Amino acid dipepetide frequency for Desulfovibrio alkalitolerans DSM 16529

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.199AlaAla: 15.199 ± 0.213	1.662AlaCys: 1.662 ± 0.046	5.686AlaAsp: 5.686 ± 0.081	7.899AlaGlu: 7.899 ± 0.09	4.353AlaPhe: 4.353 ± 0.077	9.379AlaGly: 9.379 ± 0.12	2.292AlaHis: 2.292 ± 0.052	4.402AlaIle: 4.402 ± 0.072	4.263AlaLys: 4.263 ± 0.086	13.343AlaLeu: 13.343 ± 0.151	3.459AlaMet: 3.459 ± 0.059	2.3AlaAsn: 2.3 ± 0.047	5.156AlaPro: 5.156 ± 0.101	3.556AlaGln: 3.556 ± 0.059	9.635AlaArg: 9.635 ± 0.144	5.607AlaSer: 5.607 ± 0.084	4.933AlaThr: 4.933 ± 0.066	8.903AlaVal: 8.903 ± 0.104	1.434AlaTrp: 1.434 ± 0.048	2.452AlaTyr: 2.452 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.457CysAla: 1.457 ± 0.044	0.229CysCys: 0.229 ± 0.017	0.669CysAsp: 0.669 ± 0.025	0.692CysGlu: 0.692 ± 0.024	0.509CysPhe: 0.509 ± 0.024	1.404CysGly: 1.404 ± 0.048	0.397CysHis: 0.397 ± 0.028	0.551CysIle: 0.551 ± 0.023	0.374CysLys: 0.374 ± 0.02	1.488CysLeu: 1.488 ± 0.042	0.284CysMet: 0.284 ± 0.016	0.289CysAsn: 0.289 ± 0.018	0.888CysPro: 0.888 ± 0.036	0.296CysGln: 0.296 ± 0.017	0.978CysArg: 0.978 ± 0.035	0.626CysSer: 0.626 ± 0.027	0.577CysThr: 0.577 ± 0.026	0.878CysVal: 0.878 ± 0.029	0.13CysTrp: 0.13 ± 0.012	0.267CysTyr: 0.267 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.967AspAla: 5.967 ± 0.081	0.632AspCys: 0.632 ± 0.026	2.916AspAsp: 2.916 ± 0.066	4.115AspGlu: 4.115 ± 0.073	2.437AspPhe: 2.437 ± 0.056	4.277AspGly: 4.277 ± 0.073	1.101AspHis: 1.101 ± 0.035	3.097AspIle: 3.097 ± 0.055	2.098AspLys: 2.098 ± 0.051	6.085AspLeu: 6.085 ± 0.092	1.586AspMet: 1.586 ± 0.041	1.239AspAsn: 1.239 ± 0.036	3.195AspPro: 3.195 ± 0.061	1.418AspGln: 1.418 ± 0.039	3.287AspArg: 3.287 ± 0.067	2.215AspSer: 2.215 ± 0.056	2.143AspThr: 2.143 ± 0.045	4.27AspVal: 4.27 ± 0.063	0.73AspTrp: 0.73 ± 0.029	1.504AspTyr: 1.504 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.912GluAla: 7.912 ± 0.122	0.632GluCys: 0.632 ± 0.025	3.302GluAsp: 3.302 ± 0.06	4.47GluGlu: 4.47 ± 0.08	2.3GluPhe: 2.3 ± 0.049	4.534GluGly: 4.534 ± 0.071	1.417GluHis: 1.417 ± 0.038	3.788GluIle: 3.788 ± 0.072	3.152GluLys: 3.152 ± 0.071	6.328GluLeu: 6.328 ± 0.091	1.973GluMet: 1.973 ± 0.051	2.019GluAsn: 2.019 ± 0.045	2.866GluPro: 2.866 ± 0.063	2.279GluGln: 2.279 ± 0.049	5.986GluArg: 5.986 ± 0.089	3.123GluSer: 3.123 ± 0.063	3.606GluThr: 3.606 ± 0.066	4.432GluVal: 4.432 ± 0.074	0.651GluTrp: 0.651 ± 0.025	1.397GluTyr: 1.397 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	4.615PheAla: 4.615 ± 0.081	0.599PheCys: 0.599 ± 0.025	2.377PheAsp: 2.377 ± 0.048	2.416PheGlu: 2.416 ± 0.05	1.783PhePhe: 1.783 ± 0.046	3.463PheGly: 3.463 ± 0.069	0.754PheHis: 0.754 ± 0.031	1.707PheIle: 1.707 ± 0.051	1.309PheLys: 1.309 ± 0.039	4.275PheLeu: 4.275 ± 0.078	1.005PheMet: 1.005 ± 0.036	1.04PheAsn: 1.04 ± 0.035	1.773PhePro: 1.773 ± 0.039	1.013PheGln: 1.013 ± 0.033	2.338PheArg: 2.338 ± 0.053	2.494PheSer: 2.494 ± 0.055	2.229PheThr: 2.229 ± 0.044	3.011PheVal: 3.011 ± 0.062	0.589PheTrp: 0.589 ± 0.027	1.029PheTyr: 1.029 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	7.946GlyAla: 7.946 ± 0.102	1.206GlyCys: 1.206 ± 0.039	3.948GlyAsp: 3.948 ± 0.064	5.549GlyGlu: 5.549 ± 0.083	3.64GlyPhe: 3.64 ± 0.07	6.905GlyGly: 6.905 ± 0.121	1.953GlyHis: 1.953 ± 0.052	4.024GlyIle: 4.024 ± 0.072	3.637GlyLys: 3.637 ± 0.069	10.195GlyLeu: 10.195 ± 0.139	2.525GlyMet: 2.525 ± 0.06	1.874GlyAsn: 1.874 ± 0.046	3.334GlyPro: 3.334 ± 0.07	2.924GlyGln: 2.924 ± 0.062	6.804GlyArg: 6.804 ± 0.101	4.017GlySer: 4.017 ± 0.071	3.477GlyThr: 3.477 ± 0.071	6.358GlyVal: 6.358 ± 0.081	0.916GlyTrp: 0.916 ± 0.032	2.085GlyTyr: 2.085 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.303HisAla: 2.303 ± 0.058	0.3HisCys: 0.3 ± 0.019	1.32HisAsp: 1.32 ± 0.036	1.385HisGlu: 1.385 ± 0.033	0.913HisPhe: 0.913 ± 0.035	2.085HisGly: 2.085 ± 0.047	0.581HisHis: 0.581 ± 0.029	0.872HisIle: 0.872 ± 0.031	0.682HisLys: 0.682 ± 0.027	2.336HisLeu: 2.336 ± 0.052	0.457HisMet: 0.457 ± 0.022	0.53HisAsn: 0.53 ± 0.023	1.367HisPro: 1.367 ± 0.041	0.488HisGln: 0.488 ± 0.024	1.192HisArg: 1.192 ± 0.037	0.943HisSer: 0.943 ± 0.03	0.889HisThr: 0.889 ± 0.033	1.524HisVal: 1.524 ± 0.039	0.24HisTrp: 0.24 ± 0.016	0.558HisTyr: 0.558 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	4.983IleAla: 4.983 ± 0.078	0.62IleCys: 0.62 ± 0.025	2.665IleAsp: 2.665 ± 0.059	3.476IleGlu: 3.476 ± 0.065	1.82IlePhe: 1.82 ± 0.043	3.728IleGly: 3.728 ± 0.067	0.975IleHis: 0.975 ± 0.033	2.243IleIle: 2.243 ± 0.057	1.721IleLys: 1.721 ± 0.049	4.921IleLeu: 4.921 ± 0.073	1.169IleMet: 1.169 ± 0.04	1.241IleAsn: 1.241 ± 0.042	2.337IlePro: 2.337 ± 0.051	1.211IleGln: 1.211 ± 0.035	3.051IleArg: 3.051 ± 0.054	2.672IleSer: 2.672 ± 0.056	2.214IleThr: 2.214 ± 0.052	3.763IleVal: 3.763 ± 0.065	0.502IleTrp: 0.502 ± 0.025	1.127IleTyr: 1.127 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.64LysAla: 4.64 ± 0.088	0.336LysCys: 0.336 ± 0.023	2.068LysAsp: 2.068 ± 0.056	2.426LysGlu: 2.426 ± 0.061	0.997LysPhe: 0.997 ± 0.035	3.216LysGly: 3.216 ± 0.067	0.688LysHis: 0.688 ± 0.024	1.838LysIle: 1.838 ± 0.045	2.008LysLys: 2.008 ± 0.057	3.482LysLeu: 3.482 ± 0.069	0.925LysMet: 0.925 ± 0.036	1.234LysAsn: 1.234 ± 0.039	2.118LysPro: 2.118 ± 0.063	1.006LysGln: 1.006 ± 0.039	2.636LysArg: 2.636 ± 0.057	1.993LysSer: 1.993 ± 0.042	2.198LysThr: 2.198 ± 0.05	2.582LysVal: 2.582 ± 0.062	0.313LysTrp: 0.313 ± 0.017	0.783LysTyr: 0.783 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	15.46LeuAla: 15.46 ± 0.163	1.484LeuCys: 1.484 ± 0.043	6.908LeuAsp: 6.908 ± 0.091	5.997LeuGlu: 5.997 ± 0.092	4.223LeuPhe: 4.223 ± 0.074	9.044LeuGly: 9.044 ± 0.111	2.184LeuHis: 2.184 ± 0.052	4.113LeuIle: 4.113 ± 0.069	3.885LeuLys: 3.885 ± 0.08	11.175LeuLeu: 11.175 ± 0.13	2.449LeuMet: 2.449 ± 0.053	2.609LeuAsn: 2.609 ± 0.053	6.129LeuPro: 6.129 ± 0.088	2.411LeuGln: 2.411 ± 0.053	7.68LeuArg: 7.68 ± 0.106	7.12LeuSer: 7.12 ± 0.1	5.647LeuThr: 5.647 ± 0.073	7.849LeuVal: 7.849 ± 0.113	1.162LeuTrp: 1.162 ± 0.037	2.134LeuTyr: 2.134 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.319MetAla: 3.319 ± 0.06	0.253MetCys: 0.253 ± 0.016	1.573MetAsp: 1.573 ± 0.046	1.631MetGlu: 1.631 ± 0.043	0.747MetPhe: 0.747 ± 0.027	2.093MetGly: 2.093 ± 0.046	0.566MetHis: 0.566 ± 0.025	1.121MetIle: 1.121 ± 0.04	1.048MetLys: 1.048 ± 0.037	2.594MetLeu: 2.594 ± 0.055	0.455MetMet: 0.455 ± 0.021	0.895MetAsn: 0.895 ± 0.03	1.512MetPro: 1.512 ± 0.035	0.813MetGln: 0.813 ± 0.03	2.107MetArg: 2.107 ± 0.051	1.565MetSer: 1.565 ± 0.035	1.514MetThr: 1.514 ± 0.037	1.705MetVal: 1.705 ± 0.044	0.196MetTrp: 0.196 ± 0.014	0.439MetTyr: 0.439 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.598AsnAla: 2.598 ± 0.052	0.326AsnCys: 0.326 ± 0.021	1.156AsnAsp: 1.156 ± 0.036	1.348AsnGlu: 1.348 ± 0.038	1.007AsnPhe: 1.007 ± 0.035	1.861AsnGly: 1.861 ± 0.052	0.481AsnHis: 0.481 ± 0.022	1.428AsnIle: 1.428 ± 0.039	0.854AsnLys: 0.854 ± 0.038	2.832AsnLeu: 2.832 ± 0.068	0.694AsnMet: 0.694 ± 0.028	0.623AsnAsn: 0.623 ± 0.029	1.805AsnPro: 1.805 ± 0.047	0.711AsnGln: 0.711 ± 0.031	1.646AsnArg: 1.646 ± 0.044	1.098AsnSer: 1.098 ± 0.037	1.167AsnThr: 1.167 ± 0.037	1.992AsnVal: 1.992 ± 0.05	0.33AsnTrp: 0.33 ± 0.019	0.641AsnTyr: 0.641 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.377ProAla: 5.377 ± 0.093	0.682ProCys: 0.682 ± 0.034	3.556ProAsp: 3.556 ± 0.067	4.562ProGlu: 4.562 ± 0.069	2.063ProPhe: 2.063 ± 0.047	5.218ProGly: 5.218 ± 0.072	1.119ProHis: 1.119 ± 0.036	1.759ProIle: 1.759 ± 0.042	1.796ProLys: 1.796 ± 0.057	5.109ProLeu: 5.109 ± 0.084	1.18ProMet: 1.18 ± 0.034	0.977ProAsn: 0.977 ± 0.031	2.521ProPro: 2.521 ± 0.06	1.407ProGln: 1.407 ± 0.035	3.326ProArg: 3.326 ± 0.068	2.543ProSer: 2.543 ± 0.055	2.079ProThr: 2.079 ± 0.051	4.062ProVal: 4.062 ± 0.078	0.736ProTrp: 0.736 ± 0.031	1.117ProTyr: 1.117 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.173GlnAla: 4.173 ± 0.078	0.305GlnCys: 0.305 ± 0.02	1.46GlnAsp: 1.46 ± 0.043	1.945GlnGlu: 1.945 ± 0.045	0.841GlnPhe: 0.841 ± 0.034	2.859GlnGly: 2.859 ± 0.058	0.496GlnHis: 0.496 ± 0.023	1.521GlnIle: 1.521 ± 0.041	1.231GlnLys: 1.231 ± 0.045	2.138GlnLeu: 2.138 ± 0.054	0.792GlnMet: 0.792 ± 0.027	0.834GlnAsn: 0.834 ± 0.03	1.198GlnPro: 1.198 ± 0.036	0.828GlnGln: 0.828 ± 0.033	2.038GlnArg: 2.038 ± 0.047	1.51GlnSer: 1.51 ± 0.048	1.565GlnThr: 1.565 ± 0.035	2.079GlnVal: 2.079 ± 0.047	0.316GlnTrp: 0.316 ± 0.02	0.546GlnTyr: 0.546 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.724ArgAla: 7.724 ± 0.118	0.828ArgCys: 0.828 ± 0.036	4.13ArgAsp: 4.13 ± 0.07	6.108ArgGlu: 6.108 ± 0.099	3.242ArgPhe: 3.242 ± 0.058	5.004ArgGly: 5.004 ± 0.081	1.757ArgHis: 1.757 ± 0.042	4.04ArgIle: 4.04 ± 0.071	2.702ArgLys: 2.702 ± 0.051	9.373ArgLeu: 9.373 ± 0.134	1.974ArgMet: 1.974 ± 0.04	1.707ArgAsn: 1.707 ± 0.046	3.514ArgPro: 3.514 ± 0.073	2.5ArgGln: 2.5 ± 0.046	5.639ArgArg: 5.639 ± 0.104	3.182ArgSer: 3.182 ± 0.059	3.287ArgThr: 3.287 ± 0.062	5.037ArgVal: 5.037 ± 0.081	0.711ArgTrp: 0.711 ± 0.029	1.659ArgTyr: 1.659 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.208SerAla: 5.208 ± 0.07	0.682SerCys: 0.682 ± 0.026	2.361SerAsp: 2.361 ± 0.052	2.988SerGlu: 2.988 ± 0.061	2.303SerPhe: 2.303 ± 0.051	5.446SerGly: 5.446 ± 0.084	1.051SerHis: 1.051 ± 0.033	2.546SerIle: 2.546 ± 0.06	1.637SerLys: 1.637 ± 0.051	6.219SerLeu: 6.219 ± 0.091	1.446SerMet: 1.446 ± 0.039	1.027SerAsn: 1.027 ± 0.035	2.945SerPro: 2.945 ± 0.052	1.506SerGln: 1.506 ± 0.039	3.972SerArg: 3.972 ± 0.063	2.63SerSer: 2.63 ± 0.062	2.278SerThr: 2.278 ± 0.059	3.779SerVal: 3.779 ± 0.059	0.702SerTrp: 0.702 ± 0.026	1.139SerTyr: 1.139 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.452ThrAla: 5.452 ± 0.083	0.577ThrCys: 0.577 ± 0.021	2.354ThrAsp: 2.354 ± 0.052	2.348ThrGlu: 2.348 ± 0.045	1.874ThrPhe: 1.874 ± 0.044	4.596ThrGly: 4.596 ± 0.067	0.931ThrHis: 0.931 ± 0.03	2.373ThrIle: 2.373 ± 0.054	1.449ThrLys: 1.449 ± 0.043	5.465ThrLeu: 5.465 ± 0.073	1.174ThrMet: 1.174 ± 0.035	1.139ThrAsn: 1.139 ± 0.032	3.311ThrPro: 3.311 ± 0.062	1.186ThrGln: 1.186 ± 0.038	3.293ThrArg: 3.293 ± 0.069	2.362ThrSer: 2.362 ± 0.047	2.452ThrThr: 2.452 ± 0.053	3.734ThrVal: 3.734 ± 0.065	0.552ThrTrp: 0.552 ± 0.024	1.152ThrTyr: 1.152 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.144ValAla: 8.144 ± 0.109	1.12ValCys: 1.12 ± 0.037	3.922ValAsp: 3.922 ± 0.067	4.832ValGlu: 4.832 ± 0.074	3.217ValPhe: 3.217 ± 0.054	5.348ValGly: 5.348 ± 0.078	1.497ValHis: 1.497 ± 0.042	3.635ValIle: 3.635 ± 0.07	2.48ValLys: 2.48 ± 0.055	8.247ValLeu: 8.247 ± 0.112	1.826ValMet: 1.826 ± 0.043	2.083ValAsn: 2.083 ± 0.05	3.396ValPro: 3.396 ± 0.05	2.053ValGln: 2.053 ± 0.046	5.86ValArg: 5.86 ± 0.077	4.385ValSer: 4.385 ± 0.065	3.903ValThr: 3.903 ± 0.065	6.24ValVal: 6.24 ± 0.084	0.895ValTrp: 0.895 ± 0.031	1.452ValTyr: 1.452 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.076TrpAla: 1.076 ± 0.039	0.153TrpCys: 0.153 ± 0.014	0.583TrpAsp: 0.583 ± 0.025	0.678TrpGlu: 0.678 ± 0.029	0.518TrpPhe: 0.518 ± 0.026	0.865TrpGly: 0.865 ± 0.032	0.267TrpHis: 0.267 ± 0.016	0.513TrpIle: 0.513 ± 0.025	0.409TrpLys: 0.409 ± 0.021	1.589TrpLeu: 1.589 ± 0.043	0.285TrpMet: 0.285 ± 0.018	0.356TrpAsn: 0.356 ± 0.019	0.701TrpPro: 0.701 ± 0.026	0.399TrpGln: 0.399 ± 0.022	1.03TrpArg: 1.03 ± 0.038	0.569TrpSer: 0.569 ± 0.027	0.58TrpThr: 0.58 ± 0.022	0.626TrpVal: 0.626 ± 0.029	0.192TrpTrp: 0.192 ± 0.016	0.253TrpTyr: 0.253 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.36TyrAla: 2.36 ± 0.054	0.355TyrCys: 0.355 ± 0.018	1.361TyrAsp: 1.361 ± 0.042	1.302TyrGlu: 1.302 ± 0.037	1.032TyrPhe: 1.032 ± 0.039	1.992TyrGly: 1.992 ± 0.045	0.46TyrHis: 0.46 ± 0.023	0.869TyrIle: 0.869 ± 0.029	0.752TyrLys: 0.752 ± 0.034	2.468TyrLeu: 2.468 ± 0.056	0.488TyrMet: 0.488 ± 0.023	0.581TyrAsn: 0.581 ± 0.024	1.121TyrPro: 1.121 ± 0.035	0.669TyrGln: 0.669 ± 0.027	1.622TyrArg: 1.622 ± 0.044	1.211TyrSer: 1.211 ± 0.036	1.035TyrThr: 1.035 ± 0.034	1.71TyrVal: 1.71 ± 0.046	0.347TyrTrp: 0.347 ± 0.021	0.658TyrTyr: 0.658 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2924 proteins (955238 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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