Amino acid dipepetide frequency for Rubripirellula reticaptiva

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.148AlaAla: 11.148 ± 0.091	1.066AlaCys: 1.066 ± 0.028	6.623AlaAsp: 6.623 ± 0.063	5.925AlaGlu: 5.925 ± 0.066	3.307AlaPhe: 3.307 ± 0.045	7.836AlaGly: 7.836 ± 0.081	1.449AlaHis: 1.449 ± 0.026	6.491AlaIle: 6.491 ± 0.066	4.36AlaLys: 4.36 ± 0.061	7.142AlaLeu: 7.142 ± 0.068	3.016AlaMet: 3.016 ± 0.048	3.498AlaAsn: 3.498 ± 0.055	3.645AlaPro: 3.645 ± 0.051	2.825AlaGln: 2.825 ± 0.037	4.907AlaArg: 4.907 ± 0.049	7.177AlaSer: 7.177 ± 0.073	6.278AlaThr: 6.278 ± 0.072	6.911AlaVal: 6.911 ± 0.065	1.275AlaTrp: 1.275 ± 0.028	1.977AlaTyr: 1.977 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	0.72CysAla: 0.72 ± 0.02	0.214CysCys: 0.214 ± 0.012	0.773CysAsp: 0.773 ± 0.024	0.67CysGlu: 0.67 ± 0.021	0.452CysPhe: 0.452 ± 0.015	1.034CysGly: 1.034 ± 0.031	0.416CysHis: 0.416 ± 0.017	0.459CysIle: 0.459 ± 0.015	0.323CysLys: 0.323 ± 0.011	1.015CysLeu: 1.015 ± 0.026	0.196CysMet: 0.196 ± 0.01	0.337CysAsn: 0.337 ± 0.012	0.52CysPro: 0.52 ± 0.018	0.422CysGln: 0.422 ± 0.014	0.753CysArg: 0.753 ± 0.02	0.655CysSer: 0.655 ± 0.017	0.479CysThr: 0.479 ± 0.016	0.872CysVal: 0.872 ± 0.024	0.159CysTrp: 0.159 ± 0.009	0.296CysTyr: 0.296 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.791AspAla: 6.791 ± 0.076	0.626AspCys: 0.626 ± 0.016	4.744AspAsp: 4.744 ± 0.073	4.456AspGlu: 4.456 ± 0.055	2.58AspPhe: 2.58 ± 0.039	5.99AspGly: 5.99 ± 0.094	1.56AspHis: 1.56 ± 0.033	2.658AspIle: 2.658 ± 0.039	1.95AspLys: 1.95 ± 0.035	5.88AspLeu: 5.88 ± 0.055	1.089AspMet: 1.089 ± 0.025	1.906AspAsn: 1.906 ± 0.039	3.644AspPro: 3.644 ± 0.047	2.874AspGln: 2.874 ± 0.038	4.539AspArg: 4.539 ± 0.045	4.433AspSer: 4.433 ± 0.06	2.929AspThr: 2.929 ± 0.062	4.705AspVal: 4.705 ± 0.054	1.118AspTrp: 1.118 ± 0.024	1.581AspTyr: 1.581 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	5.277GluAla: 5.277 ± 0.059	0.459GluCys: 0.459 ± 0.015	2.651GluAsp: 2.651 ± 0.045	2.7GluGlu: 2.7 ± 0.048	2.229GluPhe: 2.229 ± 0.033	3.388GluGly: 3.388 ± 0.045	1.204GluHis: 1.204 ± 0.025	3.505GluIle: 3.505 ± 0.038	2.441GluLys: 2.441 ± 0.048	6.271GluLeu: 6.271 ± 0.063	1.617GluMet: 1.617 ± 0.033	2.058GluAsn: 2.058 ± 0.033	2.589GluPro: 2.589 ± 0.033	2.487GluGln: 2.487 ± 0.039	3.353GluArg: 3.353 ± 0.046	4.753GluSer: 4.753 ± 0.045	3.972GluThr: 3.972 ± 0.047	4.082GluVal: 4.082 ± 0.052	0.607GluTrp: 0.607 ± 0.017	1.236GluTyr: 1.236 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.021PheAla: 4.021 ± 0.04	0.477PheCys: 0.477 ± 0.015	3.154PheAsp: 3.154 ± 0.043	2.206PheGlu: 2.206 ± 0.035	1.471PhePhe: 1.471 ± 0.025	3.466PheGly: 3.466 ± 0.044	0.754PheHis: 0.754 ± 0.019	1.525PheIle: 1.525 ± 0.023	1.119PheLys: 1.119 ± 0.024	3.181PheLeu: 3.181 ± 0.045	0.66PheMet: 0.66 ± 0.018	1.254PheAsn: 1.254 ± 0.026	1.608PhePro: 1.608 ± 0.024	1.277PheGln: 1.277 ± 0.024	2.301PheArg: 2.301 ± 0.036	2.477PheSer: 2.477 ± 0.034	2.15PheThr: 2.15 ± 0.044	2.957PheVal: 2.957 ± 0.039	0.513PheTrp: 0.513 ± 0.018	0.959PheTyr: 0.959 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	5.726GlyAla: 5.726 ± 0.068	1.001GlyCys: 1.001 ± 0.031	5.311GlyAsp: 5.311 ± 0.085	4.485GlyGlu: 4.485 ± 0.045	3.163GlyPhe: 3.163 ± 0.043	6.928GlyGly: 6.928 ± 0.137	1.64GlyHis: 1.64 ± 0.03	4.118GlyIle: 4.118 ± 0.047	3.678GlyLys: 3.678 ± 0.062	6.717GlyLeu: 6.717 ± 0.071	1.933GlyMet: 1.933 ± 0.036	3.108GlyAsn: 3.108 ± 0.071	3.077GlyPro: 3.077 ± 0.043	2.956GlyGln: 2.956 ± 0.042	4.88GlyArg: 4.88 ± 0.056	5.328GlySer: 5.328 ± 0.085	4.668GlyThr: 4.668 ± 0.099	5.503GlyVal: 5.503 ± 0.059	1.271GlyTrp: 1.271 ± 0.027	2.158GlyTyr: 2.158 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	1.929HisAla: 1.929 ± 0.031	0.326HisCys: 0.326 ± 0.01	1.403HisAsp: 1.403 ± 0.028	1.122HisGlu: 1.122 ± 0.023	0.925HisPhe: 0.925 ± 0.019	1.718HisGly: 1.718 ± 0.031	0.687HisHis: 0.687 ± 0.02	0.807HisIle: 0.807 ± 0.021	0.528HisLys: 0.528 ± 0.016	1.997HisLeu: 1.997 ± 0.038	0.361HisMet: 0.361 ± 0.013	0.599HisAsn: 0.599 ± 0.017	1.288HisPro: 1.288 ± 0.026	0.912HisGln: 0.912 ± 0.022	1.621HisArg: 1.621 ± 0.029	1.368HisSer: 1.368 ± 0.024	0.926HisThr: 0.926 ± 0.018	1.502HisVal: 1.502 ± 0.027	0.436HisTrp: 0.436 ± 0.014	0.587HisTyr: 0.587 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.602IleAla: 6.602 ± 0.067	0.606IleCys: 0.606 ± 0.018	4.76IleAsp: 4.76 ± 0.051	4.142IleGlu: 4.142 ± 0.046	1.514IlePhe: 1.514 ± 0.027	4.718IleGly: 4.718 ± 0.049	1.106IleHis: 1.106 ± 0.023	1.98IleIle: 1.98 ± 0.029	1.672IleLys: 1.672 ± 0.034	3.885IleLeu: 3.885 ± 0.054	0.754IleMet: 0.754 ± 0.022	1.817IleAsn: 1.817 ± 0.034	2.456IlePro: 2.456 ± 0.035	1.874IleGln: 1.874 ± 0.031	3.557IleArg: 3.557 ± 0.04	3.459IleSer: 3.459 ± 0.045	2.971IleThr: 2.971 ± 0.053	4.255IleVal: 4.255 ± 0.05	0.607IleTrp: 0.607 ± 0.019	1.187IleTyr: 1.187 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.118LysAla: 3.118 ± 0.049	0.307LysCys: 0.307 ± 0.013	1.833LysAsp: 1.833 ± 0.032	1.813LysGlu: 1.813 ± 0.034	1.334LysPhe: 1.334 ± 0.025	1.977LysGly: 1.977 ± 0.031	0.868LysHis: 0.868 ± 0.022	1.996LysIle: 1.996 ± 0.035	1.736LysLys: 1.736 ± 0.043	3.899LysLeu: 3.899 ± 0.051	1.004LysMet: 1.004 ± 0.023	1.297LysAsn: 1.297 ± 0.024	2.339LysPro: 2.339 ± 0.043	1.7LysGln: 1.7 ± 0.033	2.597LysArg: 2.597 ± 0.039	2.741LysSer: 2.741 ± 0.047	2.448LysThr: 2.448 ± 0.042	2.441LysVal: 2.441 ± 0.036	0.564LysTrp: 0.564 ± 0.018	0.897LysTyr: 0.897 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	10.289LeuAla: 10.289 ± 0.086	1.036LeuCys: 1.036 ± 0.027	5.933LeuAsp: 5.933 ± 0.061	4.663LeuGlu: 4.663 ± 0.058	3.226LeuPhe: 3.226 ± 0.046	6.724LeuGly: 6.724 ± 0.061	1.863LeuHis: 1.863 ± 0.031	4.931LeuIle: 4.931 ± 0.063	3.391LeuLys: 3.391 ± 0.042	8.514LeuLeu: 8.514 ± 0.088	2.154LeuMet: 2.154 ± 0.033	2.824LeuAsn: 2.824 ± 0.039	5.065LeuPro: 5.065 ± 0.051	3.258LeuGln: 3.258 ± 0.039	5.967LeuArg: 5.967 ± 0.061	6.584LeuSer: 6.584 ± 0.062	5.458LeuThr: 5.458 ± 0.067	6.931LeuVal: 6.931 ± 0.058	1.124LeuTrp: 1.124 ± 0.024	1.88LeuTyr: 1.88 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.252MetAla: 2.252 ± 0.037	0.205MetCys: 0.205 ± 0.01	1.175MetAsp: 1.175 ± 0.026	1.037MetGlu: 1.037 ± 0.023	0.829MetPhe: 0.829 ± 0.022	1.585MetGly: 1.585 ± 0.037	0.517MetHis: 0.517 ± 0.015	1.458MetIle: 1.458 ± 0.028	1.096MetLys: 1.096 ± 0.021	2.495MetLeu: 2.495 ± 0.038	0.701MetMet: 0.701 ± 0.019	0.956MetAsn: 0.956 ± 0.023	1.45MetPro: 1.45 ± 0.029	1.007MetGln: 1.007 ± 0.023	1.468MetArg: 1.468 ± 0.03	1.681MetSer: 1.681 ± 0.029	1.697MetThr: 1.697 ± 0.03	1.65MetVal: 1.65 ± 0.033	0.233MetTrp: 0.233 ± 0.011	0.393MetTyr: 0.393 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.148AsnAla: 3.148 ± 0.049	0.36AsnCys: 0.36 ± 0.013	2.37AsnAsp: 2.37 ± 0.052	2.051AsnGlu: 2.051 ± 0.031	1.31AsnPhe: 1.31 ± 0.029	2.936AsnGly: 2.936 ± 0.07	0.86AsnHis: 0.86 ± 0.02	1.443AsnIle: 1.443 ± 0.025	0.92AsnLys: 0.92 ± 0.02	3.125AsnLeu: 3.125 ± 0.043	0.579AsnMet: 0.579 ± 0.017	1.204AsnAsn: 1.204 ± 0.041	2.042AsnPro: 2.042 ± 0.034	1.507AsnGln: 1.507 ± 0.026	2.434AsnArg: 2.434 ± 0.037	2.303AsnSer: 2.303 ± 0.043	1.711AsnThr: 1.711 ± 0.046	2.64AsnVal: 2.64 ± 0.045	0.542AsnTrp: 0.542 ± 0.017	0.875AsnTyr: 0.875 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	4.861ProAla: 4.861 ± 0.06	0.347ProCys: 0.347 ± 0.013	3.343ProAsp: 3.343 ± 0.038	3.175ProGlu: 3.175 ± 0.04	1.767ProPhe: 1.767 ± 0.029	3.712ProGly: 3.712 ± 0.049	0.973ProHis: 0.973 ± 0.026	2.973ProIle: 2.973 ± 0.041	1.943ProLys: 1.943 ± 0.034	4.131ProLeu: 4.131 ± 0.048	1.304ProMet: 1.304 ± 0.025	1.973ProAsn: 1.973 ± 0.032	2.532ProPro: 2.532 ± 0.055	1.622ProGln: 1.622 ± 0.025	2.473ProArg: 2.473 ± 0.038	3.8ProSer: 3.8 ± 0.044	3.331ProThr: 3.331 ± 0.043	3.682ProVal: 3.682 ± 0.049	0.701ProTrp: 0.701 ± 0.02	1.088ProTyr: 1.088 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.474GlnAla: 3.474 ± 0.042	0.401GlnCys: 0.401 ± 0.014	1.685GlnAsp: 1.685 ± 0.025	1.516GlnGlu: 1.516 ± 0.028	1.603GlnPhe: 1.603 ± 0.024	2.126GlnGly: 2.126 ± 0.032	0.842GlnHis: 0.842 ± 0.02	2.289GlnIle: 2.289 ± 0.036	1.283GlnLys: 1.283 ± 0.024	3.95GlnLeu: 3.95 ± 0.05	0.992GlnMet: 0.992 ± 0.024	1.227GlnAsn: 1.227 ± 0.025	2.057GlnPro: 2.057 ± 0.033	1.816GlnGln: 1.816 ± 0.034	2.667GlnArg: 2.667 ± 0.044	3.07GlnSer: 3.07 ± 0.039	2.582GlnThr: 2.582 ± 0.037	2.647GlnVal: 2.647 ± 0.034	0.718GlnTrp: 0.718 ± 0.02	0.93GlnTyr: 0.93 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	4.477ArgAla: 4.477 ± 0.047	0.722ArgCys: 0.722 ± 0.02	3.916ArgAsp: 3.916 ± 0.05	3.571ArgGlu: 3.571 ± 0.052	2.795ArgPhe: 2.795 ± 0.039	4.171ArgGly: 4.171 ± 0.045	1.336ArgHis: 1.336 ± 0.023	3.67ArgIle: 3.67 ± 0.045	2.303ArgLys: 2.303 ± 0.039	6.653ArgLeu: 6.653 ± 0.064	1.844ArgMet: 1.844 ± 0.031	2.119ArgAsn: 2.119 ± 0.033	3.013ArgPro: 3.013 ± 0.042	2.581ArgGln: 2.581 ± 0.031	4.842ArgArg: 4.842 ± 0.064	4.539ArgSer: 4.539 ± 0.052	3.278ArgThr: 3.278 ± 0.04	4.539ArgVal: 4.539 ± 0.047	1.176ArgTrp: 1.176 ± 0.024	1.779ArgTyr: 1.779 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.295SerAla: 6.295 ± 0.054	0.644SerCys: 0.644 ± 0.02	4.892SerAsp: 4.892 ± 0.056	3.96SerGlu: 3.96 ± 0.048	2.547SerPhe: 2.547 ± 0.039	6.191SerGly: 6.191 ± 0.097	1.464SerHis: 1.464 ± 0.029	4.11SerIle: 4.11 ± 0.043	2.489SerLys: 2.489 ± 0.034	6.923SerLeu: 6.923 ± 0.065	1.766SerMet: 1.766 ± 0.03	2.438SerAsn: 2.438 ± 0.048	3.784SerPro: 3.784 ± 0.04	2.613SerGln: 2.613 ± 0.035	4.223SerArg: 4.223 ± 0.046	4.979SerSer: 4.979 ± 0.065	4.008SerThr: 4.008 ± 0.067	5.295SerVal: 5.295 ± 0.051	0.868SerTrp: 0.868 ± 0.021	1.494SerTyr: 1.494 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.739ThrAla: 5.739 ± 0.073	0.551ThrCys: 0.551 ± 0.018	3.914ThrAsp: 3.914 ± 0.071	3.21ThrGlu: 3.21 ± 0.043	2.245ThrPhe: 2.245 ± 0.044	4.88ThrGly: 4.88 ± 0.072	1.13ThrHis: 1.13 ± 0.022	3.731ThrIle: 3.731 ± 0.059	2.032ThrLys: 2.032 ± 0.032	5.736ThrLeu: 5.736 ± 0.064	1.343ThrMet: 1.343 ± 0.022	2.077ThrAsn: 2.077 ± 0.05	3.305ThrPro: 3.305 ± 0.042	1.882ThrGln: 1.882 ± 0.033	3.221ThrArg: 3.221 ± 0.041	4.031ThrSer: 4.031 ± 0.064	3.637ThrThr: 3.637 ± 0.077	4.54ThrVal: 4.54 ± 0.082	0.78ThrTrp: 0.78 ± 0.023	1.339ThrTyr: 1.339 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.815ValAla: 7.815 ± 0.071	0.909ValCys: 0.909 ± 0.023	5.137ValAsp: 5.137 ± 0.059	4.18ValGlu: 4.18 ± 0.048	2.61ValPhe: 2.61 ± 0.034	5.51ValGly: 5.51 ± 0.051	1.412ValHis: 1.412 ± 0.024	4.063ValIle: 4.063 ± 0.043	2.331ValLys: 2.331 ± 0.04	6.433ValLeu: 6.433 ± 0.063	1.734ValMet: 1.734 ± 0.032	2.359ValAsn: 2.359 ± 0.043	3.482ValPro: 3.482 ± 0.047	2.475ValGln: 2.475 ± 0.034	4.635ValArg: 4.635 ± 0.049	5.187ValSer: 5.187 ± 0.054	4.715ValThr: 4.715 ± 0.084	5.866ValVal: 5.866 ± 0.057	1.022ValTrp: 1.022 ± 0.024	1.617ValTyr: 1.617 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.107TrpAla: 1.107 ± 0.025	0.187TrpCys: 0.187 ± 0.009	0.805TrpAsp: 0.805 ± 0.02	0.602TrpGlu: 0.602 ± 0.017	0.591TrpPhe: 0.591 ± 0.014	0.855TrpGly: 0.855 ± 0.02	0.382TrpHis: 0.382 ± 0.013	0.937TrpIle: 0.937 ± 0.023	0.655TrpLys: 0.655 ± 0.022	1.573TrpLeu: 1.573 ± 0.033	0.474TrpMet: 0.474 ± 0.017	0.597TrpAsn: 0.597 ± 0.017	0.667TrpPro: 0.667 ± 0.018	0.695TrpGln: 0.695 ± 0.017	0.909TrpArg: 0.909 ± 0.022	0.975TrpSer: 0.975 ± 0.024	0.88TrpThr: 0.88 ± 0.022	0.884TrpVal: 0.884 ± 0.021	0.25TrpTrp: 0.25 ± 0.012	0.335TrpTyr: 0.335 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.066TyrAla: 2.066 ± 0.032	0.321TyrCys: 0.321 ± 0.011	1.63TyrAsp: 1.63 ± 0.044	1.392TyrGlu: 1.392 ± 0.023	1.029TyrPhe: 1.029 ± 0.023	1.905TyrGly: 1.905 ± 0.032	0.579TyrHis: 0.579 ± 0.017	0.781TyrIle: 0.781 ± 0.019	0.66TyrLys: 0.66 ± 0.017	2.294TyrLeu: 2.294 ± 0.035	0.364TyrMet: 0.364 ± 0.012	0.711TyrAsn: 0.711 ± 0.019	1.167TyrPro: 1.167 ± 0.025	1.093TyrGln: 1.093 ± 0.023	1.981TyrArg: 1.981 ± 0.033	1.445TyrSer: 1.445 ± 0.033	1.207TyrThr: 1.207 ± 0.036	1.585TyrVal: 1.585 ± 0.027	0.398TyrTrp: 0.398 ± 0.014	0.644TyrTyr: 0.644 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6084 proteins (2326863 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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