Amino acid dipepetide frequency for Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.814AlaAla: 16.814 ± 0.128	1.051AlaCys: 1.051 ± 0.025	6.522AlaAsp: 6.522 ± 0.067	7.871AlaGlu: 7.871 ± 0.076	4.704AlaPhe: 4.704 ± 0.056	10.759AlaGly: 10.759 ± 0.087	2.143AlaHis: 2.143 ± 0.037	6.769AlaIle: 6.769 ± 0.063	4.054AlaLys: 4.054 ± 0.052	12.762AlaLeu: 12.762 ± 0.107	3.418AlaMet: 3.418 ± 0.045	2.936AlaAsn: 2.936 ± 0.04	4.855AlaPro: 4.855 ± 0.056	3.293AlaGln: 3.293 ± 0.043	8.309AlaArg: 8.309 ± 0.066	6.426AlaSer: 6.426 ± 0.061	5.659AlaThr: 5.659 ± 0.058	8.964AlaVal: 8.964 ± 0.073	1.389AlaTrp: 1.389 ± 0.028	2.545AlaTyr: 2.545 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.917CysAla: 0.917 ± 0.021	0.132CysCys: 0.132 ± 0.008	0.481CysAsp: 0.481 ± 0.016	0.462CysGlu: 0.462 ± 0.015	0.345CysPhe: 0.345 ± 0.015	0.98CysGly: 0.98 ± 0.029	0.241CysHis: 0.241 ± 0.012	0.418CysIle: 0.418 ± 0.014	0.205CysLys: 0.205 ± 0.01	0.86CysLeu: 0.86 ± 0.023	0.168CysMet: 0.168 ± 0.009	0.224CysAsn: 0.224 ± 0.01	0.429CysPro: 0.429 ± 0.017	0.228CysGln: 0.228 ± 0.012	0.693CysArg: 0.693 ± 0.023	0.509CysSer: 0.509 ± 0.018	0.408CysThr: 0.408 ± 0.015	0.583CysVal: 0.583 ± 0.02	0.114CysTrp: 0.114 ± 0.008	0.215CysTyr: 0.215 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.194AspAla: 6.194 ± 0.064	0.522AspCys: 0.522 ± 0.018	2.971AspAsp: 2.971 ± 0.055	3.525AspGlu: 3.525 ± 0.046	2.299AspPhe: 2.299 ± 0.037	5.051AspGly: 5.051 ± 0.063	1.185AspHis: 1.185 ± 0.027	3.201AspIle: 3.201 ± 0.051	1.617AspLys: 1.617 ± 0.033	5.686AspLeu: 5.686 ± 0.053	1.312AspMet: 1.312 ± 0.024	1.247AspAsn: 1.247 ± 0.027	3.299AspPro: 3.299 ± 0.042	1.542AspGln: 1.542 ± 0.03	4.367AspArg: 4.367 ± 0.052	2.044AspSer: 2.044 ± 0.035	2.384AspThr: 2.384 ± 0.041	4.084AspVal: 4.084 ± 0.056	0.938AspTrp: 0.938 ± 0.023	1.474AspTyr: 1.474 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.85GluAla: 7.85 ± 0.071	0.396GluCys: 0.396 ± 0.016	2.784GluAsp: 2.784 ± 0.042	3.867GluGlu: 3.867 ± 0.055	1.94GluPhe: 1.94 ± 0.033	4.507GluGly: 4.507 ± 0.048	1.273GluHis: 1.273 ± 0.026	3.862GluIle: 3.862 ± 0.044	2.647GluLys: 2.647 ± 0.04	5.584GluLeu: 5.584 ± 0.06	1.625GluMet: 1.625 ± 0.029	1.882GluAsn: 1.882 ± 0.027	2.834GluPro: 2.834 ± 0.042	1.994GluGln: 1.994 ± 0.033	5.34GluArg: 5.34 ± 0.064	2.604GluSer: 2.604 ± 0.038	3.691GluThr: 3.691 ± 0.047	3.932GluVal: 3.932 ± 0.045	0.74GluTrp: 0.74 ± 0.02	1.019GluTyr: 1.019 ± 0.021	0.001GluXaa: 0.001 ± 0.001
Phe	4.712PheAla: 4.712 ± 0.057	0.404PheCys: 0.404 ± 0.015	2.7PheAsp: 2.7 ± 0.039	2.252PheGlu: 2.252 ± 0.033	1.61PhePhe: 1.61 ± 0.035	3.768PheGly: 3.768 ± 0.053	0.831PheHis: 0.831 ± 0.022	1.862PheIle: 1.862 ± 0.033	1.067PheLys: 1.067 ± 0.024	3.731PheLeu: 3.731 ± 0.047	0.847PheMet: 0.847 ± 0.021	1.084PheAsn: 1.084 ± 0.024	1.653PhePro: 1.653 ± 0.031	1.038PheGln: 1.038 ± 0.026	2.538PheArg: 2.538 ± 0.039	2.464PheSer: 2.464 ± 0.033	1.971PheThr: 1.971 ± 0.032	3.039PheVal: 3.039 ± 0.044	0.591PheTrp: 0.591 ± 0.02	0.981PheTyr: 0.981 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.92GlyAla: 8.92 ± 0.098	0.886GlyCys: 0.886 ± 0.02	4.276GlyAsp: 4.276 ± 0.056	5.176GlyGlu: 5.176 ± 0.055	3.669GlyPhe: 3.669 ± 0.045	7.397GlyGly: 7.397 ± 0.153	1.916GlyHis: 1.916 ± 0.031	5.086GlyIle: 5.086 ± 0.052	3.504GlyLys: 3.504 ± 0.053	8.647GlyLeu: 8.647 ± 0.07	2.325GlyMet: 2.325 ± 0.037	2.334GlyAsn: 2.334 ± 0.043	3.237GlyPro: 3.237 ± 0.05	2.601GlyGln: 2.601 ± 0.039	6.357GlyArg: 6.357 ± 0.065	4.946GlySer: 4.946 ± 0.063	4.585GlyThr: 4.585 ± 0.054	5.902GlyVal: 5.902 ± 0.066	1.287GlyTrp: 1.287 ± 0.029	2.331GlyTyr: 2.331 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.222HisAla: 2.222 ± 0.037	0.247HisCys: 0.247 ± 0.012	1.218HisAsp: 1.218 ± 0.026	1.131HisGlu: 1.131 ± 0.026	0.929HisPhe: 0.929 ± 0.02	1.924HisGly: 1.924 ± 0.034	0.548HisHis: 0.548 ± 0.02	0.952HisIle: 0.952 ± 0.025	0.498HisLys: 0.498 ± 0.016	2.121HisLeu: 2.121 ± 0.037	0.557HisMet: 0.557 ± 0.018	0.449HisAsn: 0.449 ± 0.016	1.326HisPro: 1.326 ± 0.025	0.603HisGln: 0.603 ± 0.018	1.509HisArg: 1.509 ± 0.03	1.054HisSer: 1.054 ± 0.024	0.777HisThr: 0.777 ± 0.019	1.524HisVal: 1.524 ± 0.024	0.298HisTrp: 0.298 ± 0.012	0.578HisTyr: 0.578 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.777IleAla: 7.777 ± 0.067	0.559IleCys: 0.559 ± 0.017	3.697IleAsp: 3.697 ± 0.04	3.805IleGlu: 3.805 ± 0.045	1.987IlePhe: 1.987 ± 0.03	5.355IleGly: 5.355 ± 0.061	0.949IleHis: 0.949 ± 0.022	2.491IleIle: 2.491 ± 0.043	1.421IleLys: 1.421 ± 0.026	4.773IleLeu: 4.773 ± 0.061	1.071IleMet: 1.071 ± 0.029	1.454IleAsn: 1.454 ± 0.031	2.364IlePro: 2.364 ± 0.039	1.179IleGln: 1.179 ± 0.024	3.603IleArg: 3.603 ± 0.045	3.204IleSer: 3.204 ± 0.044	2.613IleThr: 2.613 ± 0.039	4.65IleVal: 4.65 ± 0.047	0.594IleTrp: 0.594 ± 0.017	1.226IleTyr: 1.226 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	4.421LysAla: 4.421 ± 0.049	0.178LysCys: 0.178 ± 0.01	1.743LysAsp: 1.743 ± 0.037	1.967LysGlu: 1.967 ± 0.031	0.953LysPhe: 0.953 ± 0.022	2.813LysGly: 2.813 ± 0.041	0.661LysHis: 0.661 ± 0.02	1.89LysIle: 1.89 ± 0.034	1.345LysLys: 1.345 ± 0.032	3.476LysLeu: 3.476 ± 0.045	0.825LysMet: 0.825 ± 0.021	0.892LysAsn: 0.892 ± 0.023	2.06LysPro: 2.06 ± 0.037	1.0LysGln: 1.0 ± 0.023	2.457LysArg: 2.457 ± 0.038	2.02LysSer: 2.02 ± 0.039	1.976LysThr: 1.976 ± 0.034	2.463LysVal: 2.463 ± 0.033	0.394LysTrp: 0.394 ± 0.013	0.654LysTyr: 0.654 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.151LeuAla: 13.151 ± 0.113	0.878LeuCys: 0.878 ± 0.021	5.773LeuAsp: 5.773 ± 0.056	5.5LeuGlu: 5.5 ± 0.063	3.894LeuPhe: 3.894 ± 0.056	8.066LeuGly: 8.066 ± 0.073	1.835LeuHis: 1.835 ± 0.031	5.218LeuIle: 5.218 ± 0.054	3.908LeuLys: 3.908 ± 0.048	9.376LeuLeu: 9.376 ± 0.097	2.346LeuMet: 2.346 ± 0.036	2.571LeuAsn: 2.571 ± 0.036	5.395LeuPro: 5.395 ± 0.062	2.682LeuGln: 2.682 ± 0.041	6.565LeuArg: 6.565 ± 0.067	6.763LeuSer: 6.763 ± 0.058	5.393LeuThr: 5.393 ± 0.057	7.632LeuVal: 7.632 ± 0.067	1.12LeuTrp: 1.12 ± 0.026	2.139LeuTyr: 2.139 ± 0.031	0.001LeuXaa: 0.001 ± 0.001
Met	3.059MetAla: 3.059 ± 0.035	0.146MetCys: 0.146 ± 0.008	1.064MetAsp: 1.064 ± 0.023	1.252MetGlu: 1.252 ± 0.021	0.712MetPhe: 0.712 ± 0.022	1.737MetGly: 1.737 ± 0.032	0.474MetHis: 0.474 ± 0.016	1.498MetIle: 1.498 ± 0.027	1.115MetLys: 1.115 ± 0.027	2.571MetLeu: 2.571 ± 0.034	0.729MetMet: 0.729 ± 0.021	0.833MetAsn: 0.833 ± 0.02	1.503MetPro: 1.503 ± 0.031	0.819MetGln: 0.819 ± 0.021	1.863MetArg: 1.863 ± 0.029	1.705MetSer: 1.705 ± 0.026	1.908MetThr: 1.908 ± 0.031	1.684MetVal: 1.684 ± 0.03	0.2MetTrp: 0.2 ± 0.009	0.312MetTyr: 0.312 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.202AsnAla: 3.202 ± 0.041	0.237AsnCys: 0.237 ± 0.012	1.44AsnAsp: 1.44 ± 0.03	1.417AsnGlu: 1.417 ± 0.027	1.039AsnPhe: 1.039 ± 0.023	2.573AsnGly: 2.573 ± 0.039	0.534AsnHis: 0.534 ± 0.016	1.448AsnIle: 1.448 ± 0.031	0.7AsnLys: 0.7 ± 0.021	2.624AsnLeu: 2.624 ± 0.036	0.667AsnMet: 0.667 ± 0.017	0.698AsnAsn: 0.698 ± 0.02	1.808AsnPro: 1.808 ± 0.035	0.729AsnGln: 0.729 ± 0.02	1.913AsnArg: 1.913 ± 0.034	1.305AsnSer: 1.305 ± 0.026	1.281AsnThr: 1.281 ± 0.026	1.965AsnVal: 1.965 ± 0.037	0.464AsnTrp: 0.464 ± 0.015	0.687AsnTyr: 0.687 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	5.717ProAla: 5.717 ± 0.059	0.328ProCys: 0.328 ± 0.013	3.35ProAsp: 3.35 ± 0.05	3.787ProGlu: 3.787 ± 0.045	2.058ProPhe: 2.058 ± 0.036	4.296ProGly: 4.296 ± 0.053	1.102ProHis: 1.102 ± 0.028	2.267ProIle: 2.267 ± 0.035	1.713ProLys: 1.713 ± 0.033	4.78ProLeu: 4.78 ± 0.055	1.122ProMet: 1.122 ± 0.021	1.324ProAsn: 1.324 ± 0.03	2.314ProPro: 2.314 ± 0.042	1.57ProGln: 1.57 ± 0.031	2.801ProArg: 2.801 ± 0.038	2.804ProSer: 2.804 ± 0.041	2.255ProThr: 2.255 ± 0.03	4.174ProVal: 4.174 ± 0.049	0.638ProTrp: 0.638 ± 0.021	1.178ProTyr: 1.178 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.646GlnAla: 3.646 ± 0.049	0.194GlnCys: 0.194 ± 0.01	1.256GlnAsp: 1.256 ± 0.029	1.588GlnGlu: 1.588 ± 0.031	1.057GlnPhe: 1.057 ± 0.023	2.12GlnGly: 2.12 ± 0.033	0.548GlnHis: 0.548 ± 0.018	1.691GlnIle: 1.691 ± 0.032	1.073GlnLys: 1.073 ± 0.025	2.716GlnLeu: 2.716 ± 0.04	0.899GlnMet: 0.899 ± 0.023	0.823GlnAsn: 0.823 ± 0.021	1.614GlnPro: 1.614 ± 0.032	1.159GlnGln: 1.159 ± 0.031	2.256GlnArg: 2.256 ± 0.039	1.8GlnSer: 1.8 ± 0.031	1.575GlnThr: 1.575 ± 0.03	2.016GlnVal: 2.016 ± 0.035	0.385GlnTrp: 0.385 ± 0.014	0.566GlnTyr: 0.566 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	7.472ArgAla: 7.472 ± 0.074	0.554ArgCys: 0.554 ± 0.019	3.896ArgAsp: 3.896 ± 0.049	4.389ArgGlu: 4.389 ± 0.057	2.982ArgPhe: 2.982 ± 0.041	4.679ArgGly: 4.679 ± 0.048	1.809ArgHis: 1.809 ± 0.029	4.206ArgIle: 4.206 ± 0.048	2.552ArgLys: 2.552 ± 0.041	7.806ArgLeu: 7.806 ± 0.082	1.936ArgMet: 1.936 ± 0.033	2.094ArgAsn: 2.094 ± 0.037	3.551ArgPro: 3.551 ± 0.045	2.607ArgGln: 2.607 ± 0.042	6.071ArgArg: 6.071 ± 0.072	4.195ArgSer: 4.195 ± 0.057	3.439ArgThr: 3.439 ± 0.048	4.706ArgVal: 4.706 ± 0.057	0.955ArgTrp: 0.955 ± 0.023	1.79ArgTyr: 1.79 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.355SerAla: 6.355 ± 0.071	0.458SerCys: 0.458 ± 0.017	3.021SerAsp: 3.021 ± 0.039	3.144SerGlu: 3.144 ± 0.042	2.458SerPhe: 2.458 ± 0.037	5.876SerGly: 5.876 ± 0.061	1.17SerHis: 1.17 ± 0.024	3.107SerIle: 3.107 ± 0.047	1.713SerLys: 1.713 ± 0.032	5.716SerLeu: 5.716 ± 0.063	1.439SerMet: 1.439 ± 0.028	1.424SerAsn: 1.424 ± 0.032	2.854SerPro: 2.854 ± 0.038	1.584SerGln: 1.584 ± 0.029	3.976SerArg: 3.976 ± 0.045	3.153SerSer: 3.153 ± 0.048	2.754SerThr: 2.754 ± 0.04	4.27SerVal: 4.27 ± 0.051	0.794SerTrp: 0.794 ± 0.019	1.37SerTyr: 1.37 ± 0.029	0.001SerXaa: 0.001 ± 0.001
Thr	6.005ThrAla: 6.005 ± 0.053	0.419ThrCys: 0.419 ± 0.015	2.63ThrAsp: 2.63 ± 0.041	2.761ThrGlu: 2.761 ± 0.039	2.028ThrPhe: 2.028 ± 0.039	4.969ThrGly: 4.969 ± 0.054	0.984ThrHis: 0.984 ± 0.023	3.083ThrIle: 3.083 ± 0.041	1.495ThrLys: 1.495 ± 0.028	5.443ThrLeu: 5.443 ± 0.055	1.246ThrMet: 1.246 ± 0.027	1.321ThrAsn: 1.321 ± 0.026	2.928ThrPro: 2.928 ± 0.043	1.231ThrGln: 1.231 ± 0.026	3.258ThrArg: 3.258 ± 0.043	2.822ThrSer: 2.822 ± 0.037	2.654ThrThr: 2.654 ± 0.044	4.449ThrVal: 4.449 ± 0.049	0.631ThrTrp: 0.631 ± 0.021	1.216ThrTyr: 1.216 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	9.172ValAla: 9.172 ± 0.072	0.628ValCys: 0.628 ± 0.02	4.119ValAsp: 4.119 ± 0.044	4.601ValGlu: 4.601 ± 0.054	2.954ValPhe: 2.954 ± 0.044	5.519ValGly: 5.519 ± 0.069	1.419ValHis: 1.419 ± 0.028	4.092ValIle: 4.092 ± 0.051	2.406ValLys: 2.406 ± 0.037	7.619ValLeu: 7.619 ± 0.073	1.845ValMet: 1.845 ± 0.032	2.068ValAsn: 2.068 ± 0.035	3.725ValPro: 3.725 ± 0.046	1.873ValGln: 1.873 ± 0.033	4.892ValArg: 4.892 ± 0.052	4.726ValSer: 4.726 ± 0.048	4.47ValThr: 4.47 ± 0.058	6.036ValVal: 6.036 ± 0.072	0.855ValTrp: 0.855 ± 0.022	1.532ValTyr: 1.532 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.178TrpAla: 1.178 ± 0.024	0.14TrpCys: 0.14 ± 0.009	0.606TrpAsp: 0.606 ± 0.021	0.584TrpGlu: 0.584 ± 0.019	0.533TrpPhe: 0.533 ± 0.017	0.849TrpGly: 0.849 ± 0.02	0.319TrpHis: 0.319 ± 0.014	0.672TrpIle: 0.672 ± 0.021	0.52TrpLys: 0.52 ± 0.016	1.601TrpLeu: 1.601 ± 0.028	0.369TrpMet: 0.369 ± 0.014	0.467TrpAsn: 0.467 ± 0.015	0.677TrpPro: 0.677 ± 0.021	0.559TrpGln: 0.559 ± 0.019	1.039TrpArg: 1.039 ± 0.027	0.829TrpSer: 0.829 ± 0.024	0.741TrpThr: 0.741 ± 0.02	0.772TrpVal: 0.772 ± 0.021	0.23TrpTrp: 0.23 ± 0.012	0.304TrpTyr: 0.304 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.456TyrAla: 2.456 ± 0.035	0.254TyrCys: 0.254 ± 0.011	1.393TyrAsp: 1.393 ± 0.028	1.295TyrGlu: 1.295 ± 0.026	0.991TyrPhe: 0.991 ± 0.025	2.143TyrGly: 2.143 ± 0.036	0.523TyrHis: 0.523 ± 0.016	0.961TyrIle: 0.961 ± 0.021	0.633TyrLys: 0.633 ± 0.019	2.316TyrLeu: 2.316 ± 0.035	0.442TyrMet: 0.442 ± 0.015	0.603TyrAsn: 0.603 ± 0.019	1.152TyrPro: 1.152 ± 0.025	0.688TyrGln: 0.688 ± 0.018	1.882TyrArg: 1.882 ± 0.033	1.265TyrSer: 1.265 ± 0.03	1.041TyrThr: 1.041 ± 0.025	1.707TyrVal: 1.707 ± 0.031	0.372TyrTrp: 0.372 ± 0.014	0.64TyrTyr: 0.64 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6169 proteins (1905276 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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