Amino acid dipepetide frequency for Elysia chlorotica (Eastern emerald elysia) (Sea slug)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.813AlaAla: 5.813 ± 0.037	1.389AlaCys: 1.389 ± 0.016	3.469AlaAsp: 3.469 ± 0.022	4.04AlaGlu: 4.04 ± 0.03	2.341AlaPhe: 2.341 ± 0.021	4.458AlaGly: 4.458 ± 0.031	1.539AlaHis: 1.539 ± 0.017	2.934AlaIle: 2.934 ± 0.023	3.55AlaLys: 3.55 ± 0.025	5.957AlaLeu: 5.957 ± 0.036	1.652AlaMet: 1.652 ± 0.017	2.476AlaAsn: 2.476 ± 0.019	3.228AlaPro: 3.228 ± 0.023	2.785AlaGln: 2.785 ± 0.021	3.566AlaArg: 3.566 ± 0.026	6.292AlaSer: 6.292 ± 0.038	3.9AlaThr: 3.9 ± 0.026	4.583AlaVal: 4.583 ± 0.028	0.715AlaTrp: 0.715 ± 0.011	1.56AlaTyr: 1.56 ± 0.015	0.001AlaXaa: 0.001 ± 0.0
Cys	1.192CysAla: 1.192 ± 0.014	0.605CysCys: 0.605 ± 0.013	1.217CysAsp: 1.217 ± 0.017	1.141CysGlu: 1.141 ± 0.016	0.792CysPhe: 0.792 ± 0.011	1.467CysGly: 1.467 ± 0.021	0.603CysHis: 0.603 ± 0.011	0.952CysIle: 0.952 ± 0.015	1.004CysLys: 1.004 ± 0.015	2.112CysLeu: 2.112 ± 0.021	0.443CysMet: 0.443 ± 0.009	0.858CysAsn: 0.858 ± 0.015	1.258CysPro: 1.258 ± 0.029	0.917CysGln: 0.917 ± 0.012	1.177CysArg: 1.177 ± 0.014	1.877CysSer: 1.877 ± 0.019	1.108CysThr: 1.108 ± 0.017	1.505CysVal: 1.505 ± 0.022	0.245CysTrp: 0.245 ± 0.006	0.627CysTyr: 0.627 ± 0.03	0.0CysXaa: 0.0 ± 0.0
Asp	3.408AspAla: 3.408 ± 0.023	1.077AspCys: 1.077 ± 0.016	6.418AspAsp: 6.418 ± 0.148	3.835AspGlu: 3.835 ± 0.028	2.266AspPhe: 2.266 ± 0.016	3.977AspGly: 3.977 ± 0.041	1.339AspHis: 1.339 ± 0.017	3.039AspIle: 3.039 ± 0.025	3.191AspLys: 3.191 ± 0.025	5.058AspLeu: 5.058 ± 0.028	1.361AspMet: 1.361 ± 0.014	2.481AspAsn: 2.481 ± 0.021	2.676AspPro: 2.676 ± 0.022	2.143AspGln: 2.143 ± 0.016	2.946AspArg: 2.946 ± 0.026	4.852AspSer: 4.852 ± 0.033	3.09AspThr: 3.09 ± 0.025	3.664AspVal: 3.664 ± 0.024	0.653AspTrp: 0.653 ± 0.009	1.642AspTyr: 1.642 ± 0.019	0.001AspXaa: 0.001 ± 0.0
Glu	4.177GluAla: 4.177 ± 0.029	1.067GluCys: 1.067 ± 0.017	4.256GluAsp: 4.256 ± 0.034	6.701GluGlu: 6.701 ± 0.127	1.926GluPhe: 1.926 ± 0.016	3.414GluGly: 3.414 ± 0.022	1.388GluHis: 1.388 ± 0.018	2.929GluIle: 2.929 ± 0.025	4.502GluLys: 4.502 ± 0.04	4.954GluLeu: 4.954 ± 0.032	1.597GluMet: 1.597 ± 0.017	2.954GluAsn: 2.954 ± 0.025	2.332GluPro: 2.332 ± 0.021	2.499GluGln: 2.499 ± 0.024	3.666GluArg: 3.666 ± 0.033	4.546GluSer: 4.546 ± 0.031	3.548GluThr: 3.548 ± 0.03	3.519GluVal: 3.519 ± 0.026	0.585GluTrp: 0.585 ± 0.01	1.418GluTyr: 1.418 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	2.081PheAla: 2.081 ± 0.016	0.879PheCys: 0.879 ± 0.013	2.066PheAsp: 2.066 ± 0.018	1.914PheGlu: 1.914 ± 0.018	1.674PhePhe: 1.674 ± 0.022	2.278PheGly: 2.278 ± 0.021	1.001PheHis: 1.001 ± 0.012	1.846PheIle: 1.846 ± 0.02	1.902PheLys: 1.902 ± 0.017	3.622PheLeu: 3.622 ± 0.029	0.858PheMet: 0.858 ± 0.01	1.58PheAsn: 1.58 ± 0.017	1.806PhePro: 1.806 ± 0.019	1.526PheGln: 1.526 ± 0.015	1.891PheArg: 1.891 ± 0.016	3.381PheSer: 3.381 ± 0.022	2.171PheThr: 2.171 ± 0.018	2.409PheVal: 2.409 ± 0.021	0.435PheTrp: 0.435 ± 0.008	1.271PheTyr: 1.271 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	4.108GlyAla: 4.108 ± 0.031	1.202GlyCys: 1.202 ± 0.015	3.769GlyAsp: 3.769 ± 0.03	3.605GlyGlu: 3.605 ± 0.028	2.351GlyPhe: 2.351 ± 0.022	5.601GlyGly: 5.601 ± 0.078	1.766GlyHis: 1.766 ± 0.016	2.759GlyIle: 2.759 ± 0.028	3.571GlyLys: 3.571 ± 0.025	5.16GlyLeu: 5.16 ± 0.032	1.452GlyMet: 1.452 ± 0.017	2.678GlyAsn: 2.678 ± 0.023	2.783GlyPro: 2.783 ± 0.024	2.768GlyGln: 2.768 ± 0.024	3.674GlyArg: 3.674 ± 0.029	5.769GlySer: 5.769 ± 0.038	3.371GlyThr: 3.371 ± 0.023	3.906GlyVal: 3.906 ± 0.031	0.786GlyTrp: 0.786 ± 0.024	1.879GlyTyr: 1.879 ± 0.023	0.001GlyXaa: 0.001 ± 0.0
His	1.499HisAla: 1.499 ± 0.013	0.631HisCys: 0.631 ± 0.01	1.213HisAsp: 1.213 ± 0.016	1.206HisGlu: 1.206 ± 0.016	1.029HisPhe: 1.029 ± 0.013	1.654HisGly: 1.654 ± 0.017	1.306HisHis: 1.306 ± 0.018	1.294HisIle: 1.294 ± 0.016	1.392HisLys: 1.392 ± 0.016	2.502HisLeu: 2.502 ± 0.02	0.64HisMet: 0.64 ± 0.01	1.165HisAsn: 1.165 ± 0.014	1.535HisPro: 1.535 ± 0.022	1.468HisGln: 1.468 ± 0.02	1.65HisArg: 1.65 ± 0.016	2.377HisSer: 2.377 ± 0.02	1.527HisThr: 1.527 ± 0.016	1.618HisVal: 1.618 ± 0.016	0.32HisTrp: 0.32 ± 0.007	0.822HisTyr: 0.822 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	2.79IleAla: 2.79 ± 0.023	1.055IleCys: 1.055 ± 0.014	2.466IleAsp: 2.466 ± 0.02	2.491IleGlu: 2.491 ± 0.022	1.911IlePhe: 1.911 ± 0.018	2.569IleGly: 2.569 ± 0.028	1.266IleHis: 1.266 ± 0.016	2.552IleIle: 2.552 ± 0.037	2.63IleLys: 2.63 ± 0.019	4.165IleLeu: 4.165 ± 0.028	1.062IleMet: 1.062 ± 0.014	2.124IleAsn: 2.124 ± 0.021	2.502IlePro: 2.502 ± 0.022	1.936IleGln: 1.936 ± 0.018	2.329IleArg: 2.329 ± 0.02	4.091IleSer: 4.091 ± 0.027	2.731IleThr: 2.731 ± 0.023	3.003IleVal: 3.003 ± 0.024	0.486IleTrp: 0.486 ± 0.01	1.513IleTyr: 1.513 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.773LysAla: 3.773 ± 0.025	1.062LysCys: 1.062 ± 0.016	3.43LysAsp: 3.43 ± 0.024	4.243LysGlu: 4.243 ± 0.035	1.878LysPhe: 1.878 ± 0.016	2.992LysGly: 2.992 ± 0.023	1.457LysHis: 1.457 ± 0.018	2.639LysIle: 2.639 ± 0.021	5.363LysLys: 5.363 ± 0.109	4.8LysLeu: 4.8 ± 0.03	1.438LysMet: 1.438 ± 0.016	2.508LysAsn: 2.508 ± 0.027	2.829LysPro: 2.829 ± 0.026	2.497LysGln: 2.497 ± 0.021	3.559LysArg: 3.559 ± 0.027	4.661LysSer: 4.661 ± 0.034	3.53LysThr: 3.53 ± 0.023	3.419LysVal: 3.419 ± 0.025	0.562LysTrp: 0.562 ± 0.009	1.531LysTyr: 1.531 ± 0.014	0.001LysXaa: 0.001 ± 0.0
Leu	6.014LeuAla: 6.014 ± 0.037	1.993LeuCys: 1.993 ± 0.022	4.899LeuAsp: 4.899 ± 0.027	5.391LeuGlu: 5.391 ± 0.041	3.216LeuPhe: 3.216 ± 0.025	4.952LeuGly: 4.952 ± 0.036	2.467LeuHis: 2.467 ± 0.022	3.57LeuIle: 3.57 ± 0.026	5.082LeuLys: 5.082 ± 0.032	8.126LeuLeu: 8.126 ± 0.055	2.048LeuMet: 2.048 ± 0.02	3.593LeuAsn: 3.593 ± 0.027	4.825LeuPro: 4.825 ± 0.027	4.218LeuGln: 4.218 ± 0.032	4.942LeuArg: 4.942 ± 0.028	8.173LeuSer: 8.173 ± 0.047	5.279LeuThr: 5.279 ± 0.038	5.551LeuVal: 5.551 ± 0.034	0.917LeuTrp: 0.917 ± 0.012	2.511LeuTyr: 2.511 ± 0.022	0.001LeuXaa: 0.001 ± 0.0
Met	1.967MetAla: 1.967 ± 0.014	0.492MetCys: 0.492 ± 0.01	1.457MetAsp: 1.457 ± 0.026	1.624MetGlu: 1.624 ± 0.02	0.927MetPhe: 0.927 ± 0.012	1.42MetGly: 1.42 ± 0.02	0.508MetHis: 0.508 ± 0.011	0.937MetIle: 0.937 ± 0.012	1.379MetLys: 1.379 ± 0.015	2.012MetLeu: 2.012 ± 0.018	0.791MetMet: 0.791 ± 0.02	0.94MetAsn: 0.94 ± 0.012	1.145MetPro: 1.145 ± 0.013	0.91MetGln: 0.91 ± 0.011	1.233MetArg: 1.233 ± 0.015	2.087MetSer: 2.087 ± 0.02	1.376MetThr: 1.376 ± 0.019	1.499MetVal: 1.499 ± 0.017	0.257MetTrp: 0.257 ± 0.006	0.677MetTyr: 0.677 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.487AsnAla: 2.487 ± 0.018	0.874AsnCys: 0.874 ± 0.013	2.186AsnAsp: 2.186 ± 0.019	2.191AsnGlu: 2.191 ± 0.02	1.709AsnPhe: 1.709 ± 0.016	2.794AsnGly: 2.794 ± 0.024	1.132AsnHis: 1.132 ± 0.015	2.508AsnIle: 2.508 ± 0.019	2.538AsnLys: 2.538 ± 0.026	3.736AsnLeu: 3.736 ± 0.025	1.098AsnMet: 1.098 ± 0.013	2.66AsnAsn: 2.66 ± 0.036	2.256AsnPro: 2.256 ± 0.022	1.898AsnGln: 1.898 ± 0.025	2.176AsnArg: 2.176 ± 0.019	4.006AsnSer: 4.006 ± 0.029	2.629AsnThr: 2.629 ± 0.024	2.71AsnVal: 2.71 ± 0.022	0.434AsnTrp: 0.434 ± 0.009	1.211AsnTyr: 1.211 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	3.74ProAla: 3.74 ± 0.028	0.983ProCys: 0.983 ± 0.019	2.889ProAsp: 2.889 ± 0.023	3.155ProGlu: 3.155 ± 0.026	1.678ProPhe: 1.678 ± 0.018	3.638ProGly: 3.638 ± 0.032	1.444ProHis: 1.444 ± 0.019	1.984ProIle: 1.984 ± 0.018	2.583ProLys: 2.583 ± 0.023	4.178ProLeu: 4.178 ± 0.026	1.038ProMet: 1.038 ± 0.013	2.087ProAsn: 2.087 ± 0.021	4.237ProPro: 4.237 ± 0.046	2.345ProGln: 2.345 ± 0.023	2.87ProArg: 2.87 ± 0.025	5.37ProSer: 5.37 ± 0.037	3.235ProThr: 3.235 ± 0.029	3.5ProVal: 3.5 ± 0.027	0.523ProTrp: 0.523 ± 0.011	1.4ProTyr: 1.4 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	3.209GlnAla: 3.209 ± 0.02	0.88GlnCys: 0.88 ± 0.013	2.276GlnAsp: 2.276 ± 0.018	2.821GlnGlu: 2.821 ± 0.024	1.388GlnPhe: 1.388 ± 0.013	2.607GlnGly: 2.607 ± 0.023	1.482GlnHis: 1.482 ± 0.021	1.887GlnIle: 1.887 ± 0.016	2.374GlnLys: 2.374 ± 0.021	3.703GlnLeu: 3.703 ± 0.033	1.082GlnMet: 1.082 ± 0.013	1.934GlnAsn: 1.934 ± 0.018	2.325GlnPro: 2.325 ± 0.026	3.678GlnGln: 3.678 ± 0.073	2.722GlnArg: 2.722 ± 0.024	3.5GlnSer: 3.5 ± 0.026	2.62GlnThr: 2.62 ± 0.021	2.617GlnVal: 2.617 ± 0.023	0.473GlnTrp: 0.473 ± 0.009	1.159GlnTyr: 1.159 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	3.495ArgAla: 3.495 ± 0.026	1.163ArgCys: 1.163 ± 0.016	3.13ArgAsp: 3.13 ± 0.026	3.597ArgGlu: 3.597 ± 0.03	1.97ArgPhe: 1.97 ± 0.02	3.368ArgGly: 3.368 ± 0.032	1.688ArgHis: 1.688 ± 0.019	2.296ArgIle: 2.296 ± 0.018	3.633ArgLys: 3.633 ± 0.025	5.106ArgLeu: 5.106 ± 0.028	1.273ArgMet: 1.273 ± 0.013	2.291ArgAsn: 2.291 ± 0.02	2.979ArgPro: 2.979 ± 0.025	2.786ArgGln: 2.786 ± 0.023	4.371ArgArg: 4.371 ± 0.04	4.75ArgSer: 4.75 ± 0.032	2.826ArgThr: 2.826 ± 0.021	3.2ArgVal: 3.2 ± 0.029	0.682ArgTrp: 0.682 ± 0.015	1.568ArgTyr: 1.568 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	5.991SerAla: 5.991 ± 0.036	1.744SerCys: 1.744 ± 0.019	4.961SerAsp: 4.961 ± 0.032	4.841SerGlu: 4.841 ± 0.029	3.131SerPhe: 3.131 ± 0.024	6.064SerGly: 6.064 ± 0.045	2.377SerHis: 2.377 ± 0.021	3.853SerIle: 3.853 ± 0.036	4.727SerLys: 4.727 ± 0.033	8.067SerLeu: 8.067 ± 0.04	1.923SerMet: 1.923 ± 0.016	3.938SerAsn: 3.938 ± 0.03	5.628SerPro: 5.628 ± 0.047	3.972SerGln: 3.972 ± 0.035	4.925SerArg: 4.925 ± 0.03	11.284SerSer: 11.284 ± 0.087	5.514SerThr: 5.514 ± 0.034	5.668SerVal: 5.668 ± 0.035	0.865SerTrp: 0.865 ± 0.011	2.177SerTyr: 2.177 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	4.136ThrAla: 4.136 ± 0.022	1.421ThrCys: 1.421 ± 0.022	3.242ThrAsp: 3.242 ± 0.025	3.403ThrGlu: 3.403 ± 0.028	2.225ThrPhe: 2.225 ± 0.021	3.746ThrGly: 3.746 ± 0.027	1.44ThrHis: 1.44 ± 0.018	2.695ThrIle: 2.695 ± 0.023	2.973ThrLys: 2.973 ± 0.022	5.074ThrLeu: 5.074 ± 0.031	1.286ThrMet: 1.286 ± 0.015	2.519ThrAsn: 2.519 ± 0.024	3.557ThrPro: 3.557 ± 0.029	2.273ThrGln: 2.273 ± 0.023	2.85ThrArg: 2.85 ± 0.025	5.801ThrSer: 5.801 ± 0.037	4.041ThrThr: 4.041 ± 0.051	4.067ThrVal: 4.067 ± 0.032	0.667ThrTrp: 0.667 ± 0.01	1.553ThrTyr: 1.553 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	4.237ValAla: 4.237 ± 0.024	1.64ValCys: 1.64 ± 0.022	3.649ValAsp: 3.649 ± 0.026	3.79ValGlu: 3.79 ± 0.03	2.518ValPhe: 2.518 ± 0.021	3.618ValGly: 3.618 ± 0.028	1.548ValHis: 1.548 ± 0.013	3.013ValIle: 3.013 ± 0.024	3.624ValLys: 3.624 ± 0.023	5.658ValLeu: 5.658 ± 0.042	1.541ValMet: 1.541 ± 0.016	2.651ValAsn: 2.651 ± 0.02	3.157ValPro: 3.157 ± 0.024	2.501ValGln: 2.501 ± 0.019	3.216ValArg: 3.216 ± 0.022	5.597ValSer: 5.597 ± 0.038	4.137ValThr: 4.137 ± 0.033	4.581ValVal: 4.581 ± 0.06	0.755ValTrp: 0.755 ± 0.011	1.914ValTyr: 1.914 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	0.671TrpAla: 0.671 ± 0.009	0.245TrpCys: 0.245 ± 0.007	0.593TrpAsp: 0.593 ± 0.011	0.581TrpGlu: 0.581 ± 0.01	0.456TrpPhe: 0.456 ± 0.011	0.593TrpGly: 0.593 ± 0.009	0.258TrpHis: 0.258 ± 0.007	0.511TrpIle: 0.511 ± 0.011	0.656TrpLys: 0.656 ± 0.014	1.066TrpLeu: 1.066 ± 0.016	0.364TrpMet: 0.364 ± 0.018	0.478TrpAsn: 0.478 ± 0.008	0.46TrpPro: 0.46 ± 0.008	0.438TrpGln: 0.438 ± 0.008	0.739TrpArg: 0.739 ± 0.013	0.935TrpSer: 0.935 ± 0.017	0.679TrpThr: 0.679 ± 0.009	0.639TrpVal: 0.639 ± 0.01	0.179TrpTrp: 0.179 ± 0.006	0.329TrpTyr: 0.329 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.461TyrAla: 1.461 ± 0.015	0.701TyrCys: 0.701 ± 0.032	1.531TyrAsp: 1.531 ± 0.015	1.406TyrGlu: 1.406 ± 0.014	1.204TyrPhe: 1.204 ± 0.014	1.748TyrGly: 1.748 ± 0.017	0.839TyrHis: 0.839 ± 0.015	1.473TyrIle: 1.473 ± 0.024	1.498TyrLys: 1.498 ± 0.016	2.71TyrLeu: 2.71 ± 0.03	0.69TyrMet: 0.69 ± 0.011	1.321TyrAsn: 1.321 ± 0.016	1.359TyrPro: 1.359 ± 0.018	1.181TyrGln: 1.181 ± 0.014	1.668TyrArg: 1.668 ± 0.02	2.299TyrSer: 2.299 ± 0.022	1.655TyrThr: 1.655 ± 0.022	1.688TyrVal: 1.688 ± 0.018	0.332TyrTrp: 0.332 ± 0.008	0.962TyrTyr: 0.962 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.315XaaXaa: 0.315 ± 0.053

Statistics based on 23836 proteins (10343547 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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