Amino acid dipepetide frequency for Bordetella avium (strain 197N)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.94AlaAla: 16.94 ± 0.229	1.284AlaCys: 1.284 ± 0.037	6.62AlaAsp: 6.62 ± 0.074	6.477AlaGlu: 6.477 ± 0.092	3.837AlaPhe: 3.837 ± 0.062	10.685AlaGly: 10.685 ± 0.144	2.476AlaHis: 2.476 ± 0.049	5.548AlaIle: 5.548 ± 0.07	3.237AlaLys: 3.237 ± 0.071	15.092AlaLeu: 15.092 ± 0.168	3.303AlaMet: 3.303 ± 0.055	2.942AlaAsn: 2.942 ± 0.071	5.54AlaPro: 5.54 ± 0.086	6.189AlaGln: 6.189 ± 0.081	9.445AlaArg: 9.445 ± 0.116	6.786AlaSer: 6.786 ± 0.1	5.407AlaThr: 5.407 ± 0.078	8.624AlaVal: 8.624 ± 0.116	1.873AlaTrp: 1.873 ± 0.047	2.867AlaTyr: 2.867 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.115CysAla: 1.115 ± 0.035	0.135CysCys: 0.135 ± 0.011	0.502CysAsp: 0.502 ± 0.023	0.459CysGlu: 0.459 ± 0.022	0.305CysPhe: 0.305 ± 0.018	0.958CysGly: 0.958 ± 0.032	0.211CysHis: 0.211 ± 0.014	0.367CysIle: 0.367 ± 0.016	0.179CysLys: 0.179 ± 0.011	0.932CysLeu: 0.932 ± 0.032	0.198CysMet: 0.198 ± 0.014	0.234CysAsn: 0.234 ± 0.013	0.468CysPro: 0.468 ± 0.02	0.292CysGln: 0.292 ± 0.013	0.616CysArg: 0.616 ± 0.023	0.444CysSer: 0.444 ± 0.02	0.404CysThr: 0.404 ± 0.019	0.735CysVal: 0.735 ± 0.028	0.118CysTrp: 0.118 ± 0.012	0.233CysTyr: 0.233 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	6.651AspAla: 6.651 ± 0.095	0.489AspCys: 0.489 ± 0.02	2.651AspAsp: 2.651 ± 0.057	2.999AspGlu: 2.999 ± 0.06	2.023AspPhe: 2.023 ± 0.044	4.528AspGly: 4.528 ± 0.085	1.024AspHis: 1.024 ± 0.034	2.934AspIle: 2.934 ± 0.058	1.59AspLys: 1.59 ± 0.041	5.648AspLeu: 5.648 ± 0.076	1.297AspMet: 1.297 ± 0.033	1.348AspAsn: 1.348 ± 0.036	3.07AspPro: 3.07 ± 0.053	1.746AspGln: 1.746 ± 0.047	3.359AspArg: 3.359 ± 0.077	2.465AspSer: 2.465 ± 0.054	2.673AspThr: 2.673 ± 0.051	3.973AspVal: 3.973 ± 0.068	0.963AspTrp: 0.963 ± 0.031	1.56AspTyr: 1.56 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.64GluAla: 6.64 ± 0.086	0.37GluCys: 0.37 ± 0.018	2.276GluAsp: 2.276 ± 0.05	2.367GluGlu: 2.367 ± 0.056	1.714GluPhe: 1.714 ± 0.046	3.767GluGly: 3.767 ± 0.062	1.285GluHis: 1.285 ± 0.037	2.768GluIle: 2.768 ± 0.051	1.725GluLys: 1.725 ± 0.042	5.493GluLeu: 5.493 ± 0.095	1.235GluMet: 1.235 ± 0.035	1.403GluAsn: 1.403 ± 0.036	2.45GluPro: 2.45 ± 0.048	2.65GluGln: 2.65 ± 0.055	4.582GluArg: 4.582 ± 0.071	2.531GluSer: 2.531 ± 0.05	2.526GluThr: 2.526 ± 0.062	3.947GluVal: 3.947 ± 0.07	0.629GluTrp: 0.629 ± 0.024	1.146GluTyr: 1.146 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.847PheAla: 3.847 ± 0.061	0.357PheCys: 0.357 ± 0.02	2.342PheAsp: 2.342 ± 0.045	1.877PheGlu: 1.877 ± 0.045	1.295PhePhe: 1.295 ± 0.046	3.306PheGly: 3.306 ± 0.064	0.666PheHis: 0.666 ± 0.025	1.607PheIle: 1.607 ± 0.043	1.112PheLys: 1.112 ± 0.038	3.082PheLeu: 3.082 ± 0.057	0.829PheMet: 0.829 ± 0.03	1.131PheAsn: 1.131 ± 0.034	1.472PhePro: 1.472 ± 0.038	1.149PheGln: 1.149 ± 0.03	1.848PheArg: 1.848 ± 0.04	2.347PheSer: 2.347 ± 0.047	1.779PheThr: 1.779 ± 0.039	2.567PheVal: 2.567 ± 0.056	0.513PheTrp: 0.513 ± 0.027	0.941PheTyr: 0.941 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	8.933GlyAla: 8.933 ± 0.144	0.836GlyCys: 0.836 ± 0.031	3.946GlyAsp: 3.946 ± 0.077	4.201GlyGlu: 4.201 ± 0.065	3.137GlyPhe: 3.137 ± 0.066	6.79GlyGly: 6.79 ± 0.126	1.818GlyHis: 1.818 ± 0.049	4.019GlyIle: 4.019 ± 0.061	3.396GlyLys: 3.396 ± 0.058	9.625GlyLeu: 9.625 ± 0.113	2.431GlyMet: 2.431 ± 0.047	2.353GlyAsn: 2.353 ± 0.071	3.116GlyPro: 3.116 ± 0.06	3.724GlyGln: 3.724 ± 0.054	5.702GlyArg: 5.702 ± 0.088	4.687GlySer: 4.687 ± 0.11	3.902GlyThr: 3.902 ± 0.068	6.697GlyVal: 6.697 ± 0.098	1.42GlyTrp: 1.42 ± 0.041	2.409GlyTyr: 2.409 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.59HisAla: 2.59 ± 0.054	0.254HisCys: 0.254 ± 0.016	1.194HisAsp: 1.194 ± 0.035	1.073HisGlu: 1.073 ± 0.034	0.787HisPhe: 0.787 ± 0.027	1.959HisGly: 1.959 ± 0.049	0.571HisHis: 0.571 ± 0.027	1.089HisIle: 1.089 ± 0.031	0.526HisLys: 0.526 ± 0.023	2.158HisLeu: 2.158 ± 0.053	0.46HisMet: 0.46 ± 0.021	0.53HisAsn: 0.53 ± 0.022	1.431HisPro: 1.431 ± 0.041	0.772HisGln: 0.772 ± 0.027	1.363HisArg: 1.363 ± 0.042	1.066HisSer: 1.066 ± 0.037	1.041HisThr: 1.041 ± 0.034	1.415HisVal: 1.415 ± 0.033	0.337HisTrp: 0.337 ± 0.016	0.658HisTyr: 0.658 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.169IleAla: 6.169 ± 0.081	0.473IleCys: 0.473 ± 0.021	3.203IleAsp: 3.203 ± 0.058	3.185IleGlu: 3.185 ± 0.059	1.431IlePhe: 1.431 ± 0.041	4.263IleGly: 4.263 ± 0.069	0.858IleHis: 0.858 ± 0.03	1.985IleIle: 1.985 ± 0.055	1.625IleLys: 1.625 ± 0.049	3.969IleLeu: 3.969 ± 0.07	0.998IleMet: 0.998 ± 0.035	1.645IleAsn: 1.645 ± 0.037	2.246IlePro: 2.246 ± 0.054	1.448IleGln: 1.448 ± 0.042	2.761IleArg: 2.761 ± 0.054	2.807IleSer: 2.807 ± 0.051	2.568IleThr: 2.568 ± 0.047	3.649IleVal: 3.649 ± 0.058	0.598IleTrp: 0.598 ± 0.025	1.091IleTyr: 1.091 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.4LysAla: 3.4 ± 0.074	0.119LysCys: 0.119 ± 0.01	1.473LysAsp: 1.473 ± 0.038	1.405LysGlu: 1.405 ± 0.045	0.799LysPhe: 0.799 ± 0.027	2.185LysGly: 2.185 ± 0.046	0.645LysHis: 0.645 ± 0.027	1.462LysIle: 1.462 ± 0.037	1.183LysLys: 1.183 ± 0.047	3.343LysLeu: 3.343 ± 0.058	0.686LysMet: 0.686 ± 0.029	0.892LysAsn: 0.892 ± 0.035	1.915LysPro: 1.915 ± 0.049	1.347LysGln: 1.347 ± 0.043	2.243LysArg: 2.243 ± 0.044	1.663LysSer: 1.663 ± 0.045	1.849LysThr: 1.849 ± 0.045	2.371LysVal: 2.371 ± 0.055	0.362LysTrp: 0.362 ± 0.018	0.681LysTyr: 0.681 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	15.659LeuAla: 15.659 ± 0.172	1.029LeuCys: 1.029 ± 0.034	6.15LeuAsp: 6.15 ± 0.086	5.118LeuGlu: 5.118 ± 0.095	3.569LeuPhe: 3.569 ± 0.065	8.831LeuGly: 8.831 ± 0.1	2.262LeuHis: 2.262 ± 0.05	5.135LeuIle: 5.135 ± 0.083	3.278LeuLys: 3.278 ± 0.053	11.682LeuLeu: 11.682 ± 0.185	2.556LeuMet: 2.556 ± 0.05	3.131LeuAsn: 3.131 ± 0.061	6.49LeuPro: 6.49 ± 0.089	3.943LeuGln: 3.943 ± 0.053	8.436LeuArg: 8.436 ± 0.116	7.167LeuSer: 7.167 ± 0.093	5.796LeuThr: 5.796 ± 0.09	7.38LeuVal: 7.38 ± 0.104	1.225LeuTrp: 1.225 ± 0.044	2.207LeuTyr: 2.207 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.957MetAla: 2.957 ± 0.057	0.148MetCys: 0.148 ± 0.012	1.09MetAsp: 1.09 ± 0.034	0.943MetGlu: 0.943 ± 0.033	0.7MetPhe: 0.7 ± 0.032	1.861MetGly: 1.861 ± 0.047	0.5MetHis: 0.5 ± 0.022	1.001MetIle: 1.001 ± 0.029	0.855MetLys: 0.855 ± 0.029	2.87MetLeu: 2.87 ± 0.063	0.639MetMet: 0.639 ± 0.026	0.79MetAsn: 0.79 ± 0.026	1.477MetPro: 1.477 ± 0.036	1.159MetGln: 1.159 ± 0.031	1.891MetArg: 1.891 ± 0.046	1.734MetSer: 1.734 ± 0.044	1.572MetThr: 1.572 ± 0.038	1.666MetVal: 1.666 ± 0.037	0.178MetTrp: 0.178 ± 0.014	0.375MetTyr: 0.375 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.276AsnAla: 3.276 ± 0.066	0.216AsnCys: 0.216 ± 0.015	1.44AsnAsp: 1.44 ± 0.036	1.293AsnGlu: 1.293 ± 0.034	0.935AsnPhe: 0.935 ± 0.032	2.281AsnGly: 2.281 ± 0.062	0.54AsnHis: 0.54 ± 0.024	1.447AsnIle: 1.447 ± 0.043	0.864AsnLys: 0.864 ± 0.031	2.92AsnLeu: 2.92 ± 0.06	0.64AsnMet: 0.64 ± 0.026	0.881AsnAsn: 0.881 ± 0.038	1.887AsnPro: 1.887 ± 0.041	1.029AsnGln: 1.029 ± 0.033	1.764AsnArg: 1.764 ± 0.04	1.372AsnSer: 1.372 ± 0.046	1.661AsnThr: 1.661 ± 0.047	2.023AsnVal: 2.023 ± 0.062	0.42AsnTrp: 0.42 ± 0.02	0.724AsnTyr: 0.724 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.725ProAla: 6.725 ± 0.091	0.367ProCys: 0.367 ± 0.019	3.372ProAsp: 3.372 ± 0.062	3.456ProGlu: 3.456 ± 0.064	1.743ProPhe: 1.743 ± 0.04	4.603ProGly: 4.603 ± 0.072	1.075ProHis: 1.075 ± 0.031	1.979ProIle: 1.979 ± 0.048	1.441ProLys: 1.441 ± 0.04	5.352ProLeu: 5.352 ± 0.086	1.241ProMet: 1.241 ± 0.034	1.317ProAsn: 1.317 ± 0.035	2.537ProPro: 2.537 ± 0.099	2.298ProGln: 2.298 ± 0.055	2.953ProArg: 2.953 ± 0.054	2.734ProSer: 2.734 ± 0.046	2.195ProThr: 2.195 ± 0.047	4.138ProVal: 4.138 ± 0.068	0.793ProTrp: 0.793 ± 0.03	1.334ProTyr: 1.334 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	6.805GlnAla: 6.805 ± 0.097	0.266GlnCys: 0.266 ± 0.017	1.932GlnAsp: 1.932 ± 0.043	1.941GlnGlu: 1.941 ± 0.043	1.232GlnPhe: 1.232 ± 0.031	3.604GlnGly: 3.604 ± 0.07	0.983GlnHis: 0.983 ± 0.034	1.956GlnIle: 1.956 ± 0.042	0.979GlnLys: 0.979 ± 0.032	3.926GlnLeu: 3.926 ± 0.061	0.947GlnMet: 0.947 ± 0.028	1.043GlnAsn: 1.043 ± 0.031	2.166GlnPro: 2.166 ± 0.053	1.94GlnGln: 1.94 ± 0.054	3.327GlnArg: 3.327 ± 0.069	2.116GlnSer: 2.116 ± 0.052	2.296GlnThr: 2.296 ± 0.047	2.973GlnVal: 2.973 ± 0.05	0.72GlnTrp: 0.72 ± 0.026	0.917GlnTyr: 0.917 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.221ArgAla: 8.221 ± 0.102	0.596ArgCys: 0.596 ± 0.025	3.837ArgAsp: 3.837 ± 0.055	4.254ArgGlu: 4.254 ± 0.08	2.683ArgPhe: 2.683 ± 0.052	4.836ArgGly: 4.836 ± 0.07	1.813ArgHis: 1.813 ± 0.048	3.768ArgIle: 3.768 ± 0.067	2.108ArgLys: 2.108 ± 0.042	8.417ArgLeu: 8.417 ± 0.116	1.77ArgMet: 1.77 ± 0.041	2.089ArgAsn: 2.089 ± 0.041	3.373ArgPro: 3.373 ± 0.06	3.326ArgGln: 3.326 ± 0.064	5.397ArgArg: 5.397 ± 0.084	3.57ArgSer: 3.57 ± 0.059	2.77ArgThr: 2.77 ± 0.048	5.134ArgVal: 5.134 ± 0.071	1.067ArgTrp: 1.067 ± 0.027	2.163ArgTyr: 2.163 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	6.702SerAla: 6.702 ± 0.103	0.467SerCys: 0.467 ± 0.021	2.639SerAsp: 2.639 ± 0.046	2.486SerGlu: 2.486 ± 0.049	2.064SerPhe: 2.064 ± 0.046	5.488SerGly: 5.488 ± 0.107	1.206SerHis: 1.206 ± 0.035	2.514SerIle: 2.514 ± 0.05	1.549SerLys: 1.549 ± 0.038	6.472SerLeu: 6.472 ± 0.095	1.371SerMet: 1.371 ± 0.04	1.541SerAsn: 1.541 ± 0.047	2.933SerPro: 2.933 ± 0.054	2.214SerGln: 2.214 ± 0.049	3.847SerArg: 3.847 ± 0.058	3.241SerSer: 3.241 ± 0.066	2.747SerThr: 2.747 ± 0.059	4.142SerVal: 4.142 ± 0.085	0.801SerTrp: 0.801 ± 0.026	1.385SerTyr: 1.385 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.464ThrAla: 5.464 ± 0.083	0.358ThrCys: 0.358 ± 0.018	2.499ThrAsp: 2.499 ± 0.056	2.36ThrGlu: 2.36 ± 0.045	1.531ThrPhe: 1.531 ± 0.038	4.541ThrGly: 4.541 ± 0.076	1.104ThrHis: 1.104 ± 0.029	2.241ThrIle: 2.241 ± 0.053	1.0ThrLys: 1.0 ± 0.031	6.653ThrLeu: 6.653 ± 0.086	1.061ThrMet: 1.061 ± 0.032	1.096ThrAsn: 1.096 ± 0.039	3.339ThrPro: 3.339 ± 0.061	2.168ThrGln: 2.168 ± 0.05	3.341ThrArg: 3.341 ± 0.053	2.459ThrSer: 2.459 ± 0.051	2.443ThrThr: 2.443 ± 0.054	3.993ThrVal: 3.993 ± 0.094	0.65ThrTrp: 0.65 ± 0.026	1.06ThrTyr: 1.06 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.914ValAla: 8.914 ± 0.114	0.741ValCys: 0.741 ± 0.026	3.834ValAsp: 3.834 ± 0.061	3.842ValGlu: 3.842 ± 0.064	2.789ValPhe: 2.789 ± 0.061	5.548ValGly: 5.548 ± 0.083	1.394ValHis: 1.394 ± 0.037	3.551ValIle: 3.551 ± 0.061	2.289ValLys: 2.289 ± 0.049	8.664ValLeu: 8.664 ± 0.114	1.849ValMet: 1.849 ± 0.045	2.168ValAsn: 2.168 ± 0.068	3.722ValPro: 3.722 ± 0.066	2.905ValGln: 2.905 ± 0.055	4.966ValArg: 4.966 ± 0.076	4.553ValSer: 4.553 ± 0.102	3.812ValThr: 3.812 ± 0.073	5.961ValVal: 5.961 ± 0.091	0.936ValTrp: 0.936 ± 0.036	1.718ValTyr: 1.718 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.261TrpAla: 1.261 ± 0.033	0.123TrpCys: 0.123 ± 0.01	0.585TrpAsp: 0.585 ± 0.023	0.554TrpGlu: 0.554 ± 0.023	0.531TrpPhe: 0.531 ± 0.023	0.907TrpGly: 0.907 ± 0.036	0.338TrpHis: 0.338 ± 0.018	0.658TrpIle: 0.658 ± 0.025	0.442TrpLys: 0.442 ± 0.023	2.097TrpLeu: 2.097 ± 0.057	0.429TrpMet: 0.429 ± 0.021	0.432TrpAsn: 0.432 ± 0.02	0.743TrpPro: 0.743 ± 0.025	0.773TrpGln: 0.773 ± 0.029	1.385TrpArg: 1.385 ± 0.04	0.748TrpSer: 0.748 ± 0.029	0.63TrpThr: 0.63 ± 0.024	1.029TrpVal: 1.029 ± 0.033	0.247TrpTrp: 0.247 ± 0.018	0.312TrpTyr: 0.312 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.903TyrAla: 2.903 ± 0.053	0.275TyrCys: 0.275 ± 0.016	1.405TyrAsp: 1.405 ± 0.038	1.213TyrGlu: 1.213 ± 0.038	0.961TyrPhe: 0.961 ± 0.03	2.201TyrGly: 2.201 ± 0.05	0.507TyrHis: 0.507 ± 0.022	0.941TyrIle: 0.941 ± 0.032	0.646TyrLys: 0.646 ± 0.024	2.652TyrLeu: 2.652 ± 0.048	0.465TyrMet: 0.465 ± 0.023	0.646TyrAsn: 0.646 ± 0.025	1.279TyrPro: 1.279 ± 0.036	0.998TyrGln: 0.998 ± 0.03	1.97TyrArg: 1.97 ± 0.042	1.321TyrSer: 1.321 ± 0.039	1.287TyrThr: 1.287 ± 0.04	1.737TyrVal: 1.737 ± 0.042	0.376TyrTrp: 0.376 ± 0.019	0.644TyrTyr: 0.644 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3372 proteins (1096534 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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