Amino acid dipepetide frequency for Loktanella sp. 5RATIMAR09

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.441AlaAla: 16.441 ± 0.184	1.144AlaCys: 1.144 ± 0.035	7.399AlaAsp: 7.399 ± 0.094	7.486AlaGlu: 7.486 ± 0.091	4.584AlaPhe: 4.584 ± 0.072	10.237AlaGly: 10.237 ± 0.113	2.356AlaHis: 2.356 ± 0.054	6.529AlaIle: 6.529 ± 0.078	4.172AlaLys: 4.172 ± 0.068	13.425AlaLeu: 13.425 ± 0.152	3.904AlaMet: 3.904 ± 0.061	3.104AlaAsn: 3.104 ± 0.059	5.608AlaPro: 5.608 ± 0.081	4.835AlaGln: 4.835 ± 0.071	7.838AlaArg: 7.838 ± 0.091	5.449AlaSer: 5.449 ± 0.066	6.584AlaThr: 6.584 ± 0.08	8.546AlaVal: 8.546 ± 0.093	1.443AlaTrp: 1.443 ± 0.036	2.574AlaTyr: 2.574 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.122CysAla: 1.122 ± 0.034	0.126CysCys: 0.126 ± 0.01	0.647CysAsp: 0.647 ± 0.028	0.487CysGlu: 0.487 ± 0.025	0.343CysPhe: 0.343 ± 0.018	0.966CysGly: 0.966 ± 0.033	0.275CysHis: 0.275 ± 0.022	0.454CysIle: 0.454 ± 0.022	0.245CysLys: 0.245 ± 0.014	0.778CysLeu: 0.778 ± 0.026	0.165CysMet: 0.165 ± 0.012	0.234CysAsn: 0.234 ± 0.014	0.47CysPro: 0.47 ± 0.021	0.265CysGln: 0.265 ± 0.015	0.475CysArg: 0.475 ± 0.02	0.428CysSer: 0.428 ± 0.019	0.443CysThr: 0.443 ± 0.02	0.653CysVal: 0.653 ± 0.029	0.125CysTrp: 0.125 ± 0.011	0.213CysTyr: 0.213 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.882AspAla: 7.882 ± 0.095	0.527AspCys: 0.527 ± 0.026	3.812AspAsp: 3.812 ± 0.089	3.448AspGlu: 3.448 ± 0.061	2.429AspPhe: 2.429 ± 0.046	5.479AspGly: 5.479 ± 0.074	1.481AspHis: 1.481 ± 0.043	3.403AspIle: 3.403 ± 0.062	1.842AspLys: 1.842 ± 0.043	6.423AspLeu: 6.423 ± 0.097	1.812AspMet: 1.812 ± 0.049	1.469AspAsn: 1.469 ± 0.036	3.568AspPro: 3.568 ± 0.063	2.044AspGln: 2.044 ± 0.039	3.987AspArg: 3.987 ± 0.062	2.114AspSer: 2.114 ± 0.046	3.161AspThr: 3.161 ± 0.058	4.693AspVal: 4.693 ± 0.066	1.113AspTrp: 1.113 ± 0.03	1.625AspTyr: 1.625 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.201GluAla: 7.201 ± 0.091	0.35GluCys: 0.35 ± 0.019	3.283GluAsp: 3.283 ± 0.064	3.35GluGlu: 3.35 ± 0.066	1.753GluPhe: 1.753 ± 0.041	4.492GluGly: 4.492 ± 0.066	1.03GluHis: 1.03 ± 0.029	3.604GluIle: 3.604 ± 0.063	2.162GluLys: 2.162 ± 0.054	4.693GluLeu: 4.693 ± 0.083	1.825GluMet: 1.825 ± 0.044	1.936GluAsn: 1.936 ± 0.04	2.181GluPro: 2.181 ± 0.042	1.839GluGln: 1.839 ± 0.04	3.771GluArg: 3.771 ± 0.075	2.014GluSer: 2.014 ± 0.044	3.795GluThr: 3.795 ± 0.06	4.286GluVal: 4.286 ± 0.071	0.691GluTrp: 0.691 ± 0.025	1.043GluTyr: 1.043 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.759PheAla: 4.759 ± 0.076	0.442PheCys: 0.442 ± 0.02	2.944PheAsp: 2.944 ± 0.053	2.24PheGlu: 2.24 ± 0.045	1.6PhePhe: 1.6 ± 0.046	3.919PheGly: 3.919 ± 0.064	0.752PheHis: 0.752 ± 0.028	1.884PheIle: 1.884 ± 0.048	0.98PheLys: 0.98 ± 0.03	3.506PheLeu: 3.506 ± 0.07	0.957PheMet: 0.957 ± 0.031	1.133PheAsn: 1.133 ± 0.032	1.538PhePro: 1.538 ± 0.037	1.079PheGln: 1.079 ± 0.032	1.992PheArg: 1.992 ± 0.049	2.169PheSer: 2.169 ± 0.046	2.158PheThr: 2.158 ± 0.049	2.913PheVal: 2.913 ± 0.051	0.665PheTrp: 0.665 ± 0.028	1.014PheTyr: 1.014 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.622GlyAla: 9.622 ± 0.092	0.848GlyCys: 0.848 ± 0.028	4.731GlyAsp: 4.731 ± 0.072	4.344GlyGlu: 4.344 ± 0.066	3.769GlyPhe: 3.769 ± 0.064	7.065GlyGly: 7.065 ± 0.125	1.854GlyHis: 1.854 ± 0.048	4.667GlyIle: 4.667 ± 0.073	3.23GlyLys: 3.23 ± 0.067	8.799GlyLeu: 8.799 ± 0.107	2.613GlyMet: 2.613 ± 0.054	2.173GlyAsn: 2.173 ± 0.046	3.459GlyPro: 3.459 ± 0.052	3.246GlyGln: 3.246 ± 0.06	5.199GlyArg: 5.199 ± 0.069	4.002GlySer: 4.002 ± 0.065	4.811GlyThr: 4.811 ± 0.088	6.612GlyVal: 6.612 ± 0.074	1.435GlyTrp: 1.435 ± 0.041	2.268GlyTyr: 2.268 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.278HisAla: 2.278 ± 0.05	0.231HisCys: 0.231 ± 0.016	1.256HisAsp: 1.256 ± 0.039	1.036HisGlu: 1.036 ± 0.031	0.808HisPhe: 0.808 ± 0.026	1.837HisGly: 1.837 ± 0.046	0.541HisHis: 0.541 ± 0.025	1.096HisIle: 1.096 ± 0.032	0.614HisLys: 0.614 ± 0.025	2.079HisLeu: 2.079 ± 0.047	0.55HisMet: 0.55 ± 0.024	0.516HisAsn: 0.516 ± 0.023	1.263HisPro: 1.263 ± 0.033	0.628HisGln: 0.628 ± 0.023	1.189HisArg: 1.189 ± 0.034	0.879HisSer: 0.879 ± 0.029	0.903HisThr: 0.903 ± 0.03	1.482HisVal: 1.482 ± 0.032	0.338HisTrp: 0.338 ± 0.019	0.567HisTyr: 0.567 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.884IleAla: 7.884 ± 0.082	0.66IleCys: 0.66 ± 0.025	3.726IleAsp: 3.726 ± 0.063	3.325IleGlu: 3.325 ± 0.055	1.993IlePhe: 1.993 ± 0.056	5.316IleGly: 5.316 ± 0.07	0.916IleHis: 0.916 ± 0.031	2.792IleIle: 2.792 ± 0.055	1.737IleLys: 1.737 ± 0.037	4.95IleLeu: 4.95 ± 0.071	1.319IleMet: 1.319 ± 0.033	1.686IleAsn: 1.686 ± 0.04	2.493IlePro: 2.493 ± 0.053	1.218IleGln: 1.218 ± 0.032	2.937IleArg: 2.937 ± 0.046	3.104IleSer: 3.104 ± 0.055	3.341IleThr: 3.341 ± 0.062	4.175IleVal: 4.175 ± 0.069	0.756IleTrp: 0.756 ± 0.026	1.281IleTyr: 1.281 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.216LysAla: 4.216 ± 0.081	0.208LysCys: 0.208 ± 0.015	1.956LysAsp: 1.956 ± 0.047	1.68LysGlu: 1.68 ± 0.045	0.956LysPhe: 0.956 ± 0.026	2.727LysGly: 2.727 ± 0.06	0.667LysHis: 0.667 ± 0.027	1.795LysIle: 1.795 ± 0.04	1.326LysLys: 1.326 ± 0.042	3.099LysLeu: 3.099 ± 0.052	0.969LysMet: 0.969 ± 0.034	0.864LysAsn: 0.864 ± 0.031	1.816LysPro: 1.816 ± 0.046	0.965LysGln: 0.965 ± 0.03	2.239LysArg: 2.239 ± 0.049	1.888LysSer: 1.888 ± 0.045	2.135LysThr: 2.135 ± 0.047	2.292LysVal: 2.292 ± 0.051	0.415LysTrp: 0.415 ± 0.02	0.68LysTyr: 0.68 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.451LeuAla: 12.451 ± 0.14	0.95LeuCys: 0.95 ± 0.032	5.816LeuAsp: 5.816 ± 0.076	4.969LeuGlu: 4.969 ± 0.074	3.587LeuPhe: 3.587 ± 0.079	8.176LeuGly: 8.176 ± 0.094	1.816LeuHis: 1.816 ± 0.04	5.59LeuIle: 5.59 ± 0.086	3.083LeuLys: 3.083 ± 0.059	8.716LeuLeu: 8.716 ± 0.129	2.763LeuMet: 2.763 ± 0.048	2.783LeuAsn: 2.783 ± 0.059	5.284LeuPro: 5.284 ± 0.078	2.977LeuGln: 2.977 ± 0.058	6.7LeuArg: 6.7 ± 0.091	6.289LeuSer: 6.289 ± 0.073	6.185LeuThr: 6.185 ± 0.091	6.822LeuVal: 6.822 ± 0.106	1.327LeuTrp: 1.327 ± 0.037	1.96LeuTyr: 1.96 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.543MetAla: 3.543 ± 0.055	0.201MetCys: 0.201 ± 0.015	1.544MetAsp: 1.544 ± 0.041	1.287MetGlu: 1.287 ± 0.037	0.867MetPhe: 0.867 ± 0.032	2.302MetGly: 2.302 ± 0.049	0.519MetHis: 0.519 ± 0.024	1.822MetIle: 1.822 ± 0.041	1.107MetLys: 1.107 ± 0.035	2.751MetLeu: 2.751 ± 0.055	0.864MetMet: 0.864 ± 0.032	0.967MetAsn: 0.967 ± 0.031	1.586MetPro: 1.586 ± 0.038	1.115MetGln: 1.115 ± 0.034	1.92MetArg: 1.92 ± 0.048	1.75MetSer: 1.75 ± 0.041	2.328MetThr: 2.328 ± 0.045	1.984MetVal: 1.984 ± 0.04	0.284MetTrp: 0.284 ± 0.015	0.392MetTyr: 0.392 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.619AsnAla: 3.619 ± 0.057	0.281AsnCys: 0.281 ± 0.016	1.71AsnAsp: 1.71 ± 0.044	1.281AsnGlu: 1.281 ± 0.038	1.018AsnPhe: 1.018 ± 0.034	2.515AsnGly: 2.515 ± 0.058	0.549AsnHis: 0.549 ± 0.025	1.609AsnIle: 1.609 ± 0.042	0.737AsnLys: 0.737 ± 0.026	2.629AsnLeu: 2.629 ± 0.059	0.802AsnMet: 0.802 ± 0.025	0.763AsnAsn: 0.763 ± 0.032	1.884AsnPro: 1.884 ± 0.045	0.818AsnGln: 0.818 ± 0.03	1.764AsnArg: 1.764 ± 0.044	1.144AsnSer: 1.144 ± 0.032	1.525AsnThr: 1.525 ± 0.037	2.013AsnVal: 2.013 ± 0.044	0.476AsnTrp: 0.476 ± 0.023	0.72AsnTyr: 0.72 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.689ProAla: 5.689 ± 0.086	0.359ProCys: 0.359 ± 0.019	3.915ProAsp: 3.915 ± 0.058	3.611ProGlu: 3.611 ± 0.067	2.094ProPhe: 2.094 ± 0.04	3.65ProGly: 3.65 ± 0.06	1.054ProHis: 1.054 ± 0.031	2.346ProIle: 2.346 ± 0.044	1.676ProLys: 1.676 ± 0.045	4.567ProLeu: 4.567 ± 0.067	1.316ProMet: 1.316 ± 0.034	1.33ProAsn: 1.33 ± 0.04	2.07ProPro: 2.07 ± 0.055	1.797ProGln: 1.797 ± 0.042	2.48ProArg: 2.48 ± 0.045	2.406ProSer: 2.406 ± 0.051	2.557ProThr: 2.557 ± 0.047	4.184ProVal: 4.184 ± 0.07	0.62ProTrp: 0.62 ± 0.025	1.156ProTyr: 1.156 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.173GlnAla: 4.173 ± 0.065	0.218GlnCys: 0.218 ± 0.015	1.868GlnAsp: 1.868 ± 0.048	1.715GlnGlu: 1.715 ± 0.044	1.195GlnPhe: 1.195 ± 0.039	2.586GlnGly: 2.586 ± 0.058	0.596GlnHis: 0.596 ± 0.025	2.196GlnIle: 2.196 ± 0.047	1.103GlnLys: 1.103 ± 0.032	2.955GlnLeu: 2.955 ± 0.055	1.239GlnMet: 1.239 ± 0.034	1.054GlnAsn: 1.054 ± 0.032	1.578GlnPro: 1.578 ± 0.038	1.155GlnGln: 1.155 ± 0.038	2.15GlnArg: 2.15 ± 0.049	1.961GlnSer: 1.961 ± 0.044	2.118GlnThr: 2.118 ± 0.044	2.515GlnVal: 2.515 ± 0.044	0.417GlnTrp: 0.417 ± 0.023	0.623GlnTyr: 0.623 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.255ArgAla: 7.255 ± 0.084	0.428ArgCys: 0.428 ± 0.019	4.091ArgAsp: 4.091 ± 0.069	3.354ArgGlu: 3.354 ± 0.066	2.594ArgPhe: 2.594 ± 0.05	4.207ArgGly: 4.207 ± 0.067	1.38ArgHis: 1.38 ± 0.038	3.716ArgIle: 3.716 ± 0.06	2.356ArgLys: 2.356 ± 0.049	6.378ArgLeu: 6.378 ± 0.09	1.934ArgMet: 1.934 ± 0.048	1.809ArgAsn: 1.809 ± 0.041	2.973ArgPro: 2.973 ± 0.061	2.151ArgGln: 2.151 ± 0.043	4.279ArgArg: 4.279 ± 0.066	3.011ArgSer: 3.011 ± 0.053	3.036ArgThr: 3.036 ± 0.056	4.352ArgVal: 4.352 ± 0.065	0.851ArgTrp: 0.851 ± 0.026	1.485ArgTyr: 1.485 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.704SerAla: 5.704 ± 0.073	0.448SerCys: 0.448 ± 0.02	3.331SerAsp: 3.331 ± 0.053	2.783SerGlu: 2.783 ± 0.051	2.313SerPhe: 2.313 ± 0.045	5.014SerGly: 5.014 ± 0.082	0.998SerHis: 0.998 ± 0.033	2.568SerIle: 2.568 ± 0.049	1.555SerLys: 1.555 ± 0.039	4.856SerLeu: 4.856 ± 0.065	1.345SerMet: 1.345 ± 0.037	1.372SerAsn: 1.372 ± 0.04	2.345SerPro: 2.345 ± 0.05	1.762SerGln: 1.762 ± 0.043	2.969SerArg: 2.969 ± 0.051	2.408SerSer: 2.408 ± 0.048	2.524SerThr: 2.524 ± 0.051	3.726SerVal: 3.726 ± 0.054	0.692SerTrp: 0.692 ± 0.026	1.293SerTyr: 1.293 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.64ThrAla: 6.64 ± 0.083	0.514ThrCys: 0.514 ± 0.024	3.475ThrAsp: 3.475 ± 0.064	2.911ThrGlu: 2.911 ± 0.053	2.185ThrPhe: 2.185 ± 0.046	5.406ThrGly: 5.406 ± 0.09	1.145ThrHis: 1.145 ± 0.033	3.15ThrIle: 3.15 ± 0.054	1.746ThrLys: 1.746 ± 0.042	6.213ThrLeu: 6.213 ± 0.084	1.484ThrMet: 1.484 ± 0.034	1.511ThrAsn: 1.511 ± 0.039	3.473ThrPro: 3.473 ± 0.055	1.855ThrGln: 1.855 ± 0.045	3.255ThrArg: 3.255 ± 0.06	2.871ThrSer: 2.871 ± 0.045	3.147ThrThr: 3.147 ± 0.064	4.561ThrVal: 4.561 ± 0.072	0.689ThrTrp: 0.689 ± 0.023	1.456ThrTyr: 1.456 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.109ValAla: 9.109 ± 0.09	0.646ValCys: 0.646 ± 0.026	4.251ValAsp: 4.251 ± 0.065	4.086ValGlu: 4.086 ± 0.062	3.039ValPhe: 3.039 ± 0.05	5.67ValGly: 5.67 ± 0.077	1.318ValHis: 1.318 ± 0.04	4.632ValIle: 4.632 ± 0.075	2.185ValLys: 2.185 ± 0.051	7.509ValLeu: 7.509 ± 0.106	2.273ValMet: 2.273 ± 0.048	2.036ValAsn: 2.036 ± 0.04	3.495ValPro: 3.495 ± 0.057	2.309ValGln: 2.309 ± 0.043	4.02ValArg: 4.02 ± 0.06	4.292ValSer: 4.292 ± 0.061	4.913ValThr: 4.913 ± 0.062	5.862ValVal: 5.862 ± 0.075	1.009ValTrp: 1.009 ± 0.035	1.549ValTyr: 1.549 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.422TrpAla: 1.422 ± 0.034	0.135TrpCys: 0.135 ± 0.011	0.835TrpAsp: 0.835 ± 0.029	0.691TrpGlu: 0.691 ± 0.024	0.579TrpPhe: 0.579 ± 0.024	1.015TrpGly: 1.015 ± 0.033	0.321TrpHis: 0.321 ± 0.018	0.745TrpIle: 0.745 ± 0.026	0.435TrpLys: 0.435 ± 0.018	1.566TrpLeu: 1.566 ± 0.041	0.474TrpMet: 0.474 ± 0.019	0.441TrpAsn: 0.441 ± 0.019	0.674TrpPro: 0.674 ± 0.024	0.593TrpGln: 0.593 ± 0.023	0.99TrpArg: 0.99 ± 0.033	0.741TrpSer: 0.741 ± 0.028	0.823TrpThr: 0.823 ± 0.029	0.985TrpVal: 0.985 ± 0.03	0.242TrpTrp: 0.242 ± 0.015	0.281TrpTyr: 0.281 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.649TyrAla: 2.649 ± 0.046	0.2TyrCys: 0.2 ± 0.014	1.721TyrAsp: 1.721 ± 0.039	1.216TyrGlu: 1.216 ± 0.039	0.938TyrPhe: 0.938 ± 0.029	2.169TyrGly: 2.169 ± 0.045	0.524TyrHis: 0.524 ± 0.022	1.01TyrIle: 1.01 ± 0.03	0.601TyrLys: 0.601 ± 0.024	2.351TyrLeu: 2.351 ± 0.046	0.521TyrMet: 0.521 ± 0.022	0.678TyrAsn: 0.678 ± 0.024	1.121TyrPro: 1.121 ± 0.033	0.763TyrGln: 0.763 ± 0.025	1.485TyrArg: 1.485 ± 0.043	1.086TyrSer: 1.086 ± 0.031	1.2TyrThr: 1.2 ± 0.037	1.547TyrVal: 1.547 ± 0.031	0.402TyrTrp: 0.402 ± 0.02	0.611TyrTyr: 0.611 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3530 proteins (1075750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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