Amino acid dipepetide frequency for Brevibacillus panacihumi W25

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.001AlaAla: 8.001 ± 0.091	0.777AlaCys: 0.777 ± 0.021	4.181AlaAsp: 4.181 ± 0.052	5.767AlaGlu: 5.767 ± 0.072	3.353AlaPhe: 3.353 ± 0.043	6.476AlaGly: 6.476 ± 0.068	1.559AlaHis: 1.559 ± 0.035	5.874AlaIle: 5.874 ± 0.072	4.727AlaLys: 4.727 ± 0.064	8.245AlaLeu: 8.245 ± 0.076	2.467AlaMet: 2.467 ± 0.037	2.661AlaAsn: 2.661 ± 0.043	2.717AlaPro: 2.717 ± 0.048	3.194AlaGln: 3.194 ± 0.048	3.879AlaArg: 3.879 ± 0.054	4.797AlaSer: 4.797 ± 0.06	4.018AlaThr: 4.018 ± 0.057	6.353AlaVal: 6.353 ± 0.082	0.871AlaTrp: 0.871 ± 0.025	2.625AlaTyr: 2.625 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.507CysAla: 0.507 ± 0.019	0.115CysCys: 0.115 ± 0.009	0.424CysAsp: 0.424 ± 0.016	0.473CysGlu: 0.473 ± 0.02	0.33CysPhe: 0.33 ± 0.015	0.754CysGly: 0.754 ± 0.024	0.201CysHis: 0.201 ± 0.012	0.499CysIle: 0.499 ± 0.019	0.361CysLys: 0.361 ± 0.016	0.805CysLeu: 0.805 ± 0.024	0.218CysMet: 0.218 ± 0.011	0.265CysAsn: 0.265 ± 0.015	0.386CysPro: 0.386 ± 0.016	0.301CysGln: 0.301 ± 0.014	0.466CysArg: 0.466 ± 0.02	0.557CysSer: 0.557 ± 0.02	0.405CysThr: 0.405 ± 0.017	0.49CysVal: 0.49 ± 0.016	0.087CysTrp: 0.087 ± 0.008	0.273CysTyr: 0.273 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.764AspAla: 3.764 ± 0.055	0.37AspCys: 0.37 ± 0.018	2.198AspAsp: 2.198 ± 0.043	4.058AspGlu: 4.058 ± 0.058	2.106AspPhe: 2.106 ± 0.036	3.513AspGly: 3.513 ± 0.051	1.148AspHis: 1.148 ± 0.029	3.054AspIle: 3.054 ± 0.052	2.52AspLys: 2.52 ± 0.049	4.976AspLeu: 4.976 ± 0.053	1.336AspMet: 1.336 ± 0.028	1.375AspAsn: 1.375 ± 0.031	2.371AspPro: 2.371 ± 0.04	2.213AspGln: 2.213 ± 0.041	2.739AspArg: 2.739 ± 0.042	2.436AspSer: 2.436 ± 0.042	2.306AspThr: 2.306 ± 0.039	3.847AspVal: 3.847 ± 0.054	0.752AspTrp: 0.752 ± 0.023	1.716AspTyr: 1.716 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.285GluAla: 6.285 ± 0.079	0.408GluCys: 0.408 ± 0.018	3.209GluAsp: 3.209 ± 0.045	6.536GluGlu: 6.536 ± 0.082	2.03GluPhe: 2.03 ± 0.038	4.404GluGly: 4.404 ± 0.052	1.531GluHis: 1.531 ± 0.035	4.745GluIle: 4.745 ± 0.062	5.15GluLys: 5.15 ± 0.072	7.087GluLeu: 7.087 ± 0.074	2.389GluMet: 2.389 ± 0.038	2.562GluAsn: 2.562 ± 0.041	2.328GluPro: 2.328 ± 0.036	3.988GluGln: 3.988 ± 0.06	4.488GluArg: 4.488 ± 0.067	3.428GluSer: 3.428 ± 0.05	3.416GluThr: 3.416 ± 0.053	5.156GluVal: 5.156 ± 0.059	1.049GluTrp: 1.049 ± 0.025	1.932GluTyr: 1.932 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.531PheAla: 3.531 ± 0.046	0.415PheCys: 0.415 ± 0.016	2.088PheAsp: 2.088 ± 0.04	2.239PheGlu: 2.239 ± 0.035	2.033PhePhe: 2.033 ± 0.046	3.185PheGly: 3.185 ± 0.048	1.02PheHis: 1.02 ± 0.029	2.532PheIle: 2.532 ± 0.044	1.426PheLys: 1.426 ± 0.035	4.566PheLeu: 4.566 ± 0.074	0.967PheMet: 0.967 ± 0.027	1.188PheAsn: 1.188 ± 0.03	1.689PhePro: 1.689 ± 0.032	1.588PheGln: 1.588 ± 0.035	1.965PheArg: 1.965 ± 0.038	2.893PheSer: 2.893 ± 0.041	2.398PheThr: 2.398 ± 0.039	3.063PheVal: 3.063 ± 0.058	0.532PheTrp: 0.532 ± 0.024	1.327PheTyr: 1.327 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	5.259GlyAla: 5.259 ± 0.061	0.724GlyCys: 0.724 ± 0.023	3.192GlyAsp: 3.192 ± 0.048	4.816GlyGlu: 4.816 ± 0.057	3.145GlyPhe: 3.145 ± 0.051	5.214GlyGly: 5.214 ± 0.074	1.468GlyHis: 1.468 ± 0.036	5.664GlyIle: 5.664 ± 0.073	4.753GlyLys: 4.753 ± 0.062	7.003GlyLeu: 7.003 ± 0.082	2.505GlyMet: 2.505 ± 0.047	2.516GlyAsn: 2.516 ± 0.05	1.886GlyPro: 1.886 ± 0.037	2.585GlyGln: 2.585 ± 0.043	3.419GlyArg: 3.419 ± 0.052	4.212GlySer: 4.212 ± 0.059	4.247GlyThr: 4.247 ± 0.063	5.578GlyVal: 5.578 ± 0.064	1.034GlyTrp: 1.034 ± 0.032	2.797GlyTyr: 2.797 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	1.756HisAla: 1.756 ± 0.037	0.206HisCys: 0.206 ± 0.012	1.109HisAsp: 1.109 ± 0.027	1.403HisGlu: 1.403 ± 0.032	1.056HisPhe: 1.056 ± 0.025	1.502HisGly: 1.502 ± 0.034	0.631HisHis: 0.631 ± 0.022	1.335HisIle: 1.335 ± 0.031	0.831HisLys: 0.831 ± 0.023	2.407HisLeu: 2.407 ± 0.038	0.571HisMet: 0.571 ± 0.019	0.62HisAsn: 0.62 ± 0.022	1.33HisPro: 1.33 ± 0.035	0.99HisGln: 0.99 ± 0.027	1.119HisArg: 1.119 ± 0.025	1.231HisSer: 1.231 ± 0.029	1.165HisThr: 1.165 ± 0.028	1.7HisVal: 1.7 ± 0.031	0.282HisTrp: 0.282 ± 0.014	0.785HisTyr: 0.785 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.238IleAla: 6.238 ± 0.07	0.69IleCys: 0.69 ± 0.023	3.414IleAsp: 3.414 ± 0.05	4.394IleGlu: 4.394 ± 0.059	2.411IlePhe: 2.411 ± 0.042	5.369IleGly: 5.369 ± 0.07	1.557IleHis: 1.557 ± 0.031	3.797IleIle: 3.797 ± 0.06	2.894IleLys: 2.894 ± 0.048	6.452IleLeu: 6.452 ± 0.086	1.654IleMet: 1.654 ± 0.034	2.201IleAsn: 2.201 ± 0.038	3.318IlePro: 3.318 ± 0.044	2.643IleGln: 2.643 ± 0.046	3.739IleArg: 3.739 ± 0.057	4.21IleSer: 4.21 ± 0.056	3.642IleThr: 3.642 ± 0.045	5.173IleVal: 5.173 ± 0.063	0.719IleTrp: 0.719 ± 0.02	1.87IleTyr: 1.87 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.36LysAla: 4.36 ± 0.069	0.248LysCys: 0.248 ± 0.013	2.62LysAsp: 2.62 ± 0.047	4.911LysGlu: 4.911 ± 0.068	1.333LysPhe: 1.333 ± 0.032	3.751LysGly: 3.751 ± 0.054	1.165LysHis: 1.165 ± 0.026	3.248LysIle: 3.248 ± 0.052	3.957LysLys: 3.957 ± 0.062	5.061LysLeu: 5.061 ± 0.064	1.837LysMet: 1.837 ± 0.037	2.033LysAsn: 2.033 ± 0.046	2.283LysPro: 2.283 ± 0.038	2.802LysGln: 2.802 ± 0.052	3.311LysArg: 3.311 ± 0.046	2.881LysSer: 2.881 ± 0.046	2.964LysThr: 2.964 ± 0.04	3.739LysVal: 3.739 ± 0.06	0.805LysTrp: 0.805 ± 0.022	1.517LysTyr: 1.517 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	9.016LeuAla: 9.016 ± 0.086	0.809LeuCys: 0.809 ± 0.02	5.137LeuAsp: 5.137 ± 0.059	6.758LeuGlu: 6.758 ± 0.075	4.726LeuPhe: 4.726 ± 0.076	7.095LeuGly: 7.095 ± 0.072	2.352LeuHis: 2.352 ± 0.037	6.433LeuIle: 6.433 ± 0.071	4.737LeuLys: 4.737 ± 0.066	11.414LeuLeu: 11.414 ± 0.129	2.553LeuMet: 2.553 ± 0.043	3.219LeuAsn: 3.219 ± 0.048	4.717LeuPro: 4.717 ± 0.067	4.581LeuGln: 4.581 ± 0.062	5.195LeuArg: 5.195 ± 0.063	6.74LeuSer: 6.74 ± 0.08	5.633LeuThr: 5.633 ± 0.057	7.083LeuVal: 7.083 ± 0.076	0.946LeuTrp: 0.946 ± 0.025	3.148LeuTyr: 3.148 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.397MetAla: 2.397 ± 0.041	0.172MetCys: 0.172 ± 0.01	1.497MetAsp: 1.497 ± 0.033	2.142MetGlu: 2.142 ± 0.04	0.992MetPhe: 0.992 ± 0.026	2.046MetGly: 2.046 ± 0.045	0.514MetHis: 0.514 ± 0.019	1.968MetIle: 1.968 ± 0.039	1.984MetLys: 1.984 ± 0.041	2.943MetLeu: 2.943 ± 0.05	0.917MetMet: 0.917 ± 0.025	1.324MetAsn: 1.324 ± 0.027	1.188MetPro: 1.188 ± 0.026	1.117MetGln: 1.117 ± 0.029	1.517MetArg: 1.517 ± 0.034	1.737MetSer: 1.737 ± 0.034	1.694MetThr: 1.694 ± 0.031	1.978MetVal: 1.978 ± 0.034	0.238MetTrp: 0.238 ± 0.013	0.77MetTyr: 0.77 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.52AsnAla: 2.52 ± 0.044	0.259AsnCys: 0.259 ± 0.013	1.468AsnAsp: 1.468 ± 0.035	2.321AsnGlu: 2.321 ± 0.038	1.124AsnPhe: 1.124 ± 0.031	2.745AsnGly: 2.745 ± 0.049	0.811AsnHis: 0.811 ± 0.025	2.089AsnIle: 2.089 ± 0.041	1.87AsnLys: 1.87 ± 0.04	3.324AsnLeu: 3.324 ± 0.046	0.966AsnMet: 0.966 ± 0.026	1.196AsnAsn: 1.196 ± 0.032	2.039AsnPro: 2.039 ± 0.046	1.717AsnGln: 1.717 ± 0.037	2.125AsnArg: 2.125 ± 0.038	1.681AsnSer: 1.681 ± 0.034	1.686AsnThr: 1.686 ± 0.036	2.372AsnVal: 2.372 ± 0.037	0.497AsnTrp: 0.497 ± 0.019	1.031AsnTyr: 1.031 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	3.37ProAla: 3.37 ± 0.046	0.236ProCys: 0.236 ± 0.014	2.57ProAsp: 2.57 ± 0.039	3.271ProGlu: 3.271 ± 0.048	2.012ProPhe: 2.012 ± 0.038	2.991ProGly: 2.991 ± 0.053	1.027ProHis: 1.027 ± 0.026	2.689ProIle: 2.689 ± 0.04	1.937ProLys: 1.937 ± 0.036	4.126ProLeu: 4.126 ± 0.056	1.022ProMet: 1.022 ± 0.028	1.406ProAsn: 1.406 ± 0.035	1.544ProPro: 1.544 ± 0.049	1.644ProGln: 1.644 ± 0.038	1.681ProArg: 1.681 ± 0.036	2.498ProSer: 2.498 ± 0.04	2.125ProThr: 2.125 ± 0.035	3.507ProVal: 3.507 ± 0.044	0.452ProTrp: 0.452 ± 0.022	1.559ProTyr: 1.559 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.003GlnAla: 4.003 ± 0.055	0.195GlnCys: 0.195 ± 0.011	1.824GlnAsp: 1.824 ± 0.033	3.483GlnGlu: 3.483 ± 0.055	1.52GlnPhe: 1.52 ± 0.032	2.599GlnGly: 2.599 ± 0.046	0.893GlnHis: 0.893 ± 0.025	2.987GlnIle: 2.987 ± 0.044	2.614GlnLys: 2.614 ± 0.046	4.291GlnLeu: 4.291 ± 0.055	1.412GlnMet: 1.412 ± 0.027	1.438GlnAsn: 1.438 ± 0.029	1.777GlnPro: 1.777 ± 0.041	2.342GlnGln: 2.342 ± 0.048	2.204GlnArg: 2.204 ± 0.039	2.312GlnSer: 2.312 ± 0.039	2.271GlnThr: 2.271 ± 0.039	3.227GlnVal: 3.227 ± 0.048	0.555GlnTrp: 0.555 ± 0.021	1.255GlnTyr: 1.255 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.483ArgAla: 3.483 ± 0.043	0.399ArgCys: 0.399 ± 0.017	2.626ArgAsp: 2.626 ± 0.039	4.357ArgGlu: 4.357 ± 0.069	2.373ArgPhe: 2.373 ± 0.044	3.061ArgGly: 3.061 ± 0.048	1.181ArgHis: 1.181 ± 0.026	3.742ArgIle: 3.742 ± 0.048	3.21ArgLys: 3.21 ± 0.046	5.549ArgLeu: 5.549 ± 0.072	1.76ArgMet: 1.76 ± 0.034	1.93ArgAsn: 1.93 ± 0.04	1.855ArgPro: 1.855 ± 0.04	2.373ArgGln: 2.373 ± 0.043	2.881ArgArg: 2.881 ± 0.048	2.836ArgSer: 2.836 ± 0.046	2.574ArgThr: 2.574 ± 0.042	3.66ArgVal: 3.66 ± 0.051	0.629ArgTrp: 0.629 ± 0.021	1.955ArgTyr: 1.955 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.348SerAla: 4.348 ± 0.056	0.438SerCys: 0.438 ± 0.017	2.628SerAsp: 2.628 ± 0.048	3.591SerGlu: 3.591 ± 0.051	2.98SerPhe: 2.98 ± 0.046	4.693SerGly: 4.693 ± 0.056	1.299SerHis: 1.299 ± 0.034	4.078SerIle: 4.078 ± 0.054	2.872SerLys: 2.872 ± 0.047	6.463SerLeu: 6.463 ± 0.072	1.794SerMet: 1.794 ± 0.031	1.869SerAsn: 1.869 ± 0.039	2.516SerPro: 2.516 ± 0.04	2.313SerGln: 2.313 ± 0.041	3.055SerArg: 3.055 ± 0.04	3.782SerSer: 3.782 ± 0.055	2.955SerThr: 2.955 ± 0.046	4.152SerVal: 4.152 ± 0.047	0.757SerTrp: 0.757 ± 0.023	2.049SerTyr: 2.049 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	4.5ThrAla: 4.5 ± 0.059	0.436ThrCys: 0.436 ± 0.017	2.503ThrAsp: 2.503 ± 0.044	3.296ThrGlu: 3.296 ± 0.049	2.298ThrPhe: 2.298 ± 0.04	4.354ThrGly: 4.354 ± 0.057	1.112ThrHis: 1.112 ± 0.027	3.872ThrIle: 3.872 ± 0.047	2.582ThrLys: 2.582 ± 0.044	5.304ThrLeu: 5.304 ± 0.054	1.407ThrMet: 1.407 ± 0.031	1.781ThrAsn: 1.781 ± 0.04	2.666ThrPro: 2.666 ± 0.044	1.825ThrGln: 1.825 ± 0.039	2.458ThrArg: 2.458 ± 0.041	3.163ThrSer: 3.163 ± 0.049	2.803ThrThr: 2.803 ± 0.047	4.203ThrVal: 4.203 ± 0.059	0.613ThrTrp: 0.613 ± 0.018	1.881ThrTyr: 1.881 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	6.036ValAla: 6.036 ± 0.069	0.651ValCys: 0.651 ± 0.021	3.773ValAsp: 3.773 ± 0.051	5.204ValGlu: 5.204 ± 0.062	2.918ValPhe: 2.918 ± 0.054	4.965ValGly: 4.965 ± 0.061	1.547ValHis: 1.547 ± 0.033	5.149ValIle: 5.149 ± 0.069	4.163ValLys: 4.163 ± 0.063	7.34ValLeu: 7.34 ± 0.071	2.144ValMet: 2.144 ± 0.04	2.666ValAsn: 2.666 ± 0.036	3.185ValPro: 3.185 ± 0.048	2.89ValGln: 2.89 ± 0.041	3.648ValArg: 3.648 ± 0.051	4.636ValSer: 4.636 ± 0.052	4.391ValThr: 4.391 ± 0.062	5.568ValVal: 5.568 ± 0.068	0.812ValTrp: 0.812 ± 0.026	2.257ValTyr: 2.257 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.737TrpAla: 0.737 ± 0.023	0.093TrpCys: 0.093 ± 0.008	0.586TrpAsp: 0.586 ± 0.017	0.903TrpGlu: 0.903 ± 0.024	0.526TrpPhe: 0.526 ± 0.02	0.828TrpGly: 0.828 ± 0.025	0.227TrpHis: 0.227 ± 0.01	0.867TrpIle: 0.867 ± 0.025	0.783TrpLys: 0.783 ± 0.023	1.477TrpLeu: 1.477 ± 0.038	0.436TrpMet: 0.436 ± 0.02	0.531TrpAsn: 0.531 ± 0.022	0.346TrpPro: 0.346 ± 0.017	0.532TrpGln: 0.532 ± 0.019	0.64TrpArg: 0.64 ± 0.021	0.739TrpSer: 0.739 ± 0.024	0.607TrpThr: 0.607 ± 0.019	0.812TrpVal: 0.812 ± 0.023	0.181TrpTrp: 0.181 ± 0.01	0.377TrpTyr: 0.377 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.433TyrAla: 2.433 ± 0.042	0.278TyrCys: 0.278 ± 0.014	1.75TyrAsp: 1.75 ± 0.038	2.199TyrGlu: 2.199 ± 0.038	1.379TyrPhe: 1.379 ± 0.035	2.472TyrGly: 2.472 ± 0.04	0.786TyrHis: 0.786 ± 0.022	1.76TyrIle: 1.76 ± 0.033	1.459TyrLys: 1.459 ± 0.037	3.46TyrLeu: 3.46 ± 0.05	0.777TyrMet: 0.777 ± 0.02	1.061TyrAsn: 1.061 ± 0.029	1.525TyrPro: 1.525 ± 0.031	1.563TyrGln: 1.563 ± 0.034	1.903TyrArg: 1.903 ± 0.042	1.862TyrSer: 1.862 ± 0.04	1.758TyrThr: 1.758 ± 0.039	2.281TyrVal: 2.281 ± 0.035	0.418TyrTrp: 0.418 ± 0.016	1.165TyrTyr: 1.165 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5188 proteins (1544730 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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