715 ± 0.054
1.278ProArg: 1.278 ± 0.038
2.113ProSer: 2.113 ± 0.059
2.758ProThr: 2.758 ± 0.067
3.375ProVal: 3.375 ± 0.065
0.422ProTrp: 0.422 ± 0.026
1.303ProTyr: 1.303 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
5.319GlnAla: 5.319 ± 0.114
0.07GlnCys: 0.07 ± 0.01
2.259GlnAsp: 2.259 ± 0.056
2.246GlnGlu: 2.246 ± 0.058
2.073GlnPhe: 2.073 ± 0.056
2.53GlnGly: 2.53 ± 0.062
1.158GlnHis: 1.158 ± 0.044
3.147GlnIle: 3.147 ± 0.065
2.425GlnLys: 2.425 ± 0.059
6.339GlnLeu: 6.339 ± 0.12
1.404GlnMet: 1.404 ± 0.043
1.936GlnAsn: 1.936 ± 0.054
2.268GlnPro: 2.268 ± 0.063
3.462GlnGln: 3.462 ± 0.106
2.265GlnArg: 2.265 ± 0.077
2.605GlnSer: 2.605 ± 0.067
3.535GlnThr: 3.535 ± 0.084
3.741GlnVal: 3.741 ± 0.076
0.679GlnTrp: 0.679 ± 0.038
1.733GlnTyr: 1.733 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
3.124ArgAla: 3.124 ± 0.059
0.093ArgCys: 0.093 ± 0.011
2.635ArgAsp: 2.635 ± 0.068
2.532ArgGlu: 2.532 ± 0.075
1.966ArgPhe: 1.966 ± 0.057
2.46ArgGly: 2.46 ± 0.064
1.1ArgHis: 1.1 ± 0.046
2.77ArgIle: 2.77 ± 0.06
1.919ArgLys: 1.919 ± 0.048
4.524ArgLeu: 4.524 ± 0.094
1.15ArgMet: 1.15 ± 0.046
1.636ArgAsn: 1.636 ± 0.054
1.531ArgPro: 1.531 ± 0.047
2.535ArgGln: 2.535 ± 0.057
2.158ArgArg: 2.158 ± 0.059
1.932ArgSer: 1.932 ± 0.058
2.116ArgThr: 2.116 ± 0.056
2.946ArgVal: 2.946 ± 0.076
0.422ArgTrp: 0.422 ± 0.025
1.896ArgTyr: 1.896 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
5.142SerAla: 5.142 ± 0.132
0.104SerCys: 0.104 ± 0.012
3.439SerAsp: 3.439 ± 0.068
2.803SerGlu: 2.803 ± 0.079
2.374SerPhe: 2.374 ± 0.062
4.683SerGly: 4.683 ± 0.096
1.173SerHis: 1.173 ± 0.042
3.217SerIle: 3.217 ± 0.075
2.741SerLys: 2.741 ± 0.082
5.485SerLeu: 5.485 ± 0.097
1.389SerMet: 1.389 ± 0.044
2.335SerAsn: 2.335 ± 0.072
2.096SerPro: 2.096 ± 0.063
2.876SerGln: 2.876 ± 0.089
2.339SerArg: 2.339 ± 0.057
3.618SerSer: 3.618 ± 0.131
3.358SerThr: 3.358 ± 0.09
4.107SerVal: 4.107 ± 0.081
0.741SerTrp: 0.741 ± 0.035
1.775SerTyr: 1.775 ± 0.054
0.001SerXaa: 0.001 ± 0.002
Thr
6.197ThrAla: 6.197 ± 0.132
0.139ThrCys: 0.139 ± 0.018
3.955ThrAsp: 3.955 ± 0.078
3.002ThrGlu: 3.002 ± 0.065
2.638ThrPhe: 2.638 ± 0.067
5.035ThrGly: 5.035 ± 0.081
1.407ThrHis: 1.407 ± 0.043
4.743ThrIle: 4.743 ± 0.099
3.392ThrLys: 3.392 ± 0.084
6.628ThrLeu: 6.628 ± 0.129
1.67ThrMet: 1.67 ± 0.051
2.774ThrAsn: 2.774 ± 0.076
3.41ThrPro: 3.41 ± 0.082
3.072ThrGln: 3.072 ± 0.094
2.322ThrArg: 2.322 ± 0.065
3.716ThrSer: 3.716 ± 0.093
4.72ThrThr: 4.72 ± 0.113
5.39ThrVal: 5.39 ± 0.1
0.786ThrTrp: 0.786 ± 0.034
2.328ThrTyr: 2.328 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
7.297ValAla: 7.297 ± 0.117
0.232ValCys: 0.232 ± 0.018
4.51ValAsp: 4.51 ± 0.099
3.346ValGlu: 3.346 ± 0.078
2.716ValPhe: 2.716 ± 0.068
5.121ValGly: 5.121 ± 0.098
1.298ValHis: 1.298 ± 0.047
5.227ValIle: 5.227 ± 0.091
3.668ValLys: 3.668 ± 0.077
7.025ValLeu: 7.025 ± 0.13
2.112ValMet: 2.112 ± 0.052
3.222ValAsn: 3.222 ± 0.073
3.134ValPro: 3.134 ± 0.076
2.708ValGln: 2.708 ± 0.063
2.56ValArg: 2.56 ± 0.071
4.692ValSer: 4.692 ± 0.087
5.716ValThr: 5.716 ± 0.096
5.727ValVal: 5.727 ± 0.095
0.788ValTrp: 0.788 ± 0.038
2.176ValTyr: 2.176 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.762TrpAla: 0.762 ± 0.038
0.037TrpCys: 0.037 ± 0.007
0.538TrpAsp: 0.538 ± 0.028
0.36TrpGlu: 0.36 ± 0.022
0.539TrpPhe: 0.539 ± 0.033
0.701TrpGly: 0.701 ± 0.036
0.335TrpHis: 0.335 ± 0.024
0.719TrpIle: 0.719 ± 0.035
0.382TrpLys: 0.382 ± 0.025
1.707TrpLeu: 1.707 ± 0.066
0.312TrpMet: 0.312 ± 0.021
0.45TrpAsn: 0.45 ± 0.025
0.426TrpPro: 0.426 ± 0.025
0.909TrpGln: 0.909 ± 0.042
0.603TrpArg: 0.603 ± 0.03
0.606TrpSer: 0.606 ± 0.032
0.615TrpThr: 0.615 ± 0.031
0.735TrpVal: 0.735 ± 0.039
0.227TrpTrp: 0.227 ± 0.02
0.443TrpTyr: 0.443 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.797TyrAla: 2.797 ± 0.063
0.09TyrCys: 0.09 ± 0.011
1.91TyrAsp: 1.91 ± 0.056
1.383TyrGlu: 1.383 ± 0.048
1.586TyrPhe: 1.586 ± 0.051
2.385TyrGly: 2.385 ± 0.061
0.898TyrHis: 0.898 ± 0.037
1.755TyrIle: 1.755 ± 0.058
1.257TyrLys: 1.257 ± 0.045
3.552TyrLeu: 3.552 ± 0.077
0.769TyrMet: 0.769 ± 0.033
1.391TyrAsn: 1.391 ± 0.05
1.486TyrPro: 1.486 ± 0.045
2.385TyrGln: 2.385 ± 0.066
1.939TyrArg: 1.939 ± 0.061
1.786TyrSer: 1.786 ± 0.055
2.141TyrThr: 2.141 ± 0.059
2.174TyrVal: 2.174 ± 0.063
0.486TyrTrp: 0.486 ± 0.03
1.314TyrTyr: 1.314 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.001XaaLys: 0.001 ± 0.002
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.005
Statistics based on 2333 proteins (699316 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski