Amino acid dipepetide frequency for Calorimonas adulescens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.765AlaAla: 5.765 ± 0.134
0.793AlaCys: 0.793 ± 0.035
3.729AlaAsp: 3.729 ± 0.077
4.424AlaGlu: 4.424 ± 0.079
2.625AlaPhe: 2.625 ± 0.062
5.482AlaGly: 5.482 ± 0.104
1.023AlaHis: 1.023 ± 0.037
6.105AlaIle: 6.105 ± 0.102
4.315AlaLys: 4.315 ± 0.084
6.664AlaLeu: 6.664 ± 0.117
2.146AlaMet: 2.146 ± 0.061
2.425AlaAsn: 2.425 ± 0.055
1.78AlaPro: 1.78 ± 0.057
1.768AlaGln: 1.768 ± 0.05
3.369AlaArg: 3.369 ± 0.071
3.737AlaSer: 3.737 ± 0.074
3.176AlaThr: 3.176 ± 0.075
5.76AlaVal: 5.76 ± 0.091
0.505AlaTrp: 0.505 ± 0.026
2.463AlaTyr: 2.463 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.652CysAla: 0.652 ± 0.032
0.135CysCys: 0.135 ± 0.013
0.637CysAsp: 0.637 ± 0.029
0.644CysGlu: 0.644 ± 0.031
0.384CysPhe: 0.384 ± 0.024
1.102CysGly: 1.102 ± 0.044
0.227CysHis: 0.227 ± 0.016
0.945CysIle: 0.945 ± 0.037
0.562CysLys: 0.562 ± 0.026
0.726CysLeu: 0.726 ± 0.032
0.283CysMet: 0.283 ± 0.019
0.474CysAsn: 0.474 ± 0.024
0.509CysPro: 0.509 ± 0.032
0.216CysGln: 0.216 ± 0.016
0.468CysArg: 0.468 ± 0.027
0.642CysSer: 0.642 ± 0.028
0.509CysThr: 0.509 ± 0.023
0.602CysVal: 0.602 ± 0.029
0.067CysTrp: 0.067 ± 0.009
0.368CysTyr: 0.368 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.671AspAla: 3.671 ± 0.078
0.557AspCys: 0.557 ± 0.03
3.268AspAsp: 3.268 ± 0.07
5.129AspGlu: 5.129 ± 0.087
2.504AspPhe: 2.504 ± 0.063
4.347AspGly: 4.347 ± 0.097
0.65AspHis: 0.65 ± 0.029
6.763AspIle: 6.763 ± 0.103
4.066AspLys: 4.066 ± 0.085
4.661AspLeu: 4.661 ± 0.073
2.076AspMet: 2.076 ± 0.059
2.727AspAsn: 2.727 ± 0.067
1.916AspPro: 1.916 ± 0.054
0.857AspGln: 0.857 ± 0.032
3.184AspArg: 3.184 ± 0.065
3.037AspSer: 3.037 ± 0.07
2.797AspThr: 2.797 ± 0.066
4.631AspVal: 4.631 ± 0.083
0.429AspTrp: 0.429 ± 0.027
2.535AspTyr: 2.535 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
4.975GluAla: 4.975 ± 0.088
0.633GluCys: 0.633 ± 0.034
4.243GluAsp: 4.243 ± 0.087
6.141GluGlu: 6.141 ± 0.125
2.685GluPhe: 2.685 ± 0.058
4.49GluGly: 4.49 ± 0.096
0.951GluHis: 0.951 ± 0.037
6.727GluIle: 6.727 ± 0.107
5.971GluLys: 5.971 ± 0.095
6.552GluLeu: 6.552 ± 0.118
2.328GluMet: 2.328 ± 0.062
3.813GluAsn: 3.813 ± 0.076
1.792GluPro: 1.792 ± 0.046
1.59GluGln: 1.59 ± 0.052
3.821GluArg: 3.821 ± 0.088
3.156GluSer: 3.156 ± 0.067
2.917GluThr: 2.917 ± 0.065
5.157GluVal: 5.157 ± 0.088
0.533GluTrp: 0.533 ± 0.028
2.86GluTyr: 2.86 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
2.397PheAla: 2.397 ± 0.061
0.414PheCys: 0.414 ± 0.025
2.569PheAsp: 2.569 ± 0.057
2.405PheGlu: 2.405 ± 0.061
1.523PhePhe: 1.523 ± 0.051
2.87PheGly: 2.87 ± 0.064
0.558PheHis: 0.558 ± 0.027
3.735PheIle: 3.735 ± 0.086
2.833PheLys: 2.833 ± 0.071
3.575PheLeu: 3.575 ± 0.074
1.218PheMet: 1.218 ± 0.048
2.229PheAsn: 2.229 ± 0.062
1.315PhePro: 1.315 ± 0.045
0.792PheGln: 0.792 ± 0.03
1.355PheArg: 1.355 ± 0.039
2.481PheSer: 2.481 ± 0.061
2.181PheThr: 2.181 ± 0.057
2.612PheVal: 2.612 ± 0.063
0.287PheTrp: 0.287 ± 0.018
1.586PheTyr: 1.586 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
4.941GlyAla: 4.941 ± 0.099
0.959GlyCys: 0.959 ± 0.038
3.866GlyAsp: 3.866 ± 0.067
4.512GlyGlu: 4.512 ± 0.097
3.288GlyPhe: 3.288 ± 0.066
5.261GlyGly: 5.261 ± 0.105
1.231GlyHis: 1.231 ± 0.048
7.786GlyIle: 7.786 ± 0.119
5.266GlyLys: 5.266 ± 0.072
6.866GlyLeu: 6.866 ± 0.092
2.324GlyMet: 2.324 ± 0.057
3.121GlyAsn: 3.121 ± 0.06
1.871GlyPro: 1.871 ± 0.059
1.856GlyGln: 1.856 ± 0.055
3.571GlyArg: 3.571 ± 0.078
4.006GlySer: 4.006 ± 0.091
3.821GlyThr: 3.821 ± 0.079
5.457GlyVal: 5.457 ± 0.1
0.618GlyTrp: 0.618 ± 0.029
3.517GlyTyr: 3.517 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
0.849HisAla: 0.849 ± 0.035
0.18HisCys: 0.18 ± 0.014
0.764HisAsp: 0.764 ± 0.029
0.914HisGlu: 0.914 ± 0.038
0.629HisPhe: 0.629 ± 0.028
1.179HisGly: 1.179 ± 0.044
0.296HisHis: 0.296 ± 0.021
1.346HisIle: 1.346 ± 0.044
0.85HisLys: 0.85 ± 0.03
1.27HisLeu: 1.27 ± 0.042
0.388HisMet: 0.388 ± 0.023
0.694HisAsn: 0.694 ± 0.033
0.758HisPro: 0.758 ± 0.039
0.316HisGln: 0.316 ± 0.021
0.733HisArg: 0.733 ± 0.035
0.757HisSer: 0.757 ± 0.032
0.764HisThr: 0.764 ± 0.034
0.916HisVal: 0.916 ± 0.032
0.131HisTrp: 0.131 ± 0.015
0.528HisTyr: 0.528 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.421IleAla: 6.421 ± 0.098
0.941IleCys: 0.941 ± 0.032
6.193IleAsp: 6.193 ± 0.104
6.453IleGlu: 6.453 ± 0.11
3.479IlePhe: 3.479 ± 0.084
6.554IleGly: 6.554 ± 0.114
1.134IleHis: 1.134 ± 0.04
7.914IleIle: 7.914 ± 0.146
7.145IleLys: 7.145 ± 0.127
8.192IleLeu: 8.192 ± 0.125
2.543IleMet: 2.543 ± 0.066
4.935IleAsn: 4.935 ± 0.095
3.879IlePro: 3.879 ± 0.068
1.972IleGln: 1.972 ± 0.056
3.933IleArg: 3.933 ± 0.082
6.013IleSer: 6.013 ± 0.103
4.599IleThr: 4.599 ± 0.078
6.081IleVal: 6.081 ± 0.103
0.513IleTrp: 0.513 ± 0.028
3.38IleTyr: 3.38 ± 0.084
0.0IleXaa: 0.0 ± 0.0
Lys
5.028LysAla: 5.028 ± 0.083
0.585LysCys: 0.585 ± 0.034
4.739LysAsp: 4.739 ± 0.084
6.431LysGlu: 6.431 ± 0.118
1.931LysPhe: 1.931 ± 0.05
4.916LysGly: 4.916 ± 0.103
0.804LysHis: 0.804 ± 0.033
5.868LysIle: 5.868 ± 0.091
5.588LysLys: 5.588 ± 0.094
5.857LysLeu: 5.857 ± 0.094
2.042LysMet: 2.042 ± 0.051
4.094LysAsn: 4.094 ± 0.073
2.5LysPro: 2.5 ± 0.054
1.643LysGln: 1.643 ± 0.046
3.743LysArg: 3.743 ± 0.07
3.709LysSer: 3.709 ± 0.07
3.394LysThr: 3.394 ± 0.064
4.543LysVal: 4.543 ± 0.077
0.521LysTrp: 0.521 ± 0.031
2.864LysTyr: 2.864 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
6.005LeuAla: 6.005 ± 0.118
0.947LeuCys: 0.947 ± 0.041
5.195LeuAsp: 5.195 ± 0.089
5.569LeuGlu: 5.569 ± 0.089
3.482LeuPhe: 3.482 ± 0.073
6.409LeuGly: 6.409 ± 0.11
1.187LeuHis: 1.187 ± 0.036
7.737LeuIle: 7.737 ± 0.114
7.816LeuLys: 7.816 ± 0.117
8.096LeuLeu: 8.096 ± 0.131
2.611LeuMet: 2.611 ± 0.063
5.144LeuAsn: 5.144 ± 0.096
3.509LeuPro: 3.509 ± 0.074
2.112LeuGln: 2.112 ± 0.056
4.074LeuArg: 4.074 ± 0.071
6.421LeuSer: 6.421 ± 0.118
4.463LeuThr: 4.463 ± 0.069
5.517LeuVal: 5.517 ± 0.093
0.66LeuTrp: 0.66 ± 0.032
3.268LeuTyr: 3.268 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
2.451MetAla: 2.451 ± 0.058
0.245MetCys: 0.245 ± 0.017
2.027MetAsp: 2.027 ± 0.059
2.236MetGlu: 2.236 ± 0.051
0.946MetPhe: 0.946 ± 0.037
2.52MetGly: 2.52 ± 0.061
0.389MetHis: 0.389 ± 0.024
2.291MetIle: 2.291 ± 0.058
2.027MetLys: 2.027 ± 0.049
2.533MetLeu: 2.533 ± 0.064
0.904MetMet: 0.904 ± 0.036
1.441MetAsn: 1.441 ± 0.041
1.227MetPro: 1.227 ± 0.041
0.721MetGln: 0.721 ± 0.03
1.439MetArg: 1.439 ± 0.051
1.767MetSer: 1.767 ± 0.053
1.474MetThr: 1.474 ± 0.044
2.233MetVal: 2.233 ± 0.054
0.18MetTrp: 0.18 ± 0.013
0.938MetTyr: 0.938 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.014AsnAla: 3.014 ± 0.057
0.436AsnCys: 0.436 ± 0.029
2.484AsnAsp: 2.484 ± 0.07
3.257AsnGlu: 3.257 ± 0.074
1.866AsnPhe: 1.866 ± 0.056
3.671AsnGly: 3.671 ± 0.079
0.648AsnHis: 0.648 ± 0.031
5.251AsnIle: 5.251 ± 0.107
3.16AsnLys: 3.16 ± 0.077
4.307AsnLeu: 4.307 ± 0.088
1.495AsnMet: 1.495 ± 0.045
2.459AsnAsn: 2.459 ± 0.063
2.329AsnPro: 2.329 ± 0.056
1.17AsnGln: 1.17 ± 0.039
2.189AsnArg: 2.189 ± 0.055
2.743AsnSer: 2.743 ± 0.061
2.375AsnThr: 2.375 ± 0.056
3.401AsnVal: 3.401 ± 0.064
0.313AsnTrp: 0.313 ± 0.023
1.87AsnTyr: 1.87 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.26ProAla: 2.26 ± 0.06
0.329ProCys: 0.329 ± 0.021
2.515ProAsp: 2.515 ± 0.067
3.18ProGlu: 3.18 ± 0.072
1.495ProPhe: 1.495 ± 0.045
2.998ProGly: 2.998 ± 0.065
0.682ProHis: 0.682 ± 0.029
2.671ProIle: 2.671 ± 0.059
1.852ProLys: 1.852 ± 0.042
3.11ProLeu: 3.11 ± 0.059
0.884ProMet: 0.884 ± 0.032
1.294ProAsn: 1.294 ± 0.045
1.182ProPro: 1.182 ± 0.042
1.101ProGln: 1.101 ± 0.034
1.231ProArg: 1.231 ± 0.039
1.971ProSer: 1.971 ± 0.054
1.778ProThr: 1.778 ± 0.052
3.334ProVal: 3.334 ± 0.071
0.316ProTrp: 0.316 ± 0.018
1.598ProTyr: 1.598 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
1.798GlnAla: 1.798 ± 0.056
0.176GlnCys: 0.176 ± 0.015
1.339GlnAsp: 1.339 ± 0.043
1.767GlnGlu: 1.767 ± 0.048
0.846GlnPhe: 0.846 ± 0.031
1.485GlnGly: 1.485 ± 0.051
0.344GlnHis: 0.344 ± 0.022
1.992GlnIle: 1.992 ± 0.058
1.827GlnLys: 1.827 ± 0.054
2.108GlnLeu: 2.108 ± 0.054
0.753GlnMet: 0.753 ± 0.034
1.253GlnAsn: 1.253 ± 0.043
0.85GlnPro: 0.85 ± 0.038
0.864GlnGln: 0.864 ± 0.043
1.166GlnArg: 1.166 ± 0.04
1.222GlnSer: 1.222 ± 0.042
1.046GlnThr: 1.046 ± 0.042
1.588GlnVal: 1.588 ± 0.052
0.213GlnTrp: 0.213 ± 0.016
1.003GlnTyr: 1.003 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.965ArgAla: 2.965 ± 0.06
0.497ArgCys: 0.497 ± 0.024
2.789ArgAsp: 2.789 ± 0.068
3.875ArgGlu: 3.875 ± 0.075
1.978ArgPhe: 1.978 ± 0.052
3.074ArgGly: 3.074 ± 0.062
0.726ArgHis: 0.726 ± 0.027
4.291ArgIle: 4.291 ± 0.086
3.006ArgLys: 3.006 ± 0.065
4.604ArgLeu: 4.604 ± 0.083
1.442ArgMet: 1.442 ± 0.044
2.09ArgAsn: 2.09 ± 0.053
1.663ArgPro: 1.663 ± 0.049
1.273ArgGln: 1.273 ± 0.044
2.144ArgArg: 2.144 ± 0.061
2.132ArgSer: 2.132 ± 0.053
1.998ArgThr: 1.998 ± 0.053
3.471ArgVal: 3.471 ± 0.074
0.41ArgTrp: 0.41 ± 0.025
2.191ArgTyr: 2.191 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
3.521SerAla: 3.521 ± 0.077
0.606SerCys: 0.606 ± 0.029
3.302SerAsp: 3.302 ± 0.073
3.638SerGlu: 3.638 ± 0.073
2.551SerPhe: 2.551 ± 0.063
4.773SerGly: 4.773 ± 0.092
0.868SerHis: 0.868 ± 0.037
5.449SerIle: 5.449 ± 0.097
3.807SerLys: 3.807 ± 0.082
5.706SerLeu: 5.706 ± 0.1
1.835SerMet: 1.835 ± 0.059
2.465SerAsn: 2.465 ± 0.059
2.018SerPro: 2.018 ± 0.054
1.497SerGln: 1.497 ± 0.051
2.64SerArg: 2.64 ± 0.053
3.778SerSer: 3.778 ± 0.083
2.829SerThr: 2.829 ± 0.057
3.905SerVal: 3.905 ± 0.072
0.401SerTrp: 0.401 ± 0.024
2.299SerTyr: 2.299 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
3.707ThrAla: 3.707 ± 0.07
0.453ThrCys: 0.453 ± 0.027
2.656ThrAsp: 2.656 ± 0.058
2.86ThrGlu: 2.86 ± 0.061
1.844ThrPhe: 1.844 ± 0.053
4.564ThrGly: 4.564 ± 0.095
0.778ThrHis: 0.778 ± 0.03
4.302ThrIle: 4.302 ± 0.077
2.583ThrLys: 2.583 ± 0.057
4.616ThrLeu: 4.616 ± 0.075
1.315ThrMet: 1.315 ± 0.039
1.868ThrAsn: 1.868 ± 0.056
2.164ThrPro: 2.164 ± 0.059
1.191ThrGln: 1.191 ± 0.042
2.099ThrArg: 2.099 ± 0.062
2.877ThrSer: 2.877 ± 0.064
2.536ThrThr: 2.536 ± 0.067
4.066ThrVal: 4.066 ± 0.086
0.345ThrTrp: 0.345 ± 0.026
1.904ThrTyr: 1.904 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
4.849ValAla: 4.849 ± 0.092
0.74ValCys: 0.74 ± 0.032
4.6ValAsp: 4.6 ± 0.082
4.815ValGlu: 4.815 ± 0.095
2.841ValPhe: 2.841 ± 0.063
4.949ValGly: 4.949 ± 0.101
0.987ValHis: 0.987 ± 0.036
6.595ValIle: 6.595 ± 0.094
5.088ValLys: 5.088 ± 0.083
6.507ValLeu: 6.507 ± 0.097
2.078ValMet: 2.078 ± 0.05
3.373ValAsn: 3.373 ± 0.062
2.653ValPro: 2.653 ± 0.058
1.479ValGln: 1.479 ± 0.049
3.056ValArg: 3.056 ± 0.079
4.672ValSer: 4.672 ± 0.072
3.741ValThr: 3.741 ± 0.085
5.337ValVal: 5.337 ± 0.101
0.476ValTrp: 0.476 ± 0.029
2.789ValTyr: 2.789 ± 0.072
0.0ValXaa: 0.0 ± 0.0
Trp
0.482TrpAla: 0.482 ± 0.029
0.084TrpCys: 0.084 ± 0.012
0.493TrpAsp: 0.493 ± 0.024
0.481TrpGlu: 0.481 ± 0.025
0.334TrpPhe: 0.334 ± 0.021
0.568TrpGly: 0.568 ± 0.031
0.111TrpHis: 0.111 ± 0.011
0.585TrpIle: 0.585 ± 0.03
0.393TrpLys: 0.393 ± 0.024
0.688TrpLeu: 0.688 ± 0.039
0.243TrpMet: 0.243 ± 0.02
0.364TrpAsn: 0.364 ± 0.025
0.287TrpPro: 0.287 ± 0.021
0.227TrpGln: 0.227 ± 0.019
0.373TrpArg: 0.373 ± 0.025
0.398TrpSer: 0.398 ± 0.025
0.328TrpThr: 0.328 ± 0.026
0.493TrpVal: 0.493 ± 0.027
0.107TrpTrp: 0.107 ± 0.014
0.32TrpTyr: 0.32 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.303TyrAla: 2.303 ± 0.052
0.44TyrCys: 0.44 ± 0.025
2.399TyrAsp: 2.399 ± 0.059
2.604TyrGlu: 2.604 ± 0.061
1.707TyrPhe: 1.707 ± 0.054
2.926TyrGly: 2.926 ± 0.063
0.665TyrHis: 0.665 ± 0.028
3.919TyrIle: 3.919 ± 0.072
2.641TyrLys: 2.641 ± 0.064
3.579TyrLeu: 3.579 ± 0.08
1.085TyrMet: 1.085 ± 0.036
2.175TyrAsn: 2.175 ± 0.058
1.576TyrPro: 1.576 ± 0.048
0.997TyrGln: 0.997 ± 0.039
2.032TyrArg: 2.032 ± 0.048
2.369TyrSer: 2.369 ± 0.059
2.006TyrThr: 2.006 ± 0.061
2.521TyrVal: 2.521 ± 0.062
0.333TyrTrp: 0.333 ± 0.023
1.682TyrTyr: 1.682 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2527 proteins (750405 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski