Amino acid dipepetide frequency for Solitalea koreensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.554AlaAla: 5.554 ± 0.096	0.709AlaCys: 0.709 ± 0.029	3.924AlaAsp: 3.924 ± 0.064	4.544AlaGlu: 4.544 ± 0.082	3.492AlaPhe: 3.492 ± 0.067	5.035AlaGly: 5.035 ± 0.083	1.164AlaHis: 1.164 ± 0.036	5.608AlaIle: 5.608 ± 0.087	5.008AlaLys: 5.008 ± 0.077	6.769AlaLeu: 6.769 ± 0.1	1.841AlaMet: 1.841 ± 0.053	3.751AlaAsn: 3.751 ± 0.067	2.316AlaPro: 2.316 ± 0.058	2.89AlaGln: 2.89 ± 0.053	2.423AlaArg: 2.423 ± 0.056	4.546AlaSer: 4.546 ± 0.078	3.889AlaThr: 3.889 ± 0.089	4.608AlaVal: 4.608 ± 0.069	0.733AlaTrp: 0.733 ± 0.03	2.684AlaTyr: 2.684 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.556CysAla: 0.556 ± 0.025	0.13CysCys: 0.13 ± 0.013	0.459CysAsp: 0.459 ± 0.023	0.477CysGlu: 0.477 ± 0.021	0.468CysPhe: 0.468 ± 0.023	0.723CysGly: 0.723 ± 0.029	0.201CysHis: 0.201 ± 0.016	0.667CysIle: 0.667 ± 0.028	0.57CysLys: 0.57 ± 0.029	0.792CysLeu: 0.792 ± 0.032	0.216CysMet: 0.216 ± 0.016	0.472CysAsn: 0.472 ± 0.024	0.391CysPro: 0.391 ± 0.027	0.233CysGln: 0.233 ± 0.018	0.293CysArg: 0.293 ± 0.016	0.654CysSer: 0.654 ± 0.034	0.497CysThr: 0.497 ± 0.024	0.49CysVal: 0.49 ± 0.024	0.092CysTrp: 0.092 ± 0.009	0.321CysTyr: 0.321 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.801AspAla: 3.801 ± 0.066	0.415AspCys: 0.415 ± 0.023	2.338AspAsp: 2.338 ± 0.053	3.44AspGlu: 3.44 ± 0.056	3.11AspPhe: 3.11 ± 0.066	3.374AspGly: 3.374 ± 0.059	0.969AspHis: 0.969 ± 0.034	3.897AspIle: 3.897 ± 0.057	4.054AspLys: 4.054 ± 0.076	4.942AspLeu: 4.942 ± 0.079	1.102AspMet: 1.102 ± 0.035	2.608AspAsn: 2.608 ± 0.055	2.12AspPro: 2.12 ± 0.047	1.718AspGln: 1.718 ± 0.045	2.004AspArg: 2.004 ± 0.049	3.042AspSer: 3.042 ± 0.059	2.412AspThr: 2.412 ± 0.056	3.349AspVal: 3.349 ± 0.065	0.698AspTrp: 0.698 ± 0.032	2.394AspTyr: 2.394 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	4.152GluAla: 4.152 ± 0.075	0.412GluCys: 0.412 ± 0.019	2.662GluAsp: 2.662 ± 0.057	4.196GluGlu: 4.196 ± 0.091	2.691GluPhe: 2.691 ± 0.054	3.486GluGly: 3.486 ± 0.064	1.246GluHis: 1.246 ± 0.036	4.716GluIle: 4.716 ± 0.087	5.242GluLys: 5.242 ± 0.081	6.412GluLeu: 6.412 ± 0.095	1.655GluMet: 1.655 ± 0.038	3.674GluAsn: 3.674 ± 0.069	1.631GluPro: 1.631 ± 0.039	2.593GluGln: 2.593 ± 0.06	2.678GluArg: 2.678 ± 0.055	3.021GluSer: 3.021 ± 0.054	3.052GluThr: 3.052 ± 0.054	4.096GluVal: 4.096 ± 0.065	0.646GluTrp: 0.646 ± 0.027	2.18GluTyr: 2.18 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.349PheAla: 3.349 ± 0.062	0.518PheCys: 0.518 ± 0.025	2.963PheAsp: 2.963 ± 0.059	2.994PheGlu: 2.994 ± 0.06	2.542PhePhe: 2.542 ± 0.06	3.534PheGly: 3.534 ± 0.068	0.839PheHis: 0.839 ± 0.032	3.77PheIle: 3.77 ± 0.077	3.406PheLys: 3.406 ± 0.061	4.518PheLeu: 4.518 ± 0.084	1.21PheMet: 1.21 ± 0.039	3.17PheAsn: 3.17 ± 0.066	1.813PhePro: 1.813 ± 0.041	1.462PheGln: 1.462 ± 0.042	1.737PheArg: 1.737 ± 0.044	3.894PheSer: 3.894 ± 0.066	2.992PheThr: 2.992 ± 0.056	3.071PheVal: 3.071 ± 0.059	0.562PheTrp: 0.562 ± 0.026	2.055PheTyr: 2.055 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.519GlyAla: 4.519 ± 0.083	0.713GlyCys: 0.713 ± 0.046	3.168GlyAsp: 3.168 ± 0.068	3.541GlyGlu: 3.541 ± 0.063	3.664GlyPhe: 3.664 ± 0.074	4.624GlyGly: 4.624 ± 0.089	1.198GlyHis: 1.198 ± 0.037	5.442GlyIle: 5.442 ± 0.077	5.47GlyLys: 5.47 ± 0.075	6.008GlyLeu: 6.008 ± 0.081	1.72GlyMet: 1.72 ± 0.048	3.513GlyAsn: 3.513 ± 0.07	1.657GlyPro: 1.657 ± 0.047	2.035GlyGln: 2.035 ± 0.042	2.359GlyArg: 2.359 ± 0.056	4.466GlySer: 4.466 ± 0.084	3.965GlyThr: 3.965 ± 0.073	4.477GlyVal: 4.477 ± 0.092	0.876GlyTrp: 0.876 ± 0.031	2.861GlyTyr: 2.861 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.133HisAla: 1.133 ± 0.032	0.215HisCys: 0.215 ± 0.014	0.889HisAsp: 0.889 ± 0.028	1.039HisGlu: 1.039 ± 0.033	1.122HisPhe: 1.122 ± 0.037	1.18HisGly: 1.18 ± 0.039	0.488HisHis: 0.488 ± 0.024	1.33HisIle: 1.33 ± 0.036	1.106HisLys: 1.106 ± 0.03	1.911HisLeu: 1.911 ± 0.049	0.35HisMet: 0.35 ± 0.021	0.942HisAsn: 0.942 ± 0.032	0.967HisPro: 0.967 ± 0.035	0.709HisGln: 0.709 ± 0.03	0.684HisArg: 0.684 ± 0.029	1.16HisSer: 1.16 ± 0.034	0.998HisThr: 0.998 ± 0.033	0.948HisVal: 0.948 ± 0.031	0.235HisTrp: 0.235 ± 0.015	0.83HisTyr: 0.83 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.064IleAla: 6.064 ± 0.087	0.78IleCys: 0.78 ± 0.03	4.571IleAsp: 4.571 ± 0.078	4.869IleGlu: 4.869 ± 0.08	3.095IlePhe: 3.095 ± 0.065	5.069IleGly: 5.069 ± 0.08	1.422IleHis: 1.422 ± 0.04	5.634IleIle: 5.634 ± 0.112	5.561IleLys: 5.561 ± 0.085	6.348IleLeu: 6.348 ± 0.092	1.523IleMet: 1.523 ± 0.048	4.494IleAsn: 4.494 ± 0.074	3.125IlePro: 3.125 ± 0.063	2.442IleGln: 2.442 ± 0.051	2.823IleArg: 2.823 ± 0.053	5.334IleSer: 5.334 ± 0.096	4.572IleThr: 4.572 ± 0.077	4.733IleVal: 4.733 ± 0.092	0.688IleTrp: 0.688 ± 0.027	2.577IleTyr: 2.577 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	5.497LysAla: 5.497 ± 0.09	0.378LysCys: 0.378 ± 0.018	4.025LysAsp: 4.025 ± 0.058	5.253LysGlu: 5.253 ± 0.087	2.95LysPhe: 2.95 ± 0.06	4.619LysGly: 4.619 ± 0.064	1.337LysHis: 1.337 ± 0.041	5.572LysIle: 5.572 ± 0.073	6.039LysLys: 6.039 ± 0.099	6.726LysLeu: 6.726 ± 0.09	2.108LysMet: 2.108 ± 0.051	4.675LysAsn: 4.675 ± 0.072	2.762LysPro: 2.762 ± 0.062	2.88LysGln: 2.88 ± 0.062	2.813LysArg: 2.813 ± 0.056	4.261LysSer: 4.261 ± 0.073	4.413LysThr: 4.413 ± 0.058	4.943LysVal: 4.943 ± 0.08	0.814LysTrp: 0.814 ± 0.033	2.968LysTyr: 2.968 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	6.694LeuAla: 6.694 ± 0.088	0.796LeuCys: 0.796 ± 0.033	4.472LeuAsp: 4.472 ± 0.081	5.099LeuGlu: 5.099 ± 0.087	4.798LeuPhe: 4.798 ± 0.074	6.087LeuGly: 6.087 ± 0.099	1.672LeuHis: 1.672 ± 0.043	7.012LeuIle: 7.012 ± 0.106	7.727LeuLys: 7.727 ± 0.097	9.205LeuLeu: 9.205 ± 0.126	2.33LeuMet: 2.33 ± 0.049	5.691LeuAsn: 5.691 ± 0.104	3.888LeuPro: 3.888 ± 0.064	3.409LeuGln: 3.409 ± 0.071	3.501LeuArg: 3.501 ± 0.063	6.867LeuSer: 6.867 ± 0.082	5.346LeuThr: 5.346 ± 0.073	5.558LeuVal: 5.558 ± 0.073	0.832LeuTrp: 0.832 ± 0.029	3.195LeuTyr: 3.195 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.828MetAla: 1.828 ± 0.052	0.134MetCys: 0.134 ± 0.011	1.238MetAsp: 1.238 ± 0.037	1.445MetGlu: 1.445 ± 0.039	0.913MetPhe: 0.913 ± 0.032	1.661MetGly: 1.661 ± 0.041	0.496MetHis: 0.496 ± 0.021	1.734MetIle: 1.734 ± 0.043	2.299MetLys: 2.299 ± 0.045	2.233MetLeu: 2.233 ± 0.053	0.665MetMet: 0.665 ± 0.025	1.5MetAsn: 1.5 ± 0.035	1.017MetPro: 1.017 ± 0.032	0.94MetGln: 0.94 ± 0.029	0.973MetArg: 0.973 ± 0.03	1.418MetSer: 1.418 ± 0.038	1.134MetThr: 1.134 ± 0.033	1.581MetVal: 1.581 ± 0.041	0.181MetTrp: 0.181 ± 0.013	0.7MetTyr: 0.7 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	4.137AsnAla: 4.137 ± 0.069	0.477AsnCys: 0.477 ± 0.027	3.028AsnAsp: 3.028 ± 0.067	3.43AsnGlu: 3.43 ± 0.06	2.892AsnPhe: 2.892 ± 0.055	3.874AsnGly: 3.874 ± 0.075	0.997AsnHis: 0.997 ± 0.031	4.117AsnIle: 4.117 ± 0.071	4.09AsnLys: 4.09 ± 0.075	5.125AsnLeu: 5.125 ± 0.088	1.284AsnMet: 1.284 ± 0.036	3.543AsnAsn: 3.543 ± 0.085	2.683AsnPro: 2.683 ± 0.065	2.053AsnGln: 2.053 ± 0.053	2.256AsnArg: 2.256 ± 0.048	3.628AsnSer: 3.628 ± 0.079	3.138AsnThr: 3.138 ± 0.072	3.51AsnVal: 3.51 ± 0.066	0.774AsnTrp: 0.774 ± 0.031	2.735AsnTyr: 2.735 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	2.755ProAla: 2.755 ± 0.061	0.306ProCys: 0.306 ± 0.018	2.288ProAsp: 2.288 ± 0.049	2.802ProGlu: 2.802 ± 0.053	1.977ProPhe: 1.977 ± 0.047	2.508ProGly: 2.508 ± 0.05	0.689ProHis: 0.689 ± 0.027	2.738ProIle: 2.738 ± 0.053	2.363ProLys: 2.363 ± 0.051	3.19ProLeu: 3.19 ± 0.055	0.779ProMet: 0.779 ± 0.032	2.026ProAsn: 2.026 ± 0.05	0.958ProPro: 0.958 ± 0.047	1.269ProGln: 1.269 ± 0.038	1.084ProArg: 1.084 ± 0.032	2.381ProSer: 2.381 ± 0.052	2.12ProThr: 2.12 ± 0.052	2.914ProVal: 2.914 ± 0.057	0.408ProTrp: 0.408 ± 0.019	1.523ProTyr: 1.523 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.397GlnAla: 2.397 ± 0.051	0.21GlnCys: 0.21 ± 0.015	1.487GlnAsp: 1.487 ± 0.04	1.987GlnGlu: 1.987 ± 0.047	1.786GlnPhe: 1.786 ± 0.043	2.022GlnGly: 2.022 ± 0.045	0.719GlnHis: 0.719 ± 0.024	2.522GlnIle: 2.522 ± 0.046	2.763GlnLys: 2.763 ± 0.057	3.954GlnLeu: 3.954 ± 0.072	0.936GlnMet: 0.936 ± 0.031	2.031GlnAsn: 2.031 ± 0.049	1.415GlnPro: 1.415 ± 0.033	1.736GlnGln: 1.736 ± 0.056	1.434GlnArg: 1.434 ± 0.042	2.21GlnSer: 2.21 ± 0.05	1.979GlnThr: 1.979 ± 0.042	2.187GlnVal: 2.187 ± 0.049	0.378GlnTrp: 0.378 ± 0.025	1.442GlnTyr: 1.442 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.211ArgAla: 2.211 ± 0.05	0.263ArgCys: 0.263 ± 0.016	1.69ArgAsp: 1.69 ± 0.036	2.345ArgGlu: 2.345 ± 0.059	2.056ArgPhe: 2.056 ± 0.049	2.109ArgGly: 2.109 ± 0.052	0.655ArgHis: 0.655 ± 0.026	3.166ArgIle: 3.166 ± 0.055	2.935ArgLys: 2.935 ± 0.061	3.586ArgLeu: 3.586 ± 0.067	1.072ArgMet: 1.072 ± 0.037	2.217ArgAsn: 2.217 ± 0.048	1.281ArgPro: 1.281 ± 0.039	1.258ArgGln: 1.258 ± 0.042	1.432ArgArg: 1.432 ± 0.042	2.208ArgSer: 2.208 ± 0.061	1.946ArgThr: 1.946 ± 0.046	2.29ArgVal: 2.29 ± 0.05	0.464ArgTrp: 0.464 ± 0.023	1.69ArgTyr: 1.69 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.574SerAla: 4.574 ± 0.079	0.658SerCys: 0.658 ± 0.029	3.173SerAsp: 3.173 ± 0.061	3.396SerGlu: 3.396 ± 0.061	3.846SerPhe: 3.846 ± 0.068	4.688SerGly: 4.688 ± 0.084	1.086SerHis: 1.086 ± 0.037	5.173SerIle: 5.173 ± 0.076	4.49SerLys: 4.49 ± 0.068	6.261SerLeu: 6.261 ± 0.078	1.479SerMet: 1.479 ± 0.041	3.523SerAsn: 3.523 ± 0.074	2.324SerPro: 2.324 ± 0.052	2.035SerGln: 2.035 ± 0.047	2.24SerArg: 2.24 ± 0.06	4.551SerSer: 4.551 ± 0.094	3.782SerThr: 3.782 ± 0.067	4.423SerVal: 4.423 ± 0.074	0.732SerTrp: 0.732 ± 0.031	2.706SerTyr: 2.706 ± 0.068	0.0SerXaa: 0.0 ± 0.0
Thr	4.246ThrAla: 4.246 ± 0.084	0.435ThrCys: 0.435 ± 0.025	3.134ThrAsp: 3.134 ± 0.058	3.201ThrGlu: 3.201 ± 0.063	2.704ThrPhe: 2.704 ± 0.049	4.375ThrGly: 4.375 ± 0.094	0.998ThrHis: 0.998 ± 0.029	4.593ThrIle: 4.593 ± 0.081	3.349ThrLys: 3.349 ± 0.06	5.213ThrLeu: 5.213 ± 0.075	1.096ThrMet: 1.096 ± 0.033	2.921ThrAsn: 2.921 ± 0.074	2.528ThrPro: 2.528 ± 0.054	1.869ThrGln: 1.869 ± 0.042	1.758ThrArg: 1.758 ± 0.044	3.564ThrSer: 3.564 ± 0.075	3.394ThrThr: 3.394 ± 0.073	3.928ThrVal: 3.928 ± 0.08	0.61ThrTrp: 0.61 ± 0.027	2.204ThrTyr: 2.204 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	4.587ValAla: 4.587 ± 0.082	0.636ValCys: 0.636 ± 0.027	3.508ValAsp: 3.508 ± 0.063	3.742ValGlu: 3.742 ± 0.062	3.466ValPhe: 3.466 ± 0.064	3.895ValGly: 3.895 ± 0.077	1.082ValHis: 1.082 ± 0.035	4.872ValIle: 4.872 ± 0.073	4.834ValLys: 4.834 ± 0.065	6.09ValLeu: 6.09 ± 0.083	1.551ValMet: 1.551 ± 0.044	3.824ValAsn: 3.824 ± 0.075	2.287ValPro: 2.287 ± 0.051	2.058ValGln: 2.058 ± 0.052	2.326ValArg: 2.326 ± 0.046	4.417ValSer: 4.417 ± 0.071	3.641ValThr: 3.641 ± 0.083	4.38ValVal: 4.38 ± 0.089	0.625ValTrp: 0.625 ± 0.025	2.453ValTyr: 2.453 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.769TrpAla: 0.769 ± 0.03	0.146TrpCys: 0.146 ± 0.011	0.597TrpAsp: 0.597 ± 0.023	0.621TrpGlu: 0.621 ± 0.029	0.57TrpPhe: 0.57 ± 0.028	0.776TrpGly: 0.776 ± 0.034	0.222TrpHis: 0.222 ± 0.016	0.738TrpIle: 0.738 ± 0.028	0.844TrpLys: 0.844 ± 0.031	1.058TrpLeu: 1.058 ± 0.034	0.348TrpMet: 0.348 ± 0.019	0.662TrpAsn: 0.662 ± 0.027	0.322TrpPro: 0.322 ± 0.022	0.466TrpGln: 0.466 ± 0.024	0.405TrpArg: 0.405 ± 0.023	0.629TrpSer: 0.629 ± 0.028	0.549TrpThr: 0.549 ± 0.026	0.671TrpVal: 0.671 ± 0.029	0.187TrpTrp: 0.187 ± 0.014	0.44TrpTyr: 0.44 ± 0.03	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.663TyrAla: 2.663 ± 0.059	0.374TyrCys: 0.374 ± 0.02	2.173TyrAsp: 2.173 ± 0.055	2.022TyrGlu: 2.022 ± 0.046	2.255TyrPhe: 2.255 ± 0.046	2.637TyrGly: 2.637 ± 0.054	0.755TyrHis: 0.755 ± 0.029	2.424TyrIle: 2.424 ± 0.056	2.882TyrLys: 2.882 ± 0.055	3.836TyrLeu: 3.836 ± 0.066	0.826TyrMet: 0.826 ± 0.036	2.534TyrAsn: 2.534 ± 0.062	1.595TyrPro: 1.595 ± 0.042	1.54TyrGln: 1.54 ± 0.043	1.65TyrArg: 1.65 ± 0.047	2.891TyrSer: 2.891 ± 0.063	2.3TyrThr: 2.3 ± 0.057	2.115TyrVal: 2.115 ± 0.052	0.486TyrTrp: 0.486 ± 0.02	1.813TyrTyr: 1.813 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2864 proteins (989305 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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