Amino acid dipepetide frequency for Sphingomonas crocodyli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.615AlaAla: 18.615 ± 0.18	1.065AlaCys: 1.065 ± 0.03	8.07AlaAsp: 8.07 ± 0.088	7.481AlaGlu: 7.481 ± 0.099	4.536AlaPhe: 4.536 ± 0.053	11.279AlaGly: 11.279 ± 0.113	2.335AlaHis: 2.335 ± 0.041	7.764AlaIle: 7.764 ± 0.073	4.624AlaLys: 4.624 ± 0.067	13.392AlaLeu: 13.392 ± 0.12	3.988AlaMet: 3.988 ± 0.055	3.273AlaAsn: 3.273 ± 0.052	6.347AlaPro: 6.347 ± 0.088	4.332AlaGln: 4.332 ± 0.06	9.242AlaArg: 9.242 ± 0.093	6.506AlaSer: 6.506 ± 0.073	6.968AlaThr: 6.968 ± 0.088	8.384AlaVal: 8.384 ± 0.084	1.644AlaTrp: 1.644 ± 0.038	2.729AlaTyr: 2.729 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.968CysAla: 0.968 ± 0.026	0.081CysCys: 0.081 ± 0.007	0.53CysAsp: 0.53 ± 0.023	0.395CysGlu: 0.395 ± 0.016	0.32CysPhe: 0.32 ± 0.015	0.863CysGly: 0.863 ± 0.026	0.216CysHis: 0.216 ± 0.017	0.376CysIle: 0.376 ± 0.019	0.155CysLys: 0.155 ± 0.011	0.691CysLeu: 0.691 ± 0.023	0.13CysMet: 0.13 ± 0.01	0.185CysAsn: 0.185 ± 0.012	0.431CysPro: 0.431 ± 0.018	0.209CysGln: 0.209 ± 0.012	0.556CysArg: 0.556 ± 0.02	0.421CysSer: 0.421 ± 0.018	0.376CysThr: 0.376 ± 0.015	0.538CysVal: 0.538 ± 0.02	0.112CysTrp: 0.112 ± 0.009	0.168CysTyr: 0.168 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.204AspAla: 8.204 ± 0.091	0.453AspCys: 0.453 ± 0.018	3.513AspAsp: 3.513 ± 0.056	3.319AspGlu: 3.319 ± 0.054	2.244AspPhe: 2.244 ± 0.043	5.751AspGly: 5.751 ± 0.064	1.419AspHis: 1.419 ± 0.036	3.257AspIle: 3.257 ± 0.045	1.823AspLys: 1.823 ± 0.038	5.825AspLeu: 5.825 ± 0.073	1.529AspMet: 1.529 ± 0.029	1.383AspAsn: 1.383 ± 0.031	3.893AspPro: 3.893 ± 0.06	1.879AspGln: 1.879 ± 0.038	5.245AspArg: 5.245 ± 0.077	2.206AspSer: 2.206 ± 0.043	2.496AspThr: 2.496 ± 0.044	4.345AspVal: 4.345 ± 0.058	1.153AspTrp: 1.153 ± 0.027	1.689AspTyr: 1.689 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.78GluAla: 7.78 ± 0.084	0.292GluCys: 0.292 ± 0.014	2.65GluAsp: 2.65 ± 0.047	2.718GluGlu: 2.718 ± 0.057	1.402GluPhe: 1.402 ± 0.033	4.492GluGly: 4.492 ± 0.057	1.079GluHis: 1.079 ± 0.031	2.943GluIle: 2.943 ± 0.049	1.928GluLys: 1.928 ± 0.044	4.77GluLeu: 4.77 ± 0.064	1.407GluMet: 1.407 ± 0.031	1.188GluAsn: 1.188 ± 0.029	2.546GluPro: 2.546 ± 0.048	1.962GluGln: 1.962 ± 0.041	4.619GluArg: 4.619 ± 0.067	2.05GluSer: 2.05 ± 0.042	2.999GluThr: 2.999 ± 0.042	3.388GluVal: 3.388 ± 0.049	0.769GluTrp: 0.769 ± 0.021	0.921GluTyr: 0.921 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.962PheAla: 4.962 ± 0.066	0.346PheCys: 0.346 ± 0.015	2.817PheAsp: 2.817 ± 0.044	1.988PheGlu: 1.988 ± 0.036	1.246PhePhe: 1.246 ± 0.03	3.763PheGly: 3.763 ± 0.057	0.749PheHis: 0.749 ± 0.027	1.448PheIle: 1.448 ± 0.029	0.939PheLys: 0.939 ± 0.03	3.013PheLeu: 3.013 ± 0.05	0.731PheMet: 0.731 ± 0.025	1.055PheAsn: 1.055 ± 0.029	1.527PhePro: 1.527 ± 0.033	0.919PheGln: 0.919 ± 0.028	2.205PheArg: 2.205 ± 0.041	1.925PheSer: 1.925 ± 0.036	2.006PheThr: 2.006 ± 0.041	2.761PheVal: 2.761 ± 0.048	0.516PheTrp: 0.516 ± 0.019	0.859PheTyr: 0.859 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.149GlyAla: 10.149 ± 0.127	0.806GlyCys: 0.806 ± 0.023	5.095GlyAsp: 5.095 ± 0.062	4.565GlyGlu: 4.565 ± 0.057	3.787GlyPhe: 3.787 ± 0.062	8.542GlyGly: 8.542 ± 0.15	1.892GlyHis: 1.892 ± 0.042	4.621GlyIle: 4.621 ± 0.058	3.292GlyLys: 3.292 ± 0.059	8.628GlyLeu: 8.628 ± 0.088	2.267GlyMet: 2.267 ± 0.045	2.261GlyAsn: 2.261 ± 0.059	3.764GlyPro: 3.764 ± 0.057	2.952GlyGln: 2.952 ± 0.048	6.61GlyArg: 6.61 ± 0.073	4.78GlySer: 4.78 ± 0.073	4.761GlyThr: 4.761 ± 0.081	6.422GlyVal: 6.422 ± 0.07	1.71GlyTrp: 1.71 ± 0.037	2.391GlyTyr: 2.391 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.372HisAla: 2.372 ± 0.044	0.212HisCys: 0.212 ± 0.013	1.325HisAsp: 1.325 ± 0.033	0.986HisGlu: 0.986 ± 0.026	0.833HisPhe: 0.833 ± 0.022	1.896HisGly: 1.896 ± 0.039	0.578HisHis: 0.578 ± 0.025	0.981HisIle: 0.981 ± 0.03	0.508HisLys: 0.508 ± 0.022	1.903HisLeu: 1.903 ± 0.036	0.521HisMet: 0.521 ± 0.021	0.463HisAsn: 0.463 ± 0.016	1.311HisPro: 1.311 ± 0.027	0.528HisGln: 0.528 ± 0.021	1.43HisArg: 1.43 ± 0.032	0.987HisSer: 0.987 ± 0.027	0.673HisThr: 0.673 ± 0.021	1.465HisVal: 1.465 ± 0.034	0.361HisTrp: 0.361 ± 0.018	0.586HisTyr: 0.586 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	8.629IleAla: 8.629 ± 0.086	0.469IleCys: 0.469 ± 0.019	4.476IleAsp: 4.476 ± 0.058	3.87IleGlu: 3.87 ± 0.057	1.755IlePhe: 1.755 ± 0.037	5.383IleGly: 5.383 ± 0.065	0.938IleHis: 0.938 ± 0.023	2.242IleIle: 2.242 ± 0.047	1.359IleLys: 1.359 ± 0.034	4.224IleLeu: 4.224 ± 0.06	0.958IleMet: 0.958 ± 0.025	1.447IleAsn: 1.447 ± 0.038	2.327IlePro: 2.327 ± 0.039	1.203IleGln: 1.203 ± 0.029	3.35IleArg: 3.35 ± 0.046	2.815IleSer: 2.815 ± 0.054	2.712IleThr: 2.712 ± 0.056	4.616IleVal: 4.616 ± 0.059	0.626IleTrp: 0.626 ± 0.022	1.095IleTyr: 1.095 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.485LysAla: 4.485 ± 0.07	0.153LysCys: 0.153 ± 0.01	1.662LysAsp: 1.662 ± 0.04	1.251LysGlu: 1.251 ± 0.033	0.812LysPhe: 0.812 ± 0.029	2.871LysGly: 2.871 ± 0.046	0.554LysHis: 0.554 ± 0.023	1.667LysIle: 1.667 ± 0.037	1.125LysLys: 1.125 ± 0.034	3.409LysLeu: 3.409 ± 0.055	0.803LysMet: 0.803 ± 0.027	0.74LysAsn: 0.74 ± 0.025	2.182LysPro: 2.182 ± 0.045	0.914LysGln: 0.914 ± 0.028	2.298LysArg: 2.298 ± 0.043	1.601LysSer: 1.601 ± 0.042	1.731LysThr: 1.731 ± 0.04	2.357LysVal: 2.357 ± 0.04	0.384LysTrp: 0.384 ± 0.016	0.59LysTyr: 0.59 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.994LeuAla: 12.994 ± 0.126	0.822LeuCys: 0.822 ± 0.022	6.072LeuAsp: 6.072 ± 0.064	4.184LeuGlu: 4.184 ± 0.062	3.513LeuPhe: 3.513 ± 0.054	8.141LeuGly: 8.141 ± 0.09	1.846LeuHis: 1.846 ± 0.041	5.505LeuIle: 5.505 ± 0.07	3.067LeuLys: 3.067 ± 0.051	9.042LeuLeu: 9.042 ± 0.108	2.213LeuMet: 2.213 ± 0.042	2.443LeuAsn: 2.443 ± 0.045	5.395LeuPro: 5.395 ± 0.053	2.399LeuGln: 2.399 ± 0.034	6.643LeuArg: 6.643 ± 0.062	6.079LeuSer: 6.079 ± 0.073	5.676LeuThr: 5.676 ± 0.074	6.584LeuVal: 6.584 ± 0.073	1.219LeuTrp: 1.219 ± 0.032	2.026LeuTyr: 2.026 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.392MetAla: 3.392 ± 0.046	0.171MetCys: 0.171 ± 0.009	1.089MetAsp: 1.089 ± 0.03	1.005MetGlu: 1.005 ± 0.025	0.767MetPhe: 0.767 ± 0.024	2.011MetGly: 2.011 ± 0.043	0.413MetHis: 0.413 ± 0.018	1.588MetIle: 1.588 ± 0.038	0.922MetLys: 0.922 ± 0.025	2.644MetLeu: 2.644 ± 0.042	0.742MetMet: 0.742 ± 0.026	0.69MetAsn: 0.69 ± 0.021	1.572MetPro: 1.572 ± 0.036	0.672MetGln: 0.672 ± 0.019	1.899MetArg: 1.899 ± 0.034	1.56MetSer: 1.56 ± 0.033	1.769MetThr: 1.769 ± 0.037	1.585MetVal: 1.585 ± 0.032	0.242MetTrp: 0.242 ± 0.014	0.262MetTyr: 0.262 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.315AsnAla: 3.315 ± 0.063	0.237AsnCys: 0.237 ± 0.012	1.477AsnAsp: 1.477 ± 0.035	1.076AsnGlu: 1.076 ± 0.028	0.943AsnPhe: 0.943 ± 0.031	2.509AsnGly: 2.509 ± 0.063	0.453AsnHis: 0.453 ± 0.018	1.394AsnIle: 1.394 ± 0.038	0.66AsnLys: 0.66 ± 0.023	2.537AsnLeu: 2.537 ± 0.046	0.588AsnMet: 0.588 ± 0.019	0.718AsnAsn: 0.718 ± 0.028	1.773AsnPro: 1.773 ± 0.037	0.72AsnGln: 0.72 ± 0.021	1.837AsnArg: 1.837 ± 0.039	1.264AsnSer: 1.264 ± 0.038	1.118AsnThr: 1.118 ± 0.037	1.976AsnVal: 1.976 ± 0.046	0.406AsnTrp: 0.406 ± 0.015	0.691AsnTyr: 0.691 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.994ProAla: 6.994 ± 0.08	0.306ProCys: 0.306 ± 0.014	3.797ProAsp: 3.797 ± 0.057	3.331ProGlu: 3.331 ± 0.055	1.971ProPhe: 1.971 ± 0.038	4.639ProGly: 4.639 ± 0.051	1.062ProHis: 1.062 ± 0.023	2.877ProIle: 2.877 ± 0.045	1.757ProLys: 1.757 ± 0.038	4.799ProLeu: 4.799 ± 0.058	1.33ProMet: 1.33 ± 0.034	1.428ProAsn: 1.428 ± 0.031	2.719ProPro: 2.719 ± 0.069	1.607ProGln: 1.607 ± 0.035	3.0ProArg: 3.0 ± 0.049	2.703ProSer: 2.703 ± 0.048	2.865ProThr: 2.865 ± 0.043	4.197ProVal: 4.197 ± 0.06	0.714ProTrp: 0.714 ± 0.024	1.107ProTyr: 1.107 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.087GlnAla: 4.087 ± 0.058	0.213GlnCys: 0.213 ± 0.012	1.366GlnAsp: 1.366 ± 0.031	1.167GlnGlu: 1.167 ± 0.033	1.034GlnPhe: 1.034 ± 0.029	2.425GlnGly: 2.425 ± 0.04	0.607GlnHis: 0.607 ± 0.022	1.847GlnIle: 1.847 ± 0.038	0.917GlnLys: 0.917 ± 0.028	2.901GlnLeu: 2.901 ± 0.048	0.808GlnMet: 0.808 ± 0.023	0.799GlnAsn: 0.799 ± 0.024	1.753GlnPro: 1.753 ± 0.037	1.08GlnGln: 1.08 ± 0.029	2.415GlnArg: 2.415 ± 0.039	1.665GlnSer: 1.665 ± 0.036	1.616GlnThr: 1.616 ± 0.037	2.127GlnVal: 2.127 ± 0.037	0.404GlnTrp: 0.404 ± 0.015	0.634GlnTyr: 0.634 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.764ArgAla: 8.764 ± 0.09	0.504ArgCys: 0.504 ± 0.021	4.429ArgAsp: 4.429 ± 0.074	3.819ArgGlu: 3.819 ± 0.058	3.113ArgPhe: 3.113 ± 0.051	5.087ArgGly: 5.087 ± 0.057	1.651ArgHis: 1.651 ± 0.035	4.225ArgIle: 4.225 ± 0.056	2.107ArgLys: 2.107 ± 0.039	7.78ArgLeu: 7.78 ± 0.092	1.939ArgMet: 1.939 ± 0.038	1.812ArgAsn: 1.812 ± 0.036	3.671ArgPro: 3.671 ± 0.059	2.359ArgGln: 2.359 ± 0.049	5.775ArgArg: 5.775 ± 0.078	3.683ArgSer: 3.683 ± 0.059	3.511ArgThr: 3.511 ± 0.053	4.768ArgVal: 4.768 ± 0.059	1.26ArgTrp: 1.26 ± 0.029	1.983ArgTyr: 1.983 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.426SerAla: 6.426 ± 0.074	0.378SerCys: 0.378 ± 0.017	3.125SerAsp: 3.125 ± 0.048	2.293SerGlu: 2.293 ± 0.041	2.222SerPhe: 2.222 ± 0.041	5.223SerGly: 5.223 ± 0.072	1.005SerHis: 1.005 ± 0.028	2.913SerIle: 2.913 ± 0.059	1.542SerLys: 1.542 ± 0.038	4.998SerLeu: 4.998 ± 0.066	1.251SerMet: 1.251 ± 0.027	1.368SerAsn: 1.368 ± 0.035	2.819SerPro: 2.819 ± 0.04	1.492SerGln: 1.492 ± 0.034	3.4SerArg: 3.4 ± 0.048	2.863SerSer: 2.863 ± 0.054	2.747SerThr: 2.747 ± 0.061	3.717SerVal: 3.717 ± 0.056	0.798SerTrp: 0.798 ± 0.023	1.432SerTyr: 1.432 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.525ThrAla: 6.525 ± 0.075	0.354ThrCys: 0.354 ± 0.017	3.027ThrAsp: 3.027 ± 0.048	2.3ThrGlu: 2.3 ± 0.041	1.805ThrPhe: 1.805 ± 0.039	5.332ThrGly: 5.332 ± 0.085	0.985ThrHis: 0.985 ± 0.027	3.381ThrIle: 3.381 ± 0.061	1.567ThrLys: 1.567 ± 0.04	5.559ThrLeu: 5.559 ± 0.066	1.238ThrMet: 1.238 ± 0.027	1.438ThrAsn: 1.438 ± 0.041	3.465ThrPro: 3.465 ± 0.049	1.409ThrGln: 1.409 ± 0.033	3.273ThrArg: 3.273 ± 0.049	2.815ThrSer: 2.815 ± 0.063	3.01ThrThr: 3.01 ± 0.099	3.993ThrVal: 3.993 ± 0.063	0.596ThrTrp: 0.596 ± 0.022	1.263ThrTyr: 1.263 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.747ValAla: 9.747 ± 0.089	0.523ValCys: 0.523 ± 0.019	4.707ValAsp: 4.707 ± 0.057	4.378ValGlu: 4.378 ± 0.065	2.014ValPhe: 2.014 ± 0.04	5.904ValGly: 5.904 ± 0.074	1.291ValHis: 1.291 ± 0.028	3.74ValIle: 3.74 ± 0.053	2.153ValLys: 2.153 ± 0.046	6.037ValLeu: 6.037 ± 0.061	1.704ValMet: 1.704 ± 0.037	1.957ValAsn: 1.957 ± 0.047	3.894ValPro: 3.894 ± 0.056	1.949ValGln: 1.949 ± 0.037	5.182ValArg: 5.182 ± 0.064	3.998ValSer: 3.998 ± 0.054	4.398ValThr: 4.398 ± 0.072	5.291ValVal: 5.291 ± 0.062	0.808ValTrp: 0.808 ± 0.023	1.293ValTyr: 1.293 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.448TrpAla: 1.448 ± 0.033	0.116TrpCys: 0.116 ± 0.01	0.77TrpAsp: 0.77 ± 0.023	0.587TrpGlu: 0.587 ± 0.023	0.57TrpPhe: 0.57 ± 0.023	0.988TrpGly: 0.988 ± 0.025	0.346TrpHis: 0.346 ± 0.016	0.794TrpIle: 0.794 ± 0.024	0.499TrpLys: 0.499 ± 0.018	1.662TrpLeu: 1.662 ± 0.035	0.373TrpMet: 0.373 ± 0.016	0.397TrpAsn: 0.397 ± 0.016	0.733TrpPro: 0.733 ± 0.024	0.547TrpGln: 0.547 ± 0.019	1.38TrpArg: 1.38 ± 0.032	0.882TrpSer: 0.882 ± 0.027	0.866TrpThr: 0.866 ± 0.023	0.846TrpVal: 0.846 ± 0.024	0.246TrpTrp: 0.246 ± 0.015	0.28TrpTyr: 0.28 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.719TyrAla: 2.719 ± 0.046	0.216TyrCys: 0.216 ± 0.013	1.63TyrAsp: 1.63 ± 0.035	1.189TyrGlu: 1.189 ± 0.028	0.888TyrPhe: 0.888 ± 0.026	2.196TyrGly: 2.196 ± 0.042	0.498TyrHis: 0.498 ± 0.018	0.93TyrIle: 0.93 ± 0.027	0.645TyrLys: 0.645 ± 0.025	2.048TyrLeu: 2.048 ± 0.041	0.478TyrMet: 0.478 ± 0.02	0.649TyrAsn: 0.649 ± 0.027	1.082TyrPro: 1.082 ± 0.035	0.734TyrGln: 0.734 ± 0.025	1.88TyrArg: 1.88 ± 0.033	1.208TyrSer: 1.208 ± 0.032	1.037TyrThr: 1.037 ± 0.028	1.61TyrVal: 1.61 ± 0.032	0.364TyrTrp: 0.364 ± 0.015	0.592TyrTyr: 0.592 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4579 proteins (1452114 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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