Amino acid dipepetide frequency for Thalassococcus profundi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.705AlaAla: 17.705 ± 0.207	1.122AlaCys: 1.122 ± 0.032	7.39AlaAsp: 7.39 ± 0.113	8.665AlaGlu: 8.665 ± 0.104	4.342AlaPhe: 4.342 ± 0.06	10.831AlaGly: 10.831 ± 0.127	2.187AlaHis: 2.187 ± 0.047	5.516AlaIle: 5.516 ± 0.076	3.295AlaLys: 3.295 ± 0.062	14.343AlaLeu: 14.343 ± 0.156	3.725AlaMet: 3.725 ± 0.057	2.583AlaAsn: 2.583 ± 0.052	6.278AlaPro: 6.278 ± 0.106	4.802AlaGln: 4.802 ± 0.068	9.51AlaArg: 9.51 ± 0.133	5.548AlaSer: 5.548 ± 0.064	6.117AlaThr: 6.117 ± 0.08	8.563AlaVal: 8.563 ± 0.095	1.438AlaTrp: 1.438 ± 0.03	2.41AlaTyr: 2.41 ± 0.045	0.001AlaXaa: 0.001 ± 0.001
Cys	1.134CysAla: 1.134 ± 0.03	0.126CysCys: 0.126 ± 0.01	0.621CysAsp: 0.621 ± 0.025	0.402CysGlu: 0.402 ± 0.016	0.313CysPhe: 0.313 ± 0.013	0.977CysGly: 0.977 ± 0.033	0.288CysHis: 0.288 ± 0.016	0.402CysIle: 0.402 ± 0.019	0.203CysLys: 0.203 ± 0.013	0.844CysLeu: 0.844 ± 0.024	0.163CysMet: 0.163 ± 0.012	0.19CysAsn: 0.19 ± 0.011	0.483CysPro: 0.483 ± 0.02	0.225CysGln: 0.225 ± 0.013	0.582CysArg: 0.582 ± 0.023	0.397CysSer: 0.397 ± 0.019	0.451CysThr: 0.451 ± 0.02	0.618CysVal: 0.618 ± 0.027	0.107CysTrp: 0.107 ± 0.01	0.195CysTyr: 0.195 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.194AspAla: 8.194 ± 0.115	0.518AspCys: 0.518 ± 0.024	3.815AspAsp: 3.815 ± 0.101	3.439AspGlu: 3.439 ± 0.058	2.41AspPhe: 2.41 ± 0.048	6.314AspGly: 6.314 ± 0.139	1.33AspHis: 1.33 ± 0.035	3.128AspIle: 3.128 ± 0.057	1.557AspLys: 1.557 ± 0.035	6.916AspLeu: 6.916 ± 0.096	1.658AspMet: 1.658 ± 0.037	1.318AspAsn: 1.318 ± 0.042	3.998AspPro: 3.998 ± 0.069	1.771AspGln: 1.771 ± 0.038	5.009AspArg: 5.009 ± 0.061	2.467AspSer: 2.467 ± 0.054	3.758AspThr: 3.758 ± 0.1	4.362AspVal: 4.362 ± 0.076	1.282AspTrp: 1.282 ± 0.035	1.561AspTyr: 1.561 ± 0.038	0.004AspXaa: 0.004 ± 0.002
Glu	8.226GluAla: 8.226 ± 0.094	0.333GluCys: 0.333 ± 0.016	3.726GluAsp: 3.726 ± 0.066	3.52GluGlu: 3.52 ± 0.071	1.714GluPhe: 1.714 ± 0.038	4.595GluGly: 4.595 ± 0.067	1.068GluHis: 1.068 ± 0.031	3.356GluIle: 3.356 ± 0.053	2.009GluLys: 2.009 ± 0.051	4.95GluLeu: 4.95 ± 0.072	1.856GluMet: 1.856 ± 0.045	1.686GluAsn: 1.686 ± 0.039	2.479GluPro: 2.479 ± 0.046	1.814GluGln: 1.814 ± 0.044	4.135GluArg: 4.135 ± 0.066	2.243GluSer: 2.243 ± 0.045	3.924GluThr: 3.924 ± 0.062	4.517GluVal: 4.517 ± 0.058	0.607GluTrp: 0.607 ± 0.02	1.0GluTyr: 1.0 ± 0.028	0.001GluXaa: 0.001 ± 0.001
Phe	4.537PheAla: 4.537 ± 0.056	0.375PheCys: 0.375 ± 0.016	3.065PheAsp: 3.065 ± 0.067	2.224PheGlu: 2.224 ± 0.04	1.418PhePhe: 1.418 ± 0.032	3.731PheGly: 3.731 ± 0.067	0.721PheHis: 0.721 ± 0.023	1.56PheIle: 1.56 ± 0.039	0.857PheLys: 0.857 ± 0.024	3.383PheLeu: 3.383 ± 0.054	0.75PheMet: 0.75 ± 0.027	1.013PheAsn: 1.013 ± 0.028	1.473PhePro: 1.473 ± 0.034	0.982PheGln: 0.982 ± 0.028	2.23PheArg: 2.23 ± 0.044	2.049PheSer: 2.049 ± 0.042	2.058PheThr: 2.058 ± 0.051	2.671PheVal: 2.671 ± 0.049	0.553PheTrp: 0.553 ± 0.021	0.853PheTyr: 0.853 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.376GlyAla: 10.376 ± 0.118	0.837GlyCys: 0.837 ± 0.029	5.331GlyAsp: 5.331 ± 0.15	4.434GlyGlu: 4.434 ± 0.068	3.699GlyPhe: 3.699 ± 0.061	7.813GlyGly: 7.813 ± 0.159	1.888GlyHis: 1.888 ± 0.044	4.406GlyIle: 4.406 ± 0.075	2.73GlyLys: 2.73 ± 0.058	9.381GlyLeu: 9.381 ± 0.094	2.534GlyMet: 2.534 ± 0.047	2.252GlyAsn: 2.252 ± 0.073	3.949GlyPro: 3.949 ± 0.055	3.225GlyGln: 3.225 ± 0.052	5.914GlyArg: 5.914 ± 0.073	4.568GlySer: 4.568 ± 0.083	5.395GlyThr: 5.395 ± 0.102	6.337GlyVal: 6.337 ± 0.072	1.491GlyTrp: 1.491 ± 0.035	2.274GlyTyr: 2.274 ± 0.038	0.003GlyXaa: 0.003 ± 0.002
His	2.319HisAla: 2.319 ± 0.043	0.212HisCys: 0.212 ± 0.012	1.235HisAsp: 1.235 ± 0.033	0.99HisGlu: 0.99 ± 0.024	0.76HisPhe: 0.76 ± 0.025	1.868HisGly: 1.868 ± 0.042	0.519HisHis: 0.519 ± 0.021	0.869HisIle: 0.869 ± 0.029	0.467HisLys: 0.467 ± 0.019	2.076HisLeu: 2.076 ± 0.05	0.524HisMet: 0.524 ± 0.022	0.385HisAsn: 0.385 ± 0.017	1.304HisPro: 1.304 ± 0.033	0.516HisGln: 0.516 ± 0.019	1.366HisArg: 1.366 ± 0.038	0.848HisSer: 0.848 ± 0.024	0.815HisThr: 0.815 ± 0.025	1.524HisVal: 1.524 ± 0.036	0.337HisTrp: 0.337 ± 0.016	0.499HisTyr: 0.499 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.798IleAla: 6.798 ± 0.078	0.567IleCys: 0.567 ± 0.021	3.622IleAsp: 3.622 ± 0.063	3.37IleGlu: 3.37 ± 0.052	1.666IlePhe: 1.666 ± 0.041	4.738IleGly: 4.738 ± 0.067	0.806IleHis: 0.806 ± 0.026	1.818IleIle: 1.818 ± 0.044	1.226IleLys: 1.226 ± 0.034	4.558IleLeu: 4.558 ± 0.065	0.939IleMet: 0.939 ± 0.03	1.206IleAsn: 1.206 ± 0.037	2.239IlePro: 2.239 ± 0.04	1.134IleGln: 1.134 ± 0.031	3.031IleArg: 3.031 ± 0.048	2.702IleSer: 2.702 ± 0.052	2.83IleThr: 2.83 ± 0.062	3.602IleVal: 3.602 ± 0.05	0.655IleTrp: 0.655 ± 0.019	1.07IleTyr: 1.07 ± 0.032	0.001IleXaa: 0.001 ± 0.001
Lys	3.452LysAla: 3.452 ± 0.056	0.17LysCys: 0.17 ± 0.013	1.61LysAsp: 1.61 ± 0.041	1.344LysGlu: 1.344 ± 0.04	0.794LysPhe: 0.794 ± 0.026	2.375LysGly: 2.375 ± 0.063	0.523LysHis: 0.523 ± 0.019	1.374LysIle: 1.374 ± 0.04	1.065LysLys: 1.065 ± 0.033	2.618LysLeu: 2.618 ± 0.054	0.69LysMet: 0.69 ± 0.026	0.664LysAsn: 0.664 ± 0.022	1.634LysPro: 1.634 ± 0.04	0.774LysGln: 0.774 ± 0.026	2.022LysArg: 2.022 ± 0.047	1.597LysSer: 1.597 ± 0.041	1.766LysThr: 1.766 ± 0.039	2.086LysVal: 2.086 ± 0.054	0.335LysTrp: 0.335 ± 0.019	0.562LysTyr: 0.562 ± 0.021	0.006LysXaa: 0.006 ± 0.003
Leu	12.962LeuAla: 12.962 ± 0.138	1.04LeuCys: 1.04 ± 0.036	6.563LeuAsp: 6.563 ± 0.068	5.14LeuGlu: 5.14 ± 0.072	3.488LeuPhe: 3.488 ± 0.06	8.652LeuGly: 8.652 ± 0.088	1.901LeuHis: 1.901 ± 0.046	4.876LeuIle: 4.876 ± 0.064	2.711LeuLys: 2.711 ± 0.05	9.154LeuLeu: 9.154 ± 0.106	2.571LeuMet: 2.571 ± 0.049	2.536LeuAsn: 2.536 ± 0.045	5.74LeuPro: 5.74 ± 0.084	2.734LeuGln: 2.734 ± 0.048	7.862LeuArg: 7.862 ± 0.097	6.82LeuSer: 6.82 ± 0.072	6.238LeuThr: 6.238 ± 0.075	7.05LeuVal: 7.05 ± 0.08	1.352LeuTrp: 1.352 ± 0.037	1.951LeuTyr: 1.951 ± 0.042	0.005LeuXaa: 0.005 ± 0.002
Met	3.392MetAla: 3.392 ± 0.059	0.174MetCys: 0.174 ± 0.013	1.413MetAsp: 1.413 ± 0.036	1.216MetGlu: 1.216 ± 0.036	0.768MetPhe: 0.768 ± 0.025	2.156MetGly: 2.156 ± 0.049	0.488MetHis: 0.488 ± 0.022	1.502MetIle: 1.502 ± 0.032	0.923MetLys: 0.923 ± 0.03	2.511MetLeu: 2.511 ± 0.048	0.77MetMet: 0.77 ± 0.026	0.721MetAsn: 0.721 ± 0.023	1.511MetPro: 1.511 ± 0.038	1.027MetGln: 1.027 ± 0.027	1.938MetArg: 1.938 ± 0.04	1.619MetSer: 1.619 ± 0.033	2.143MetThr: 2.143 ± 0.044	1.789MetVal: 1.789 ± 0.036	0.227MetTrp: 0.227 ± 0.012	0.315MetTyr: 0.315 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.152AsnAla: 3.152 ± 0.051	0.236AsnCys: 0.236 ± 0.013	1.579AsnAsp: 1.579 ± 0.07	1.102AsnGlu: 1.102 ± 0.031	0.89AsnPhe: 0.89 ± 0.027	2.384AsnGly: 2.384 ± 0.054	0.456AsnHis: 0.456 ± 0.021	1.259AsnIle: 1.259 ± 0.029	0.534AsnLys: 0.534 ± 0.02	2.416AsnLeu: 2.416 ± 0.049	0.655AsnMet: 0.655 ± 0.025	0.669AsnAsn: 0.669 ± 0.026	1.668AsnPro: 1.668 ± 0.035	0.662AsnGln: 0.662 ± 0.024	1.708AsnArg: 1.708 ± 0.042	1.055AsnSer: 1.055 ± 0.028	1.321AsnThr: 1.321 ± 0.037	1.77AsnVal: 1.77 ± 0.041	0.382AsnTrp: 0.382 ± 0.016	0.58AsnTyr: 0.58 ± 0.022	0.004AsnXaa: 0.004 ± 0.002
Pro	5.977ProAla: 5.977 ± 0.091	0.367ProCys: 0.367 ± 0.018	4.266ProAsp: 4.266 ± 0.064	4.347ProGlu: 4.347 ± 0.065	1.933ProPhe: 1.933 ± 0.037	4.916ProGly: 4.916 ± 0.072	0.996ProHis: 0.996 ± 0.027	2.111ProIle: 2.111 ± 0.042	1.453ProLys: 1.453 ± 0.035	4.752ProLeu: 4.752 ± 0.068	1.283ProMet: 1.283 ± 0.036	1.219ProAsn: 1.219 ± 0.031	2.442ProPro: 2.442 ± 0.059	1.747ProGln: 1.747 ± 0.038	3.047ProArg: 3.047 ± 0.06	2.437ProSer: 2.437 ± 0.041	2.321ProThr: 2.321 ± 0.04	4.423ProVal: 4.423 ± 0.071	0.676ProTrp: 0.676 ± 0.024	1.113ProTyr: 1.113 ± 0.032	0.001ProXaa: 0.001 ± 0.001
Gln	4.045GlnAla: 4.045 ± 0.06	0.194GlnCys: 0.194 ± 0.012	1.872GlnAsp: 1.872 ± 0.037	1.648GlnGlu: 1.648 ± 0.04	1.015GlnPhe: 1.015 ± 0.027	2.7GlnGly: 2.7 ± 0.045	0.562GlnHis: 0.562 ± 0.019	1.841GlnIle: 1.841 ± 0.038	0.924GlnLys: 0.924 ± 0.029	2.75GlnLeu: 2.75 ± 0.054	1.056GlnMet: 1.056 ± 0.029	0.899GlnAsn: 0.899 ± 0.025	1.638GlnPro: 1.638 ± 0.034	1.03GlnGln: 1.03 ± 0.037	2.177GlnArg: 2.177 ± 0.044	1.853GlnSer: 1.853 ± 0.038	1.9GlnThr: 1.9 ± 0.035	2.427GlnVal: 2.427 ± 0.039	0.371GlnTrp: 0.371 ± 0.017	0.56GlnTyr: 0.56 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.694ArgAla: 8.694 ± 0.105	0.492ArgCys: 0.492 ± 0.02	4.952ArgAsp: 4.952 ± 0.066	3.67ArgGlu: 3.67 ± 0.068	2.796ArgPhe: 2.796 ± 0.045	5.027ArgGly: 5.027 ± 0.057	1.588ArgHis: 1.588 ± 0.036	4.017ArgIle: 4.017 ± 0.046	2.079ArgLys: 2.079 ± 0.048	7.69ArgLeu: 7.69 ± 0.098	2.012ArgMet: 2.012 ± 0.048	1.742ArgAsn: 1.742 ± 0.041	3.423ArgPro: 3.423 ± 0.055	2.317ArgGln: 2.317 ± 0.047	5.467ArgArg: 5.467 ± 0.091	3.444ArgSer: 3.444 ± 0.06	3.319ArgThr: 3.319 ± 0.051	4.853ArgVal: 4.853 ± 0.072	0.96ArgTrp: 0.96 ± 0.026	1.54ArgTyr: 1.54 ± 0.036	0.001ArgXaa: 0.001 ± 0.001
Ser	5.979SerAla: 5.979 ± 0.083	0.432SerCys: 0.432 ± 0.02	3.558SerAsp: 3.558 ± 0.068	2.918SerGlu: 2.918 ± 0.051	2.175SerPhe: 2.175 ± 0.04	5.511SerGly: 5.511 ± 0.08	0.995SerHis: 0.995 ± 0.031	2.355SerIle: 2.355 ± 0.046	1.297SerLys: 1.297 ± 0.034	4.997SerLeu: 4.997 ± 0.063	1.27SerMet: 1.27 ± 0.035	1.299SerAsn: 1.299 ± 0.031	2.44SerPro: 2.44 ± 0.045	1.584SerGln: 1.584 ± 0.034	3.244SerArg: 3.244 ± 0.053	2.459SerSer: 2.459 ± 0.047	2.458SerThr: 2.458 ± 0.041	3.921SerVal: 3.921 ± 0.057	0.682SerTrp: 0.682 ± 0.023	1.3SerTyr: 1.3 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.711ThrAla: 6.711 ± 0.09	0.488ThrCys: 0.488 ± 0.018	3.615ThrAsp: 3.615 ± 0.078	3.213ThrGlu: 3.213 ± 0.053	2.047ThrPhe: 2.047 ± 0.043	5.845ThrGly: 5.845 ± 0.085	1.084ThrHis: 1.084 ± 0.03	2.574ThrIle: 2.574 ± 0.063	1.256ThrLys: 1.256 ± 0.04	6.496ThrLeu: 6.496 ± 0.085	1.215ThrMet: 1.215 ± 0.031	1.271ThrAsn: 1.271 ± 0.036	3.537ThrPro: 3.537 ± 0.054	1.625ThrGln: 1.625 ± 0.035	3.755ThrArg: 3.755 ± 0.054	2.685ThrSer: 2.685 ± 0.051	2.808ThrThr: 2.808 ± 0.059	4.611ThrVal: 4.611 ± 0.08	0.713ThrTrp: 0.713 ± 0.025	1.266ThrTyr: 1.266 ± 0.033	0.001ThrXaa: 0.001 ± 0.001
Val	8.921ValAla: 8.921 ± 0.093	0.667ValCys: 0.667 ± 0.025	4.168ValAsp: 4.168 ± 0.064	4.265ValGlu: 4.265 ± 0.057	2.858ValPhe: 2.858 ± 0.05	5.365ValGly: 5.365 ± 0.073	1.279ValHis: 1.279 ± 0.034	4.037ValIle: 4.037 ± 0.061	1.95ValLys: 1.95 ± 0.047	7.729ValLeu: 7.729 ± 0.088	2.065ValMet: 2.065 ± 0.045	1.883ValAsn: 1.883 ± 0.044	3.868ValPro: 3.868 ± 0.062	2.228ValGln: 2.228 ± 0.04	4.408ValArg: 4.408 ± 0.055	4.226ValSer: 4.226 ± 0.06	5.136ValThr: 5.136 ± 0.101	5.566ValVal: 5.566 ± 0.069	0.971ValTrp: 0.971 ± 0.029	1.441ValTyr: 1.441 ± 0.033	0.002ValXaa: 0.002 ± 0.001
Trp	1.338TrpAla: 1.338 ± 0.033	0.145TrpCys: 0.145 ± 0.01	0.795TrpAsp: 0.795 ± 0.023	0.622TrpGlu: 0.622 ± 0.022	0.543TrpPhe: 0.543 ± 0.02	0.996TrpGly: 0.996 ± 0.03	0.315TrpHis: 0.315 ± 0.016	0.694TrpIle: 0.694 ± 0.024	0.414TrpLys: 0.414 ± 0.019	1.561TrpLeu: 1.561 ± 0.038	0.393TrpMet: 0.393 ± 0.017	0.392TrpAsn: 0.392 ± 0.018	0.69TrpPro: 0.69 ± 0.02	0.621TrpGln: 0.621 ± 0.022	1.123TrpArg: 1.123 ± 0.033	0.804TrpSer: 0.804 ± 0.024	0.869TrpThr: 0.869 ± 0.027	0.882TrpVal: 0.882 ± 0.024	0.216TrpTrp: 0.216 ± 0.012	0.275TrpTyr: 0.275 ± 0.014	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.459TyrAla: 2.459 ± 0.044	0.226TyrCys: 0.226 ± 0.011	1.611TyrAsp: 1.611 ± 0.035	1.227TyrGlu: 1.227 ± 0.032	0.874TyrPhe: 0.874 ± 0.026	2.041TyrGly: 2.041 ± 0.043	0.437TyrHis: 0.437 ± 0.018	0.882TyrIle: 0.882 ± 0.028	0.505TyrLys: 0.505 ± 0.02	2.219TyrLeu: 2.219 ± 0.045	0.474TyrMet: 0.474 ± 0.019	0.55TyrAsn: 0.55 ± 0.023	1.036TyrPro: 1.036 ± 0.027	0.644TyrGln: 0.644 ± 0.02	1.554TyrArg: 1.554 ± 0.037	1.05TyrSer: 1.05 ± 0.027	1.186TyrThr: 1.186 ± 0.035	1.458TyrVal: 1.458 ± 0.033	0.333TyrTrp: 0.333 ± 0.015	0.508TyrTyr: 0.508 ± 0.02	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.003XaaAsp: 0.003 ± 0.001	0.003XaaGlu: 0.003 ± 0.002	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.003XaaLys: 0.003 ± 0.002	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.003XaaAsn: 0.003 ± 0.002	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.003XaaArg: 0.003 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.001XaaTyr: 0.001 ± 0.001	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4371 proteins (1404347 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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