Amino acid dipepetide frequency for Thermophagus xiamenensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.333AlaAla: 4.333 ± 0.081	0.568AlaCys: 0.568 ± 0.026	3.28AlaAsp: 3.28 ± 0.065	3.874AlaGlu: 3.874 ± 0.064	3.357AlaPhe: 3.357 ± 0.07	4.82AlaGly: 4.82 ± 0.073	1.238AlaHis: 1.238 ± 0.037	4.82AlaIle: 4.82 ± 0.073	3.469AlaLys: 3.469 ± 0.065	6.4AlaLeu: 6.4 ± 0.094	1.526AlaMet: 1.526 ± 0.044	2.836AlaAsn: 2.836 ± 0.057	2.004AlaPro: 2.004 ± 0.044	2.332AlaGln: 2.332 ± 0.055	3.202AlaArg: 3.202 ± 0.057	3.959AlaSer: 3.959 ± 0.07	3.061AlaThr: 3.061 ± 0.067	4.007AlaVal: 4.007 ± 0.067	0.845AlaTrp: 0.845 ± 0.028	2.317AlaTyr: 2.317 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.42CysAla: 0.42 ± 0.019	0.115CysCys: 0.115 ± 0.012	0.462CysAsp: 0.462 ± 0.021	0.494CysGlu: 0.494 ± 0.025	0.446CysPhe: 0.446 ± 0.023	0.652CysGly: 0.652 ± 0.032	0.254CysHis: 0.254 ± 0.018	0.529CysIle: 0.529 ± 0.023	0.429CysLys: 0.429 ± 0.019	0.712CysLeu: 0.712 ± 0.026	0.157CysMet: 0.157 ± 0.012	0.442CysAsn: 0.442 ± 0.021	0.401CysPro: 0.401 ± 0.024	0.289CysGln: 0.289 ± 0.017	0.461CysArg: 0.461 ± 0.021	0.589CysSer: 0.589 ± 0.035	0.357CysThr: 0.357 ± 0.02	0.458CysVal: 0.458 ± 0.021	0.094CysTrp: 0.094 ± 0.01	0.292CysTyr: 0.292 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.333AspAla: 3.333 ± 0.063	0.402AspCys: 0.402 ± 0.021	3.035AspAsp: 3.035 ± 0.067	4.029AspGlu: 4.029 ± 0.069	3.323AspPhe: 3.323 ± 0.068	3.759AspGly: 3.759 ± 0.075	1.029AspHis: 1.029 ± 0.029	4.362AspIle: 4.362 ± 0.068	3.514AspLys: 3.514 ± 0.064	5.043AspLeu: 5.043 ± 0.073	1.235AspMet: 1.235 ± 0.036	2.771AspAsn: 2.771 ± 0.052	2.298AspPro: 2.298 ± 0.061	1.773AspGln: 1.773 ± 0.041	2.276AspArg: 2.276 ± 0.044	3.067AspSer: 3.067 ± 0.078	2.43AspThr: 2.43 ± 0.065	3.421AspVal: 3.421 ± 0.07	0.803AspTrp: 0.803 ± 0.031	2.625AspTyr: 2.625 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	4.641GluAla: 4.641 ± 0.073	0.433GluCys: 0.433 ± 0.018	3.441GluAsp: 3.441 ± 0.067	5.25GluGlu: 5.25 ± 0.087	2.565GluPhe: 2.565 ± 0.056	4.196GluGly: 4.196 ± 0.067	1.192GluHis: 1.192 ± 0.04	5.344GluIle: 5.344 ± 0.072	6.018GluLys: 6.018 ± 0.083	6.254GluLeu: 6.254 ± 0.09	1.849GluMet: 1.849 ± 0.045	4.008GluAsn: 4.008 ± 0.063	2.04GluPro: 2.04 ± 0.042	2.456GluGln: 2.456 ± 0.047	2.94GluArg: 2.94 ± 0.056	3.178GluSer: 3.178 ± 0.055	3.336GluThr: 3.336 ± 0.056	4.683GluVal: 4.683 ± 0.077	0.858GluTrp: 0.858 ± 0.032	2.476GluTyr: 2.476 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	2.712PheAla: 2.712 ± 0.058	0.517PheCys: 0.517 ± 0.022	3.117PheAsp: 3.117 ± 0.056	3.191PheGlu: 3.191 ± 0.059	3.039PhePhe: 3.039 ± 0.068	3.459PheGly: 3.459 ± 0.071	0.953PheHis: 0.953 ± 0.037	3.75PheIle: 3.75 ± 0.063	3.134PheLys: 3.134 ± 0.065	4.955PheLeu: 4.955 ± 0.101	1.244PheMet: 1.244 ± 0.036	2.887PheAsn: 2.887 ± 0.063	1.991PhePro: 1.991 ± 0.055	1.61PheGln: 1.61 ± 0.038	2.405PheArg: 2.405 ± 0.049	4.264PheSer: 4.264 ± 0.076	2.532PheThr: 2.532 ± 0.05	3.105PheVal: 3.105 ± 0.055	0.671PheTrp: 0.671 ± 0.026	2.149PheTyr: 2.149 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.063GlyAla: 4.063 ± 0.072	0.743GlyCys: 0.743 ± 0.042	3.49GlyAsp: 3.49 ± 0.069	4.179GlyGlu: 4.179 ± 0.064	3.639GlyPhe: 3.639 ± 0.064	4.701GlyGly: 4.701 ± 0.096	1.335GlyHis: 1.335 ± 0.038	5.782GlyIle: 5.782 ± 0.079	4.897GlyLys: 4.897 ± 0.071	6.281GlyLeu: 6.281 ± 0.092	1.765GlyMet: 1.765 ± 0.041	3.633GlyAsn: 3.633 ± 0.067	1.859GlyPro: 1.859 ± 0.046	2.317GlyGln: 2.317 ± 0.051	2.916GlyArg: 2.916 ± 0.056	3.943GlySer: 3.943 ± 0.082	3.939GlyThr: 3.939 ± 0.092	4.417GlyVal: 4.417 ± 0.077	0.938GlyTrp: 0.938 ± 0.034	3.067GlyTyr: 3.067 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.059HisAla: 1.059 ± 0.035	0.23HisCys: 0.23 ± 0.016	0.925HisAsp: 0.925 ± 0.027	1.103HisGlu: 1.103 ± 0.034	1.271HisPhe: 1.271 ± 0.036	1.164HisGly: 1.164 ± 0.036	0.584HisHis: 0.584 ± 0.028	1.465HisIle: 1.465 ± 0.035	1.181HisLys: 1.181 ± 0.036	2.097HisLeu: 2.097 ± 0.051	0.375HisMet: 0.375 ± 0.021	1.027HisAsn: 1.027 ± 0.029	1.212HisPro: 1.212 ± 0.037	0.842HisGln: 0.842 ± 0.029	0.942HisArg: 0.942 ± 0.029	1.207HisSer: 1.207 ± 0.034	0.91HisThr: 0.91 ± 0.029	0.991HisVal: 0.991 ± 0.031	0.28HisTrp: 0.28 ± 0.017	0.89HisTyr: 0.89 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	4.831IleAla: 4.831 ± 0.071	0.612IleCys: 0.612 ± 0.024	4.607IleAsp: 4.607 ± 0.068	5.391IleGlu: 5.391 ± 0.073	3.697IlePhe: 3.697 ± 0.069	4.852IleGly: 4.852 ± 0.073	1.491IleHis: 1.491 ± 0.04	5.705IleIle: 5.705 ± 0.092	5.163IleLys: 5.163 ± 0.07	6.827IleLeu: 6.827 ± 0.091	1.475IleMet: 1.475 ± 0.039	4.361IleAsn: 4.361 ± 0.074	3.606IlePro: 3.606 ± 0.059	2.373IleGln: 2.373 ± 0.046	3.591IleArg: 3.591 ± 0.064	5.542IleSer: 5.542 ± 0.075	4.163IleThr: 4.163 ± 0.075	4.575IleVal: 4.575 ± 0.078	0.835IleTrp: 0.835 ± 0.031	2.793IleTyr: 2.793 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	4.476LysAla: 4.476 ± 0.073	0.427LysCys: 0.427 ± 0.021	3.485LysAsp: 3.485 ± 0.061	5.753LysGlu: 5.753 ± 0.093	2.543LysPhe: 2.543 ± 0.046	4.556LysGly: 4.556 ± 0.067	1.262LysHis: 1.262 ± 0.04	5.45LysIle: 5.45 ± 0.079	5.589LysLys: 5.589 ± 0.097	5.633LysLeu: 5.633 ± 0.073	1.901LysMet: 1.901 ± 0.044	4.215LysAsn: 4.215 ± 0.077	2.55LysPro: 2.55 ± 0.052	2.285LysGln: 2.285 ± 0.049	3.036LysArg: 3.036 ± 0.058	3.816LysSer: 3.816 ± 0.063	3.716LysThr: 3.716 ± 0.064	4.571LysVal: 4.571 ± 0.076	0.812LysTrp: 0.812 ± 0.03	2.763LysTyr: 2.763 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	6.146LeuAla: 6.146 ± 0.099	0.635LeuCys: 0.635 ± 0.025	4.793LeuAsp: 4.793 ± 0.076	5.971LeuGlu: 5.971 ± 0.086	5.102LeuPhe: 5.102 ± 0.081	5.751LeuGly: 5.751 ± 0.079	1.658LeuHis: 1.658 ± 0.045	6.887LeuIle: 6.887 ± 0.102	7.688LeuLys: 7.688 ± 0.109	9.095LeuLeu: 9.095 ± 0.125	2.417LeuMet: 2.417 ± 0.052	5.403LeuAsn: 5.403 ± 0.085	4.037LeuPro: 4.037 ± 0.065	3.214LeuGln: 3.214 ± 0.058	3.844LeuArg: 3.844 ± 0.066	6.842LeuSer: 6.842 ± 0.096	5.056LeuThr: 5.056 ± 0.09	5.538LeuVal: 5.538 ± 0.089	1.118LeuTrp: 1.118 ± 0.034	3.281LeuTyr: 3.281 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.932MetAla: 1.932 ± 0.047	0.126MetCys: 0.126 ± 0.011	1.306MetAsp: 1.306 ± 0.039	1.614MetGlu: 1.614 ± 0.039	0.907MetPhe: 0.907 ± 0.03	1.779MetGly: 1.779 ± 0.043	0.393MetHis: 0.393 ± 0.02	1.542MetIle: 1.542 ± 0.04	1.976MetLys: 1.976 ± 0.045	2.04MetLeu: 2.04 ± 0.048	0.578MetMet: 0.578 ± 0.028	1.222MetAsn: 1.222 ± 0.034	1.029MetPro: 1.029 ± 0.027	0.775MetGln: 0.775 ± 0.026	1.041MetArg: 1.041 ± 0.037	1.349MetSer: 1.349 ± 0.036	1.212MetThr: 1.212 ± 0.038	1.887MetVal: 1.887 ± 0.047	0.218MetTrp: 0.218 ± 0.013	0.576MetTyr: 0.576 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.163AsnAla: 3.163 ± 0.059	0.413AsnCys: 0.413 ± 0.02	2.88AsnAsp: 2.88 ± 0.059	3.221AsnGlu: 3.221 ± 0.058	2.624AsnPhe: 2.624 ± 0.056	3.753AsnGly: 3.753 ± 0.079	1.259AsnHis: 1.259 ± 0.035	4.598AsnIle: 4.598 ± 0.071	3.516AsnLys: 3.516 ± 0.063	5.17AsnLeu: 5.17 ± 0.1	1.165AsnMet: 1.165 ± 0.029	3.279AsnAsn: 3.279 ± 0.077	2.813AsnPro: 2.813 ± 0.054	2.093AsnGln: 2.093 ± 0.042	2.527AsnArg: 2.527 ± 0.051	3.17AsnSer: 3.17 ± 0.06	2.706AsnThr: 2.706 ± 0.05	3.097AsnVal: 3.097 ± 0.064	0.724AsnTrp: 0.724 ± 0.025	2.414AsnTyr: 2.414 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	2.488ProAla: 2.488 ± 0.052	0.258ProCys: 0.258 ± 0.015	2.978ProAsp: 2.978 ± 0.064	3.57ProGlu: 3.57 ± 0.054	2.138ProPhe: 2.138 ± 0.043	2.989ProGly: 2.989 ± 0.06	0.829ProHis: 0.829 ± 0.027	2.481ProIle: 2.481 ± 0.049	2.023ProLys: 2.023 ± 0.047	3.667ProLeu: 3.667 ± 0.064	0.805ProMet: 0.805 ± 0.03	1.937ProAsn: 1.937 ± 0.051	1.261ProPro: 1.261 ± 0.038	1.515ProGln: 1.515 ± 0.039	1.461ProArg: 1.461 ± 0.035	2.534ProSer: 2.534 ± 0.048	1.663ProThr: 1.663 ± 0.041	3.275ProVal: 3.275 ± 0.061	0.5ProTrp: 0.5 ± 0.023	1.572ProTyr: 1.572 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.085GlnAla: 2.085 ± 0.043	0.215GlnCys: 0.215 ± 0.016	1.429GlnAsp: 1.429 ± 0.038	2.284GlnGlu: 2.284 ± 0.047	1.508GlnPhe: 1.508 ± 0.039	1.877GlnGly: 1.877 ± 0.044	0.699GlnHis: 0.699 ± 0.025	2.635GlnIle: 2.635 ± 0.051	3.13GlnLys: 3.13 ± 0.059	3.511GlnLeu: 3.511 ± 0.065	0.934GlnMet: 0.934 ± 0.029	2.131GlnAsn: 2.131 ± 0.048	1.32GlnPro: 1.32 ± 0.037	1.556GlnGln: 1.556 ± 0.052	1.57GlnArg: 1.57 ± 0.035	2.031GlnSer: 2.031 ± 0.047	1.902GlnThr: 1.902 ± 0.041	2.01GlnVal: 2.01 ± 0.048	0.573GlnTrp: 0.573 ± 0.027	1.505GlnTyr: 1.505 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.455ArgAla: 2.455 ± 0.046	0.352ArgCys: 0.352 ± 0.022	2.213ArgAsp: 2.213 ± 0.049	3.159ArgGlu: 3.159 ± 0.066	2.636ArgPhe: 2.636 ± 0.052	2.401ArgGly: 2.401 ± 0.057	0.989ArgHis: 0.989 ± 0.03	3.668ArgIle: 3.668 ± 0.057	3.439ArgLys: 3.439 ± 0.066	4.511ArgLeu: 4.511 ± 0.073	1.136ArgMet: 1.136 ± 0.033	2.504ArgAsn: 2.504 ± 0.055	1.632ArgPro: 1.632 ± 0.043	1.864ArgGln: 1.864 ± 0.047	2.113ArgArg: 2.113 ± 0.052	2.359ArgSer: 2.359 ± 0.047	2.01ArgThr: 2.01 ± 0.047	2.626ArgVal: 2.626 ± 0.054	0.66ArgTrp: 0.66 ± 0.03	2.084ArgTyr: 2.084 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.867SerAla: 3.867 ± 0.058	0.53SerCys: 0.53 ± 0.023	3.654SerAsp: 3.654 ± 0.064	3.918SerGlu: 3.918 ± 0.061	3.789SerPhe: 3.789 ± 0.065	5.135SerGly: 5.135 ± 0.11	1.285SerHis: 1.285 ± 0.036	4.57SerIle: 4.57 ± 0.069	3.581SerLys: 3.581 ± 0.061	6.232SerLeu: 6.232 ± 0.085	1.377SerMet: 1.377 ± 0.038	3.021SerAsn: 3.021 ± 0.066	2.585SerPro: 2.585 ± 0.053	2.111SerGln: 2.111 ± 0.044	2.831SerArg: 2.831 ± 0.051	4.125SerSer: 4.125 ± 0.084	3.048SerThr: 3.048 ± 0.064	4.25SerVal: 4.25 ± 0.066	0.75SerTrp: 0.75 ± 0.026	2.483SerTyr: 2.483 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.181ThrAla: 3.181 ± 0.058	0.376ThrCys: 0.376 ± 0.022	2.983ThrAsp: 2.983 ± 0.062	2.906ThrGlu: 2.906 ± 0.06	2.734ThrPhe: 2.734 ± 0.054	4.36ThrGly: 4.36 ± 0.075	0.938ThrHis: 0.938 ± 0.03	4.47ThrIle: 4.47 ± 0.075	2.585ThrLys: 2.585 ± 0.049	4.968ThrLeu: 4.968 ± 0.079	0.938ThrMet: 0.938 ± 0.029	2.527ThrAsn: 2.527 ± 0.056	2.415ThrPro: 2.415 ± 0.054	1.602ThrGln: 1.602 ± 0.04	2.152ThrArg: 2.152 ± 0.046	3.256ThrSer: 3.256 ± 0.056	2.914ThrThr: 2.914 ± 0.062	3.305ThrVal: 3.305 ± 0.087	0.61ThrTrp: 0.61 ± 0.026	1.9ThrTyr: 1.9 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	4.157ValAla: 4.157 ± 0.069	0.566ValCys: 0.566 ± 0.026	3.575ValAsp: 3.575 ± 0.065	4.257ValGlu: 4.257 ± 0.074	3.368ValPhe: 3.368 ± 0.062	3.894ValGly: 3.894 ± 0.06	1.078ValHis: 1.078 ± 0.031	4.963ValIle: 4.963 ± 0.078	4.326ValLys: 4.326 ± 0.068	5.865ValLeu: 5.865 ± 0.075	1.478ValMet: 1.478 ± 0.039	3.362ValAsn: 3.362 ± 0.053	2.722ValPro: 2.722 ± 0.054	1.689ValGln: 1.689 ± 0.04	2.817ValArg: 2.817 ± 0.06	4.385ValSer: 4.385 ± 0.072	3.493ValThr: 3.493 ± 0.092	4.89ValVal: 4.89 ± 0.083	0.767ValTrp: 0.767 ± 0.029	2.37ValTyr: 2.37 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.718TrpAla: 0.718 ± 0.025	0.134TrpCys: 0.134 ± 0.013	0.697TrpAsp: 0.697 ± 0.028	0.854TrpGlu: 0.854 ± 0.03	0.66TrpPhe: 0.66 ± 0.028	0.965TrpGly: 0.965 ± 0.03	0.283TrpHis: 0.283 ± 0.018	0.892TrpIle: 0.892 ± 0.029	0.786TrpLys: 0.786 ± 0.032	1.295TrpLeu: 1.295 ± 0.037	0.367TrpMet: 0.367 ± 0.017	0.751TrpAsn: 0.751 ± 0.026	0.442TrpPro: 0.442 ± 0.021	0.536TrpGln: 0.536 ± 0.025	0.559TrpArg: 0.559 ± 0.023	0.748TrpSer: 0.748 ± 0.029	0.654TrpThr: 0.654 ± 0.032	0.768TrpVal: 0.768 ± 0.029	0.225TrpTrp: 0.225 ± 0.016	0.515TrpTyr: 0.515 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.186TyrAla: 2.186 ± 0.051	0.401TyrCys: 0.401 ± 0.019	2.181TyrAsp: 2.181 ± 0.05	2.142TyrGlu: 2.142 ± 0.047	2.337TyrPhe: 2.337 ± 0.046	2.842TyrGly: 2.842 ± 0.057	1.008TyrHis: 1.008 ± 0.026	2.577TyrIle: 2.577 ± 0.049	2.396TyrLys: 2.396 ± 0.049	3.917TyrLeu: 3.917 ± 0.064	0.779TyrMet: 0.779 ± 0.026	2.268TyrAsn: 2.268 ± 0.05	1.727TyrPro: 1.727 ± 0.046	1.673TyrGln: 1.673 ± 0.043	2.127TyrArg: 2.127 ± 0.044	2.778TyrSer: 2.778 ± 0.052	2.017TyrThr: 2.017 ± 0.05	2.147TyrVal: 2.147 ± 0.045	0.566TyrTrp: 0.566 ± 0.023	1.918TyrTyr: 1.918 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3056 proteins (1082107 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---