Amino acid dipepetide frequency for Tropicibacter phthalicicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.05AlaAla: 14.05 ± 0.143
1.097AlaCys: 1.097 ± 0.026
6.59AlaAsp: 6.59 ± 0.078
7.936AlaGlu: 7.936 ± 0.113
4.128AlaPhe: 4.128 ± 0.055
9.439AlaGly: 9.439 ± 0.097
2.247AlaHis: 2.247 ± 0.041
5.652AlaIle: 5.652 ± 0.056
4.615AlaLys: 4.615 ± 0.06
12.897AlaLeu: 12.897 ± 0.119
3.67AlaMet: 3.67 ± 0.056
2.904AlaAsn: 2.904 ± 0.047
5.198AlaPro: 5.198 ± 0.067
4.906AlaGln: 4.906 ± 0.063
7.363AlaArg: 7.363 ± 0.09
5.739AlaSer: 5.739 ± 0.067
5.438AlaThr: 5.438 ± 0.067
7.655AlaVal: 7.655 ± 0.099
1.39AlaTrp: 1.39 ± 0.033
2.501AlaTyr: 2.501 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.095CysAla: 1.095 ± 0.03
0.132CysCys: 0.132 ± 0.009
0.679CysAsp: 0.679 ± 0.021
0.509CysGlu: 0.509 ± 0.021
0.39CysPhe: 0.39 ± 0.016
0.957CysGly: 0.957 ± 0.028
0.306CysHis: 0.306 ± 0.018
0.428CysIle: 0.428 ± 0.019
0.285CysLys: 0.285 ± 0.014
0.954CysLeu: 0.954 ± 0.024
0.193CysMet: 0.193 ± 0.012
0.255CysAsn: 0.255 ± 0.014
0.53CysPro: 0.53 ± 0.019
0.312CysGln: 0.312 ± 0.016
0.502CysArg: 0.502 ± 0.017
0.54CysSer: 0.54 ± 0.02
0.462CysThr: 0.462 ± 0.02
0.641CysVal: 0.641 ± 0.021
0.125CysTrp: 0.125 ± 0.008
0.226CysTyr: 0.226 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.606AspAla: 6.606 ± 0.078
0.593AspCys: 0.593 ± 0.022
3.456AspAsp: 3.456 ± 0.082
3.63AspGlu: 3.63 ± 0.056
2.425AspPhe: 2.425 ± 0.044
5.602AspGly: 5.602 ± 0.087
1.464AspHis: 1.464 ± 0.036
3.231AspIle: 3.231 ± 0.052
2.101AspLys: 2.101 ± 0.047
6.703AspLeu: 6.703 ± 0.075
1.771AspMet: 1.771 ± 0.035
1.485AspAsn: 1.485 ± 0.035
3.521AspPro: 3.521 ± 0.056
2.29AspGln: 2.29 ± 0.038
3.839AspArg: 3.839 ± 0.053
2.421AspSer: 2.421 ± 0.05
3.115AspThr: 3.115 ± 0.068
4.391AspVal: 4.391 ± 0.053
1.216AspTrp: 1.216 ± 0.03
1.597AspTyr: 1.597 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
8.1GluAla: 8.1 ± 0.103
0.388GluCys: 0.388 ± 0.014
3.455GluAsp: 3.455 ± 0.055
3.958GluGlu: 3.958 ± 0.077
2.03GluPhe: 2.03 ± 0.039
4.609GluGly: 4.609 ± 0.067
1.203GluHis: 1.203 ± 0.031
3.974GluIle: 3.974 ± 0.049
2.43GluLys: 2.43 ± 0.049
5.701GluLeu: 5.701 ± 0.066
1.882GluMet: 1.882 ± 0.037
2.083GluAsn: 2.083 ± 0.033
2.52GluPro: 2.52 ± 0.046
2.337GluGln: 2.337 ± 0.039
3.958GluArg: 3.958 ± 0.065
2.302GluSer: 2.302 ± 0.042
4.138GluThr: 4.138 ± 0.057
4.319GluVal: 4.319 ± 0.054
0.728GluTrp: 0.728 ± 0.023
1.094GluTyr: 1.094 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.507PheAla: 4.507 ± 0.059
0.474PheCys: 0.474 ± 0.017
3.07PheAsp: 3.07 ± 0.05
2.485PheGlu: 2.485 ± 0.053
1.543PhePhe: 1.543 ± 0.035
3.803PheGly: 3.803 ± 0.057
0.808PheHis: 0.808 ± 0.023
1.639PheIle: 1.639 ± 0.038
1.124PheLys: 1.124 ± 0.024
3.686PheLeu: 3.686 ± 0.067
0.911PheMet: 0.911 ± 0.025
1.136PheAsn: 1.136 ± 0.026
1.605PhePro: 1.605 ± 0.037
1.223PheGln: 1.223 ± 0.03
2.021PheArg: 2.021 ± 0.04
2.333PheSer: 2.333 ± 0.042
2.067PheThr: 2.067 ± 0.037
2.764PheVal: 2.764 ± 0.04
0.627PheTrp: 0.627 ± 0.024
0.948PheTyr: 0.948 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
9.115GlyAla: 9.115 ± 0.095
0.907GlyCys: 0.907 ± 0.025
4.985GlyAsp: 4.985 ± 0.109
4.805GlyGlu: 4.805 ± 0.057
3.888GlyPhe: 3.888 ± 0.051
7.15GlyGly: 7.15 ± 0.114
1.93GlyHis: 1.93 ± 0.037
4.312GlyIle: 4.312 ± 0.061
3.398GlyLys: 3.398 ± 0.05
8.74GlyLeu: 8.74 ± 0.099
2.483GlyMet: 2.483 ± 0.041
2.378GlyAsn: 2.378 ± 0.056
3.341GlyPro: 3.341 ± 0.047
3.421GlyGln: 3.421 ± 0.047
4.896GlyArg: 4.896 ± 0.063
4.483GlySer: 4.483 ± 0.065
4.441GlyThr: 4.441 ± 0.076
6.222GlyVal: 6.222 ± 0.069
1.406GlyTrp: 1.406 ± 0.029
2.323GlyTyr: 2.323 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.15HisAla: 2.15 ± 0.044
0.241HisCys: 0.241 ± 0.012
1.241HisAsp: 1.241 ± 0.035
1.138HisGlu: 1.138 ± 0.025
0.885HisPhe: 0.885 ± 0.027
1.927HisGly: 1.927 ± 0.043
0.602HisHis: 0.602 ± 0.022
1.038HisIle: 1.038 ± 0.031
0.658HisLys: 0.658 ± 0.021
2.224HisLeu: 2.224 ± 0.046
0.626HisMet: 0.626 ± 0.02
0.531HisAsn: 0.531 ± 0.018
1.321HisPro: 1.321 ± 0.033
0.696HisGln: 0.696 ± 0.024
1.215HisArg: 1.215 ± 0.028
1.071HisSer: 1.071 ± 0.031
0.802HisThr: 0.802 ± 0.021
1.582HisVal: 1.582 ± 0.031
0.381HisTrp: 0.381 ± 0.018
0.601HisTyr: 0.601 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.648IleAla: 6.648 ± 0.07
0.653IleCys: 0.653 ± 0.022
3.418IleAsp: 3.418 ± 0.047
3.612IleGlu: 3.612 ± 0.052
1.831IlePhe: 1.831 ± 0.041
4.764IleGly: 4.764 ± 0.066
0.957IleHis: 0.957 ± 0.027
2.268IleIle: 2.268 ± 0.047
1.716IleLys: 1.716 ± 0.038
4.952IleLeu: 4.952 ± 0.059
1.154IleMet: 1.154 ± 0.033
1.522IleAsn: 1.522 ± 0.033
2.339IlePro: 2.339 ± 0.043
1.424IleGln: 1.424 ± 0.029
3.007IleArg: 3.007 ± 0.042
3.287IleSer: 3.287 ± 0.053
3.088IleThr: 3.088 ± 0.041
3.569IleVal: 3.569 ± 0.054
0.803IleTrp: 0.803 ± 0.026
1.195IleTyr: 1.195 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
4.37LysAla: 4.37 ± 0.066
0.228LysCys: 0.228 ± 0.012
2.115LysAsp: 2.115 ± 0.042
2.045LysGlu: 2.045 ± 0.043
1.111LysPhe: 1.111 ± 0.032
3.073LysGly: 3.073 ± 0.051
0.747LysHis: 0.747 ± 0.024
1.941LysIle: 1.941 ± 0.045
1.426LysLys: 1.426 ± 0.034
3.517LysLeu: 3.517 ± 0.05
1.008LysMet: 1.008 ± 0.03
0.94LysAsn: 0.94 ± 0.027
2.188LysPro: 2.188 ± 0.047
1.17LysGln: 1.17 ± 0.03
2.493LysArg: 2.493 ± 0.053
2.176LysSer: 2.176 ± 0.044
2.288LysThr: 2.288 ± 0.043
2.547LysVal: 2.547 ± 0.046
0.467LysTrp: 0.467 ± 0.02
0.7LysTyr: 0.7 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
12.065LeuAla: 12.065 ± 0.098
0.982LeuCys: 0.982 ± 0.028
6.037LeuAsp: 6.037 ± 0.075
5.548LeuGlu: 5.548 ± 0.068
3.754LeuPhe: 3.754 ± 0.06
8.318LeuGly: 8.318 ± 0.09
1.875LeuHis: 1.875 ± 0.036
5.331LeuIle: 5.331 ± 0.073
3.584LeuLys: 3.584 ± 0.057
8.675LeuLeu: 8.675 ± 0.101
2.634LeuMet: 2.634 ± 0.045
3.058LeuAsn: 3.058 ± 0.042
5.509LeuPro: 5.509 ± 0.067
3.237LeuGln: 3.237 ± 0.05
6.585LeuArg: 6.585 ± 0.085
7.098LeuSer: 7.098 ± 0.091
6.01LeuThr: 6.01 ± 0.069
6.71LeuVal: 6.71 ± 0.081
1.358LeuTrp: 1.358 ± 0.036
2.018LeuTyr: 2.018 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
3.377MetAla: 3.377 ± 0.049
0.228MetCys: 0.228 ± 0.012
1.45MetAsp: 1.45 ± 0.032
1.392MetGlu: 1.392 ± 0.037
0.91MetPhe: 0.91 ± 0.027
2.266MetGly: 2.266 ± 0.038
0.461MetHis: 0.461 ± 0.019
1.605MetIle: 1.605 ± 0.031
1.117MetLys: 1.117 ± 0.025
2.488MetLeu: 2.488 ± 0.045
0.817MetMet: 0.817 ± 0.027
0.816MetAsn: 0.816 ± 0.024
1.561MetPro: 1.561 ± 0.034
1.088MetGln: 1.088 ± 0.028
1.858MetArg: 1.858 ± 0.036
2.009MetSer: 2.009 ± 0.037
2.044MetThr: 2.044 ± 0.041
1.863MetVal: 1.863 ± 0.039
0.269MetTrp: 0.269 ± 0.013
0.392MetTyr: 0.392 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.31AsnAla: 3.31 ± 0.048
0.327AsnCys: 0.327 ± 0.013
1.702AsnAsp: 1.702 ± 0.047
1.332AsnGlu: 1.332 ± 0.029
1.113AsnPhe: 1.113 ± 0.031
2.696AsnGly: 2.696 ± 0.049
0.6AsnHis: 0.6 ± 0.025
1.482AsnIle: 1.482 ± 0.034
0.914AsnLys: 0.914 ± 0.027
2.847AsnLeu: 2.847 ± 0.041
0.783AsnMet: 0.783 ± 0.023
0.802AsnAsn: 0.802 ± 0.03
1.992AsnPro: 1.992 ± 0.04
0.893AsnGln: 0.893 ± 0.025
1.749AsnArg: 1.749 ± 0.032
1.41AsnSer: 1.41 ± 0.034
1.485AsnThr: 1.485 ± 0.035
1.915AsnVal: 1.915 ± 0.039
0.521AsnTrp: 0.521 ± 0.021
0.703AsnTyr: 0.703 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
4.953ProAla: 4.953 ± 0.065
0.401ProCys: 0.401 ± 0.019
3.851ProAsp: 3.851 ± 0.056
4.116ProGlu: 4.116 ± 0.057
1.969ProPhe: 1.969 ± 0.04
4.055ProGly: 4.055 ± 0.06
1.057ProHis: 1.057 ± 0.026
2.321ProIle: 2.321 ± 0.042
2.03ProLys: 2.03 ± 0.044
4.455ProLeu: 4.455 ± 0.058
1.305ProMet: 1.305 ± 0.033
1.507ProAsn: 1.507 ± 0.033
1.976ProPro: 1.976 ± 0.044
1.729ProGln: 1.729 ± 0.039
2.435ProArg: 2.435 ± 0.042
2.622ProSer: 2.622 ± 0.047
2.323ProThr: 2.323 ± 0.045
4.052ProVal: 4.052 ± 0.061
0.637ProTrp: 0.637 ± 0.021
1.145ProTyr: 1.145 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
4.404GlnAla: 4.404 ± 0.063
0.248GlnCys: 0.248 ± 0.014
2.166GlnAsp: 2.166 ± 0.041
2.034GlnGlu: 2.034 ± 0.042
1.249GlnPhe: 1.249 ± 0.031
2.853GlnGly: 2.853 ± 0.037
0.696GlnHis: 0.696 ± 0.021
2.298GlnIle: 2.298 ± 0.043
1.316GlnLys: 1.316 ± 0.03
3.231GlnLeu: 3.231 ± 0.05
1.148GlnMet: 1.148 ± 0.028
1.159GlnAsn: 1.159 ± 0.024
1.654GlnPro: 1.654 ± 0.035
1.242GlnGln: 1.242 ± 0.035
2.239GlnArg: 2.239 ± 0.046
2.186GlnSer: 2.186 ± 0.042
2.025GlnThr: 2.025 ± 0.041
2.688GlnVal: 2.688 ± 0.042
0.414GlnTrp: 0.414 ± 0.018
0.637GlnTyr: 0.637 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
6.936ArgAla: 6.936 ± 0.08
0.471ArgCys: 0.471 ± 0.019
3.981ArgAsp: 3.981 ± 0.051
3.593ArgGlu: 3.593 ± 0.052
2.647ArgPhe: 2.647 ± 0.045
4.032ArgGly: 4.032 ± 0.061
1.406ArgHis: 1.406 ± 0.035
3.342ArgIle: 3.342 ± 0.044
2.565ArgLys: 2.565 ± 0.046
6.602ArgLeu: 6.602 ± 0.082
1.821ArgMet: 1.821 ± 0.036
1.863ArgAsn: 1.863 ± 0.039
2.817ArgPro: 2.817 ± 0.043
2.322ArgGln: 2.322 ± 0.045
4.017ArgArg: 4.017 ± 0.067
3.141ArgSer: 3.141 ± 0.049
2.45ArgThr: 2.45 ± 0.047
4.308ArgVal: 4.308 ± 0.057
0.821ArgTrp: 0.821 ± 0.026
1.394ArgTyr: 1.394 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
5.928SerAla: 5.928 ± 0.068
0.551SerCys: 0.551 ± 0.018
3.726SerAsp: 3.726 ± 0.058
3.416SerGlu: 3.416 ± 0.053
2.469SerPhe: 2.469 ± 0.05
5.539SerGly: 5.539 ± 0.079
1.181SerHis: 1.181 ± 0.03
2.663SerIle: 2.663 ± 0.044
1.94SerLys: 1.94 ± 0.034
5.491SerLeu: 5.491 ± 0.069
1.483SerMet: 1.483 ± 0.033
1.604SerAsn: 1.604 ± 0.035
2.549SerPro: 2.549 ± 0.043
1.894SerGln: 1.894 ± 0.037
3.045SerArg: 3.045 ± 0.047
2.931SerSer: 2.931 ± 0.054
2.673SerThr: 2.673 ± 0.052
3.979SerVal: 3.979 ± 0.05
0.751SerTrp: 0.751 ± 0.022
1.438SerTyr: 1.438 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
5.838ThrAla: 5.838 ± 0.068
0.567ThrCys: 0.567 ± 0.021
2.959ThrAsp: 2.959 ± 0.053
2.954ThrGlu: 2.954 ± 0.048
1.952ThrPhe: 1.952 ± 0.039
5.251ThrGly: 5.251 ± 0.069
1.194ThrHis: 1.194 ± 0.033
2.765ThrIle: 2.765 ± 0.055
1.783ThrLys: 1.783 ± 0.033
6.023ThrLeu: 6.023 ± 0.065
1.305ThrMet: 1.305 ± 0.03
1.426ThrAsn: 1.426 ± 0.036
3.233ThrPro: 3.233 ± 0.052
1.87ThrGln: 1.87 ± 0.035
3.31ThrArg: 3.31 ± 0.059
2.813ThrSer: 2.813 ± 0.047
2.748ThrThr: 2.748 ± 0.054
3.979ThrVal: 3.979 ± 0.062
0.699ThrTrp: 0.699 ± 0.024
1.365ThrTyr: 1.365 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
8.162ValAla: 8.162 ± 0.091
0.632ValCys: 0.632 ± 0.022
4.187ValAsp: 4.187 ± 0.059
4.605ValGlu: 4.605 ± 0.061
2.942ValPhe: 2.942 ± 0.046
5.058ValGly: 5.058 ± 0.062
1.288ValHis: 1.288 ± 0.03
4.243ValIle: 4.243 ± 0.053
2.389ValLys: 2.389 ± 0.048
7.286ValLeu: 7.286 ± 0.075
2.142ValMet: 2.142 ± 0.041
2.061ValAsn: 2.061 ± 0.037
3.329ValPro: 3.329 ± 0.042
2.366ValGln: 2.366 ± 0.041
3.575ValArg: 3.575 ± 0.051
4.553ValSer: 4.553 ± 0.057
4.606ValThr: 4.606 ± 0.077
5.312ValVal: 5.312 ± 0.07
0.925ValTrp: 0.925 ± 0.028
1.378ValTyr: 1.378 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.36TrpAla: 1.36 ± 0.033
0.143TrpCys: 0.143 ± 0.009
0.802TrpAsp: 0.802 ± 0.024
0.685TrpGlu: 0.685 ± 0.02
0.564TrpPhe: 0.564 ± 0.02
1.044TrpGly: 1.044 ± 0.026
0.376TrpHis: 0.376 ± 0.018
0.738TrpIle: 0.738 ± 0.023
0.479TrpLys: 0.479 ± 0.022
1.605TrpLeu: 1.605 ± 0.039
0.396TrpMet: 0.396 ± 0.016
0.43TrpAsn: 0.43 ± 0.02
0.708TrpPro: 0.708 ± 0.024
0.706TrpGln: 0.706 ± 0.025
0.999TrpArg: 0.999 ± 0.028
0.866TrpSer: 0.866 ± 0.026
0.726TrpThr: 0.726 ± 0.024
0.992TrpVal: 0.992 ± 0.027
0.209TrpTrp: 0.209 ± 0.013
0.289TrpTyr: 0.289 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.437TyrAla: 2.437 ± 0.046
0.259TyrCys: 0.259 ± 0.013
1.586TyrAsp: 1.586 ± 0.042
1.417TyrGlu: 1.417 ± 0.034
0.975TyrPhe: 0.975 ± 0.026
2.188TyrGly: 2.188 ± 0.038
0.531TyrHis: 0.531 ± 0.02
0.939TyrIle: 0.939 ± 0.026
0.68TyrLys: 0.68 ± 0.023
2.307TyrLeu: 2.307 ± 0.043
0.478TyrMet: 0.478 ± 0.019
0.616TyrAsn: 0.616 ± 0.02
1.046TyrPro: 1.046 ± 0.026
0.759TyrGln: 0.759 ± 0.024
1.422TyrArg: 1.422 ± 0.033
1.271TyrSer: 1.271 ± 0.03
1.108TyrThr: 1.108 ± 0.031
1.552TyrVal: 1.552 ± 0.036
0.373TyrTrp: 0.373 ± 0.017
0.598TyrTyr: 0.598 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4708 proteins (1437188 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski