Amino acid dipepetide frequency for Sulfolobus sp. SCGC AB-777_G06

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.107AlaAla: 3.107 ± 0.162
0.311AlaCys: 0.311 ± 0.036
2.482AlaAsp: 2.482 ± 0.098
3.847AlaGlu: 3.847 ± 0.13
2.709AlaPhe: 2.709 ± 0.126
3.764AlaGly: 3.764 ± 0.148
0.762AlaHis: 0.762 ± 0.053
5.371AlaIle: 5.371 ± 0.167
4.497AlaLys: 4.497 ± 0.132
6.921AlaLeu: 6.921 ± 0.218
1.337AlaMet: 1.337 ± 0.072
2.045AlaAsn: 2.045 ± 0.082
1.788AlaPro: 1.788 ± 0.083
1.329AlaGln: 1.329 ± 0.067
2.471AlaArg: 2.471 ± 0.116
3.894AlaSer: 3.894 ± 0.13
2.72AlaThr: 2.72 ± 0.103
4.49AlaVal: 4.49 ± 0.171
0.535AlaTrp: 0.535 ± 0.046
2.875AlaTyr: 2.875 ± 0.113
0.0AlaXaa: 0.0 ± 0.0
Cys
0.235CysAla: 0.235 ± 0.027
0.087CysCys: 0.087 ± 0.019
0.444CysAsp: 0.444 ± 0.048
0.48CysGlu: 0.48 ± 0.045
0.224CysPhe: 0.224 ± 0.03
0.654CysGly: 0.654 ± 0.056
0.148CysHis: 0.148 ± 0.023
0.491CysIle: 0.491 ± 0.051
0.491CysLys: 0.491 ± 0.044
0.39CysLeu: 0.39 ± 0.04
0.105CysMet: 0.105 ± 0.023
0.3CysAsn: 0.3 ± 0.038
0.502CysPro: 0.502 ± 0.054
0.148CysGln: 0.148 ± 0.023
0.303CysArg: 0.303 ± 0.033
0.376CysSer: 0.376 ± 0.044
0.26CysThr: 0.26 ± 0.035
0.405CysVal: 0.405 ± 0.037
0.069CysTrp: 0.069 ± 0.016
0.289CysTyr: 0.289 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
2.507AspAla: 2.507 ± 0.095
0.34AspCys: 0.34 ± 0.031
2.084AspAsp: 2.084 ± 0.094
4.122AspGlu: 4.122 ± 0.145
2.243AspPhe: 2.243 ± 0.081
2.688AspGly: 2.688 ± 0.103
0.582AspHis: 0.582 ± 0.046
4.36AspIle: 4.36 ± 0.151
3.876AspLys: 3.876 ± 0.135
5.039AspLeu: 5.039 ± 0.158
1.095AspMet: 1.095 ± 0.067
1.799AspAsn: 1.799 ± 0.088
2.395AspPro: 2.395 ± 0.109
0.932AspGln: 0.932 ± 0.053
1.886AspArg: 1.886 ± 0.087
2.294AspSer: 2.294 ± 0.091
1.777AspThr: 1.777 ± 0.081
4.273AspVal: 4.273 ± 0.146
0.491AspTrp: 0.491 ± 0.043
2.731AspTyr: 2.731 ± 0.095
0.0AspXaa: 0.0 ± 0.0
Glu
4.158GluAla: 4.158 ± 0.132
0.527GluCys: 0.527 ± 0.05
3.388GluAsp: 3.388 ± 0.127
6.918GluGlu: 6.918 ± 0.251
2.72GluPhe: 2.72 ± 0.104
4.429GluGly: 4.429 ± 0.141
0.777GluHis: 0.777 ± 0.052
6.965GluIle: 6.965 ± 0.198
6.618GluLys: 6.618 ± 0.219
7.308GluLeu: 7.308 ± 0.18
1.506GluMet: 1.506 ± 0.069
3.331GluAsn: 3.331 ± 0.127
1.828GluPro: 1.828 ± 0.085
1.452GluGln: 1.452 ± 0.082
3.331GluArg: 3.331 ± 0.108
3.266GluSer: 3.266 ± 0.12
2.5GluThr: 2.5 ± 0.104
6.069GluVal: 6.069 ± 0.143
0.712GluTrp: 0.712 ± 0.055
2.977GluTyr: 2.977 ± 0.115
0.0GluXaa: 0.0 ± 0.0
Phe
2.381PheAla: 2.381 ± 0.109
0.275PheCys: 0.275 ± 0.029
2.081PheAsp: 2.081 ± 0.079
2.232PheGlu: 2.232 ± 0.098
1.961PhePhe: 1.961 ± 0.106
2.716PheGly: 2.716 ± 0.109
0.701PheHis: 0.701 ± 0.053
3.663PheIle: 3.663 ± 0.124
2.742PheLys: 2.742 ± 0.096
4.963PheLeu: 4.963 ± 0.198
1.04PheMet: 1.04 ± 0.073
2.319PheAsn: 2.319 ± 0.091
1.792PhePro: 1.792 ± 0.09
0.921PheGln: 0.921 ± 0.064
1.824PheArg: 1.824 ± 0.076
3.558PheSer: 3.558 ± 0.14
2.561PheThr: 2.561 ± 0.113
3.219PheVal: 3.219 ± 0.114
0.408PheTrp: 0.408 ± 0.044
2.11PheTyr: 2.11 ± 0.091
0.0PheXaa: 0.0 ± 0.0
Gly
3.479GlyAla: 3.479 ± 0.147
0.412GlyCys: 0.412 ± 0.042
3.28GlyAsp: 3.28 ± 0.107
4.573GlyGlu: 4.573 ± 0.126
3.247GlyPhe: 3.247 ± 0.122
4.45GlyGly: 4.45 ± 0.183
0.824GlyHis: 0.824 ± 0.061
6.813GlyIle: 6.813 ± 0.167
5.859GlyLys: 5.859 ± 0.162
6.368GlyLeu: 6.368 ± 0.203
1.604GlyMet: 1.604 ± 0.082
2.648GlyAsn: 2.648 ± 0.111
1.615GlyPro: 1.615 ± 0.088
1.239GlyGln: 1.239 ± 0.072
2.912GlyArg: 2.912 ± 0.102
3.782GlySer: 3.782 ± 0.134
3.15GlyThr: 3.15 ± 0.118
5.545GlyVal: 5.545 ± 0.158
0.769GlyTrp: 0.769 ± 0.056
3.392GlyTyr: 3.392 ± 0.129
0.0GlyXaa: 0.0 ± 0.0
His
0.668HisAla: 0.668 ± 0.046
0.137HisCys: 0.137 ± 0.022
0.549HisAsp: 0.549 ± 0.047
0.932HisGlu: 0.932 ± 0.064
0.596HisPhe: 0.596 ± 0.05
1.131HisGly: 1.131 ± 0.074
0.224HisHis: 0.224 ± 0.025
0.986HisIle: 0.986 ± 0.062
0.842HisLys: 0.842 ± 0.053
1.279HisLeu: 1.279 ± 0.075
0.307HisMet: 0.307 ± 0.034
0.52HisAsn: 0.52 ± 0.041
0.632HisPro: 0.632 ± 0.048
0.256HisGln: 0.256 ± 0.03
0.506HisArg: 0.506 ± 0.044
0.838HisSer: 0.838 ± 0.064
0.668HisThr: 0.668 ± 0.048
1.04HisVal: 1.04 ± 0.063
0.188HisTrp: 0.188 ± 0.024
0.766HisTyr: 0.766 ± 0.059
0.0HisXaa: 0.0 ± 0.0
Ile
5.603IleAla: 5.603 ± 0.157
0.433IleCys: 0.433 ± 0.041
4.508IleAsp: 4.508 ± 0.135
5.567IleGlu: 5.567 ± 0.167
3.443IlePhe: 3.443 ± 0.121
5.816IleGly: 5.816 ± 0.182
1.174IleHis: 1.174 ± 0.058
8.023IleIle: 8.023 ± 0.213
6.383IleLys: 6.383 ± 0.17
8.554IleLeu: 8.554 ± 0.225
1.929IleMet: 1.929 ± 0.101
4.32IleAsn: 4.32 ± 0.133
4.151IlePro: 4.151 ± 0.145
2.005IleGln: 2.005 ± 0.084
3.97IleArg: 3.97 ± 0.139
6.733IleSer: 6.733 ± 0.174
4.866IleThr: 4.866 ± 0.132
6.676IleVal: 6.676 ± 0.177
0.607IleTrp: 0.607 ± 0.047
3.93IleTyr: 3.93 ± 0.118
0.0IleXaa: 0.0 ± 0.0
Lys
4.486LysAla: 4.486 ± 0.144
0.661LysCys: 0.661 ± 0.062
4.118LysAsp: 4.118 ± 0.142
7.243LysGlu: 7.243 ± 0.203
2.893LysPhe: 2.893 ± 0.104
5.512LysGly: 5.512 ± 0.143
0.795LysHis: 0.795 ± 0.054
6.903LysIle: 6.903 ± 0.198
6.087LysLys: 6.087 ± 0.196
7.81LysLeu: 7.81 ± 0.198
1.683LysMet: 1.683 ± 0.073
3.204LysAsn: 3.204 ± 0.125
2.597LysPro: 2.597 ± 0.081
1.647LysGln: 1.647 ± 0.087
3.847LysArg: 3.847 ± 0.133
3.901LysSer: 3.901 ± 0.131
3.24LysThr: 3.24 ± 0.112
7.026LysVal: 7.026 ± 0.166
0.816LysTrp: 0.816 ± 0.057
3.609LysTyr: 3.609 ± 0.127
0.0LysXaa: 0.0 ± 0.0
Leu
6.625LeuAla: 6.625 ± 0.189
0.52LeuCys: 0.52 ± 0.046
4.956LeuAsp: 4.956 ± 0.137
6.43LeuGlu: 6.43 ± 0.171
4.53LeuPhe: 4.53 ± 0.182
7.156LeuGly: 7.156 ± 0.213
1.365LeuHis: 1.365 ± 0.071
8.536LeuIle: 8.536 ± 0.21
8.023LeuLys: 8.023 ± 0.2
10.14LeuLeu: 10.14 ± 0.255
2.402LeuMet: 2.402 ± 0.085
4.692LeuAsn: 4.692 ± 0.145
4.158LeuPro: 4.158 ± 0.124
2.341LeuGln: 2.341 ± 0.086
5.169LeuArg: 5.169 ± 0.135
7.839LeuSer: 7.839 ± 0.211
5.404LeuThr: 5.404 ± 0.144
7.481LeuVal: 7.481 ± 0.166
0.834LeuTrp: 0.834 ± 0.062
4.158LeuTyr: 4.158 ± 0.15
0.0LeuXaa: 0.0 ± 0.0
Met
1.369MetAla: 1.369 ± 0.077
0.105MetCys: 0.105 ± 0.019
0.99MetAsp: 0.99 ± 0.056
1.412MetGlu: 1.412 ± 0.067
0.863MetPhe: 0.863 ± 0.062
1.647MetGly: 1.647 ± 0.083
0.22MetHis: 0.22 ± 0.028
1.842MetIle: 1.842 ± 0.092
2.063MetLys: 2.063 ± 0.082
2.193MetLeu: 2.193 ± 0.079
0.477MetMet: 0.477 ± 0.047
0.91MetAsn: 0.91 ± 0.062
0.831MetPro: 0.831 ± 0.049
0.56MetGln: 0.56 ± 0.046
1.196MetArg: 1.196 ± 0.065
1.532MetSer: 1.532 ± 0.076
1.076MetThr: 1.076 ± 0.064
1.568MetVal: 1.568 ± 0.071
0.213MetTrp: 0.213 ± 0.028
0.863MetTyr: 0.863 ± 0.071
0.0MetXaa: 0.0 ± 0.0
Asn
2.655AsnAla: 2.655 ± 0.116
0.314AsnCys: 0.314 ± 0.04
1.94AsnAsp: 1.94 ± 0.072
3.135AsnGlu: 3.135 ± 0.13
2.034AsnPhe: 2.034 ± 0.102
3.052AsnGly: 3.052 ± 0.168
0.509AsnHis: 0.509 ± 0.046
3.674AsnIle: 3.674 ± 0.125
3.298AsnLys: 3.298 ± 0.129
4.385AsnLeu: 4.385 ± 0.124
0.928AsnMet: 0.928 ± 0.061
2.2AsnAsn: 2.2 ± 0.112
2.381AsnPro: 2.381 ± 0.113
0.939AsnGln: 0.939 ± 0.062
1.806AsnArg: 1.806 ± 0.081
3.07AsnSer: 3.07 ± 0.118
2.055AsnThr: 2.055 ± 0.083
4.053AsnVal: 4.053 ± 0.127
0.415AsnTrp: 0.415 ± 0.038
2.341AsnTyr: 2.341 ± 0.116
0.0AsnXaa: 0.0 ± 0.0
Pro
2.012ProAla: 2.012 ± 0.092
0.246ProCys: 0.246 ± 0.033
1.936ProAsp: 1.936 ± 0.094
2.673ProGlu: 2.673 ± 0.108
1.972ProPhe: 1.972 ± 0.085
2.128ProGly: 2.128 ± 0.108
0.675ProHis: 0.675 ± 0.051
3.078ProIle: 3.078 ± 0.097
2.789ProLys: 2.789 ± 0.104
4.118ProLeu: 4.118 ± 0.147
0.694ProMet: 0.694 ± 0.049
1.925ProAsn: 1.925 ± 0.098
2.066ProPro: 2.066 ± 0.099
1.214ProGln: 1.214 ± 0.079
1.398ProArg: 1.398 ± 0.068
2.886ProSer: 2.886 ± 0.099
1.929ProThr: 1.929 ± 0.088
2.778ProVal: 2.778 ± 0.103
0.491ProTrp: 0.491 ± 0.047
2.312ProTyr: 2.312 ± 0.12
0.0ProXaa: 0.0 ± 0.0
Gln
1.293GlnAla: 1.293 ± 0.086
0.13GlnCys: 0.13 ± 0.024
0.946GlnAsp: 0.946 ± 0.06
1.355GlnGlu: 1.355 ± 0.068
0.809GlnPhe: 0.809 ± 0.063
1.716GlnGly: 1.716 ± 0.097
0.321GlnHis: 0.321 ± 0.035
2.077GlnIle: 2.077 ± 0.079
1.683GlnLys: 1.683 ± 0.088
2.384GlnLeu: 2.384 ± 0.107
0.574GlnMet: 0.574 ± 0.044
1.026GlnAsn: 1.026 ± 0.066
0.903GlnPro: 0.903 ± 0.064
0.918GlnGln: 0.918 ± 0.068
1.004GlnArg: 1.004 ± 0.06
1.308GlnSer: 1.308 ± 0.078
1.123GlnThr: 1.123 ± 0.071
1.716GlnVal: 1.716 ± 0.076
0.264GlnTrp: 0.264 ± 0.035
1.044GlnTyr: 1.044 ± 0.06
0.0GlnXaa: 0.0 ± 0.0
Arg
2.572ArgAla: 2.572 ± 0.108
0.368ArgCys: 0.368 ± 0.039
2.518ArgAsp: 2.518 ± 0.102
3.829ArgGlu: 3.829 ± 0.148
1.607ArgPhe: 1.607 ± 0.079
3.128ArgGly: 3.128 ± 0.099
0.509ArgHis: 0.509 ± 0.046
3.818ArgIle: 3.818 ± 0.138
4.302ArgLys: 4.302 ± 0.129
4.234ArgLeu: 4.234 ± 0.114
0.997ArgMet: 0.997 ± 0.052
1.925ArgAsn: 1.925 ± 0.083
1.55ArgPro: 1.55 ± 0.081
0.979ArgGln: 0.979 ± 0.057
2.731ArgArg: 2.731 ± 0.111
2.193ArgSer: 2.193 ± 0.081
1.9ArgThr: 1.9 ± 0.092
3.424ArgVal: 3.424 ± 0.118
0.444ArgTrp: 0.444 ± 0.039
1.795ArgTyr: 1.795 ± 0.079
0.0ArgXaa: 0.0 ± 0.0
Ser
3.32SerAla: 3.32 ± 0.122
0.408SerCys: 0.408 ± 0.039
2.655SerAsp: 2.655 ± 0.09
3.981SerGlu: 3.981 ± 0.138
3.07SerPhe: 3.07 ± 0.126
4.241SerGly: 4.241 ± 0.132
1.011SerHis: 1.011 ± 0.065
5.509SerIle: 5.509 ± 0.159
4.877SerLys: 4.877 ± 0.139
7.86SerLeu: 7.86 ± 0.23
1.488SerMet: 1.488 ± 0.075
2.879SerAsn: 2.879 ± 0.119
2.695SerPro: 2.695 ± 0.108
1.817SerGln: 1.817 ± 0.078
2.565SerArg: 2.565 ± 0.109
5.328SerSer: 5.328 ± 0.175
3.717SerThr: 3.717 ± 0.152
4.544SerVal: 4.544 ± 0.163
0.665SerTrp: 0.665 ± 0.054
2.984SerTyr: 2.984 ± 0.116
0.0SerXaa: 0.0 ± 0.0
Thr
3.161ThrAla: 3.161 ± 0.129
0.311ThrCys: 0.311 ± 0.039
2.045ThrAsp: 2.045 ± 0.089
2.81ThrGlu: 2.81 ± 0.106
2.33ThrPhe: 2.33 ± 0.102
3.258ThrGly: 3.258 ± 0.115
0.672ThrHis: 0.672 ± 0.046
4.179ThrIle: 4.179 ± 0.127
2.893ThrLys: 2.893 ± 0.101
5.371ThrLeu: 5.371 ± 0.146
1.058ThrMet: 1.058 ± 0.061
2.066ThrAsn: 2.066 ± 0.096
2.46ThrPro: 2.46 ± 0.093
1.196ThrGln: 1.196 ± 0.077
1.933ThrArg: 1.933 ± 0.068
3.576ThrSer: 3.576 ± 0.141
3.009ThrThr: 3.009 ± 0.157
4.338ThrVal: 4.338 ± 0.15
0.415ThrTrp: 0.415 ± 0.038
2.33ThrTyr: 2.33 ± 0.119
0.0ThrXaa: 0.0 ± 0.0
Val
4.299ValAla: 4.299 ± 0.157
0.39ValCys: 0.39 ± 0.038
3.771ValAsp: 3.771 ± 0.139
5.574ValGlu: 5.574 ± 0.156
3.345ValPhe: 3.345 ± 0.122
4.721ValGly: 4.721 ± 0.145
0.91ValHis: 0.91 ± 0.058
7.882ValIle: 7.882 ± 0.185
7.116ValLys: 7.116 ± 0.188
7.488ValLeu: 7.488 ± 0.191
1.626ValMet: 1.626 ± 0.074
4.089ValAsn: 4.089 ± 0.129
2.716ValPro: 2.716 ± 0.09
1.441ValGln: 1.441 ± 0.075
3.724ValArg: 3.724 ± 0.134
5.216ValSer: 5.216 ± 0.162
4.58ValThr: 4.58 ± 0.152
6.423ValVal: 6.423 ± 0.175
0.6ValTrp: 0.6 ± 0.048
3.822ValTyr: 3.822 ± 0.134
0.0ValXaa: 0.0 ± 0.0
Trp
0.564TrpAla: 0.564 ± 0.043
0.033TrpCys: 0.033 ± 0.011
0.531TrpAsp: 0.531 ± 0.046
0.639TrpGlu: 0.639 ± 0.049
0.535TrpPhe: 0.535 ± 0.05
0.657TrpGly: 0.657 ± 0.05
0.152TrpHis: 0.152 ± 0.027
0.827TrpIle: 0.827 ± 0.061
0.719TrpLys: 0.719 ± 0.05
0.957TrpLeu: 0.957 ± 0.071
0.191TrpMet: 0.191 ± 0.03
0.538TrpAsn: 0.538 ± 0.051
0.217TrpPro: 0.217 ± 0.029
0.202TrpGln: 0.202 ± 0.028
0.585TrpArg: 0.585 ± 0.044
0.549TrpSer: 0.549 ± 0.046
0.372TrpThr: 0.372 ± 0.037
0.672TrpVal: 0.672 ± 0.053
0.181TrpTrp: 0.181 ± 0.028
0.574TrpTyr: 0.574 ± 0.053
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.763TyrAla: 2.763 ± 0.116
0.394TyrCys: 0.394 ± 0.043
2.29TyrAsp: 2.29 ± 0.095
3.023TyrGlu: 3.023 ± 0.105
2.334TyrPhe: 2.334 ± 0.1
3.099TyrGly: 3.099 ± 0.1
0.733TyrHis: 0.733 ± 0.05
3.692TyrIle: 3.692 ± 0.123
2.922TyrLys: 2.922 ± 0.108
4.996TyrLeu: 4.996 ± 0.13
0.885TyrMet: 0.885 ± 0.06
2.449TyrAsn: 2.449 ± 0.134
2.045TyrPro: 2.045 ± 0.103
1.058TyrGln: 1.058 ± 0.075
1.665TyrArg: 1.665 ± 0.085
3.475TyrSer: 3.475 ± 0.129
2.503TyrThr: 2.503 ± 0.111
3.995TyrVal: 3.995 ± 0.126
0.578TyrTrp: 0.578 ± 0.047
2.821TyrTyr: 2.821 ± 0.114
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1085 proteins (276833 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski