Amino acid dipepetide frequency for Streptococcus phage P7571

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.066AlaAla: 6.066 ± 2.058
0.373AlaCys: 0.373 ± 0.245
4.199AlaAsp: 4.199 ± 0.975
4.199AlaGlu: 4.199 ± 0.688
2.986AlaPhe: 2.986 ± 1.089
5.412AlaGly: 5.412 ± 1.278
0.933AlaHis: 0.933 ± 0.289
6.906AlaIle: 6.906 ± 1.625
4.759AlaLys: 4.759 ± 0.823
6.812AlaLeu: 6.812 ± 1.572
2.52AlaMet: 2.52 ± 1.141
3.919AlaAsn: 3.919 ± 0.706
2.52AlaPro: 2.52 ± 0.468
2.893AlaGln: 2.893 ± 1.076
3.08AlaArg: 3.08 ± 0.654
6.532AlaSer: 6.532 ± 1.741
5.039AlaThr: 5.039 ± 1.102
3.919AlaVal: 3.919 ± 1.081
0.467AlaTrp: 0.467 ± 0.169
2.24AlaTyr: 2.24 ± 0.539
0.0AlaXaa: 0.0 ± 0.0
Cys
0.187CysAla: 0.187 ± 0.139
0.187CysCys: 0.187 ± 0.143
0.56CysAsp: 0.56 ± 0.287
0.56CysGlu: 0.56 ± 0.274
0.0CysPhe: 0.0 ± 0.0
0.467CysGly: 0.467 ± 0.254
0.28CysHis: 0.28 ± 0.174
0.28CysIle: 0.28 ± 0.134
0.467CysLys: 0.467 ± 0.218
0.373CysLeu: 0.373 ± 0.237
0.093CysMet: 0.093 ± 0.087
0.653CysAsn: 0.653 ± 0.224
0.187CysPro: 0.187 ± 0.132
0.093CysGln: 0.093 ± 0.105
0.467CysArg: 0.467 ± 0.246
0.56CysSer: 0.56 ± 0.355
0.093CysThr: 0.093 ± 0.094
0.373CysVal: 0.373 ± 0.174
0.093CysTrp: 0.093 ± 0.1
0.467CysTyr: 0.467 ± 0.238
0.0CysXaa: 0.0 ± 0.0
Asp
3.08AspAla: 3.08 ± 0.559
0.467AspCys: 0.467 ± 0.217
4.386AspAsp: 4.386 ± 0.609
4.386AspGlu: 4.386 ± 0.972
3.453AspPhe: 3.453 ± 0.488
5.692AspGly: 5.692 ± 0.891
0.747AspHis: 0.747 ± 0.296
2.8AspIle: 2.8 ± 0.614
5.226AspLys: 5.226 ± 0.657
4.386AspLeu: 4.386 ± 0.666
1.4AspMet: 1.4 ± 0.378
4.106AspAsn: 4.106 ± 0.755
0.84AspPro: 0.84 ± 0.292
1.4AspGln: 1.4 ± 0.374
2.986AspArg: 2.986 ± 0.431
4.199AspSer: 4.199 ± 0.651
3.266AspThr: 3.266 ± 0.556
3.919AspVal: 3.919 ± 0.657
1.12AspTrp: 1.12 ± 0.43
3.733AspTyr: 3.733 ± 0.761
0.0AspXaa: 0.0 ± 0.0
Glu
4.853GluAla: 4.853 ± 0.791
0.28GluCys: 0.28 ± 0.16
2.426GluAsp: 2.426 ± 0.525
3.733GluGlu: 3.733 ± 0.879
2.8GluPhe: 2.8 ± 0.597
3.919GluGly: 3.919 ± 0.555
1.213GluHis: 1.213 ± 0.489
5.039GluIle: 5.039 ± 0.774
4.573GluLys: 4.573 ± 0.961
6.719GluLeu: 6.719 ± 1.349
1.96GluMet: 1.96 ± 0.604
4.106GluAsn: 4.106 ± 0.626
1.96GluPro: 1.96 ± 0.606
2.613GluGln: 2.613 ± 0.532
3.919GluArg: 3.919 ± 0.737
2.706GluSer: 2.706 ± 0.706
3.08GluThr: 3.08 ± 0.649
5.692GluVal: 5.692 ± 0.918
1.213GluTrp: 1.213 ± 0.333
3.173GluTyr: 3.173 ± 0.922
0.0GluXaa: 0.0 ± 0.0
Phe
2.426PheAla: 2.426 ± 0.614
0.373PheCys: 0.373 ± 0.23
3.08PheAsp: 3.08 ± 0.6
3.919PheGlu: 3.919 ± 0.631
1.68PhePhe: 1.68 ± 0.579
3.826PheGly: 3.826 ± 0.648
0.373PheHis: 0.373 ± 0.188
2.426PheIle: 2.426 ± 0.417
4.293PheLys: 4.293 ± 0.575
2.613PheLeu: 2.613 ± 0.661
0.747PheMet: 0.747 ± 0.262
2.986PheAsn: 2.986 ± 0.487
0.467PhePro: 0.467 ± 0.25
1.493PheGln: 1.493 ± 0.342
1.213PheArg: 1.213 ± 0.301
2.986PheSer: 2.986 ± 0.688
2.8PheThr: 2.8 ± 0.562
2.426PheVal: 2.426 ± 0.619
0.56PheTrp: 0.56 ± 0.275
1.027PheTyr: 1.027 ± 0.365
0.0PheXaa: 0.0 ± 0.0
Gly
5.133GlyAla: 5.133 ± 1.233
0.373GlyCys: 0.373 ± 0.233
3.173GlyAsp: 3.173 ± 0.378
3.546GlyGlu: 3.546 ± 0.504
3.173GlyPhe: 3.173 ± 0.556
3.173GlyGly: 3.173 ± 0.633
0.467GlyHis: 0.467 ± 0.193
6.812GlyIle: 6.812 ± 1.848
6.532GlyLys: 6.532 ± 0.967
6.346GlyLeu: 6.346 ± 0.824
1.586GlyMet: 1.586 ± 0.858
3.173GlyAsn: 3.173 ± 0.548
0.467GlyPro: 0.467 ± 0.285
2.613GlyGln: 2.613 ± 0.522
2.706GlyArg: 2.706 ± 0.614
4.853GlySer: 4.853 ± 0.937
4.759GlyThr: 4.759 ± 1.0
4.479GlyVal: 4.479 ± 0.73
1.12GlyTrp: 1.12 ± 0.41
2.986GlyTyr: 2.986 ± 0.786
0.0GlyXaa: 0.0 ± 0.0
His
0.84HisAla: 0.84 ± 0.269
0.0HisCys: 0.0 ± 0.0
1.213HisAsp: 1.213 ± 0.318
0.56HisGlu: 0.56 ± 0.194
0.467HisPhe: 0.467 ± 0.194
0.933HisGly: 0.933 ± 0.367
0.467HisHis: 0.467 ± 0.187
0.933HisIle: 0.933 ± 0.305
0.84HisLys: 0.84 ± 0.299
1.027HisLeu: 1.027 ± 0.308
0.467HisMet: 0.467 ± 0.193
0.467HisAsn: 0.467 ± 0.257
0.56HisPro: 0.56 ± 0.246
0.373HisGln: 0.373 ± 0.199
0.747HisArg: 0.747 ± 0.271
0.84HisSer: 0.84 ± 0.304
0.56HisThr: 0.56 ± 0.206
1.213HisVal: 1.213 ± 0.391
0.187HisTrp: 0.187 ± 0.126
0.467HisTyr: 0.467 ± 0.204
0.0HisXaa: 0.0 ± 0.0
Ile
5.599IleAla: 5.599 ± 1.083
0.467IleCys: 0.467 ± 0.237
5.412IleAsp: 5.412 ± 0.609
3.359IleGlu: 3.359 ± 0.506
1.68IlePhe: 1.68 ± 0.41
5.226IleGly: 5.226 ± 1.042
0.933IleHis: 0.933 ± 0.311
4.106IleIle: 4.106 ± 0.788
5.786IleLys: 5.786 ± 0.593
3.359IleLeu: 3.359 ± 0.625
2.426IleMet: 2.426 ± 0.441
3.826IleAsn: 3.826 ± 0.631
2.986IlePro: 2.986 ± 0.719
2.52IleGln: 2.52 ± 0.456
3.08IleArg: 3.08 ± 0.866
7.092IleSer: 7.092 ± 1.503
3.826IleThr: 3.826 ± 0.529
4.759IleVal: 4.759 ± 0.817
0.56IleTrp: 0.56 ± 0.222
3.173IleTyr: 3.173 ± 0.741
0.0IleXaa: 0.0 ± 0.0
Lys
6.906LysAla: 6.906 ± 1.118
0.373LysCys: 0.373 ± 0.252
4.199LysAsp: 4.199 ± 0.729
6.999LysGlu: 6.999 ± 1.06
2.24LysPhe: 2.24 ± 0.478
5.226LysGly: 5.226 ± 0.484
1.12LysHis: 1.12 ± 0.338
4.853LysIle: 4.853 ± 0.801
6.159LysLys: 6.159 ± 1.207
6.439LysLeu: 6.439 ± 0.846
1.68LysMet: 1.68 ± 0.51
4.013LysAsn: 4.013 ± 0.694
3.08LysPro: 3.08 ± 0.523
2.146LysGln: 2.146 ± 0.547
4.293LysArg: 4.293 ± 0.718
4.293LysSer: 4.293 ± 0.479
5.412LysThr: 5.412 ± 0.716
4.386LysVal: 4.386 ± 0.569
0.56LysTrp: 0.56 ± 0.201
3.639LysTyr: 3.639 ± 1.018
0.0LysXaa: 0.0 ± 0.0
Leu
5.972LeuAla: 5.972 ± 0.968
0.467LeuCys: 0.467 ± 0.245
4.386LeuAsp: 4.386 ± 0.656
5.786LeuGlu: 5.786 ± 1.134
2.986LeuPhe: 2.986 ± 0.555
5.786LeuGly: 5.786 ± 1.11
0.467LeuHis: 0.467 ± 0.209
4.479LeuIle: 4.479 ± 0.689
5.692LeuLys: 5.692 ± 0.963
5.226LeuLeu: 5.226 ± 0.839
1.866LeuMet: 1.866 ± 0.471
5.879LeuAsn: 5.879 ± 0.64
2.893LeuPro: 2.893 ± 0.53
2.8LeuGln: 2.8 ± 0.555
3.359LeuArg: 3.359 ± 0.759
5.692LeuSer: 5.692 ± 0.635
5.786LeuThr: 5.786 ± 0.878
4.666LeuVal: 4.666 ± 0.567
0.56LeuTrp: 0.56 ± 0.316
2.8LeuTyr: 2.8 ± 0.544
0.0LeuXaa: 0.0 ± 0.0
Met
2.706MetAla: 2.706 ± 0.742
0.187MetCys: 0.187 ± 0.13
0.933MetAsp: 0.933 ± 0.31
1.306MetGlu: 1.306 ± 0.402
1.027MetPhe: 1.027 ± 0.274
1.12MetGly: 1.12 ± 0.42
0.28MetHis: 0.28 ± 0.159
1.493MetIle: 1.493 ± 0.392
2.146MetLys: 2.146 ± 0.517
1.493MetLeu: 1.493 ± 0.346
1.12MetMet: 1.12 ± 0.542
1.213MetAsn: 1.213 ± 0.262
0.653MetPro: 0.653 ± 0.205
1.4MetGln: 1.4 ± 0.443
1.12MetArg: 1.12 ± 0.341
2.333MetSer: 2.333 ± 0.57
1.68MetThr: 1.68 ± 0.415
2.52MetVal: 2.52 ± 0.565
0.0MetTrp: 0.0 ± 0.0
0.56MetTyr: 0.56 ± 0.261
0.0MetXaa: 0.0 ± 0.0
Asn
3.919AsnAla: 3.919 ± 0.518
0.467AsnCys: 0.467 ± 0.171
3.826AsnAsp: 3.826 ± 0.689
4.199AsnGlu: 4.199 ± 0.889
2.053AsnPhe: 2.053 ± 0.442
5.226AsnGly: 5.226 ± 0.966
1.4AsnHis: 1.4 ± 0.448
3.733AsnIle: 3.733 ± 0.481
4.479AsnLys: 4.479 ± 0.705
3.359AsnLeu: 3.359 ± 0.566
1.306AsnMet: 1.306 ± 0.332
3.266AsnAsn: 3.266 ± 0.693
2.333AsnPro: 2.333 ± 0.443
1.773AsnGln: 1.773 ± 0.481
2.24AsnArg: 2.24 ± 0.575
2.706AsnSer: 2.706 ± 0.508
3.826AsnThr: 3.826 ± 0.7
3.08AsnVal: 3.08 ± 0.477
1.586AsnTrp: 1.586 ± 0.31
1.773AsnTyr: 1.773 ± 0.446
0.0AsnXaa: 0.0 ± 0.0
Pro
1.586ProAla: 1.586 ± 0.485
0.187ProCys: 0.187 ± 0.199
2.24ProAsp: 2.24 ± 0.472
1.866ProGlu: 1.866 ± 0.447
1.306ProPhe: 1.306 ± 0.286
1.12ProGly: 1.12 ± 0.309
0.373ProHis: 0.373 ± 0.207
1.586ProIle: 1.586 ± 0.496
2.8ProLys: 2.8 ± 0.507
2.146ProLeu: 2.146 ± 0.615
0.28ProMet: 0.28 ± 0.164
1.866ProAsn: 1.866 ± 0.53
1.213ProPro: 1.213 ± 0.48
0.933ProGln: 0.933 ± 0.29
1.493ProArg: 1.493 ± 0.484
2.426ProSer: 2.426 ± 0.485
1.866ProThr: 1.866 ± 0.564
2.146ProVal: 2.146 ± 0.457
0.28ProTrp: 0.28 ± 0.147
1.12ProTyr: 1.12 ± 0.326
0.0ProXaa: 0.0 ± 0.0
Gln
3.826GlnAla: 3.826 ± 1.042
0.373GlnCys: 0.373 ± 0.179
1.586GlnAsp: 1.586 ± 0.371
2.426GlnGlu: 2.426 ± 0.68
2.146GlnPhe: 2.146 ± 0.347
1.96GlnGly: 1.96 ± 0.678
0.28GlnHis: 0.28 ± 0.168
2.613GlnIle: 2.613 ± 0.546
2.613GlnLys: 2.613 ± 0.519
3.826GlnLeu: 3.826 ± 0.482
1.213GlnMet: 1.213 ± 0.346
1.493GlnAsn: 1.493 ± 0.342
0.747GlnPro: 0.747 ± 0.284
1.493GlnGln: 1.493 ± 0.421
1.12GlnArg: 1.12 ± 0.284
2.613GlnSer: 2.613 ± 0.497
2.52GlnThr: 2.52 ± 0.45
2.146GlnVal: 2.146 ± 0.404
0.28GlnTrp: 0.28 ± 0.162
1.586GlnTyr: 1.586 ± 0.402
0.0GlnXaa: 0.0 ± 0.0
Arg
3.453ArgAla: 3.453 ± 0.531
0.747ArgCys: 0.747 ± 0.283
2.706ArgAsp: 2.706 ± 0.533
3.08ArgGlu: 3.08 ± 0.738
1.586ArgPhe: 1.586 ± 0.39
2.706ArgGly: 2.706 ± 0.323
0.467ArgHis: 0.467 ± 0.269
3.359ArgIle: 3.359 ± 0.663
3.08ArgLys: 3.08 ± 0.642
3.639ArgLeu: 3.639 ± 0.599
1.773ArgMet: 1.773 ± 0.335
1.866ArgAsn: 1.866 ± 0.451
1.306ArgPro: 1.306 ± 0.468
1.4ArgGln: 1.4 ± 0.357
1.866ArgArg: 1.866 ± 0.501
2.426ArgSer: 2.426 ± 0.48
1.866ArgThr: 1.866 ± 0.55
3.08ArgVal: 3.08 ± 0.644
0.84ArgTrp: 0.84 ± 0.331
2.706ArgTyr: 2.706 ± 0.551
0.0ArgXaa: 0.0 ± 0.0
Ser
6.906SerAla: 6.906 ± 2.974
0.373SerCys: 0.373 ± 0.206
4.199SerAsp: 4.199 ± 0.73
3.453SerGlu: 3.453 ± 0.639
3.639SerPhe: 3.639 ± 0.64
4.759SerGly: 4.759 ± 0.605
0.747SerHis: 0.747 ± 0.232
5.599SerIle: 5.599 ± 0.882
4.573SerLys: 4.573 ± 0.637
4.946SerLeu: 4.946 ± 0.844
1.68SerMet: 1.68 ± 0.318
4.106SerAsn: 4.106 ± 0.825
1.586SerPro: 1.586 ± 0.52
3.266SerGln: 3.266 ± 0.931
2.24SerArg: 2.24 ± 0.45
4.199SerSer: 4.199 ± 1.092
4.386SerThr: 4.386 ± 0.74
5.506SerVal: 5.506 ± 0.805
0.653SerTrp: 0.653 ± 0.242
1.773SerTyr: 1.773 ± 0.38
0.0SerXaa: 0.0 ± 0.0
Thr
4.759ThrAla: 4.759 ± 1.9
0.187ThrCys: 0.187 ± 0.138
3.359ThrAsp: 3.359 ± 0.643
3.266ThrGlu: 3.266 ± 0.608
3.826ThrPhe: 3.826 ± 0.559
4.573ThrGly: 4.573 ± 0.739
1.12ThrHis: 1.12 ± 0.35
5.506ThrIle: 5.506 ± 1.065
5.599ThrLys: 5.599 ± 0.734
5.506ThrLeu: 5.506 ± 0.92
1.213ThrMet: 1.213 ± 0.643
2.613ThrAsn: 2.613 ± 0.605
1.68ThrPro: 1.68 ± 0.396
2.613ThrGln: 2.613 ± 0.487
2.053ThrArg: 2.053 ± 0.592
3.546ThrSer: 3.546 ± 0.966
4.199ThrThr: 4.199 ± 0.634
5.226ThrVal: 5.226 ± 0.736
0.373ThrTrp: 0.373 ± 0.244
2.146ThrTyr: 2.146 ± 0.716
0.0ThrXaa: 0.0 ± 0.0
Val
4.573ValAla: 4.573 ± 1.027
0.187ValCys: 0.187 ± 0.138
6.066ValAsp: 6.066 ± 0.906
5.786ValGlu: 5.786 ± 1.065
2.706ValPhe: 2.706 ± 0.547
3.546ValGly: 3.546 ± 0.593
0.653ValHis: 0.653 ± 0.254
4.853ValIle: 4.853 ± 0.844
5.226ValLys: 5.226 ± 0.69
4.386ValLeu: 4.386 ± 0.461
1.027ValMet: 1.027 ± 0.338
4.106ValAsn: 4.106 ± 0.786
2.24ValPro: 2.24 ± 0.41
2.613ValGln: 2.613 ± 0.668
2.613ValArg: 2.613 ± 0.411
5.506ValSer: 5.506 ± 0.831
4.946ValThr: 4.946 ± 0.748
4.759ValVal: 4.759 ± 0.64
0.747ValTrp: 0.747 ± 0.238
1.493ValTyr: 1.493 ± 0.455
0.0ValXaa: 0.0 ± 0.0
Trp
0.467TrpAla: 0.467 ± 0.174
0.093TrpCys: 0.093 ± 0.088
0.84TrpAsp: 0.84 ± 0.356
0.933TrpGlu: 0.933 ± 0.282
0.467TrpPhe: 0.467 ± 0.221
0.653TrpGly: 0.653 ± 0.235
0.093TrpHis: 0.093 ± 0.088
0.467TrpIle: 0.467 ± 0.218
0.653TrpLys: 0.653 ± 0.221
1.306TrpLeu: 1.306 ± 0.338
0.187TrpMet: 0.187 ± 0.147
0.467TrpAsn: 0.467 ± 0.217
0.093TrpPro: 0.093 ± 0.094
0.653TrpGln: 0.653 ± 0.268
0.467TrpArg: 0.467 ± 0.208
1.213TrpSer: 1.213 ± 0.624
1.027TrpThr: 1.027 ± 0.364
1.027TrpVal: 1.027 ± 0.249
0.28TrpTrp: 0.28 ± 0.211
0.467TrpTyr: 0.467 ± 0.332
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.52TyrAla: 2.52 ± 0.439
0.28TyrCys: 0.28 ± 0.161
2.8TyrAsp: 2.8 ± 0.813
2.706TyrGlu: 2.706 ± 0.738
1.493TyrPhe: 1.493 ± 0.454
2.146TyrGly: 2.146 ± 0.498
0.747TyrHis: 0.747 ± 0.304
2.333TyrIle: 2.333 ± 0.512
2.52TyrLys: 2.52 ± 0.55
3.639TyrLeu: 3.639 ± 0.712
0.653TyrMet: 0.653 ± 0.231
2.426TyrAsn: 2.426 ± 0.565
1.027TyrPro: 1.027 ± 0.326
1.773TyrGln: 1.773 ± 0.448
2.893TyrArg: 2.893 ± 0.778
1.866TyrSer: 1.866 ± 0.525
2.426TyrThr: 2.426 ± 0.635
2.706TyrVal: 2.706 ± 0.605
0.373TyrTrp: 0.373 ± 0.16
1.493TyrTyr: 1.493 ± 0.493
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (10717 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski