Amino acid dipepetide frequency for Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.906AlaAla: 2.906 ± 0.089
0.387AlaCys: 0.387 ± 0.021
2.338AlaAsp: 2.338 ± 0.054
3.508AlaGlu: 3.508 ± 0.069
2.744AlaPhe: 2.744 ± 0.063
3.627AlaGly: 3.627 ± 0.082
0.794AlaHis: 0.794 ± 0.031
5.908AlaIle: 5.908 ± 0.093
4.307AlaLys: 4.307 ± 0.086
6.476AlaLeu: 6.476 ± 0.101
1.248AlaMet: 1.248 ± 0.036
2.267AlaAsn: 2.267 ± 0.055
1.602AlaPro: 1.602 ± 0.049
1.245AlaGln: 1.245 ± 0.047
2.776AlaArg: 2.776 ± 0.077
3.939AlaSer: 3.939 ± 0.081
2.648AlaThr: 2.648 ± 0.062
4.061AlaVal: 4.061 ± 0.075
0.587AlaTrp: 0.587 ± 0.028
2.845AlaTyr: 2.845 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.275CysAla: 0.275 ± 0.019
0.074CysCys: 0.074 ± 0.012
0.344CysAsp: 0.344 ± 0.02
0.488CysGlu: 0.488 ± 0.022
0.199CysPhe: 0.199 ± 0.016
0.651CysGly: 0.651 ± 0.034
0.101CysHis: 0.101 ± 0.012
0.44CysIle: 0.44 ± 0.024
0.529CysLys: 0.529 ± 0.025
0.405CysLeu: 0.405 ± 0.021
0.133CysMet: 0.133 ± 0.013
0.35CysAsn: 0.35 ± 0.023
0.46CysPro: 0.46 ± 0.026
0.138CysGln: 0.138 ± 0.012
0.287CysArg: 0.287 ± 0.021
0.362CysSer: 0.362 ± 0.022
0.232CysThr: 0.232 ± 0.018
0.388CysVal: 0.388 ± 0.027
0.072CysTrp: 0.072 ± 0.009
0.254CysTyr: 0.254 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
2.558AspAla: 2.558 ± 0.063
0.256AspCys: 0.256 ± 0.02
2.133AspAsp: 2.133 ± 0.053
3.95AspGlu: 3.95 ± 0.073
2.325AspPhe: 2.325 ± 0.059
2.517AspGly: 2.517 ± 0.062
0.592AspHis: 0.592 ± 0.028
4.428AspIle: 4.428 ± 0.076
3.895AspLys: 3.895 ± 0.072
5.091AspLeu: 5.091 ± 0.082
0.984AspMet: 0.984 ± 0.04
2.188AspAsn: 2.188 ± 0.051
2.096AspPro: 2.096 ± 0.054
0.778AspGln: 0.778 ± 0.031
1.925AspArg: 1.925 ± 0.054
2.597AspSer: 2.597 ± 0.061
1.713AspThr: 1.713 ± 0.043
3.943AspVal: 3.943 ± 0.078
0.545AspTrp: 0.545 ± 0.026
2.429AspTyr: 2.429 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
3.892GluAla: 3.892 ± 0.07
0.422GluCys: 0.422 ± 0.023
3.491GluAsp: 3.491 ± 0.07
6.222GluGlu: 6.222 ± 0.124
2.808GluPhe: 2.808 ± 0.059
4.033GluGly: 4.033 ± 0.076
0.724GluHis: 0.724 ± 0.029
7.245GluIle: 7.245 ± 0.103
6.162GluLys: 6.162 ± 0.106
7.051GluLeu: 7.051 ± 0.115
1.541GluMet: 1.541 ± 0.04
3.356GluAsn: 3.356 ± 0.067
1.648GluPro: 1.648 ± 0.044
1.23GluGln: 1.23 ± 0.046
3.298GluArg: 3.298 ± 0.073
3.192GluSer: 3.192 ± 0.065
2.462GluThr: 2.462 ± 0.052
5.52GluVal: 5.52 ± 0.096
0.641GluTrp: 0.641 ± 0.028
3.13GluTyr: 3.13 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
2.359PheAla: 2.359 ± 0.062
0.239PheCys: 0.239 ± 0.016
2.038PheAsp: 2.038 ± 0.044
2.277PheGlu: 2.277 ± 0.052
1.963PhePhe: 1.963 ± 0.061
2.742PheGly: 2.742 ± 0.059
0.754PheHis: 0.754 ± 0.031
3.801PheIle: 3.801 ± 0.088
3.173PheLys: 3.173 ± 0.066
5.147PheLeu: 5.147 ± 0.098
1.016PheMet: 1.016 ± 0.037
2.359PheAsn: 2.359 ± 0.061
1.931PhePro: 1.931 ± 0.049
0.839PheGln: 0.839 ± 0.035
1.825PheArg: 1.825 ± 0.053
3.6PheSer: 3.6 ± 0.076
2.44PheThr: 2.44 ± 0.059
2.932PheVal: 2.932 ± 0.058
0.484PheTrp: 0.484 ± 0.024
2.417PheTyr: 2.417 ± 0.068
0.0PheXaa: 0.0 ± 0.0
Gly
3.271GlyAla: 3.271 ± 0.08
0.431GlyCys: 0.431 ± 0.023
2.855GlyAsp: 2.855 ± 0.059
4.152GlyGlu: 4.152 ± 0.077
3.372GlyPhe: 3.372 ± 0.07
4.235GlyGly: 4.235 ± 0.086
0.904GlyHis: 0.904 ± 0.034
7.139GlyIle: 7.139 ± 0.089
5.707GlyLys: 5.707 ± 0.089
6.183GlyLeu: 6.183 ± 0.094
1.466GlyMet: 1.466 ± 0.041
3.019GlyAsn: 3.019 ± 0.074
1.617GlyPro: 1.617 ± 0.051
1.154GlyGln: 1.154 ± 0.042
2.817GlyArg: 2.817 ± 0.058
4.004GlySer: 4.004 ± 0.076
2.895GlyThr: 2.895 ± 0.058
5.008GlyVal: 5.008 ± 0.08
0.775GlyTrp: 0.775 ± 0.033
3.397GlyTyr: 3.397 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
0.751HisAla: 0.751 ± 0.029
0.094HisCys: 0.094 ± 0.012
0.605HisAsp: 0.605 ± 0.028
0.864HisGlu: 0.864 ± 0.031
0.535HisPhe: 0.535 ± 0.027
1.018HisGly: 1.018 ± 0.036
0.271HisHis: 0.271 ± 0.019
1.028HisIle: 1.028 ± 0.038
0.876HisLys: 0.876 ± 0.036
1.344HisLeu: 1.344 ± 0.042
0.341HisMet: 0.341 ± 0.02
0.57HisAsn: 0.57 ± 0.026
0.679HisPro: 0.679 ± 0.031
0.257HisGln: 0.257 ± 0.018
0.554HisArg: 0.554 ± 0.027
0.775HisSer: 0.775 ± 0.032
0.552HisThr: 0.552 ± 0.028
1.016HisVal: 1.016 ± 0.035
0.133HisTrp: 0.133 ± 0.013
0.674HisTyr: 0.674 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.012IleAla: 6.012 ± 0.111
0.484IleCys: 0.484 ± 0.027
4.707IleAsp: 4.707 ± 0.08
5.903IleGlu: 5.903 ± 0.103
3.904IlePhe: 3.904 ± 0.082
6.151IleGly: 6.151 ± 0.1
1.179IleHis: 1.179 ± 0.04
8.865IleIle: 8.865 ± 0.144
6.664IleLys: 6.664 ± 0.099
9.557IleLeu: 9.557 ± 0.139
1.963IleMet: 1.963 ± 0.046
4.849IleAsn: 4.849 ± 0.093
4.255IlePro: 4.255 ± 0.088
1.843IleGln: 1.843 ± 0.042
4.404IleArg: 4.404 ± 0.079
7.392IleSer: 7.392 ± 0.112
4.971IleThr: 4.971 ± 0.089
6.996IleVal: 6.996 ± 0.1
0.727IleTrp: 0.727 ± 0.028
4.171IleTyr: 4.171 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
4.278LysAla: 4.278 ± 0.078
0.528LysCys: 0.528 ± 0.028
4.059LysAsp: 4.059 ± 0.078
6.767LysGlu: 6.767 ± 0.107
2.808LysPhe: 2.808 ± 0.058
5.23LysGly: 5.23 ± 0.088
0.737LysHis: 0.737 ± 0.03
7.54LysIle: 7.54 ± 0.109
5.571LysLys: 5.571 ± 0.11
7.74LysLeu: 7.74 ± 0.11
1.765LysMet: 1.765 ± 0.044
3.475LysAsn: 3.475 ± 0.073
2.667LysPro: 2.667 ± 0.057
1.474LysGln: 1.474 ± 0.042
4.095LysArg: 4.095 ± 0.075
3.986LysSer: 3.986 ± 0.079
3.02LysThr: 3.02 ± 0.067
6.505LysVal: 6.505 ± 0.087
0.789LysTrp: 0.789 ± 0.029
3.892LysTyr: 3.892 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
6.732LeuAla: 6.732 ± 0.108
0.505LeuCys: 0.505 ± 0.026
5.05LeuAsp: 5.05 ± 0.091
6.59LeuGlu: 6.59 ± 0.109
4.172LeuPhe: 4.172 ± 0.096
7.237LeuGly: 7.237 ± 0.1
1.347LeuHis: 1.347 ± 0.042
9.131LeuIle: 9.131 ± 0.118
7.755LeuLys: 7.755 ± 0.113
10.272LeuLeu: 10.272 ± 0.158
2.322LeuMet: 2.322 ± 0.056
5.275LeuAsn: 5.275 ± 0.083
4.161LeuPro: 4.161 ± 0.077
2.201LeuGln: 2.201 ± 0.056
5.219LeuArg: 5.219 ± 0.092
8.004LeuSer: 8.004 ± 0.12
4.964LeuThr: 4.964 ± 0.085
7.156LeuVal: 7.156 ± 0.108
0.902LeuTrp: 0.902 ± 0.038
4.567LeuTyr: 4.567 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
1.37MetAla: 1.37 ± 0.038
0.105MetCys: 0.105 ± 0.011
1.041MetAsp: 1.041 ± 0.04
1.552MetGlu: 1.552 ± 0.042
0.807MetPhe: 0.807 ± 0.032
1.64MetGly: 1.64 ± 0.042
0.236MetHis: 0.236 ± 0.017
2.105MetIle: 2.105 ± 0.05
1.901MetLys: 1.901 ± 0.051
2.053MetLeu: 2.053 ± 0.051
0.55MetMet: 0.55 ± 0.03
1.003MetAsn: 1.003 ± 0.033
0.897MetPro: 0.897 ± 0.035
0.504MetGln: 0.504 ± 0.024
1.314MetArg: 1.314 ± 0.042
1.534MetSer: 1.534 ± 0.04
1.013MetThr: 1.013 ± 0.037
1.398MetVal: 1.398 ± 0.04
0.22MetTrp: 0.22 ± 0.014
0.765MetTyr: 0.765 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
2.773AsnAla: 2.773 ± 0.068
0.354AsnCys: 0.354 ± 0.019
2.168AsnAsp: 2.168 ± 0.053
3.417AsnGlu: 3.417 ± 0.071
2.2AsnPhe: 2.2 ± 0.057
3.257AsnGly: 3.257 ± 0.089
0.488AsnHis: 0.488 ± 0.024
4.539AsnIle: 4.539 ± 0.09
3.436AsnLys: 3.436 ± 0.068
5.089AsnLeu: 5.089 ± 0.086
1.023AsnMet: 1.023 ± 0.034
2.631AsnAsn: 2.631 ± 0.063
2.441AsnPro: 2.441 ± 0.057
0.983AsnGln: 0.983 ± 0.037
1.96AsnArg: 1.96 ± 0.048
3.36AsnSer: 3.36 ± 0.064
2.377AsnThr: 2.377 ± 0.054
4.156AsnVal: 4.156 ± 0.075
0.515AsnTrp: 0.515 ± 0.026
2.599AsnTyr: 2.599 ± 0.071
0.0AsnXaa: 0.0 ± 0.0
Pro
1.888ProAla: 1.888 ± 0.048
0.21ProCys: 0.21 ± 0.016
1.609ProAsp: 1.609 ± 0.046
2.313ProGlu: 2.313 ± 0.061
2.061ProPhe: 2.061 ± 0.055
1.958ProGly: 1.958 ± 0.053
0.664ProHis: 0.664 ± 0.032
3.592ProIle: 3.592 ± 0.075
2.587ProLys: 2.587 ± 0.058
4.135ProLeu: 4.135 ± 0.086
0.746ProMet: 0.746 ± 0.03
1.954ProAsn: 1.954 ± 0.05
1.736ProPro: 1.736 ± 0.051
1.128ProGln: 1.128 ± 0.037
1.465ProArg: 1.465 ± 0.036
2.893ProSer: 2.893 ± 0.066
2.009ProThr: 2.009 ± 0.051
2.62ProVal: 2.62 ± 0.06
0.523ProTrp: 0.523 ± 0.025
2.044ProTyr: 2.044 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
1.197GlnAla: 1.197 ± 0.042
0.109GlnCys: 0.109 ± 0.011
0.894GlnAsp: 0.894 ± 0.032
1.344GlnGlu: 1.344 ± 0.045
0.918GlnPhe: 0.918 ± 0.032
1.442GlnGly: 1.442 ± 0.047
0.272GlnHis: 0.272 ± 0.018
2.041GlnIle: 2.041 ± 0.05
1.358GlnLys: 1.358 ± 0.047
2.314GlnLeu: 2.314 ± 0.063
0.505GlnMet: 0.505 ± 0.025
0.992GlnAsn: 0.992 ± 0.035
0.728GlnPro: 0.728 ± 0.029
0.721GlnGln: 0.721 ± 0.036
0.992GlnArg: 0.992 ± 0.036
1.138GlnSer: 1.138 ± 0.041
1.048GlnThr: 1.048 ± 0.041
1.71GlnVal: 1.71 ± 0.043
0.244GlnTrp: 0.244 ± 0.019
1.052GlnTyr: 1.052 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.568ArgAla: 2.568 ± 0.064
0.313ArgCys: 0.313 ± 0.023
2.392ArgAsp: 2.392 ± 0.057
4.063ArgGlu: 4.063 ± 0.091
2.003ArgPhe: 2.003 ± 0.048
3.108ArgGly: 3.108 ± 0.073
0.577ArgHis: 0.577 ± 0.029
4.136ArgIle: 4.136 ± 0.077
4.332ArgLys: 4.332 ± 0.092
4.439ArgLeu: 4.439 ± 0.085
1.03ArgMet: 1.03 ± 0.036
2.136ArgAsn: 2.136 ± 0.047
1.413ArgPro: 1.413 ± 0.039
0.983ArgGln: 0.983 ± 0.033
2.946ArgArg: 2.946 ± 0.066
2.543ArgSer: 2.543 ± 0.066
1.846ArgThr: 1.846 ± 0.048
3.441ArgVal: 3.441 ± 0.078
0.58ArgTrp: 0.58 ± 0.025
1.988ArgTyr: 1.988 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
3.428SerAla: 3.428 ± 0.067
0.425SerCys: 0.425 ± 0.022
2.733SerAsp: 2.733 ± 0.05
3.731SerGlu: 3.731 ± 0.062
3.4SerPhe: 3.4 ± 0.077
3.944SerGly: 3.944 ± 0.074
1.006SerHis: 1.006 ± 0.038
6.213SerIle: 6.213 ± 0.094
4.975SerLys: 4.975 ± 0.084
7.942SerLeu: 7.942 ± 0.122
1.609SerMet: 1.609 ± 0.045
3.352SerAsn: 3.352 ± 0.073
2.668SerPro: 2.668 ± 0.059
1.854SerGln: 1.854 ± 0.053
2.95SerArg: 2.95 ± 0.061
5.153SerSer: 5.153 ± 0.087
3.609SerThr: 3.609 ± 0.068
4.373SerVal: 4.373 ± 0.078
0.852SerTrp: 0.852 ± 0.035
2.941SerTyr: 2.941 ± 0.054
0.001SerXaa: 0.001 ± 0.001
Thr
2.692ThrAla: 2.692 ± 0.065
0.313ThrCys: 0.313 ± 0.018
1.765ThrAsp: 1.765 ± 0.046
2.347ThrGlu: 2.347 ± 0.057
2.338ThrPhe: 2.338 ± 0.056
3.194ThrGly: 3.194 ± 0.07
0.672ThrHis: 0.672 ± 0.028
4.568ThrIle: 4.568 ± 0.094
2.854ThrLys: 2.854 ± 0.064
5.357ThrLeu: 5.357 ± 0.094
1.011ThrMet: 1.011 ± 0.04
2.243ThrAsn: 2.243 ± 0.055
2.244ThrPro: 2.244 ± 0.052
1.097ThrGln: 1.097 ± 0.041
1.906ThrArg: 1.906 ± 0.049
3.549ThrSer: 3.549 ± 0.084
2.942ThrThr: 2.942 ± 0.081
3.465ThrVal: 3.465 ± 0.066
0.534ThrTrp: 0.534 ± 0.027
2.248ThrTyr: 2.248 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
4.091ValAla: 4.091 ± 0.074
0.428ValCys: 0.428 ± 0.025
3.72ValAsp: 3.72 ± 0.074
5.036ValGlu: 5.036 ± 0.091
2.942ValPhe: 2.942 ± 0.069
4.584ValGly: 4.584 ± 0.08
0.838ValHis: 0.838 ± 0.034
7.474ValIle: 7.474 ± 0.104
6.846ValLys: 6.846 ± 0.118
6.836ValLeu: 6.836 ± 0.099
1.582ValMet: 1.582 ± 0.046
4.222ValAsn: 4.222 ± 0.079
2.649ValPro: 2.649 ± 0.058
1.356ValGln: 1.356 ± 0.046
3.604ValArg: 3.604 ± 0.085
5.018ValSer: 5.018 ± 0.083
3.542ValThr: 3.542 ± 0.068
5.597ValVal: 5.597 ± 0.1
0.632ValTrp: 0.632 ± 0.028
3.478ValTyr: 3.478 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.605TrpAla: 0.605 ± 0.03
0.065TrpCys: 0.065 ± 0.009
0.57TrpAsp: 0.57 ± 0.027
0.604TrpGlu: 0.604 ± 0.024
0.55TrpPhe: 0.55 ± 0.026
0.713TrpGly: 0.713 ± 0.03
0.151TrpHis: 0.151 ± 0.014
0.961TrpIle: 0.961 ± 0.037
0.801TrpLys: 0.801 ± 0.031
1.051TrpLeu: 1.051 ± 0.041
0.197TrpMet: 0.197 ± 0.017
0.608TrpAsn: 0.608 ± 0.03
0.258TrpPro: 0.258 ± 0.015
0.225TrpGln: 0.225 ± 0.018
0.652TrpArg: 0.652 ± 0.029
0.681TrpSer: 0.681 ± 0.033
0.451TrpThr: 0.451 ± 0.022
0.638TrpVal: 0.638 ± 0.03
0.174TrpTrp: 0.174 ± 0.014
0.536TrpTyr: 0.536 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.566TyrAla: 2.566 ± 0.062
0.442TyrCys: 0.442 ± 0.027
2.429TyrAsp: 2.429 ± 0.057
2.938TyrGlu: 2.938 ± 0.068
2.285TyrPhe: 2.285 ± 0.063
3.121TyrGly: 3.121 ± 0.064
0.633TyrHis: 0.633 ± 0.03
3.841TyrIle: 3.841 ± 0.07
3.194TyrLys: 3.194 ± 0.069
5.079TyrLeu: 5.079 ± 0.088
0.975TyrMet: 0.975 ± 0.034
2.922TyrAsn: 2.922 ± 0.075
1.983TyrPro: 1.983 ± 0.054
1.01TyrGln: 1.01 ± 0.04
1.846TyrArg: 1.846 ± 0.045
3.44TyrSer: 3.44 ± 0.073
2.607TyrThr: 2.607 ± 0.06
3.554TyrVal: 3.554 ± 0.063
0.562TyrTrp: 0.562 ± 0.028
2.777TyrTyr: 2.777 ± 0.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.001XaaAsp: 0.001 ± 0.001
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2938 proteins (827883 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski