Amino acid dipepetide frequency for Sphingobium algorifonticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.095AlaAla: 19.095 ± 0.234	1.133AlaCys: 1.133 ± 0.031	8.364AlaAsp: 8.364 ± 0.14	6.833AlaGlu: 6.833 ± 0.103	4.55AlaPhe: 4.55 ± 0.066	10.953AlaGly: 10.953 ± 0.194	2.497AlaHis: 2.497 ± 0.052	7.333AlaIle: 7.333 ± 0.101	3.802AlaLys: 3.802 ± 0.076	14.358AlaLeu: 14.358 ± 0.153	4.132AlaMet: 4.132 ± 0.085	3.155AlaAsn: 3.155 ± 0.072	6.283AlaPro: 6.283 ± 0.102	5.197AlaGln: 5.197 ± 0.073	10.029AlaArg: 10.029 ± 0.123	6.683AlaSer: 6.683 ± 0.087	6.838AlaThr: 6.838 ± 0.097	8.608AlaVal: 8.608 ± 0.087	1.614AlaTrp: 1.614 ± 0.043	2.703AlaTyr: 2.703 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.162CysAla: 1.162 ± 0.038	0.108CysCys: 0.108 ± 0.009	0.56CysAsp: 0.56 ± 0.022	0.359CysGlu: 0.359 ± 0.019	0.29CysPhe: 0.29 ± 0.015	0.893CysGly: 0.893 ± 0.027	0.223CysHis: 0.223 ± 0.02	0.38CysIle: 0.38 ± 0.018	0.156CysLys: 0.156 ± 0.011	0.755CysLeu: 0.755 ± 0.026	0.163CysMet: 0.163 ± 0.012	0.219CysAsn: 0.219 ± 0.015	0.488CysPro: 0.488 ± 0.019	0.212CysGln: 0.212 ± 0.016	0.643CysArg: 0.643 ± 0.025	0.417CysSer: 0.417 ± 0.018	0.416CysThr: 0.416 ± 0.019	0.57CysVal: 0.57 ± 0.022	0.121CysTrp: 0.121 ± 0.011	0.21CysTyr: 0.21 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.455AspAla: 8.455 ± 0.112	0.529AspCys: 0.529 ± 0.024	3.639AspAsp: 3.639 ± 0.1	2.927AspGlu: 2.927 ± 0.051	2.269AspPhe: 2.269 ± 0.046	6.046AspGly: 6.046 ± 0.135	1.376AspHis: 1.376 ± 0.039	3.539AspIle: 3.539 ± 0.069	1.571AspLys: 1.571 ± 0.04	5.615AspLeu: 5.615 ± 0.067	1.695AspMet: 1.695 ± 0.04	1.484AspAsn: 1.484 ± 0.042	3.839AspPro: 3.839 ± 0.056	1.834AspGln: 1.834 ± 0.039	5.222AspArg: 5.222 ± 0.077	2.694AspSer: 2.694 ± 0.063	2.846AspThr: 2.846 ± 0.128	4.376AspVal: 4.376 ± 0.078	1.057AspTrp: 1.057 ± 0.033	1.75AspTyr: 1.75 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.969GluAla: 6.969 ± 0.1	0.3GluCys: 0.3 ± 0.018	2.587GluAsp: 2.587 ± 0.053	2.464GluGlu: 2.464 ± 0.054	1.213GluPhe: 1.213 ± 0.034	4.185GluGly: 4.185 ± 0.069	0.904GluHis: 0.904 ± 0.029	2.76GluIle: 2.76 ± 0.058	1.845GluLys: 1.845 ± 0.046	4.181GluLeu: 4.181 ± 0.063	1.343GluMet: 1.343 ± 0.037	1.387GluAsn: 1.387 ± 0.036	2.153GluPro: 2.153 ± 0.045	1.89GluGln: 1.89 ± 0.045	4.384GluArg: 4.384 ± 0.072	2.279GluSer: 2.279 ± 0.046	3.075GluThr: 3.075 ± 0.06	2.992GluVal: 2.992 ± 0.056	0.627GluTrp: 0.627 ± 0.025	0.906GluTyr: 0.906 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.872PheAla: 4.872 ± 0.076	0.298PheCys: 0.298 ± 0.018	2.686PheAsp: 2.686 ± 0.055	1.775PheGlu: 1.775 ± 0.042	1.251PhePhe: 1.251 ± 0.035	3.634PheGly: 3.634 ± 0.057	0.716PheHis: 0.716 ± 0.026	1.468PheIle: 1.468 ± 0.036	0.822PheLys: 0.822 ± 0.03	3.138PheLeu: 3.138 ± 0.063	0.793PheMet: 0.793 ± 0.028	1.02PheAsn: 1.02 ± 0.032	1.509PhePro: 1.509 ± 0.033	0.884PheGln: 0.884 ± 0.033	2.206PheArg: 2.206 ± 0.046	2.054PheSer: 2.054 ± 0.044	2.09PheThr: 2.09 ± 0.053	2.609PheVal: 2.609 ± 0.053	0.499PheTrp: 0.499 ± 0.023	0.927PheTyr: 0.927 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	10.292GlyAla: 10.292 ± 0.199	0.84GlyCys: 0.84 ± 0.026	5.191GlyAsp: 5.191 ± 0.207	4.259GlyGlu: 4.259 ± 0.064	3.599GlyPhe: 3.599 ± 0.064	8.325GlyGly: 8.325 ± 0.299	1.894GlyHis: 1.894 ± 0.047	4.733GlyIle: 4.733 ± 0.071	3.264GlyLys: 3.264 ± 0.063	8.396GlyLeu: 8.396 ± 0.092	2.358GlyMet: 2.358 ± 0.049	2.483GlyAsn: 2.483 ± 0.101	3.535GlyPro: 3.535 ± 0.066	3.168GlyGln: 3.168 ± 0.057	6.373GlyArg: 6.373 ± 0.087	4.848GlySer: 4.848 ± 0.151	5.212GlyThr: 5.212 ± 0.129	6.117GlyVal: 6.117 ± 0.073	1.561GlyTrp: 1.561 ± 0.039	2.31GlyTyr: 2.31 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.472HisAla: 2.472 ± 0.054	0.236HisCys: 0.236 ± 0.014	1.265HisAsp: 1.265 ± 0.034	0.853HisGlu: 0.853 ± 0.027	0.814HisPhe: 0.814 ± 0.027	1.971HisGly: 1.971 ± 0.044	0.577HisHis: 0.577 ± 0.023	0.995HisIle: 0.995 ± 0.034	0.42HisLys: 0.42 ± 0.019	1.92HisLeu: 1.92 ± 0.038	0.509HisMet: 0.509 ± 0.023	0.484HisAsn: 0.484 ± 0.023	1.307HisPro: 1.307 ± 0.039	0.561HisGln: 0.561 ± 0.019	1.501HisArg: 1.501 ± 0.035	0.95HisSer: 0.95 ± 0.028	0.574HisThr: 0.574 ± 0.021	1.662HisVal: 1.662 ± 0.039	0.34HisTrp: 0.34 ± 0.017	0.619HisTyr: 0.619 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	8.459IleAla: 8.459 ± 0.106	0.466IleCys: 0.466 ± 0.018	4.324IleAsp: 4.324 ± 0.072	3.311IleGlu: 3.311 ± 0.069	1.711IlePhe: 1.711 ± 0.045	5.268IleGly: 5.268 ± 0.085	0.899IleHis: 0.899 ± 0.029	2.324IleIle: 2.324 ± 0.05	1.177IleLys: 1.177 ± 0.034	4.294IleLeu: 4.294 ± 0.076	1.038IleMet: 1.038 ± 0.032	1.313IleAsn: 1.313 ± 0.036	2.197IlePro: 2.197 ± 0.052	1.17IleGln: 1.17 ± 0.03	3.373IleArg: 3.373 ± 0.056	2.685IleSer: 2.685 ± 0.053	2.643IleThr: 2.643 ± 0.052	4.476IleVal: 4.476 ± 0.065	0.587IleTrp: 0.587 ± 0.029	0.988IleTyr: 0.988 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.272LysAla: 4.272 ± 0.081	0.153LysCys: 0.153 ± 0.012	1.627LysAsp: 1.627 ± 0.043	1.09LysGlu: 1.09 ± 0.033	0.72LysPhe: 0.72 ± 0.026	2.601LysGly: 2.601 ± 0.053	0.481LysHis: 0.481 ± 0.02	1.44LysIle: 1.44 ± 0.036	0.962LysLys: 0.962 ± 0.042	2.826LysLeu: 2.826 ± 0.057	0.72LysMet: 0.72 ± 0.027	0.673LysAsn: 0.673 ± 0.027	1.863LysPro: 1.863 ± 0.051	0.805LysGln: 0.805 ± 0.026	2.059LysArg: 2.059 ± 0.044	1.54LysSer: 1.54 ± 0.037	1.65LysThr: 1.65 ± 0.039	2.023LysVal: 2.023 ± 0.048	0.346LysTrp: 0.346 ± 0.019	0.552LysTyr: 0.552 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.723LeuAla: 13.723 ± 0.149	0.894LeuCys: 0.894 ± 0.031	6.173LeuAsp: 6.173 ± 0.086	4.497LeuGlu: 4.497 ± 0.071	3.745LeuPhe: 3.745 ± 0.062	7.916LeuGly: 7.916 ± 0.099	1.854LeuHis: 1.854 ± 0.043	4.928LeuIle: 4.928 ± 0.075	2.899LeuLys: 2.899 ± 0.06	9.434LeuLeu: 9.434 ± 0.138	2.252LeuMet: 2.252 ± 0.052	2.44LeuAsn: 2.44 ± 0.049	5.69LeuPro: 5.69 ± 0.08	2.482LeuGln: 2.482 ± 0.051	7.012LeuArg: 7.012 ± 0.081	6.316LeuSer: 6.316 ± 0.077	5.59LeuThr: 5.59 ± 0.084	6.803LeuVal: 6.803 ± 0.113	1.357LeuTrp: 1.357 ± 0.042	2.062LeuTyr: 2.062 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.625MetAla: 3.625 ± 0.061	0.157MetCys: 0.157 ± 0.011	1.268MetAsp: 1.268 ± 0.039	1.003MetGlu: 1.003 ± 0.035	0.682MetPhe: 0.682 ± 0.028	1.973MetGly: 1.973 ± 0.048	0.464MetHis: 0.464 ± 0.018	1.472MetIle: 1.472 ± 0.038	0.934MetLys: 0.934 ± 0.034	2.836MetLeu: 2.836 ± 0.054	0.725MetMet: 0.725 ± 0.025	0.638MetAsn: 0.638 ± 0.022	1.608MetPro: 1.608 ± 0.041	0.871MetGln: 0.871 ± 0.03	1.92MetArg: 1.92 ± 0.047	1.342MetSer: 1.342 ± 0.036	1.906MetThr: 1.906 ± 0.046	1.645MetVal: 1.645 ± 0.039	0.238MetTrp: 0.238 ± 0.016	0.273MetTyr: 0.273 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.425AsnAla: 3.425 ± 0.053	0.262AsnCys: 0.262 ± 0.016	1.584AsnAsp: 1.584 ± 0.087	0.992AsnGlu: 0.992 ± 0.031	0.912AsnPhe: 0.912 ± 0.035	2.59AsnGly: 2.59 ± 0.079	0.463AsnHis: 0.463 ± 0.02	1.416AsnIle: 1.416 ± 0.037	0.561AsnLys: 0.561 ± 0.023	2.4AsnLeu: 2.4 ± 0.045	0.572AsnMet: 0.572 ± 0.021	0.716AsnAsn: 0.716 ± 0.032	1.777AsnPro: 1.777 ± 0.045	0.747AsnGln: 0.747 ± 0.027	1.881AsnArg: 1.881 ± 0.036	1.287AsnSer: 1.287 ± 0.04	1.03AsnThr: 1.03 ± 0.041	1.929AsnVal: 1.929 ± 0.043	0.433AsnTrp: 0.433 ± 0.018	0.665AsnTyr: 0.665 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.869ProAla: 6.869 ± 0.098	0.396ProCys: 0.396 ± 0.02	4.123ProAsp: 4.123 ± 0.062	2.986ProGlu: 2.986 ± 0.055	1.903ProPhe: 1.903 ± 0.042	4.665ProGly: 4.665 ± 0.079	1.09ProHis: 1.09 ± 0.034	2.397ProIle: 2.397 ± 0.044	1.415ProLys: 1.415 ± 0.042	5.032ProLeu: 5.032 ± 0.08	1.296ProMet: 1.296 ± 0.037	1.215ProAsn: 1.215 ± 0.036	2.951ProPro: 2.951 ± 0.077	1.847ProGln: 1.847 ± 0.042	3.058ProArg: 3.058 ± 0.057	2.664ProSer: 2.664 ± 0.049	2.577ProThr: 2.577 ± 0.047	4.577ProVal: 4.577 ± 0.069	0.668ProTrp: 0.668 ± 0.023	1.103ProTyr: 1.103 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.599GlnAla: 4.599 ± 0.073	0.274GlnCys: 0.274 ± 0.016	1.716GlnAsp: 1.716 ± 0.043	1.247GlnGlu: 1.247 ± 0.036	1.118GlnPhe: 1.118 ± 0.031	2.767GlnGly: 2.767 ± 0.055	0.611GlnHis: 0.611 ± 0.022	1.837GlnIle: 1.837 ± 0.041	0.884GlnLys: 0.884 ± 0.029	2.952GlnLeu: 2.952 ± 0.053	0.886GlnMet: 0.886 ± 0.026	0.788GlnAsn: 0.788 ± 0.033	1.849GlnPro: 1.849 ± 0.05	1.161GlnGln: 1.161 ± 0.036	2.483GlnArg: 2.483 ± 0.053	1.807GlnSer: 1.807 ± 0.042	1.727GlnThr: 1.727 ± 0.04	2.225GlnVal: 2.225 ± 0.052	0.55GlnTrp: 0.55 ± 0.024	0.634GlnTyr: 0.634 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.772ArgAla: 8.772 ± 0.115	0.568ArgCys: 0.568 ± 0.023	4.495ArgAsp: 4.495 ± 0.072	3.596ArgGlu: 3.596 ± 0.064	3.098ArgPhe: 3.098 ± 0.055	5.078ArgGly: 5.078 ± 0.074	1.767ArgHis: 1.767 ± 0.042	4.499ArgIle: 4.499 ± 0.072	2.101ArgLys: 2.101 ± 0.046	8.301ArgLeu: 8.301 ± 0.101	2.016ArgMet: 2.016 ± 0.042	1.949ArgAsn: 1.949 ± 0.04	3.819ArgPro: 3.819 ± 0.064	2.592ArgGln: 2.592 ± 0.049	5.648ArgArg: 5.648 ± 0.107	3.788ArgSer: 3.788 ± 0.062	3.652ArgThr: 3.652 ± 0.058	4.561ArgVal: 4.561 ± 0.055	1.117ArgTrp: 1.117 ± 0.035	1.891ArgTyr: 1.891 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.739SerAla: 6.739 ± 0.107	0.417SerCys: 0.417 ± 0.017	3.217SerAsp: 3.217 ± 0.059	2.314SerGlu: 2.314 ± 0.046	2.186SerPhe: 2.186 ± 0.052	5.642SerGly: 5.642 ± 0.118	0.982SerHis: 0.982 ± 0.031	2.786SerIle: 2.786 ± 0.064	1.37SerLys: 1.37 ± 0.038	5.295SerLeu: 5.295 ± 0.072	1.217SerMet: 1.217 ± 0.032	1.357SerAsn: 1.357 ± 0.039	2.818SerPro: 2.818 ± 0.051	1.563SerGln: 1.563 ± 0.041	3.586SerArg: 3.586 ± 0.062	2.701SerSer: 2.701 ± 0.068	2.541SerThr: 2.541 ± 0.059	3.844SerVal: 3.844 ± 0.054	0.753SerTrp: 0.753 ± 0.024	1.382SerTyr: 1.382 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.69ThrAla: 6.69 ± 0.095	0.409ThrCys: 0.409 ± 0.023	3.141ThrAsp: 3.141 ± 0.055	2.166ThrGlu: 2.166 ± 0.044	1.735ThrPhe: 1.735 ± 0.042	5.686ThrGly: 5.686 ± 0.136	0.987ThrHis: 0.987 ± 0.029	3.012ThrIle: 3.012 ± 0.065	1.284ThrLys: 1.284 ± 0.042	6.053ThrLeu: 6.053 ± 0.108	1.26ThrMet: 1.26 ± 0.033	1.314ThrAsn: 1.314 ± 0.043	3.48ThrPro: 3.48 ± 0.073	1.643ThrGln: 1.643 ± 0.04	3.463ThrArg: 3.463 ± 0.063	2.711ThrSer: 2.711 ± 0.052	2.691ThrThr: 2.691 ± 0.061	4.239ThrVal: 4.239 ± 0.06	0.584ThrTrp: 0.584 ± 0.023	1.15ThrTyr: 1.15 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.487ValAla: 9.487 ± 0.117	0.53ValCys: 0.53 ± 0.021	4.498ValAsp: 4.498 ± 0.064	4.19ValGlu: 4.19 ± 0.072	2.025ValPhe: 2.025 ± 0.045	5.555ValGly: 5.555 ± 0.072	1.363ValHis: 1.363 ± 0.032	3.771ValIle: 3.771 ± 0.069	1.984ValLys: 1.984 ± 0.046	6.471ValLeu: 6.471 ± 0.086	1.773ValMet: 1.773 ± 0.043	1.971ValAsn: 1.971 ± 0.049	3.935ValPro: 3.935 ± 0.066	2.187ValGln: 2.187 ± 0.051	5.194ValArg: 5.194 ± 0.069	3.895ValSer: 3.895 ± 0.064	4.673ValThr: 4.673 ± 0.072	5.099ValVal: 5.099 ± 0.085	0.817ValTrp: 0.817 ± 0.03	1.443ValTyr: 1.443 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.377TrpAla: 1.377 ± 0.036	0.13TrpCys: 0.13 ± 0.01	0.74TrpAsp: 0.74 ± 0.029	0.55TrpGlu: 0.55 ± 0.025	0.546TrpPhe: 0.546 ± 0.024	0.904TrpGly: 0.904 ± 0.026	0.378TrpHis: 0.378 ± 0.017	0.69TrpIle: 0.69 ± 0.028	0.423TrpLys: 0.423 ± 0.017	1.669TrpLeu: 1.669 ± 0.043	0.367TrpMet: 0.367 ± 0.019	0.407TrpAsn: 0.407 ± 0.02	0.683TrpPro: 0.683 ± 0.025	0.594TrpGln: 0.594 ± 0.023	1.301TrpArg: 1.301 ± 0.035	0.854TrpSer: 0.854 ± 0.03	0.9TrpThr: 0.9 ± 0.031	0.821TrpVal: 0.821 ± 0.029	0.242TrpTrp: 0.242 ± 0.016	0.299TrpTyr: 0.299 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.809TyrAla: 2.809 ± 0.061	0.244TyrCys: 0.244 ± 0.016	1.564TyrAsp: 1.564 ± 0.041	1.032TyrGlu: 1.032 ± 0.031	0.885TyrPhe: 0.885 ± 0.028	2.11TyrGly: 2.11 ± 0.052	0.506TyrHis: 0.506 ± 0.022	0.923TyrIle: 0.923 ± 0.03	0.527TyrLys: 0.527 ± 0.021	2.14TyrLeu: 2.14 ± 0.045	0.465TyrMet: 0.465 ± 0.02	0.628TyrAsn: 0.628 ± 0.028	1.045TyrPro: 1.045 ± 0.032	0.705TyrGln: 0.705 ± 0.025	1.971TyrArg: 1.971 ± 0.042	1.196TyrSer: 1.196 ± 0.048	1.067TyrThr: 1.067 ± 0.04	1.682TyrVal: 1.682 ± 0.035	0.367TyrTrp: 0.367 ± 0.02	0.583TyrTyr: 0.583 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3506 proteins (1150749 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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