Amino acid dipepetide frequency for Budvicia aquatica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.939AlaAla: 7.939 ± 0.09	1.006AlaCys: 1.006 ± 0.026	4.695AlaAsp: 4.695 ± 0.061	5.267AlaGlu: 5.267 ± 0.073	3.161AlaPhe: 3.161 ± 0.051	7.064AlaGly: 7.064 ± 0.107	1.472AlaHis: 1.472 ± 0.033	6.142AlaIle: 6.142 ± 0.068	4.258AlaLys: 4.258 ± 0.058	9.768AlaLeu: 9.768 ± 0.084	2.506AlaMet: 2.506 ± 0.044	3.611AlaAsn: 3.611 ± 0.072	2.993AlaPro: 2.993 ± 0.049	3.685AlaGln: 3.685 ± 0.057	3.98AlaArg: 3.98 ± 0.069	5.446AlaSer: 5.446 ± 0.069	4.791AlaThr: 4.791 ± 0.079	5.851AlaVal: 5.851 ± 0.075	1.035AlaTrp: 1.035 ± 0.022	2.338AlaTyr: 2.338 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.831CysAla: 0.831 ± 0.025	0.176CysCys: 0.176 ± 0.013	0.58CysAsp: 0.58 ± 0.02	0.57CysGlu: 0.57 ± 0.019	0.45CysPhe: 0.45 ± 0.019	1.025CysGly: 1.025 ± 0.031	0.392CysHis: 0.392 ± 0.018	0.635CysIle: 0.635 ± 0.023	0.382CysLys: 0.382 ± 0.016	1.049CysLeu: 1.049 ± 0.027	0.232CysMet: 0.232 ± 0.011	0.377CysAsn: 0.377 ± 0.016	0.497CysPro: 0.497 ± 0.02	0.506CysGln: 0.506 ± 0.018	0.585CysArg: 0.585 ± 0.021	0.743CysSer: 0.743 ± 0.023	0.525CysThr: 0.525 ± 0.021	0.694CysVal: 0.694 ± 0.023	0.16CysTrp: 0.16 ± 0.01	0.369CysTyr: 0.369 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.389AspAla: 4.389 ± 0.052	0.519AspCys: 0.519 ± 0.019	2.899AspAsp: 2.899 ± 0.052	3.191AspGlu: 3.191 ± 0.045	2.088AspPhe: 2.088 ± 0.039	4.253AspGly: 4.253 ± 0.086	0.942AspHis: 0.942 ± 0.025	4.225AspIle: 4.225 ± 0.065	2.861AspLys: 2.861 ± 0.044	4.793AspLeu: 4.793 ± 0.063	1.374AspMet: 1.374 ± 0.031	2.793AspAsn: 2.793 ± 0.054	2.059AspPro: 2.059 ± 0.043	1.617AspGln: 1.617 ± 0.035	2.669AspArg: 2.669 ± 0.036	3.506AspSer: 3.506 ± 0.059	2.645AspThr: 2.645 ± 0.053	3.593AspVal: 3.593 ± 0.056	0.8AspTrp: 0.8 ± 0.025	1.985AspTyr: 1.985 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	4.195GluAla: 4.195 ± 0.058	0.502GluCys: 0.502 ± 0.017	2.207GluAsp: 2.207 ± 0.042	2.73GluGlu: 2.73 ± 0.053	1.904GluPhe: 1.904 ± 0.035	3.405GluGly: 3.405 ± 0.056	1.252GluHis: 1.252 ± 0.03	3.433GluIle: 3.433 ± 0.06	3.092GluLys: 3.092 ± 0.051	5.772GluLeu: 5.772 ± 0.072	1.495GluMet: 1.495 ± 0.031	2.463GluAsn: 2.463 ± 0.045	1.891GluPro: 1.891 ± 0.041	3.289GluGln: 3.289 ± 0.058	3.147GluArg: 3.147 ± 0.055	3.192GluSer: 3.192 ± 0.044	2.671GluThr: 2.671 ± 0.043	3.463GluVal: 3.463 ± 0.052	0.765GluTrp: 0.765 ± 0.025	1.619GluTyr: 1.619 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.02PheAla: 3.02 ± 0.042	0.541PheCys: 0.541 ± 0.02	2.341PheAsp: 2.341 ± 0.036	1.777PheGlu: 1.777 ± 0.036	1.686PhePhe: 1.686 ± 0.041	3.145PheGly: 3.145 ± 0.053	0.738PheHis: 0.738 ± 0.024	3.054PheIle: 3.054 ± 0.053	1.541PheLys: 1.541 ± 0.037	3.217PheLeu: 3.217 ± 0.06	1.002PheMet: 1.002 ± 0.024	2.049PheAsn: 2.049 ± 0.041	1.429PhePro: 1.429 ± 0.032	1.095PheGln: 1.095 ± 0.028	1.583PheArg: 1.583 ± 0.034	3.408PheSer: 3.408 ± 0.047	2.436PheThr: 2.436 ± 0.043	2.382PheVal: 2.382 ± 0.046	0.551PheTrp: 0.551 ± 0.019	1.264PheTyr: 1.264 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.203GlyAla: 6.203 ± 0.104	1.022GlyCys: 1.022 ± 0.033	4.087GlyAsp: 4.087 ± 0.077	3.921GlyGlu: 3.921 ± 0.053	3.257GlyPhe: 3.257 ± 0.05	6.098GlyGly: 6.098 ± 0.121	1.623GlyHis: 1.623 ± 0.034	5.752GlyIle: 5.752 ± 0.076	4.019GlyLys: 4.019 ± 0.056	7.516GlyLeu: 7.516 ± 0.08	2.218GlyMet: 2.218 ± 0.04	3.533GlyAsn: 3.533 ± 0.111	1.904GlyPro: 1.904 ± 0.036	3.084GlyGln: 3.084 ± 0.06	3.275GlyArg: 3.275 ± 0.049	5.233GlySer: 5.233 ± 0.123	4.673GlyThr: 4.673 ± 0.13	5.552GlyVal: 5.552 ± 0.071	1.164GlyTrp: 1.164 ± 0.029	2.928GlyTyr: 2.928 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.531HisAla: 1.531 ± 0.034	0.32HisCys: 0.32 ± 0.014	1.042HisAsp: 1.042 ± 0.025	0.883HisGlu: 0.883 ± 0.023	0.892HisPhe: 0.892 ± 0.026	1.524HisGly: 1.524 ± 0.033	0.673HisHis: 0.673 ± 0.025	1.371HisIle: 1.371 ± 0.03	0.809HisLys: 0.809 ± 0.021	2.095HisLeu: 2.095 ± 0.038	0.489HisMet: 0.489 ± 0.017	0.905HisAsn: 0.905 ± 0.027	1.155HisPro: 1.155 ± 0.029	1.256HisGln: 1.256 ± 0.03	1.102HisArg: 1.102 ± 0.03	1.347HisSer: 1.347 ± 0.031	1.092HisThr: 1.092 ± 0.03	1.127HisVal: 1.127 ± 0.028	0.34HisTrp: 0.34 ± 0.016	0.834HisTyr: 0.834 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.502IleAla: 6.502 ± 0.07	0.775IleCys: 0.775 ± 0.028	4.092IleAsp: 4.092 ± 0.055	3.911IleGlu: 3.911 ± 0.061	2.427IlePhe: 2.427 ± 0.047	5.404IleGly: 5.404 ± 0.073	1.304IleHis: 1.304 ± 0.027	4.326IleIle: 4.326 ± 0.07	3.264IleLys: 3.264 ± 0.048	5.702IleLeu: 5.702 ± 0.087	1.399IleMet: 1.399 ± 0.036	3.603IleAsn: 3.603 ± 0.075	2.93IlePro: 2.93 ± 0.045	2.28IleGln: 2.28 ± 0.038	2.99IleArg: 2.99 ± 0.047	4.976IleSer: 4.976 ± 0.062	4.286IleThr: 4.286 ± 0.061	4.3IleVal: 4.3 ± 0.058	0.736IleTrp: 0.736 ± 0.022	1.905IleTyr: 1.905 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.13LysAla: 4.13 ± 0.067	0.29LysCys: 0.29 ± 0.012	2.439LysAsp: 2.439 ± 0.044	2.533LysGlu: 2.533 ± 0.049	1.29LysPhe: 1.29 ± 0.028	3.144LysGly: 3.144 ± 0.05	0.976LysHis: 0.976 ± 0.023	2.938LysIle: 2.938 ± 0.051	2.548LysLys: 2.548 ± 0.055	4.803LysLeu: 4.803 ± 0.061	1.377LysMet: 1.377 ± 0.034	2.26LysAsn: 2.26 ± 0.041	2.175LysPro: 2.175 ± 0.045	2.472LysGln: 2.472 ± 0.047	2.419LysArg: 2.419 ± 0.042	2.819LysSer: 2.819 ± 0.045	2.784LysThr: 2.784 ± 0.041	3.29LysVal: 3.29 ± 0.045	0.458LysTrp: 0.458 ± 0.019	1.294LysTyr: 1.294 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	9.925LeuAla: 9.925 ± 0.099	1.194LeuCys: 1.194 ± 0.029	5.252LeuAsp: 5.252 ± 0.065	4.915LeuGlu: 4.915 ± 0.068	4.152LeuPhe: 4.152 ± 0.07	7.34LeuGly: 7.34 ± 0.081	1.887LeuHis: 1.887 ± 0.041	6.559LeuIle: 6.559 ± 0.086	4.799LeuLys: 4.799 ± 0.067	10.705LeuLeu: 10.705 ± 0.112	2.742LeuMet: 2.742 ± 0.046	5.061LeuAsn: 5.061 ± 0.088	5.066LeuPro: 5.066 ± 0.073	3.616LeuGln: 3.616 ± 0.055	4.821LeuArg: 4.821 ± 0.059	8.311LeuSer: 8.311 ± 0.087	6.676LeuThr: 6.676 ± 0.103	6.746LeuVal: 6.746 ± 0.067	1.257LeuTrp: 1.257 ± 0.03	2.725LeuTyr: 2.725 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.676MetAla: 2.676 ± 0.046	0.209MetCys: 0.209 ± 0.011	1.231MetAsp: 1.231 ± 0.03	1.105MetGlu: 1.105 ± 0.028	0.906MetPhe: 0.906 ± 0.028	1.821MetGly: 1.821 ± 0.036	0.438MetHis: 0.438 ± 0.017	1.567MetIle: 1.567 ± 0.036	1.459MetLys: 1.459 ± 0.037	2.851MetLeu: 2.851 ± 0.054	0.866MetMet: 0.866 ± 0.028	1.211MetAsn: 1.211 ± 0.027	1.22MetPro: 1.22 ± 0.028	0.989MetGln: 0.989 ± 0.026	1.256MetArg: 1.256 ± 0.026	1.947MetSer: 1.947 ± 0.034	1.764MetThr: 1.764 ± 0.032	1.866MetVal: 1.866 ± 0.036	0.243MetTrp: 0.243 ± 0.012	0.539MetTyr: 0.539 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.745AsnAla: 3.745 ± 0.086	0.36AsnCys: 0.36 ± 0.017	2.355AsnAsp: 2.355 ± 0.045	2.018AsnGlu: 2.018 ± 0.035	1.486AsnPhe: 1.486 ± 0.032	4.215AsnGly: 4.215 ± 0.131	1.007AsnHis: 1.007 ± 0.027	3.208AsnIle: 3.208 ± 0.06	2.103AsnLys: 2.103 ± 0.038	4.171AsnLeu: 4.171 ± 0.07	1.091AsnMet: 1.091 ± 0.027	2.626AsnAsn: 2.626 ± 0.072	2.178AsnPro: 2.178 ± 0.039	2.186AsnGln: 2.186 ± 0.044	2.02AsnArg: 2.02 ± 0.042	3.087AsnSer: 3.087 ± 0.083	2.585AsnThr: 2.585 ± 0.067	2.999AsnVal: 2.999 ± 0.061	0.619AsnTrp: 0.619 ± 0.02	1.46AsnTyr: 1.46 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.717ProAla: 3.717 ± 0.062	0.384ProCys: 0.384 ± 0.015	2.598ProAsp: 2.598 ± 0.044	3.204ProGlu: 3.204 ± 0.052	1.636ProPhe: 1.636 ± 0.033	2.689ProGly: 2.689 ± 0.05	0.868ProHis: 0.868 ± 0.024	2.433ProIle: 2.433 ± 0.048	1.785ProLys: 1.785 ± 0.041	4.426ProLeu: 4.426 ± 0.06	1.015ProMet: 1.015 ± 0.021	1.478ProAsn: 1.478 ± 0.031	1.382ProPro: 1.382 ± 0.033	1.804ProGln: 1.804 ± 0.037	1.489ProArg: 1.489 ± 0.026	2.394ProSer: 2.394 ± 0.047	2.335ProThr: 2.335 ± 0.049	3.467ProVal: 3.467 ± 0.057	0.525ProTrp: 0.525 ± 0.018	1.361ProTyr: 1.361 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.171GlnAla: 4.171 ± 0.068	0.389GlnCys: 0.389 ± 0.015	2.037GlnAsp: 2.037 ± 0.04	1.906GlnGlu: 1.906 ± 0.038	1.525GlnPhe: 1.525 ± 0.032	3.092GlnGly: 3.092 ± 0.05	1.08GlnHis: 1.08 ± 0.028	2.657GlnIle: 2.657 ± 0.048	1.875GlnLys: 1.875 ± 0.041	4.931GlnLeu: 4.931 ± 0.066	1.097GlnMet: 1.097 ± 0.025	1.623GlnAsn: 1.623 ± 0.036	1.936GlnPro: 1.936 ± 0.04	3.191GlnGln: 3.191 ± 0.065	2.629GlnArg: 2.629 ± 0.051	2.694GlnSer: 2.694 ± 0.038	2.237GlnThr: 2.237 ± 0.041	3.03GlnVal: 3.03 ± 0.043	0.66GlnTrp: 0.66 ± 0.02	1.319GlnTyr: 1.319 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.59ArgAla: 3.59 ± 0.067	0.541ArgCys: 0.541 ± 0.02	2.434ArgAsp: 2.434 ± 0.045	2.82ArgGlu: 2.82 ± 0.054	2.159ArgPhe: 2.159 ± 0.037	2.861ArgGly: 2.861 ± 0.047	1.241ArgHis: 1.241 ± 0.031	3.243ArgIle: 3.243 ± 0.048	2.227ArgLys: 2.227 ± 0.044	5.528ArgLeu: 5.528 ± 0.062	1.298ArgMet: 1.298 ± 0.027	1.938ArgAsn: 1.938 ± 0.041	1.776ArgPro: 1.776 ± 0.037	2.557ArgGln: 2.557 ± 0.044	2.624ArgArg: 2.624 ± 0.053	2.683ArgSer: 2.683 ± 0.048	2.288ArgThr: 2.288 ± 0.038	3.172ArgVal: 3.172 ± 0.047	0.819ArgTrp: 0.819 ± 0.028	2.088ArgTyr: 2.088 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.122SerAla: 6.122 ± 0.085	0.702SerCys: 0.702 ± 0.026	3.773SerAsp: 3.773 ± 0.057	3.432SerGlu: 3.432 ± 0.055	2.619SerPhe: 2.619 ± 0.046	6.687SerGly: 6.687 ± 0.142	1.515SerHis: 1.515 ± 0.034	4.07SerIle: 4.07 ± 0.057	2.488SerLys: 2.488 ± 0.038	7.344SerLeu: 7.344 ± 0.085	1.621SerMet: 1.621 ± 0.035	2.601SerAsn: 2.601 ± 0.05	2.751SerPro: 2.751 ± 0.05	2.956SerGln: 2.956 ± 0.046	3.158SerArg: 3.158 ± 0.046	4.681SerSer: 4.681 ± 0.075	3.746SerThr: 3.746 ± 0.071	4.838SerVal: 4.838 ± 0.075	0.944SerTrp: 0.944 ± 0.023	2.081SerTyr: 2.081 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.952ThrAla: 4.952 ± 0.083	0.493ThrCys: 0.493 ± 0.02	3.14ThrAsp: 3.14 ± 0.06	2.872ThrGlu: 2.872 ± 0.042	2.05ThrPhe: 2.05 ± 0.036	5.119ThrGly: 5.119 ± 0.118	1.184ThrHis: 1.184 ± 0.026	3.751ThrIle: 3.751 ± 0.077	2.07ThrLys: 2.07 ± 0.032	7.079ThrLeu: 7.079 ± 0.122	1.192ThrMet: 1.192 ± 0.026	2.286ThrAsn: 2.286 ± 0.055	3.054ThrPro: 3.054 ± 0.044	2.389ThrGln: 2.389 ± 0.042	2.433ThrArg: 2.433 ± 0.041	3.61ThrSer: 3.61 ± 0.054	3.298ThrThr: 3.298 ± 0.077	4.328ThrVal: 4.328 ± 0.13	0.668ThrTrp: 0.668 ± 0.023	1.615ThrTyr: 1.615 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	5.965ValAla: 5.965 ± 0.073	0.764ValCys: 0.764 ± 0.026	3.801ValAsp: 3.801 ± 0.059	3.716ValGlu: 3.716 ± 0.049	2.647ValPhe: 2.647 ± 0.045	4.925ValGly: 4.925 ± 0.056	1.06ValHis: 1.06 ± 0.024	5.08ValIle: 5.08 ± 0.068	3.166ValLys: 3.166 ± 0.052	6.627ValLeu: 6.627 ± 0.075	2.058ValMet: 2.058 ± 0.034	3.349ValAsn: 3.349 ± 0.068	2.699ValPro: 2.699 ± 0.043	2.165ValGln: 2.165 ± 0.042	3.076ValArg: 3.076 ± 0.048	4.995ValSer: 4.995 ± 0.076	4.54ValThr: 4.54 ± 0.102	4.978ValVal: 4.978 ± 0.061	0.859ValTrp: 0.859 ± 0.027	1.882ValTyr: 1.882 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.94TrpAla: 0.94 ± 0.026	0.171TrpCys: 0.171 ± 0.011	0.616TrpAsp: 0.616 ± 0.021	0.504TrpGlu: 0.504 ± 0.016	0.62TrpPhe: 0.62 ± 0.022	0.855TrpGly: 0.855 ± 0.026	0.369TrpHis: 0.369 ± 0.016	0.801TrpIle: 0.801 ± 0.024	0.52TrpLys: 0.52 ± 0.018	1.942TrpLeu: 1.942 ± 0.04	0.407TrpMet: 0.407 ± 0.018	0.536TrpAsn: 0.536 ± 0.018	0.487TrpPro: 0.487 ± 0.019	0.915TrpGln: 0.915 ± 0.029	0.757TrpArg: 0.757 ± 0.021	0.845TrpSer: 0.845 ± 0.027	0.535TrpThr: 0.535 ± 0.021	0.857TrpVal: 0.857 ± 0.025	0.21TrpTrp: 0.21 ± 0.011	0.407TrpTyr: 0.407 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.464TyrAla: 2.464 ± 0.04	0.421TyrCys: 0.421 ± 0.018	1.58TyrAsp: 1.58 ± 0.039	1.213TyrGlu: 1.213 ± 0.031	1.307TyrPhe: 1.307 ± 0.03	2.394TyrGly: 2.394 ± 0.041	0.767TyrHis: 0.767 ± 0.02	1.869TyrIle: 1.869 ± 0.032	1.17TyrLys: 1.17 ± 0.031	3.429TyrLeu: 3.429 ± 0.056	0.686TyrMet: 0.686 ± 0.019	1.216TyrAsn: 1.216 ± 0.034	1.408TyrPro: 1.408 ± 0.031	2.022TyrGln: 2.022 ± 0.041	1.873TyrArg: 1.873 ± 0.034	2.215TyrSer: 2.215 ± 0.048	1.676TyrThr: 1.676 ± 0.034	1.821TyrVal: 1.821 ± 0.034	0.481TyrTrp: 0.481 ± 0.017	1.113TyrTyr: 1.113 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4968 proteins (1615998 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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