Amino acid dipepetide frequency for Pepper leaf curl virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.54AlaAla: 5.54 ± 2.19
0.923AlaCys: 0.923 ± 0.797
0.923AlaAsp: 0.923 ± 0.797
1.847AlaGlu: 1.847 ± 1.098
0.923AlaPhe: 0.923 ± 0.975
0.923AlaGly: 0.923 ± 1.063
3.693AlaHis: 3.693 ± 0.921
5.54AlaIle: 5.54 ± 1.405
5.54AlaLys: 5.54 ± 1.549
6.464AlaLeu: 6.464 ± 2.734
0.0AlaMet: 0.0 ± 0.0
4.617AlaAsn: 4.617 ± 1.217
2.77AlaPro: 2.77 ± 1.216
4.617AlaGln: 4.617 ± 2.323
4.617AlaArg: 4.617 ± 1.811
5.54AlaSer: 5.54 ± 2.663
3.693AlaThr: 3.693 ± 2.229
0.923AlaVal: 0.923 ± 0.975
0.0AlaTrp: 0.0 ± 0.0
0.923AlaTyr: 0.923 ± 0.635
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
1.847CysCys: 1.847 ± 1.993
0.0CysAsp: 0.0 ± 0.0
0.923CysGlu: 0.923 ± 0.797
0.923CysPhe: 0.923 ± 1.063
1.847CysGly: 1.847 ± 0.994
0.923CysHis: 0.923 ± 0.975
1.847CysIle: 1.847 ± 1.411
1.847CysLys: 1.847 ± 0.809
0.0CysLeu: 0.0 ± 0.0
0.923CysMet: 0.923 ± 0.997
0.923CysAsn: 0.923 ± 0.635
1.847CysPro: 1.847 ± 1.993
2.77CysGln: 2.77 ± 1.36
0.923CysArg: 0.923 ± 0.635
2.77CysSer: 2.77 ± 1.864
0.923CysThr: 0.923 ± 0.797
0.923CysVal: 0.923 ± 0.797
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.847AspAla: 1.847 ± 1.098
0.0AspCys: 0.0 ± 0.0
0.923AspAsp: 0.923 ± 0.635
0.923AspGlu: 0.923 ± 0.797
0.923AspPhe: 0.923 ± 0.797
2.77AspGly: 2.77 ± 1.353
2.77AspHis: 2.77 ± 1.36
2.77AspIle: 2.77 ± 1.478
0.923AspLys: 0.923 ± 0.635
5.54AspLeu: 5.54 ± 2.314
0.0AspMet: 0.0 ± 0.0
3.693AspAsn: 3.693 ± 2.229
1.847AspPro: 1.847 ± 1.269
0.923AspGln: 0.923 ± 0.635
2.77AspArg: 2.77 ± 1.784
5.54AspSer: 5.54 ± 1.11
0.923AspThr: 0.923 ± 0.997
6.464AspVal: 6.464 ± 2.196
0.923AspTrp: 0.923 ± 0.635
1.847AspTyr: 1.847 ± 0.91
0.0AspXaa: 0.0 ± 0.0
Glu
5.54GluAla: 5.54 ± 1.276
0.0GluCys: 0.0 ± 0.0
2.77GluAsp: 2.77 ± 1.45
5.54GluGlu: 5.54 ± 2.705
1.847GluPhe: 1.847 ± 1.269
5.54GluGly: 5.54 ± 1.461
0.0GluHis: 0.0 ± 0.0
0.923GluIle: 0.923 ± 0.797
0.923GluLys: 0.923 ± 0.635
2.77GluLeu: 2.77 ± 1.32
1.847GluMet: 1.847 ± 1.098
2.77GluAsn: 2.77 ± 1.478
2.77GluPro: 2.77 ± 1.436
1.847GluGln: 1.847 ± 1.594
0.923GluArg: 0.923 ± 1.063
1.847GluSer: 1.847 ± 1.076
1.847GluThr: 1.847 ± 1.114
0.923GluVal: 0.923 ± 0.997
1.847GluTrp: 1.847 ± 0.994
0.923GluTyr: 0.923 ± 0.635
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.0PheCys: 0.0 ± 0.0
2.77PheAsp: 2.77 ± 1.216
1.847PheGlu: 1.847 ± 0.91
1.847PhePhe: 1.847 ± 0.809
1.847PheGly: 1.847 ± 1.594
2.77PheHis: 2.77 ± 1.211
0.923PheIle: 0.923 ± 0.635
1.847PheLys: 1.847 ± 1.098
9.234PheLeu: 9.234 ± 2.665
2.77PheMet: 2.77 ± 1.074
2.77PheAsn: 2.77 ± 1.952
0.0PhePro: 0.0 ± 0.0
4.617PheGln: 4.617 ± 1.406
1.847PheArg: 1.847 ± 1.411
2.77PheSer: 2.77 ± 1.45
1.847PheThr: 1.847 ± 1.951
1.847PheVal: 1.847 ± 0.994
0.0PheTrp: 0.0 ± 0.0
0.923PheTyr: 0.923 ± 0.797
0.0PheXaa: 0.0 ± 0.0
Gly
5.54GlyAla: 5.54 ± 1.722
3.693GlyCys: 3.693 ± 1.693
1.847GlyAsp: 1.847 ± 1.269
0.0GlyGlu: 0.0 ± 0.0
1.847GlyPhe: 1.847 ± 1.459
4.617GlyGly: 4.617 ± 0.99
0.923GlyHis: 0.923 ± 0.635
0.923GlyIle: 0.923 ± 0.635
4.617GlyLys: 4.617 ± 1.966
2.77GlyLeu: 2.77 ± 1.297
0.0GlyMet: 0.0 ± 0.0
0.923GlyAsn: 0.923 ± 0.797
4.617GlyPro: 4.617 ± 1.966
4.617GlyGln: 4.617 ± 2.007
1.847GlyArg: 1.847 ± 0.809
0.923GlySer: 0.923 ± 0.635
5.54GlyThr: 5.54 ± 1.606
3.693GlyVal: 3.693 ± 2.112
0.0GlyTrp: 0.0 ± 0.0
0.923GlyTyr: 0.923 ± 0.997
0.0GlyXaa: 0.0 ± 0.0
His
0.923HisAla: 0.923 ± 0.797
1.847HisCys: 1.847 ± 0.994
2.77HisAsp: 2.77 ± 1.297
1.847HisGlu: 1.847 ± 1.098
2.77HisPhe: 2.77 ± 1.211
2.77HisGly: 2.77 ± 1.864
1.847HisHis: 1.847 ± 2.126
1.847HisIle: 1.847 ± 1.114
0.923HisLys: 0.923 ± 0.997
2.77HisLeu: 2.77 ± 1.445
0.923HisMet: 0.923 ± 1.088
2.77HisAsn: 2.77 ± 1.353
3.693HisPro: 3.693 ± 1.486
3.693HisGln: 3.693 ± 1.278
2.77HisArg: 2.77 ± 1.893
4.617HisSer: 4.617 ± 2.35
1.847HisThr: 1.847 ± 1.045
3.693HisVal: 3.693 ± 1.816
0.0HisTrp: 0.0 ± 0.0
0.923HisTyr: 0.923 ± 0.635
0.0HisXaa: 0.0 ± 0.0
Ile
1.847IleAla: 1.847 ± 0.994
3.693IleCys: 3.693 ± 1.144
2.77IleAsp: 2.77 ± 1.445
2.77IleGlu: 2.77 ± 1.904
3.693IlePhe: 3.693 ± 1.865
0.0IleGly: 0.0 ± 0.0
0.923IleHis: 0.923 ± 1.088
0.923IleIle: 0.923 ± 1.063
6.464IleLys: 6.464 ± 1.747
3.693IleLeu: 3.693 ± 1.707
1.847IleMet: 1.847 ± 1.417
1.847IleAsn: 1.847 ± 1.098
0.923IlePro: 0.923 ± 0.635
5.54IleGln: 5.54 ± 1.783
6.464IleArg: 6.464 ± 2.592
7.387IleSer: 7.387 ± 2.78
1.847IleThr: 1.847 ± 2.126
2.77IleVal: 2.77 ± 1.475
2.77IleTrp: 2.77 ± 1.952
3.693IleTyr: 3.693 ± 1.525
0.0IleXaa: 0.0 ± 0.0
Lys
4.617LysAla: 4.617 ± 1.689
0.0LysCys: 0.0 ± 0.0
0.923LysAsp: 0.923 ± 0.635
6.464LysGlu: 6.464 ± 2.611
2.77LysPhe: 2.77 ± 0.886
1.847LysGly: 1.847 ± 0.809
0.923LysHis: 0.923 ± 0.635
2.77LysIle: 2.77 ± 1.105
0.923LysLys: 0.923 ± 0.975
1.847LysLeu: 1.847 ± 1.114
0.0LysMet: 0.0 ± 0.0
8.31LysAsn: 8.31 ± 4.022
3.693LysPro: 3.693 ± 1.103
0.923LysGln: 0.923 ± 0.997
1.847LysArg: 1.847 ± 1.594
3.693LysSer: 3.693 ± 1.379
2.77LysThr: 2.77 ± 1.348
6.464LysVal: 6.464 ± 2.765
0.0LysTrp: 0.0 ± 0.0
4.617LysTyr: 4.617 ± 1.979
0.0LysXaa: 0.0 ± 0.0
Leu
2.77LeuAla: 2.77 ± 1.157
1.847LeuCys: 1.847 ± 1.269
5.54LeuAsp: 5.54 ± 2.28
2.77LeuGlu: 2.77 ± 1.312
1.847LeuPhe: 1.847 ± 1.269
3.693LeuGly: 3.693 ± 1.506
3.693LeuHis: 3.693 ± 2.196
4.617LeuIle: 4.617 ± 2.269
6.464LeuLys: 6.464 ± 2.03
2.77LeuLeu: 2.77 ± 1.784
0.0LeuMet: 0.0 ± 0.0
3.693LeuAsn: 3.693 ± 1.764
2.77LeuPro: 2.77 ± 2.231
3.693LeuGln: 3.693 ± 1.918
9.234LeuArg: 9.234 ± 3.001
3.693LeuSer: 3.693 ± 1.488
4.617LeuThr: 4.617 ± 1.727
4.617LeuVal: 4.617 ± 2.13
0.0LeuTrp: 0.0 ± 0.0
2.77LeuTyr: 2.77 ± 1.952
0.0LeuXaa: 0.0 ± 0.0
Met
1.847MetAla: 1.847 ± 0.809
0.0MetCys: 0.0 ± 0.0
1.847MetAsp: 1.847 ± 1.045
0.923MetGlu: 0.923 ± 1.088
0.923MetPhe: 0.923 ± 0.797
3.693MetGly: 3.693 ± 2.242
0.0MetHis: 0.0 ± 0.0
0.923MetIle: 0.923 ± 1.063
0.923MetLys: 0.923 ± 0.797
1.847MetLeu: 1.847 ± 1.368
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.923MetPro: 0.923 ± 1.088
0.923MetGln: 0.923 ± 0.975
0.0MetArg: 0.0 ± 0.0
1.847MetSer: 1.847 ± 1.244
0.0MetThr: 0.0 ± 0.0
0.923MetVal: 0.923 ± 0.997
0.923MetTrp: 0.923 ± 0.635
3.693MetTyr: 3.693 ± 2.229
0.0MetXaa: 0.0 ± 0.0
Asn
3.693AsnAla: 3.693 ± 1.303
0.0AsnCys: 0.0 ± 0.0
2.77AsnAsp: 2.77 ± 1.216
1.847AsnGlu: 1.847 ± 0.809
0.923AsnPhe: 0.923 ± 0.797
2.77AsnGly: 2.77 ± 0.886
4.617AsnHis: 4.617 ± 2.097
2.77AsnIle: 2.77 ± 1.312
0.923AsnLys: 0.923 ± 0.797
7.387AsnLeu: 7.387 ± 2.533
2.77AsnMet: 2.77 ± 1.463
4.617AsnAsn: 4.617 ± 1.774
4.617AsnPro: 4.617 ± 0.99
0.0AsnGln: 0.0 ± 0.0
2.77AsnArg: 2.77 ± 1.475
3.693AsnSer: 3.693 ± 2.228
3.693AsnThr: 3.693 ± 1.27
3.693AsnVal: 3.693 ± 2.196
0.923AsnTrp: 0.923 ± 0.635
2.77AsnTyr: 2.77 ± 1.445
0.0AsnXaa: 0.0 ± 0.0
Pro
2.77ProAla: 2.77 ± 1.475
2.77ProCys: 2.77 ± 1.399
2.77ProAsp: 2.77 ± 2.091
1.847ProGlu: 1.847 ± 1.951
3.693ProPhe: 3.693 ± 1.144
1.847ProGly: 1.847 ± 1.114
5.54ProHis: 5.54 ± 3.031
3.693ProIle: 3.693 ± 1.937
3.693ProLys: 3.693 ± 1.941
2.77ProLeu: 2.77 ± 1.445
0.923ProMet: 0.923 ± 1.285
1.847ProAsn: 1.847 ± 0.994
0.923ProPro: 0.923 ± 0.635
2.77ProGln: 2.77 ± 1.297
6.464ProArg: 6.464 ± 1.982
1.847ProSer: 1.847 ± 1.076
4.617ProThr: 4.617 ± 1.727
3.693ProVal: 3.693 ± 1.379
0.923ProTrp: 0.923 ± 0.635
1.847ProTyr: 1.847 ± 1.229
0.0ProXaa: 0.0 ± 0.0
Gln
4.617GlnAla: 4.617 ± 1.831
2.77GlnCys: 2.77 ± 2.066
2.77GlnAsp: 2.77 ± 2.091
3.693GlnGlu: 3.693 ± 1.572
3.693GlnPhe: 3.693 ± 1.502
2.77GlnGly: 2.77 ± 1.211
1.847GlnHis: 1.847 ± 1.411
4.617GlnIle: 4.617 ± 2.486
3.693GlnLys: 3.693 ± 3.218
1.847GlnLeu: 1.847 ± 1.368
0.923GlnMet: 0.923 ± 1.088
2.77GlnAsn: 2.77 ± 0.9
4.617GlnPro: 4.617 ± 3.328
1.847GlnGln: 1.847 ± 1.459
2.77GlnArg: 2.77 ± 1.216
5.54GlnSer: 5.54 ± 1.8
0.923GlnThr: 0.923 ± 1.063
3.693GlnVal: 3.693 ± 1.379
0.0GlnTrp: 0.0 ± 0.0
0.923GlnTyr: 0.923 ± 0.797
0.0GlnXaa: 0.0 ± 0.0
Arg
2.77ArgAla: 2.77 ± 1.478
0.923ArgCys: 0.923 ± 0.997
4.617ArgAsp: 4.617 ± 2.13
3.693ArgGlu: 3.693 ± 2.073
3.693ArgPhe: 3.693 ± 1.278
3.693ArgGly: 3.693 ± 1.379
6.464ArgHis: 6.464 ± 2.911
8.31ArgIle: 8.31 ± 1.693
2.77ArgLys: 2.77 ± 1.525
4.617ArgLeu: 4.617 ± 2.338
0.923ArgMet: 0.923 ± 0.797
1.847ArgAsn: 1.847 ± 1.098
4.617ArgPro: 4.617 ± 1.322
1.847ArgGln: 1.847 ± 0.91
8.31ArgArg: 8.31 ± 4.263
4.617ArgSer: 4.617 ± 1.727
3.693ArgThr: 3.693 ± 1.014
2.77ArgVal: 2.77 ± 1.234
0.0ArgTrp: 0.0 ± 0.0
0.923ArgTyr: 0.923 ± 0.997
0.0ArgXaa: 0.0 ± 0.0
Ser
3.693SerAla: 3.693 ± 2.538
0.0SerCys: 0.0 ± 0.0
1.847SerAsp: 1.847 ± 1.076
0.923SerGlu: 0.923 ± 1.063
1.847SerPhe: 1.847 ± 0.994
2.77SerGly: 2.77 ± 1.353
4.617SerHis: 4.617 ± 1.296
4.617SerIle: 4.617 ± 2.255
5.54SerLys: 5.54 ± 2.911
2.77SerLeu: 2.77 ± 1.904
0.923SerMet: 0.923 ± 1.088
5.54SerAsn: 5.54 ± 2.015
8.31SerPro: 8.31 ± 1.883
4.617SerGln: 4.617 ± 2.073
7.387SerArg: 7.387 ± 2.557
13.85SerSer: 13.85 ± 8.698
3.693SerThr: 3.693 ± 1.572
2.77SerVal: 2.77 ± 2.391
0.923SerTrp: 0.923 ± 0.797
2.77SerTyr: 2.77 ± 0.9
0.0SerXaa: 0.0 ± 0.0
Thr
2.77ThrAla: 2.77 ± 0.886
0.923ThrCys: 0.923 ± 1.088
0.923ThrAsp: 0.923 ± 0.635
1.847ThrGlu: 1.847 ± 1.244
1.847ThrPhe: 1.847 ± 2.177
2.77ThrGly: 2.77 ± 0.886
3.693ThrHis: 3.693 ± 1.807
3.693ThrIle: 3.693 ± 1.942
2.77ThrLys: 2.77 ± 1.904
1.847ThrLeu: 1.847 ± 1.229
1.847ThrMet: 1.847 ± 0.809
0.923ThrAsn: 0.923 ± 0.797
5.54ThrPro: 5.54 ± 1.8
1.847ThrGln: 1.847 ± 1.098
3.693ThrArg: 3.693 ± 0.921
4.617ThrSer: 4.617 ± 2.144
3.693ThrThr: 3.693 ± 3.119
4.617ThrVal: 4.617 ± 2.49
0.0ThrTrp: 0.0 ± 0.0
2.77ThrTyr: 2.77 ± 0.98
0.0ThrXaa: 0.0 ± 0.0
Val
3.693ValAla: 3.693 ± 1.17
0.0ValCys: 0.0 ± 0.0
1.847ValAsp: 1.847 ± 0.994
2.77ValGlu: 2.77 ± 1.8
2.77ValPhe: 2.77 ± 0.886
1.847ValGly: 1.847 ± 1.594
0.0ValHis: 0.0 ± 0.0
6.464ValIle: 6.464 ± 2.303
2.77ValLys: 2.77 ± 1.216
5.54ValLeu: 5.54 ± 1.994
1.847ValMet: 1.847 ± 1.229
2.77ValAsn: 2.77 ± 1.297
2.77ValPro: 2.77 ± 1.893
7.387ValGln: 7.387 ± 1.591
3.693ValArg: 3.693 ± 2.319
2.77ValSer: 2.77 ± 1.475
4.617ValThr: 4.617 ± 3.005
1.847ValVal: 1.847 ± 1.269
0.923ValTrp: 0.923 ± 0.797
3.693ValTyr: 3.693 ± 1.278
0.0ValXaa: 0.0 ± 0.0
Trp
2.77TrpAla: 2.77 ± 1.216
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.923TrpGly: 0.923 ± 0.797
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.923TrpMet: 0.923 ± 0.797
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.923TrpGln: 0.923 ± 0.635
0.923TrpArg: 0.923 ± 0.975
0.0TrpSer: 0.0 ± 0.0
1.847TrpThr: 1.847 ± 2.126
0.923TrpVal: 0.923 ± 0.635
0.0TrpTrp: 0.0 ± 0.0
0.923TrpTyr: 0.923 ± 0.635
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.77TyrAla: 2.77 ± 1.475
0.923TyrCys: 0.923 ± 0.997
3.693TyrAsp: 3.693 ± 2.521
0.923TyrGlu: 0.923 ± 0.797
3.693TyrPhe: 3.693 ± 0.921
0.923TyrGly: 0.923 ± 0.635
0.0TyrHis: 0.0 ± 0.0
3.693TyrIle: 3.693 ± 1.942
1.847TyrLys: 1.847 ± 0.809
4.617TyrLeu: 4.617 ± 1.488
1.847TyrMet: 1.847 ± 0.967
4.617TyrAsn: 4.617 ± 1.829
0.923TyrPro: 0.923 ± 0.635
0.923TyrGln: 0.923 ± 1.063
1.847TyrArg: 1.847 ± 1.594
1.847TyrSer: 1.847 ± 1.993
0.0TyrThr: 0.0 ± 0.0
2.77TyrVal: 2.77 ± 1.816
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1084 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski