Amino acid dipepetide frequency for Staphylococcus virus 96

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.708AlaAla: 0.708 ± 0.196
0.425AlaCys: 0.425 ± 0.196
2.831AlaAsp: 2.831 ± 0.524
3.751AlaGlu: 3.751 ± 0.505
2.477AlaPhe: 2.477 ± 0.694
3.397AlaGly: 3.397 ± 0.76
0.991AlaHis: 0.991 ± 0.268
5.379AlaIle: 5.379 ± 0.589
5.804AlaLys: 5.804 ± 0.664
3.963AlaLeu: 3.963 ± 0.753
1.486AlaMet: 1.486 ± 0.368
4.034AlaAsn: 4.034 ± 0.54
1.769AlaPro: 1.769 ± 0.396
2.194AlaGln: 2.194 ± 0.391
2.477AlaArg: 2.477 ± 0.369
3.963AlaSer: 3.963 ± 0.597
4.954AlaThr: 4.954 ± 0.619
3.185AlaVal: 3.185 ± 0.788
0.566AlaTrp: 0.566 ± 0.374
1.982AlaTyr: 1.982 ± 0.418
0.0AlaXaa: 0.0 ± 0.0
Cys
0.283CysAla: 0.283 ± 0.121
0.0CysCys: 0.0 ± 0.0
0.283CysAsp: 0.283 ± 0.147
0.212CysGlu: 0.212 ± 0.12
0.425CysPhe: 0.425 ± 0.2
0.354CysGly: 0.354 ± 0.152
0.071CysHis: 0.071 ± 0.073
0.283CysIle: 0.283 ± 0.151
0.425CysLys: 0.425 ± 0.154
0.425CysLeu: 0.425 ± 0.146
0.495CysMet: 0.495 ± 0.212
0.142CysAsn: 0.142 ± 0.093
0.283CysPro: 0.283 ± 0.151
0.142CysGln: 0.142 ± 0.098
0.495CysArg: 0.495 ± 0.219
0.495CysSer: 0.495 ± 0.18
0.0CysThr: 0.0 ± 0.0
0.212CysVal: 0.212 ± 0.128
0.071CysTrp: 0.071 ± 0.067
0.283CysTyr: 0.283 ± 0.127
0.0CysXaa: 0.0 ± 0.0
Asp
4.176AspAla: 4.176 ± 0.595
0.354AspCys: 0.354 ± 0.165
4.954AspAsp: 4.954 ± 0.762
4.671AspGlu: 4.671 ± 0.639
2.973AspPhe: 2.973 ± 0.53
4.176AspGly: 4.176 ± 0.511
0.354AspHis: 0.354 ± 0.127
3.963AspIle: 3.963 ± 0.514
5.945AspLys: 5.945 ± 0.739
5.308AspLeu: 5.308 ± 0.518
1.416AspMet: 1.416 ± 0.232
3.468AspAsn: 3.468 ± 0.463
1.486AspPro: 1.486 ± 0.29
1.062AspGln: 1.062 ± 0.242
2.336AspArg: 2.336 ± 0.307
4.247AspSer: 4.247 ± 0.469
3.539AspThr: 3.539 ± 0.453
4.388AspVal: 4.388 ± 0.658
0.92AspTrp: 0.92 ± 0.26
3.043AspTyr: 3.043 ± 0.424
0.0AspXaa: 0.0 ± 0.0
Glu
3.751GluAla: 3.751 ± 0.421
0.708GluCys: 0.708 ± 0.23
4.176GluAsp: 4.176 ± 0.648
5.521GluGlu: 5.521 ± 0.985
2.973GluPhe: 2.973 ± 0.486
3.185GluGly: 3.185 ± 0.433
1.699GluHis: 1.699 ± 0.318
5.45GluIle: 5.45 ± 0.681
5.662GluLys: 5.662 ± 0.702
6.795GluLeu: 6.795 ± 0.851
2.477GluMet: 2.477 ± 0.565
4.742GluAsn: 4.742 ± 0.577
1.699GluPro: 1.699 ± 0.357
4.034GluGln: 4.034 ± 0.71
2.76GluArg: 2.76 ± 0.32
3.893GluSer: 3.893 ± 0.558
3.61GluThr: 3.61 ± 0.426
5.591GluVal: 5.591 ± 0.593
1.274GluTrp: 1.274 ± 0.305
3.963GluTyr: 3.963 ± 0.586
0.0GluXaa: 0.0 ± 0.0
Phe
2.123PheAla: 2.123 ± 0.341
0.212PheCys: 0.212 ± 0.116
3.61PheAsp: 3.61 ± 0.434
3.185PheGlu: 3.185 ± 0.427
1.557PhePhe: 1.557 ± 0.507
2.477PheGly: 2.477 ± 0.754
0.637PheHis: 0.637 ± 0.216
3.61PheIle: 3.61 ± 0.548
4.813PheLys: 4.813 ± 0.534
3.185PheLeu: 3.185 ± 0.442
1.416PheMet: 1.416 ± 0.329
3.256PheAsn: 3.256 ± 0.4
0.779PhePro: 0.779 ± 0.257
1.062PheGln: 1.062 ± 0.308
1.628PheArg: 1.628 ± 0.304
2.619PheSer: 2.619 ± 0.433
3.256PheThr: 3.256 ± 0.487
2.123PheVal: 2.123 ± 0.401
0.354PheTrp: 0.354 ± 0.131
1.911PheTyr: 1.911 ± 0.325
0.0PheXaa: 0.0 ± 0.0
Gly
4.317GlyAla: 4.317 ± 0.75
0.283GlyCys: 0.283 ± 0.138
3.468GlyAsp: 3.468 ± 0.564
2.831GlyGlu: 2.831 ± 0.405
2.69GlyPhe: 2.69 ± 0.501
2.902GlyGly: 2.902 ± 0.532
1.557GlyHis: 1.557 ± 0.379
3.963GlyIle: 3.963 ± 0.603
5.167GlyLys: 5.167 ± 0.522
3.61GlyLeu: 3.61 ± 0.659
1.557GlyMet: 1.557 ± 0.349
3.114GlyAsn: 3.114 ± 0.538
0.708GlyPro: 0.708 ± 0.202
3.114GlyGln: 3.114 ± 0.398
1.982GlyArg: 1.982 ± 0.33
1.84GlySer: 1.84 ± 0.424
4.247GlyThr: 4.247 ± 0.453
4.813GlyVal: 4.813 ± 0.821
0.849GlyTrp: 0.849 ± 0.245
2.973GlyTyr: 2.973 ± 0.447
0.0GlyXaa: 0.0 ± 0.0
His
1.274HisAla: 1.274 ± 0.248
0.0HisCys: 0.0 ± 0.0
0.637HisAsp: 0.637 ± 0.181
1.274HisGlu: 1.274 ± 0.28
0.849HisPhe: 0.849 ± 0.206
1.062HisGly: 1.062 ± 0.23
0.425HisHis: 0.425 ± 0.202
0.991HisIle: 0.991 ± 0.287
1.274HisLys: 1.274 ± 0.271
0.991HisLeu: 0.991 ± 0.337
0.283HisMet: 0.283 ± 0.112
0.566HisAsn: 0.566 ± 0.225
0.991HisPro: 0.991 ± 0.286
0.92HisGln: 0.92 ± 0.253
0.566HisArg: 0.566 ± 0.235
1.486HisSer: 1.486 ± 0.34
0.849HisThr: 0.849 ± 0.246
1.203HisVal: 1.203 ± 0.281
0.142HisTrp: 0.142 ± 0.097
1.416HisTyr: 1.416 ± 0.351
0.0HisXaa: 0.0 ± 0.0
Ile
3.963IleAla: 3.963 ± 0.696
0.354IleCys: 0.354 ± 0.158
5.804IleAsp: 5.804 ± 0.742
7.927IleGlu: 7.927 ± 1.027
3.114IlePhe: 3.114 ± 0.43
4.742IleGly: 4.742 ± 0.815
0.849IleHis: 0.849 ± 0.226
3.963IleIle: 3.963 ± 0.507
7.573IleLys: 7.573 ± 0.822
3.539IleLeu: 3.539 ± 0.49
2.477IleMet: 2.477 ± 0.483
4.671IleAsn: 4.671 ± 0.717
1.769IlePro: 1.769 ± 0.292
2.973IleGln: 2.973 ± 0.438
3.326IleArg: 3.326 ± 0.501
4.813IleSer: 4.813 ± 0.564
5.379IleThr: 5.379 ± 0.658
4.105IleVal: 4.105 ± 0.468
0.849IleTrp: 0.849 ± 0.365
2.69IleTyr: 2.69 ± 0.578
0.0IleXaa: 0.0 ± 0.0
Lys
5.804LysAla: 5.804 ± 0.51
0.425LysCys: 0.425 ± 0.16
5.308LysAsp: 5.308 ± 0.603
8.21LysGlu: 8.21 ± 0.725
3.539LysPhe: 3.539 ± 0.431
4.53LysGly: 4.53 ± 0.605
1.557LysHis: 1.557 ± 0.301
5.945LysIle: 5.945 ± 0.815
8.352LysLys: 8.352 ± 1.016
7.998LysLeu: 7.998 ± 0.845
2.831LysMet: 2.831 ± 0.322
5.733LysAsn: 5.733 ± 0.808
2.548LysPro: 2.548 ± 0.473
4.176LysGln: 4.176 ± 0.66
4.317LysArg: 4.317 ± 0.632
5.521LysSer: 5.521 ± 0.698
5.167LysThr: 5.167 ± 0.618
5.237LysVal: 5.237 ± 0.639
0.779LysTrp: 0.779 ± 0.215
3.822LysTyr: 3.822 ± 0.579
0.0LysXaa: 0.0 ± 0.0
Leu
3.963LeuAla: 3.963 ± 0.582
0.354LeuCys: 0.354 ± 0.137
5.308LeuAsp: 5.308 ± 0.589
5.167LeuGlu: 5.167 ± 0.707
3.185LeuPhe: 3.185 ± 0.551
3.61LeuGly: 3.61 ± 0.63
1.203LeuHis: 1.203 ± 0.317
5.379LeuIle: 5.379 ± 0.452
7.078LeuLys: 7.078 ± 0.642
6.087LeuLeu: 6.087 ± 0.797
1.84LeuMet: 1.84 ± 0.5
5.237LeuAsn: 5.237 ± 0.469
2.902LeuPro: 2.902 ± 0.476
3.185LeuGln: 3.185 ± 0.405
3.043LeuArg: 3.043 ± 0.592
5.096LeuSer: 5.096 ± 0.642
4.671LeuThr: 4.671 ± 0.595
4.6LeuVal: 4.6 ± 0.621
0.425LeuTrp: 0.425 ± 0.232
3.822LeuTyr: 3.822 ± 0.589
0.0LeuXaa: 0.0 ± 0.0
Met
2.123MetAla: 2.123 ± 0.622
0.142MetCys: 0.142 ± 0.106
1.203MetAsp: 1.203 ± 0.31
1.132MetGlu: 1.132 ± 0.253
1.203MetPhe: 1.203 ± 0.265
0.991MetGly: 0.991 ± 0.29
0.354MetHis: 0.354 ± 0.154
1.486MetIle: 1.486 ± 0.307
2.336MetLys: 2.336 ± 0.448
2.406MetLeu: 2.406 ± 0.39
0.708MetMet: 0.708 ± 0.227
2.123MetAsn: 2.123 ± 0.371
0.991MetPro: 0.991 ± 0.248
1.486MetGln: 1.486 ± 0.389
1.132MetArg: 1.132 ± 0.233
2.194MetSer: 2.194 ± 0.447
2.406MetThr: 2.406 ± 0.393
0.991MetVal: 0.991 ± 0.278
0.566MetTrp: 0.566 ± 0.202
0.849MetTyr: 0.849 ± 0.258
0.0MetXaa: 0.0 ± 0.0
Asn
4.176AsnAla: 4.176 ± 0.642
0.354AsnCys: 0.354 ± 0.177
4.317AsnAsp: 4.317 ± 0.631
6.653AsnGlu: 6.653 ± 0.723
3.043AsnPhe: 3.043 ± 0.468
4.176AsnGly: 4.176 ± 0.63
0.849AsnHis: 0.849 ± 0.263
4.317AsnIle: 4.317 ± 0.508
6.016AsnLys: 6.016 ± 0.8
3.822AsnLeu: 3.822 ± 0.379
1.628AsnMet: 1.628 ± 0.269
4.884AsnAsn: 4.884 ± 0.841
2.69AsnPro: 2.69 ± 0.359
2.619AsnGln: 2.619 ± 0.529
2.053AsnArg: 2.053 ± 0.348
3.397AsnSer: 3.397 ± 0.376
2.902AsnThr: 2.902 ± 0.428
4.247AsnVal: 4.247 ± 0.703
0.991AsnTrp: 0.991 ± 0.246
2.123AsnTyr: 2.123 ± 0.511
0.0AsnXaa: 0.0 ± 0.0
Pro
1.274ProAla: 1.274 ± 0.311
0.071ProCys: 0.071 ± 0.064
1.416ProAsp: 1.416 ± 0.275
1.982ProGlu: 1.982 ± 0.349
1.345ProPhe: 1.345 ± 0.317
1.628ProGly: 1.628 ± 0.439
0.495ProHis: 0.495 ± 0.183
2.973ProIle: 2.973 ± 0.533
3.114ProLys: 3.114 ± 0.495
1.911ProLeu: 1.911 ± 0.452
0.779ProMet: 0.779 ± 0.211
2.336ProAsn: 2.336 ± 0.438
0.779ProPro: 0.779 ± 0.216
0.779ProGln: 0.779 ± 0.22
0.779ProArg: 0.779 ± 0.193
2.123ProSer: 2.123 ± 0.506
2.336ProThr: 2.336 ± 0.396
1.416ProVal: 1.416 ± 0.293
0.071ProTrp: 0.071 ± 0.073
1.628ProTyr: 1.628 ± 0.372
0.0ProXaa: 0.0 ± 0.0
Gln
3.114GlnAla: 3.114 ± 0.446
0.354GlnCys: 0.354 ± 0.172
2.194GlnAsp: 2.194 ± 0.449
2.69GlnGlu: 2.69 ± 0.411
2.336GlnPhe: 2.336 ± 0.358
1.982GlnGly: 1.982 ± 0.375
1.062GlnHis: 1.062 ± 0.251
3.114GlnIle: 3.114 ± 0.371
2.76GlnLys: 2.76 ± 0.548
3.043GlnLeu: 3.043 ± 0.471
1.062GlnMet: 1.062 ± 0.289
2.831GlnAsn: 2.831 ± 0.424
1.557GlnPro: 1.557 ± 0.33
2.194GlnGln: 2.194 ± 0.573
2.123GlnArg: 2.123 ± 0.411
2.477GlnSer: 2.477 ± 0.396
1.769GlnThr: 1.769 ± 0.366
2.902GlnVal: 2.902 ± 0.479
0.212GlnTrp: 0.212 ± 0.112
1.628GlnTyr: 1.628 ± 0.362
0.0GlnXaa: 0.0 ± 0.0
Arg
1.699ArgAla: 1.699 ± 0.342
0.354ArgCys: 0.354 ± 0.168
3.114ArgAsp: 3.114 ± 0.507
2.336ArgGlu: 2.336 ± 0.316
1.911ArgPhe: 1.911 ± 0.33
2.548ArgGly: 2.548 ± 0.379
1.628ArgHis: 1.628 ± 0.324
3.185ArgIle: 3.185 ± 0.441
3.893ArgLys: 3.893 ± 0.462
3.751ArgLeu: 3.751 ± 0.582
0.991ArgMet: 0.991 ± 0.263
2.69ArgAsn: 2.69 ± 0.412
1.132ArgPro: 1.132 ± 0.215
1.416ArgGln: 1.416 ± 0.348
1.557ArgArg: 1.557 ± 0.389
1.557ArgSer: 1.557 ± 0.307
1.699ArgThr: 1.699 ± 0.374
1.769ArgVal: 1.769 ± 0.296
0.495ArgTrp: 0.495 ± 0.18
2.831ArgTyr: 2.831 ± 0.417
0.0ArgXaa: 0.0 ± 0.0
Ser
4.034SerAla: 4.034 ± 0.573
0.142SerCys: 0.142 ± 0.091
3.893SerAsp: 3.893 ± 0.47
3.539SerGlu: 3.539 ± 0.671
3.185SerPhe: 3.185 ± 0.42
3.893SerGly: 3.893 ± 0.583
0.991SerHis: 0.991 ± 0.285
5.45SerIle: 5.45 ± 0.693
5.591SerLys: 5.591 ± 0.651
4.176SerLeu: 4.176 ± 0.53
1.557SerMet: 1.557 ± 0.312
3.326SerAsn: 3.326 ± 0.595
1.345SerPro: 1.345 ± 0.359
3.256SerGln: 3.256 ± 0.513
2.477SerArg: 2.477 ± 0.457
3.468SerSer: 3.468 ± 0.589
3.326SerThr: 3.326 ± 0.449
4.105SerVal: 4.105 ± 0.557
0.637SerTrp: 0.637 ± 0.189
1.911SerTyr: 1.911 ± 0.314
0.0SerXaa: 0.0 ± 0.0
Thr
3.397ThrAla: 3.397 ± 0.41
0.212ThrCys: 0.212 ± 0.137
3.256ThrAsp: 3.256 ± 0.489
3.822ThrGlu: 3.822 ± 0.485
2.548ThrPhe: 2.548 ± 0.475
4.034ThrGly: 4.034 ± 0.588
1.416ThrHis: 1.416 ± 0.316
5.804ThrIle: 5.804 ± 0.654
4.742ThrLys: 4.742 ± 0.579
5.025ThrLeu: 5.025 ± 0.636
0.991ThrMet: 0.991 ± 0.249
4.884ThrAsn: 4.884 ± 0.569
1.911ThrPro: 1.911 ± 0.343
2.548ThrGln: 2.548 ± 0.5
2.477ThrArg: 2.477 ± 0.56
4.034ThrSer: 4.034 ± 0.919
3.114ThrThr: 3.114 ± 0.514
3.539ThrVal: 3.539 ± 0.436
0.637ThrTrp: 0.637 ± 0.269
2.265ThrTyr: 2.265 ± 0.403
0.0ThrXaa: 0.0 ± 0.0
Val
3.822ValAla: 3.822 ± 0.764
0.142ValCys: 0.142 ± 0.101
4.317ValAsp: 4.317 ± 0.649
4.954ValGlu: 4.954 ± 0.57
1.982ValPhe: 1.982 ± 0.329
2.973ValGly: 2.973 ± 0.556
0.354ValHis: 0.354 ± 0.13
5.237ValIle: 5.237 ± 0.516
6.653ValLys: 6.653 ± 0.681
5.945ValLeu: 5.945 ± 0.627
1.911ValMet: 1.911 ± 0.365
3.256ValAsn: 3.256 ± 0.562
2.477ValPro: 2.477 ± 0.396
1.416ValGln: 1.416 ± 0.4
2.406ValArg: 2.406 ± 0.334
4.105ValSer: 4.105 ± 0.677
3.893ValThr: 3.893 ± 0.619
4.105ValVal: 4.105 ± 0.544
0.566ValTrp: 0.566 ± 0.205
1.982ValTyr: 1.982 ± 0.41
0.0ValXaa: 0.0 ± 0.0
Trp
0.708TrpAla: 0.708 ± 0.202
0.071TrpCys: 0.071 ± 0.067
0.354TrpAsp: 0.354 ± 0.151
0.637TrpGlu: 0.637 ± 0.201
0.566TrpPhe: 0.566 ± 0.19
0.708TrpGly: 0.708 ± 0.25
0.283TrpHis: 0.283 ± 0.126
0.849TrpIle: 0.849 ± 0.251
0.849TrpLys: 0.849 ± 0.24
1.062TrpLeu: 1.062 ± 0.267
0.283TrpMet: 0.283 ± 0.149
0.849TrpAsn: 0.849 ± 0.233
0.0TrpPro: 0.0 ± 0.0
0.495TrpGln: 0.495 ± 0.182
0.495TrpArg: 0.495 ± 0.257
0.566TrpSer: 0.566 ± 0.225
0.849TrpThr: 0.849 ± 0.216
1.062TrpVal: 1.062 ± 0.282
0.071TrpTrp: 0.071 ± 0.068
0.637TrpTyr: 0.637 ± 0.197
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.628TyrAla: 1.628 ± 0.37
0.425TyrCys: 0.425 ± 0.147
2.336TyrAsp: 2.336 ± 0.619
3.539TyrGlu: 3.539 ± 0.492
1.911TyrPhe: 1.911 ± 0.41
2.619TyrGly: 2.619 ± 0.604
0.425TyrHis: 0.425 ± 0.17
3.539TyrIle: 3.539 ± 0.449
3.751TyrLys: 3.751 ± 0.509
3.114TyrLeu: 3.114 ± 0.478
0.566TyrMet: 0.566 ± 0.173
3.114TyrAsn: 3.114 ± 0.49
1.416TyrPro: 1.416 ± 0.365
2.336TyrGln: 2.336 ± 0.443
2.123TyrArg: 2.123 ± 0.434
2.406TyrSer: 2.406 ± 0.41
2.69TyrThr: 2.69 ± 0.451
2.902TyrVal: 2.902 ± 0.426
0.92TyrTrp: 0.92 ± 0.233
1.84TyrTyr: 1.84 ± 0.343
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (14130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski