Amino acid dipepetide frequency for Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.109AlaAla: 10.109 ± 0.172	0.681AlaCys: 0.681 ± 0.034	7.881AlaAsp: 7.881 ± 0.138	6.639AlaGlu: 6.639 ± 0.121	3.178AlaPhe: 3.178 ± 0.073	7.749AlaGly: 7.749 ± 0.118	1.829AlaHis: 1.829 ± 0.051	5.733AlaIle: 5.733 ± 0.094	2.11AlaLys: 2.11 ± 0.056	8.109AlaLeu: 8.109 ± 0.137	1.774AlaMet: 1.774 ± 0.056	2.909AlaAsn: 2.909 ± 0.07	3.254AlaPro: 3.254 ± 0.064	2.762AlaGln: 2.762 ± 0.061	4.837AlaArg: 4.837 ± 0.105	5.607AlaSer: 5.607 ± 0.151	6.909AlaThr: 6.909 ± 0.171	8.56AlaVal: 8.56 ± 0.122	0.887AlaTrp: 0.887 ± 0.039	2.459AlaTyr: 2.459 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.609CysAla: 0.609 ± 0.034	0.091CysCys: 0.091 ± 0.012	0.619CysAsp: 0.619 ± 0.033	0.565CysGlu: 0.565 ± 0.03	0.202CysPhe: 0.202 ± 0.016	0.881CysGly: 0.881 ± 0.037	0.215CysHis: 0.215 ± 0.022	0.378CysIle: 0.378 ± 0.024	0.152CysLys: 0.152 ± 0.015	0.549CysLeu: 0.549 ± 0.029	0.122CysMet: 0.122 ± 0.014	0.263CysAsn: 0.263 ± 0.02	0.522CysPro: 0.522 ± 0.027	0.25CysGln: 0.25 ± 0.017	0.442CysArg: 0.442 ± 0.028	0.474CysSer: 0.474 ± 0.027	0.422CysThr: 0.422 ± 0.023	0.527CysVal: 0.527 ± 0.026	0.084CysTrp: 0.084 ± 0.011	0.188CysTyr: 0.188 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	8.309AspAla: 8.309 ± 0.128	0.552AspCys: 0.552 ± 0.03	6.532AspAsp: 6.532 ± 0.098	6.569AspGlu: 6.569 ± 0.118	1.805AspPhe: 1.805 ± 0.052	5.931AspGly: 5.931 ± 0.121	1.678AspHis: 1.678 ± 0.054	5.655AspIle: 5.655 ± 0.085	1.44AspLys: 1.44 ± 0.043	5.33AspLeu: 5.33 ± 0.101	1.303AspMet: 1.303 ± 0.05	2.539AspAsn: 2.539 ± 0.074	3.88AspPro: 3.88 ± 0.08	2.11AspGln: 2.11 ± 0.054	5.004AspArg: 5.004 ± 0.099	4.899AspSer: 4.899 ± 0.109	6.187AspThr: 6.187 ± 0.101	6.246AspVal: 6.246 ± 0.108	0.736AspTrp: 0.736 ± 0.033	1.491AspTyr: 1.491 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.993GluAla: 5.993 ± 0.118	0.541GluCys: 0.541 ± 0.029	4.352GluAsp: 4.352 ± 0.107	4.707GluGlu: 4.707 ± 0.125	2.769GluPhe: 2.769 ± 0.071	3.476GluGly: 3.476 ± 0.083	1.756GluHis: 1.756 ± 0.057	4.358GluIle: 4.358 ± 0.094	1.939GluLys: 1.939 ± 0.053	6.836GluLeu: 6.836 ± 0.122	1.87GluMet: 1.87 ± 0.056	2.655GluAsn: 2.655 ± 0.062	2.903GluPro: 2.903 ± 0.061	3.125GluGln: 3.125 ± 0.061	5.252GluArg: 5.252 ± 0.107	6.253GluSer: 6.253 ± 0.117	7.427GluThr: 7.427 ± 0.12	4.464GluVal: 4.464 ± 0.089	0.947GluTrp: 0.947 ± 0.034	2.885GluTyr: 2.885 ± 0.076	0.0GluXaa: 0.0 ± 0.0
Phe	3.116PheAla: 3.116 ± 0.073	0.289PheCys: 0.289 ± 0.022	3.048PheAsp: 3.048 ± 0.07	2.82PheGlu: 2.82 ± 0.061	0.997PhePhe: 0.997 ± 0.043	2.892PheGly: 2.892 ± 0.072	0.576PheHis: 0.576 ± 0.029	2.06PheIle: 2.06 ± 0.069	0.644PheLys: 0.644 ± 0.032	2.374PheLeu: 2.374 ± 0.067	0.513PheMet: 0.513 ± 0.024	1.089PheAsn: 1.089 ± 0.046	1.27PhePro: 1.27 ± 0.043	0.906PheGln: 0.906 ± 0.035	1.626PheArg: 1.626 ± 0.046	1.936PheSer: 1.936 ± 0.058	2.165PheThr: 2.165 ± 0.053	2.502PheVal: 2.502 ± 0.065	0.321PheTrp: 0.321 ± 0.019	0.862PheTyr: 0.862 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	6.43GlyAla: 6.43 ± 0.111	0.645GlyCys: 0.645 ± 0.036	5.298GlyAsp: 5.298 ± 0.127	5.329GlyGlu: 5.329 ± 0.097	2.835GlyPhe: 2.835 ± 0.068	6.222GlyGly: 6.222 ± 0.212	1.542GlyHis: 1.542 ± 0.048	5.119GlyIle: 5.119 ± 0.097	1.913GlyLys: 1.913 ± 0.054	6.265GlyLeu: 6.265 ± 0.155	1.498GlyMet: 1.498 ± 0.054	2.33GlyAsn: 2.33 ± 0.113	2.643GlyPro: 2.643 ± 0.065	2.22GlyGln: 2.22 ± 0.064	3.92GlyArg: 3.92 ± 0.074	5.202GlySer: 5.202 ± 0.118	5.518GlyThr: 5.518 ± 0.163	6.481GlyVal: 6.481 ± 0.104	0.945GlyTrp: 0.945 ± 0.038	2.591GlyTyr: 2.591 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	1.919HisAla: 1.919 ± 0.057	0.221HisCys: 0.221 ± 0.017	1.848HisAsp: 1.848 ± 0.054	1.525HisGlu: 1.525 ± 0.051	0.527HisPhe: 0.527 ± 0.026	1.65HisGly: 1.65 ± 0.05	0.546HisHis: 0.546 ± 0.029	1.265HisIle: 1.265 ± 0.049	0.423HisLys: 0.423 ± 0.025	1.638HisLeu: 1.638 ± 0.05	0.267HisMet: 0.267 ± 0.019	0.79HisAsn: 0.79 ± 0.032	1.261HisPro: 1.261 ± 0.043	0.69HisGln: 0.69 ± 0.03	1.206HisArg: 1.206 ± 0.039	1.204HisSer: 1.204 ± 0.042	1.617HisThr: 1.617 ± 0.049	1.57HisVal: 1.57 ± 0.052	0.247HisTrp: 0.247 ± 0.017	0.499HisTyr: 0.499 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.23IleAla: 6.23 ± 0.116	0.449IleCys: 0.449 ± 0.024	5.8IleAsp: 5.8 ± 0.092	5.672IleGlu: 5.672 ± 0.105	1.594IlePhe: 1.594 ± 0.057	5.313IleGly: 5.313 ± 0.092	1.185IleHis: 1.185 ± 0.044	3.762IleIle: 3.762 ± 0.098	1.444IleLys: 1.444 ± 0.048	4.504IleLeu: 4.504 ± 0.106	0.855IleMet: 0.855 ± 0.036	2.258IleAsn: 2.258 ± 0.059	2.982IlePro: 2.982 ± 0.08	1.961IleGln: 1.961 ± 0.05	3.212IleArg: 3.212 ± 0.067	3.947IleSer: 3.947 ± 0.086	4.553IleThr: 4.553 ± 0.084	4.525IleVal: 4.525 ± 0.096	0.451IleTrp: 0.451 ± 0.023	1.287IleTyr: 1.287 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	1.794LysAla: 1.794 ± 0.059	0.164LysCys: 0.164 ± 0.012	1.185LysAsp: 1.185 ± 0.041	1.439LysGlu: 1.439 ± 0.05	0.624LysPhe: 0.624 ± 0.027	1.344LysGly: 1.344 ± 0.046	0.658LysHis: 0.658 ± 0.031	1.276LysIle: 1.276 ± 0.048	0.822LysLys: 0.822 ± 0.038	2.003LysLeu: 2.003 ± 0.053	0.499LysMet: 0.499 ± 0.028	0.967LysAsn: 0.967 ± 0.038	1.071LysPro: 1.071 ± 0.042	1.443LysGln: 1.443 ± 0.047	1.848LysArg: 1.848 ± 0.05	1.9LysSer: 1.9 ± 0.057	2.107LysThr: 2.107 ± 0.05	1.164LysVal: 1.164 ± 0.04	0.267LysTrp: 0.267 ± 0.017	0.773LysTyr: 0.773 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	8.161LeuAla: 8.161 ± 0.138	0.657LeuCys: 0.657 ± 0.031	6.09LeuAsp: 6.09 ± 0.106	5.504LeuGlu: 5.504 ± 0.095	2.89LeuPhe: 2.89 ± 0.075	6.159LeuGly: 6.159 ± 0.114	1.462LeuHis: 1.462 ± 0.051	4.992LeuIle: 4.992 ± 0.102	1.918LeuLys: 1.918 ± 0.05	7.414LeuLeu: 7.414 ± 0.164	1.374LeuMet: 1.374 ± 0.042	2.643LeuAsn: 2.643 ± 0.063	3.789LeuPro: 3.789 ± 0.091	2.644LeuGln: 2.644 ± 0.064	4.839LeuArg: 4.839 ± 0.084	6.353LeuSer: 6.353 ± 0.086	6.369LeuThr: 6.369 ± 0.103	5.728LeuVal: 5.728 ± 0.106	0.741LeuTrp: 0.741 ± 0.034	2.117LeuTyr: 2.117 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.401MetAla: 1.401 ± 0.046	0.155MetCys: 0.155 ± 0.015	1.119MetAsp: 1.119 ± 0.041	1.017MetGlu: 1.017 ± 0.036	0.53MetPhe: 0.53 ± 0.032	1.242MetGly: 1.242 ± 0.038	0.4MetHis: 0.4 ± 0.025	1.12MetIle: 1.12 ± 0.041	0.545MetLys: 0.545 ± 0.029	1.514MetLeu: 1.514 ± 0.048	0.374MetMet: 0.374 ± 0.023	0.869MetAsn: 0.869 ± 0.036	0.759MetPro: 0.759 ± 0.033	0.671MetGln: 0.671 ± 0.03	1.064MetArg: 1.064 ± 0.041	1.963MetSer: 1.963 ± 0.05	1.75MetThr: 1.75 ± 0.058	1.052MetVal: 1.052 ± 0.041	0.159MetTrp: 0.159 ± 0.015	0.407MetTyr: 0.407 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.363AsnAla: 3.363 ± 0.094	0.259AsnCys: 0.259 ± 0.017	2.369AsnAsp: 2.369 ± 0.063	2.396AsnGlu: 2.396 ± 0.062	0.842AsnPhe: 0.842 ± 0.037	2.432AsnGly: 2.432 ± 0.097	0.834AsnHis: 0.834 ± 0.034	2.213AsnIle: 2.213 ± 0.058	0.984AsnLys: 0.984 ± 0.039	2.499AsnLeu: 2.499 ± 0.067	0.615AsnMet: 0.615 ± 0.033	1.506AsnAsn: 1.506 ± 0.063	2.069AsnPro: 2.069 ± 0.056	1.334AsnGln: 1.334 ± 0.049	2.374AsnArg: 2.374 ± 0.055	2.084AsnSer: 2.084 ± 0.069	2.719AsnThr: 2.719 ± 0.073	2.424AsnVal: 2.424 ± 0.099	0.309AsnTrp: 0.309 ± 0.019	0.808AsnTyr: 0.808 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.035ProAla: 4.035 ± 0.077	0.227ProCys: 0.227 ± 0.016	4.04ProAsp: 4.04 ± 0.075	3.57ProGlu: 3.57 ± 0.075	1.408ProPhe: 1.408 ± 0.047	3.156ProGly: 3.156 ± 0.084	0.931ProHis: 0.931 ± 0.034	2.525ProIle: 2.525 ± 0.058	0.888ProLys: 0.888 ± 0.035	3.19ProLeu: 3.19 ± 0.083	0.725ProMet: 0.725 ± 0.033	1.375ProAsn: 1.375 ± 0.046	1.895ProPro: 1.895 ± 0.053	1.414ProGln: 1.414 ± 0.041	1.998ProArg: 1.998 ± 0.059	3.09ProSer: 3.09 ± 0.071	3.86ProThr: 3.86 ± 0.132	3.761ProVal: 3.761 ± 0.069	0.403ProTrp: 0.403 ± 0.027	1.09ProTyr: 1.09 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.78GlnAla: 2.78 ± 0.06	0.243GlnCys: 0.243 ± 0.021	1.661GlnAsp: 1.661 ± 0.044	1.879GlnGlu: 1.879 ± 0.057	1.33GlnPhe: 1.33 ± 0.041	1.746GlnGly: 1.746 ± 0.046	0.758GlnHis: 0.758 ± 0.031	2.08GlnIle: 2.08 ± 0.045	0.931GlnLys: 0.931 ± 0.039	3.056GlnLeu: 3.056 ± 0.066	0.755GlnMet: 0.755 ± 0.031	1.291GlnAsn: 1.291 ± 0.054	1.388GlnPro: 1.388 ± 0.048	1.818GlnGln: 1.818 ± 0.051	2.435GlnArg: 2.435 ± 0.059	3.029GlnSer: 3.029 ± 0.073	3.354GlnThr: 3.354 ± 0.069	2.046GlnVal: 2.046 ± 0.055	0.445GlnTrp: 0.445 ± 0.025	1.264GlnTyr: 1.264 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	4.933ArgAla: 4.933 ± 0.094	0.475ArgCys: 0.475 ± 0.033	4.244ArgAsp: 4.244 ± 0.081	5.058ArgGlu: 5.058 ± 0.108	2.104ArgPhe: 2.104 ± 0.053	3.891ArgGly: 3.891 ± 0.08	1.128ArgHis: 1.128 ± 0.048	3.53ArgIle: 3.53 ± 0.073	1.47ArgLys: 1.47 ± 0.047	5.154ArgLeu: 5.154 ± 0.083	1.116ArgMet: 1.116 ± 0.041	1.839ArgAsn: 1.839 ± 0.051	2.139ArgPro: 2.139 ± 0.06	2.273ArgGln: 2.273 ± 0.058	3.981ArgArg: 3.981 ± 0.09	3.623ArgSer: 3.623 ± 0.072	3.657ArgThr: 3.657 ± 0.064	4.626ArgVal: 4.626 ± 0.08	0.651ArgTrp: 0.651 ± 0.03	1.806ArgTyr: 1.806 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.91SerAla: 5.91 ± 0.13	0.398SerCys: 0.398 ± 0.024	5.697SerAsp: 5.697 ± 0.103	5.195SerGlu: 5.195 ± 0.083	2.183SerPhe: 2.183 ± 0.059	5.72SerGly: 5.72 ± 0.164	1.327SerHis: 1.327 ± 0.043	4.181SerIle: 4.181 ± 0.073	1.726SerLys: 1.726 ± 0.056	5.473SerLeu: 5.473 ± 0.073	1.355SerMet: 1.355 ± 0.044	2.577SerAsn: 2.577 ± 0.068	2.925SerPro: 2.925 ± 0.063	2.229SerGln: 2.229 ± 0.06	3.32SerArg: 3.32 ± 0.072	4.663SerSer: 4.663 ± 0.148	5.15SerThr: 5.15 ± 0.124	5.79SerVal: 5.79 ± 0.107	0.681SerTrp: 0.681 ± 0.034	1.703SerTyr: 1.703 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	8.228ThrAla: 8.228 ± 0.154	0.461ThrCys: 0.461 ± 0.025	6.809ThrAsp: 6.809 ± 0.115	5.637ThrGlu: 5.637 ± 0.114	2.319ThrPhe: 2.319 ± 0.068	6.169ThrGly: 6.169 ± 0.172	1.72ThrHis: 1.72 ± 0.045	4.654ThrIle: 4.654 ± 0.098	1.529ThrLys: 1.529 ± 0.043	6.378ThrLeu: 6.378 ± 0.104	1.168ThrMet: 1.168 ± 0.041	2.631ThrAsn: 2.631 ± 0.079	3.938ThrPro: 3.938 ± 0.137	2.826ThrGln: 2.826 ± 0.07	3.81ThrArg: 3.81 ± 0.072	4.096ThrSer: 4.096 ± 0.094	6.426ThrThr: 6.426 ± 0.141	7.567ThrVal: 7.567 ± 0.148	0.666ThrTrp: 0.666 ± 0.032	1.946ThrTyr: 1.946 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	7.309ValAla: 7.309 ± 0.118	0.715ValCys: 0.715 ± 0.036	6.395ValAsp: 6.395 ± 0.108	6.084ValGlu: 6.084 ± 0.113	2.668ValPhe: 2.668 ± 0.076	6.218ValGly: 6.218 ± 0.16	1.436ValHis: 1.436 ± 0.049	5.071ValIle: 5.071 ± 0.105	1.54ValLys: 1.54 ± 0.048	6.24ValLeu: 6.24 ± 0.126	1.303ValMet: 1.303 ± 0.043	2.549ValAsn: 2.549 ± 0.068	3.231ValPro: 3.231 ± 0.073	2.09ValGln: 2.09 ± 0.057	4.114ValArg: 4.114 ± 0.074	5.847ValSer: 5.847 ± 0.12	6.256ValThr: 6.256 ± 0.178	6.331ValVal: 6.331 ± 0.129	0.651ValTrp: 0.651 ± 0.033	1.966ValTyr: 1.966 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.761TrpAla: 0.761 ± 0.034	0.087TrpCys: 0.087 ± 0.01	0.644TrpAsp: 0.644 ± 0.03	0.672TrpGlu: 0.672 ± 0.03	0.369TrpPhe: 0.369 ± 0.023	0.733TrpGly: 0.733 ± 0.031	0.205TrpHis: 0.205 ± 0.014	0.622TrpIle: 0.622 ± 0.033	0.355TrpLys: 0.355 ± 0.021	0.89TrpLeu: 0.89 ± 0.037	0.214TrpMet: 0.214 ± 0.016	0.388TrpAsn: 0.388 ± 0.026	0.356TrpPro: 0.356 ± 0.021	0.44TrpGln: 0.44 ± 0.025	0.689TrpArg: 0.689 ± 0.031	0.633TrpSer: 0.633 ± 0.029	0.694TrpThr: 0.694 ± 0.032	0.742TrpVal: 0.742 ± 0.036	0.186TrpTrp: 0.186 ± 0.014	0.382TrpTyr: 0.382 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.586TyrAla: 2.586 ± 0.059	0.242TyrCys: 0.242 ± 0.018	2.564TyrAsp: 2.564 ± 0.066	2.23TyrGlu: 2.23 ± 0.057	0.834TyrPhe: 0.834 ± 0.033	2.021TyrGly: 2.021 ± 0.054	0.729TyrHis: 0.729 ± 0.03	1.39TyrIle: 1.39 ± 0.047	0.575TyrLys: 0.575 ± 0.029	2.428TyrLeu: 2.428 ± 0.068	0.411TyrMet: 0.411 ± 0.022	0.965TyrAsn: 0.965 ± 0.04	1.304TyrPro: 1.304 ± 0.043	1.085TyrGln: 1.085 ± 0.039	1.729TyrArg: 1.729 ± 0.053	1.4TyrSer: 1.4 ± 0.046	1.838TyrThr: 1.838 ± 0.056	1.91TyrVal: 1.91 ± 0.054	0.284TyrTrp: 0.284 ± 0.023	0.833TyrTyr: 0.833 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2558 proteins (772216 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---