Amino acid dipepetide frequency for Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.867AlaAla: 21.867 ± 0.163	1.073AlaCys: 1.073 ± 0.021	8.6AlaAsp: 8.6 ± 0.066	8.804AlaGlu: 8.804 ± 0.088	3.483AlaPhe: 3.483 ± 0.041	13.559AlaGly: 13.559 ± 0.092	2.988AlaHis: 2.988 ± 0.035	3.097AlaIle: 3.097 ± 0.038	2.696AlaLys: 2.696 ± 0.043	14.618AlaLeu: 14.618 ± 0.097	2.427AlaMet: 2.427 ± 0.031	1.845AlaAsn: 1.845 ± 0.034	7.529AlaPro: 7.529 ± 0.081	3.653AlaGln: 3.653 ± 0.036	10.988AlaArg: 10.988 ± 0.091	5.926AlaSer: 5.926 ± 0.053	7.071AlaThr: 7.071 ± 0.052	12.582AlaVal: 12.582 ± 0.091	1.879AlaTrp: 1.879 ± 0.029	2.734AlaTyr: 2.734 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.107CysAla: 1.107 ± 0.02	0.092CysCys: 0.092 ± 0.007	0.466CysAsp: 0.466 ± 0.014	0.387CysGlu: 0.387 ± 0.013	0.213CysPhe: 0.213 ± 0.009	0.947CysGly: 0.947 ± 0.019	0.194CysHis: 0.194 ± 0.009	0.147CysIle: 0.147 ± 0.008	0.098CysLys: 0.098 ± 0.007	0.726CysLeu: 0.726 ± 0.019	0.125CysMet: 0.125 ± 0.007	0.142CysAsn: 0.142 ± 0.008	0.505CysPro: 0.505 ± 0.016	0.156CysGln: 0.156 ± 0.008	0.612CysArg: 0.612 ± 0.016	0.44CysSer: 0.44 ± 0.013	0.504CysThr: 0.504 ± 0.015	0.657CysVal: 0.657 ± 0.017	0.13CysTrp: 0.13 ± 0.007	0.14CysTyr: 0.14 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.128AspAla: 8.128 ± 0.068	0.443AspCys: 0.443 ± 0.013	3.841AspAsp: 3.841 ± 0.045	3.896AspGlu: 3.896 ± 0.037	1.648AspPhe: 1.648 ± 0.026	6.855AspGly: 6.855 ± 0.068	1.483AspHis: 1.483 ± 0.026	1.752AspIle: 1.752 ± 0.028	1.169AspLys: 1.169 ± 0.02	6.188AspLeu: 6.188 ± 0.053	0.843AspMet: 0.843 ± 0.018	0.943AspAsn: 0.943 ± 0.021	4.518AspPro: 4.518 ± 0.052	1.511AspGln: 1.511 ± 0.029	5.218AspArg: 5.218 ± 0.049	2.516AspSer: 2.516 ± 0.031	3.402AspThr: 3.402 ± 0.037	4.894AspVal: 4.894 ± 0.041	1.081AspTrp: 1.081 ± 0.02	1.109AspTyr: 1.109 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.508GluAla: 7.508 ± 0.07	0.349GluCys: 0.349 ± 0.012	2.981GluAsp: 2.981 ± 0.036	3.58GluGlu: 3.58 ± 0.046	1.358GluPhe: 1.358 ± 0.024	4.497GluGly: 4.497 ± 0.043	1.579GluHis: 1.579 ± 0.025	2.131GluIle: 2.131 ± 0.029	1.394GluLys: 1.394 ± 0.026	6.538GluLeu: 6.538 ± 0.06	0.866GluMet: 0.866 ± 0.02	1.005GluAsn: 1.005 ± 0.02	3.484GluPro: 3.484 ± 0.043	2.192GluGln: 2.192 ± 0.033	5.683GluArg: 5.683 ± 0.058	2.543GluSer: 2.543 ± 0.034	2.899GluThr: 2.899 ± 0.036	4.476GluVal: 4.476 ± 0.048	0.767GluTrp: 0.767 ± 0.019	1.136GluTyr: 1.136 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.603PheAla: 3.603 ± 0.041	0.256PheCys: 0.256 ± 0.009	1.923PheAsp: 1.923 ± 0.031	1.399PheGlu: 1.399 ± 0.027	0.85PhePhe: 0.85 ± 0.021	2.928PheGly: 2.928 ± 0.039	0.609PheHis: 0.609 ± 0.015	0.578PheIle: 0.578 ± 0.015	0.492PheLys: 0.492 ± 0.013	2.521PheLeu: 2.521 ± 0.036	0.388PheMet: 0.388 ± 0.015	0.525PheAsn: 0.525 ± 0.015	1.359PhePro: 1.359 ± 0.023	0.65PheGln: 0.65 ± 0.017	1.831PheArg: 1.831 ± 0.03	1.35PheSer: 1.35 ± 0.023	1.962PheThr: 1.962 ± 0.031	2.254PheVal: 2.254 ± 0.029	0.395PheTrp: 0.395 ± 0.013	0.549PheTyr: 0.549 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	11.609GlyAla: 11.609 ± 0.083	0.836GlyCys: 0.836 ± 0.018	5.53GlyAsp: 5.53 ± 0.051	5.232GlyGlu: 5.232 ± 0.051	2.801GlyPhe: 2.801 ± 0.033	9.254GlyGly: 9.254 ± 0.087	2.407GlyHis: 2.407 ± 0.032	3.286GlyIle: 3.286 ± 0.038	2.302GlyLys: 2.302 ± 0.031	9.397GlyLeu: 9.397 ± 0.066	1.946GlyMet: 1.946 ± 0.027	1.728GlyAsn: 1.728 ± 0.035	5.539GlyPro: 5.539 ± 0.056	2.663GlyGln: 2.663 ± 0.044	8.228GlyArg: 8.228 ± 0.063	5.345GlySer: 5.345 ± 0.058	6.662GlyThr: 6.662 ± 0.066	7.561GlyVal: 7.561 ± 0.058	1.73GlyTrp: 1.73 ± 0.028	2.162GlyTyr: 2.162 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.793HisAla: 2.793 ± 0.035	0.201HisCys: 0.201 ± 0.009	1.455HisAsp: 1.455 ± 0.025	1.239HisGlu: 1.239 ± 0.025	0.65HisPhe: 0.65 ± 0.018	2.496HisGly: 2.496 ± 0.027	0.707HisHis: 0.707 ± 0.018	0.624HisIle: 0.624 ± 0.015	0.342HisLys: 0.342 ± 0.011	2.444HisLeu: 2.444 ± 0.03	0.355HisMet: 0.355 ± 0.012	0.359HisAsn: 0.359 ± 0.01	1.835HisPro: 1.835 ± 0.032	0.645HisGln: 0.645 ± 0.017	2.26HisArg: 2.26 ± 0.028	1.029HisSer: 1.029 ± 0.02	1.38HisThr: 1.38 ± 0.024	1.769HisVal: 1.769 ± 0.03	0.391HisTrp: 0.391 ± 0.013	0.486HisTyr: 0.486 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.283IleAla: 4.283 ± 0.045	0.246IleCys: 0.246 ± 0.011	2.018IleAsp: 2.018 ± 0.028	1.778IleGlu: 1.778 ± 0.027	0.643IlePhe: 0.643 ± 0.019	3.268IleGly: 3.268 ± 0.043	0.564IleHis: 0.564 ± 0.014	0.74IleIle: 0.74 ± 0.019	0.658IleLys: 0.658 ± 0.019	2.245IleLeu: 2.245 ± 0.029	0.422IleMet: 0.422 ± 0.014	0.644IleAsn: 0.644 ± 0.017	1.588IlePro: 1.588 ± 0.026	0.649IleGln: 0.649 ± 0.018	2.058IleArg: 2.058 ± 0.029	1.464IleSer: 1.464 ± 0.027	2.079IleThr: 2.079 ± 0.032	2.526IleVal: 2.526 ± 0.035	0.345IleTrp: 0.345 ± 0.011	0.459IleTyr: 0.459 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.804LysAla: 2.804 ± 0.039	0.11LysCys: 0.11 ± 0.007	1.341LysAsp: 1.341 ± 0.025	1.184LysGlu: 1.184 ± 0.027	0.425LysPhe: 0.425 ± 0.012	1.771LysGly: 1.771 ± 0.031	0.404LysHis: 0.404 ± 0.014	0.744LysIle: 0.744 ± 0.02	0.862LysLys: 0.862 ± 0.024	1.859LysLeu: 1.859 ± 0.03	0.364LysMet: 0.364 ± 0.012	0.505LysAsn: 0.505 ± 0.016	1.236LysPro: 1.236 ± 0.026	0.698LysGln: 0.698 ± 0.019	1.418LysArg: 1.418 ± 0.026	1.099LysSer: 1.099 ± 0.023	1.233LysThr: 1.233 ± 0.026	1.78LysVal: 1.78 ± 0.03	0.26LysTrp: 0.26 ± 0.011	0.454LysTyr: 0.454 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.078LeuAla: 15.078 ± 0.102	0.836LeuCys: 0.836 ± 0.017	6.791LeuAsp: 6.791 ± 0.059	4.592LeuGlu: 4.592 ± 0.044	2.536LeuPhe: 2.536 ± 0.037	9.197LeuGly: 9.197 ± 0.069	2.292LeuHis: 2.292 ± 0.033	2.988LeuIle: 2.988 ± 0.035	1.968LeuLys: 1.968 ± 0.032	11.322LeuLeu: 11.322 ± 0.095	1.596LeuMet: 1.596 ± 0.027	1.596LeuAsn: 1.596 ± 0.024	6.492LeuPro: 6.492 ± 0.061	2.03LeuGln: 2.03 ± 0.027	8.73LeuArg: 8.73 ± 0.066	5.184LeuSer: 5.184 ± 0.055	6.91LeuThr: 6.91 ± 0.06	8.901LeuVal: 8.901 ± 0.063	1.294LeuTrp: 1.294 ± 0.022	1.855LeuTyr: 1.855 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.17MetAla: 2.17 ± 0.031	0.141MetCys: 0.141 ± 0.007	0.844MetAsp: 0.844 ± 0.019	0.732MetGlu: 0.732 ± 0.015	0.445MetPhe: 0.445 ± 0.014	1.28MetGly: 1.28 ± 0.025	0.349MetHis: 0.349 ± 0.012	0.612MetIle: 0.612 ± 0.015	0.42MetLys: 0.42 ± 0.016	1.598MetLeu: 1.598 ± 0.024	0.287MetMet: 0.287 ± 0.011	0.427MetAsn: 0.427 ± 0.012	1.14MetPro: 1.14 ± 0.023	0.416MetGln: 0.416 ± 0.013	1.44MetArg: 1.44 ± 0.024	1.336MetSer: 1.336 ± 0.023	1.576MetThr: 1.576 ± 0.022	1.227MetVal: 1.227 ± 0.023	0.222MetTrp: 0.222 ± 0.009	0.322MetTyr: 0.322 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.15AsnAla: 2.15 ± 0.032	0.154AsnCys: 0.154 ± 0.009	0.958AsnAsp: 0.958 ± 0.021	0.785AsnGlu: 0.785 ± 0.015	0.443AsnPhe: 0.443 ± 0.013	1.83AsnGly: 1.83 ± 0.033	0.406AsnHis: 0.406 ± 0.013	0.592AsnIle: 0.592 ± 0.017	0.407AsnLys: 0.407 ± 0.013	1.583AsnLeu: 1.583 ± 0.027	0.272AsnMet: 0.272 ± 0.01	0.396AsnAsn: 0.396 ± 0.014	1.276AsnPro: 1.276 ± 0.024	0.484AsnGln: 0.484 ± 0.013	1.281AsnArg: 1.281 ± 0.023	0.893AsnSer: 0.893 ± 0.02	1.083AsnThr: 1.083 ± 0.027	1.321AsnVal: 1.321 ± 0.029	0.285AsnTrp: 0.285 ± 0.012	0.393AsnTyr: 0.393 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	9.123ProAla: 9.123 ± 0.084	0.368ProCys: 0.368 ± 0.013	4.737ProAsp: 4.737 ± 0.047	4.398ProGlu: 4.398 ± 0.043	1.521ProPhe: 1.521 ± 0.024	7.064ProGly: 7.064 ± 0.069	1.472ProHis: 1.472 ± 0.024	1.109ProIle: 1.109 ± 0.02	1.089ProLys: 1.089 ± 0.023	5.343ProLeu: 5.343 ± 0.049	1.018ProMet: 1.018 ± 0.022	0.85ProAsn: 0.85 ± 0.019	3.722ProPro: 3.722 ± 0.063	1.618ProGln: 1.618 ± 0.034	4.251ProArg: 4.251 ± 0.044	3.268ProSer: 3.268 ± 0.047	3.2ProThr: 3.2 ± 0.043	5.584ProVal: 5.584 ± 0.047	0.894ProTrp: 0.894 ± 0.023	1.401ProTyr: 1.401 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.534GlnAla: 3.534 ± 0.044	0.17GlnCys: 0.17 ± 0.009	1.419GlnAsp: 1.419 ± 0.025	1.467GlnGlu: 1.467 ± 0.024	0.614GlnPhe: 0.614 ± 0.017	2.246GlnGly: 2.246 ± 0.034	0.641GlnHis: 0.641 ± 0.017	0.969GlnIle: 0.969 ± 0.022	0.591GlnLys: 0.591 ± 0.017	2.788GlnLeu: 2.788 ± 0.034	0.462GlnMet: 0.462 ± 0.014	0.481GlnAsn: 0.481 ± 0.014	1.665GlnPro: 1.665 ± 0.037	1.165GlnGln: 1.165 ± 0.031	2.314GlnArg: 2.314 ± 0.037	1.275GlnSer: 1.275 ± 0.024	1.326GlnThr: 1.326 ± 0.025	2.306GlnVal: 2.306 ± 0.027	0.461GlnTrp: 0.461 ± 0.014	0.612GlnTyr: 0.612 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.496ArgAla: 10.496 ± 0.08	0.601ArgCys: 0.601 ± 0.017	4.487ArgAsp: 4.487 ± 0.047	4.986ArgGlu: 4.986 ± 0.05	2.267ArgPhe: 2.267 ± 0.029	6.115ArgGly: 6.115 ± 0.052	2.297ArgHis: 2.297 ± 0.027	3.012ArgIle: 3.012 ± 0.034	1.604ArgLys: 1.604 ± 0.026	9.164ArgLeu: 9.164 ± 0.07	1.779ArgMet: 1.779 ± 0.027	1.315ArgAsn: 1.315 ± 0.025	5.451ArgPro: 5.451 ± 0.052	2.283ArgGln: 2.283 ± 0.036	8.419ArgArg: 8.419 ± 0.075	4.162ArgSer: 4.162 ± 0.041	5.738ArgThr: 5.738 ± 0.05	6.26ArgVal: 6.26 ± 0.055	1.408ArgTrp: 1.408 ± 0.025	1.773ArgTyr: 1.773 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.762SerAla: 6.762 ± 0.065	0.382SerCys: 0.382 ± 0.014	2.718SerAsp: 2.718 ± 0.034	2.343SerGlu: 2.343 ± 0.031	1.471SerPhe: 1.471 ± 0.023	5.948SerGly: 5.948 ± 0.059	1.029SerHis: 1.029 ± 0.02	1.277SerIle: 1.277 ± 0.025	0.967SerLys: 0.967 ± 0.023	4.728SerLeu: 4.728 ± 0.051	1.02SerMet: 1.02 ± 0.022	0.835SerAsn: 0.835 ± 0.019	3.214SerPro: 3.214 ± 0.041	1.186SerGln: 1.186 ± 0.021	3.848SerArg: 3.848 ± 0.039	2.744SerSer: 2.744 ± 0.045	3.027SerThr: 3.027 ± 0.038	4.304SerVal: 4.304 ± 0.04	0.864SerTrp: 0.864 ± 0.019	1.185SerTyr: 1.185 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	9.066ThrAla: 9.066 ± 0.065	0.447ThrCys: 0.447 ± 0.015	3.894ThrAsp: 3.894 ± 0.046	3.385ThrGlu: 3.385 ± 0.043	1.569ThrPhe: 1.569 ± 0.028	7.044ThrGly: 7.044 ± 0.065	1.237ThrHis: 1.237 ± 0.022	1.484ThrIle: 1.484 ± 0.029	1.116ThrLys: 1.116 ± 0.025	5.688ThrLeu: 5.688 ± 0.058	0.927ThrMet: 0.927 ± 0.019	0.97ThrAsn: 0.97 ± 0.021	4.168ThrPro: 4.168 ± 0.044	1.29ThrGln: 1.29 ± 0.025	4.155ThrArg: 4.155 ± 0.041	3.117ThrSer: 3.117 ± 0.042	3.787ThrThr: 3.787 ± 0.052	6.15ThrVal: 6.15 ± 0.061	0.926ThrTrp: 0.926 ± 0.021	1.356ThrTyr: 1.356 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.859ValAla: 10.859 ± 0.083	0.748ValCys: 0.748 ± 0.016	5.023ValAsp: 5.023 ± 0.046	4.746ValGlu: 4.746 ± 0.043	2.363ValPhe: 2.363 ± 0.032	6.598ValGly: 6.598 ± 0.055	2.028ValHis: 2.028 ± 0.029	2.583ValIle: 2.583 ± 0.038	1.661ValLys: 1.661 ± 0.029	9.634ValLeu: 9.634 ± 0.071	1.369ValMet: 1.369 ± 0.027	1.619ValAsn: 1.619 ± 0.028	5.484ValPro: 5.484 ± 0.047	2.027ValGln: 2.027 ± 0.032	7.657ValArg: 7.657 ± 0.066	4.263ValSer: 4.263 ± 0.042	5.714ValThr: 5.714 ± 0.05	8.226ValVal: 8.226 ± 0.07	1.178ValTrp: 1.178 ± 0.024	1.586ValTyr: 1.586 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.702TrpAla: 1.702 ± 0.027	0.159TrpCys: 0.159 ± 0.008	0.861TrpAsp: 0.861 ± 0.02	0.767TrpGlu: 0.767 ± 0.017	0.493TrpPhe: 0.493 ± 0.014	1.045TrpGly: 1.045 ± 0.021	0.391TrpHis: 0.391 ± 0.013	0.523TrpIle: 0.523 ± 0.015	0.357TrpLys: 0.357 ± 0.012	1.739TrpLeu: 1.739 ± 0.026	0.271TrpMet: 0.271 ± 0.01	0.422TrpAsn: 0.422 ± 0.015	0.796TrpPro: 0.796 ± 0.018	0.624TrpGln: 0.624 ± 0.015	1.372TrpArg: 1.372 ± 0.026	0.971TrpSer: 0.971 ± 0.018	1.053TrpThr: 1.053 ± 0.023	0.953TrpVal: 0.953 ± 0.02	0.34TrpTrp: 0.34 ± 0.014	0.365TrpTyr: 0.365 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.774TyrAla: 2.774 ± 0.029	0.173TyrCys: 0.173 ± 0.008	1.551TyrAsp: 1.551 ± 0.03	1.264TyrGlu: 1.264 ± 0.024	0.632TyrPhe: 0.632 ± 0.016	2.278TyrGly: 2.278 ± 0.033	0.385TyrHis: 0.385 ± 0.012	0.43TyrIle: 0.43 ± 0.013	0.361TyrLys: 0.361 ± 0.012	2.066TyrLeu: 2.066 ± 0.033	0.245TyrMet: 0.245 ± 0.01	0.382TyrAsn: 0.382 ± 0.012	1.032TyrPro: 1.032 ± 0.022	0.564TyrGln: 0.564 ± 0.016	1.854TyrArg: 1.854 ± 0.028	0.928TyrSer: 0.928 ± 0.02	1.172TyrThr: 1.172 ± 0.023	1.633TyrVal: 1.633 ± 0.024	0.354TyrTrp: 0.354 ± 0.013	0.467TyrTyr: 0.467 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8039 proteins (2629592 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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