Amino acid dipepetide frequency for Erythrobacter sp. SG61-1L

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.488AlaAla: 17.488 ± 0.216	1.083AlaCys: 1.083 ± 0.039	7.328AlaAsp: 7.328 ± 0.095	8.255AlaGlu: 8.255 ± 0.119	4.248AlaPhe: 4.248 ± 0.069	11.145AlaGly: 11.145 ± 0.131	2.183AlaHis: 2.183 ± 0.047	6.637AlaIle: 6.637 ± 0.087	4.391AlaLys: 4.391 ± 0.086	13.58AlaLeu: 13.58 ± 0.148	3.885AlaMet: 3.885 ± 0.075	3.426AlaAsn: 3.426 ± 0.083	5.814AlaPro: 5.814 ± 0.091	4.601AlaGln: 4.601 ± 0.085	8.635AlaArg: 8.635 ± 0.121	6.685AlaSer: 6.685 ± 0.106	5.95AlaThr: 5.95 ± 0.091	8.103AlaVal: 8.103 ± 0.103	1.607AlaTrp: 1.607 ± 0.042	2.762AlaTyr: 2.762 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.043CysAla: 1.043 ± 0.039	0.114CysCys: 0.114 ± 0.011	0.538CysAsp: 0.538 ± 0.024	0.459CysGlu: 0.459 ± 0.024	0.331CysPhe: 0.331 ± 0.02	0.922CysGly: 0.922 ± 0.034	0.234CysHis: 0.234 ± 0.015	0.351CysIle: 0.351 ± 0.02	0.219CysLys: 0.219 ± 0.014	0.708CysLeu: 0.708 ± 0.031	0.164CysMet: 0.164 ± 0.011	0.23CysAsn: 0.23 ± 0.014	0.439CysPro: 0.439 ± 0.023	0.207CysGln: 0.207 ± 0.016	0.535CysArg: 0.535 ± 0.025	0.476CysSer: 0.476 ± 0.023	0.428CysThr: 0.428 ± 0.022	0.557CysVal: 0.557 ± 0.022	0.113CysTrp: 0.113 ± 0.012	0.194CysTyr: 0.194 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.351AspAla: 7.351 ± 0.12	0.485AspCys: 0.485 ± 0.025	3.152AspAsp: 3.152 ± 0.067	3.72AspGlu: 3.72 ± 0.065	2.318AspPhe: 2.318 ± 0.051	5.803AspGly: 5.803 ± 0.078	1.261AspHis: 1.261 ± 0.037	2.882AspIle: 2.882 ± 0.06	1.869AspLys: 1.869 ± 0.051	5.659AspLeu: 5.659 ± 0.087	1.414AspMet: 1.414 ± 0.037	1.458AspAsn: 1.458 ± 0.041	3.8AspPro: 3.8 ± 0.065	1.69AspGln: 1.69 ± 0.037	4.178AspArg: 4.178 ± 0.068	2.482AspSer: 2.482 ± 0.054	2.547AspThr: 2.547 ± 0.055	4.041AspVal: 4.041 ± 0.072	1.165AspTrp: 1.165 ± 0.039	1.716AspTyr: 1.716 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.347GluAla: 8.347 ± 0.127	0.371GluCys: 0.371 ± 0.019	3.266GluAsp: 3.266 ± 0.066	4.056GluGlu: 4.056 ± 0.082	1.958GluPhe: 1.958 ± 0.05	5.299GluGly: 5.299 ± 0.08	1.186GluHis: 1.186 ± 0.038	3.189GluIle: 3.189 ± 0.06	2.457GluLys: 2.457 ± 0.058	5.79GluLeu: 5.79 ± 0.088	1.646GluMet: 1.646 ± 0.039	1.592GluAsn: 1.592 ± 0.036	2.713GluPro: 2.713 ± 0.053	2.251GluGln: 2.251 ± 0.053	4.846GluArg: 4.846 ± 0.094	2.462GluSer: 2.462 ± 0.046	3.137GluThr: 3.137 ± 0.058	4.095GluVal: 4.095 ± 0.072	0.98GluTrp: 0.98 ± 0.035	1.219GluTyr: 1.219 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.827PheAla: 4.827 ± 0.079	0.33PheCys: 0.33 ± 0.016	2.711PheAsp: 2.711 ± 0.054	2.188PheGlu: 2.188 ± 0.056	1.337PhePhe: 1.337 ± 0.038	3.821PheGly: 3.821 ± 0.068	0.713PheHis: 0.713 ± 0.028	1.492PheIle: 1.492 ± 0.041	0.952PheLys: 0.952 ± 0.037	3.142PheLeu: 3.142 ± 0.071	0.762PheMet: 0.762 ± 0.029	1.092PheAsn: 1.092 ± 0.034	1.613PhePro: 1.613 ± 0.04	0.919PheGln: 0.919 ± 0.032	2.171PheArg: 2.171 ± 0.044	2.142PheSer: 2.142 ± 0.053	2.19PheThr: 2.19 ± 0.055	2.481PheVal: 2.481 ± 0.052	0.545PheTrp: 0.545 ± 0.028	0.97PheTyr: 0.97 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.914GlyAla: 9.914 ± 0.124	0.797GlyCys: 0.797 ± 0.035	4.946GlyAsp: 4.946 ± 0.08	5.586GlyGlu: 5.586 ± 0.088	3.668GlyPhe: 3.668 ± 0.066	8.156GlyGly: 8.156 ± 0.123	1.825GlyHis: 1.825 ± 0.049	4.707GlyIle: 4.707 ± 0.075	3.952GlyLys: 3.952 ± 0.081	8.522GlyLeu: 8.522 ± 0.09	2.619GlyMet: 2.619 ± 0.057	2.717GlyAsn: 2.717 ± 0.081	3.764GlyPro: 3.764 ± 0.06	3.132GlyGln: 3.132 ± 0.054	5.756GlyArg: 5.756 ± 0.089	5.15GlySer: 5.15 ± 0.105	5.146GlyThr: 5.146 ± 0.093	6.188GlyVal: 6.188 ± 0.111	1.645GlyTrp: 1.645 ± 0.043	2.37GlyTyr: 2.37 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.193HisAla: 2.193 ± 0.06	0.242HisCys: 0.242 ± 0.016	1.159HisAsp: 1.159 ± 0.037	1.073HisGlu: 1.073 ± 0.035	0.858HisPhe: 0.858 ± 0.029	1.915HisGly: 1.915 ± 0.049	0.527HisHis: 0.527 ± 0.024	0.879HisIle: 0.879 ± 0.028	0.547HisLys: 0.547 ± 0.023	1.763HisLeu: 1.763 ± 0.052	0.49HisMet: 0.49 ± 0.024	0.459HisAsn: 0.459 ± 0.024	1.264HisPro: 1.264 ± 0.039	0.487HisGln: 0.487 ± 0.021	1.323HisArg: 1.323 ± 0.038	1.033HisSer: 1.033 ± 0.034	0.723HisThr: 0.723 ± 0.029	1.354HisVal: 1.354 ± 0.039	0.395HisTrp: 0.395 ± 0.023	0.577HisTyr: 0.577 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.382IleAla: 7.382 ± 0.1	0.466IleCys: 0.466 ± 0.022	3.623IleAsp: 3.623 ± 0.068	3.626IleGlu: 3.626 ± 0.065	1.644IlePhe: 1.644 ± 0.041	4.864IleGly: 4.864 ± 0.08	0.878IleHis: 0.878 ± 0.033	1.808IleIle: 1.808 ± 0.051	1.248IleLys: 1.248 ± 0.034	3.848IleLeu: 3.848 ± 0.071	0.921IleMet: 0.921 ± 0.034	1.336IleAsn: 1.336 ± 0.042	2.3IlePro: 2.3 ± 0.051	1.116IleGln: 1.116 ± 0.039	3.16IleArg: 3.16 ± 0.063	2.775IleSer: 2.775 ± 0.056	2.597IleThr: 2.597 ± 0.057	4.048IleVal: 4.048 ± 0.068	0.594IleTrp: 0.594 ± 0.023	1.098IleTyr: 1.098 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.399LysAla: 4.399 ± 0.073	0.184LysCys: 0.184 ± 0.012	1.761LysAsp: 1.761 ± 0.045	1.681LysGlu: 1.681 ± 0.046	0.991LysPhe: 0.991 ± 0.03	3.05LysGly: 3.05 ± 0.064	0.606LysHis: 0.606 ± 0.03	1.609LysIle: 1.609 ± 0.048	1.214LysLys: 1.214 ± 0.044	3.508LysLeu: 3.508 ± 0.06	0.795LysMet: 0.795 ± 0.032	0.82LysAsn: 0.82 ± 0.03	2.131LysPro: 2.131 ± 0.046	1.067LysGln: 1.067 ± 0.035	2.277LysArg: 2.277 ± 0.052	1.688LysSer: 1.688 ± 0.044	1.665LysThr: 1.665 ± 0.039	2.559LysVal: 2.559 ± 0.056	0.491LysTrp: 0.491 ± 0.021	0.661LysTyr: 0.661 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	14.172LeuAla: 14.172 ± 0.149	0.799LeuCys: 0.799 ± 0.031	6.077LeuAsp: 6.077 ± 0.094	5.52LeuGlu: 5.52 ± 0.088	3.509LeuPhe: 3.509 ± 0.067	8.519LeuGly: 8.519 ± 0.102	1.757LeuHis: 1.757 ± 0.043	4.484LeuIle: 4.484 ± 0.086	3.271LeuLys: 3.271 ± 0.062	9.268LeuLeu: 9.268 ± 0.126	2.129LeuMet: 2.129 ± 0.051	2.373LeuAsn: 2.373 ± 0.05	5.513LeuPro: 5.513 ± 0.08	2.571LeuGln: 2.571 ± 0.049	6.502LeuArg: 6.502 ± 0.103	6.049LeuSer: 6.049 ± 0.068	5.424LeuThr: 5.424 ± 0.08	7.03LeuVal: 7.03 ± 0.105	1.196LeuTrp: 1.196 ± 0.042	1.992LeuTyr: 1.992 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.373MetAla: 3.373 ± 0.07	0.167MetCys: 0.167 ± 0.012	1.253MetAsp: 1.253 ± 0.04	1.304MetGlu: 1.304 ± 0.04	0.713MetPhe: 0.713 ± 0.03	2.127MetGly: 2.127 ± 0.051	0.445MetHis: 0.445 ± 0.02	1.252MetIle: 1.252 ± 0.038	1.008MetLys: 1.008 ± 0.036	2.63MetLeu: 2.63 ± 0.055	0.618MetMet: 0.618 ± 0.028	0.73MetAsn: 0.73 ± 0.026	1.498MetPro: 1.498 ± 0.038	0.824MetGln: 0.824 ± 0.028	1.779MetArg: 1.779 ± 0.05	1.512MetSer: 1.512 ± 0.041	1.539MetThr: 1.539 ± 0.043	1.667MetVal: 1.667 ± 0.044	0.24MetTrp: 0.24 ± 0.017	0.284MetTyr: 0.284 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.335AsnAla: 3.335 ± 0.072	0.267AsnCys: 0.267 ± 0.016	1.417AsnAsp: 1.417 ± 0.04	1.307AsnGlu: 1.307 ± 0.036	1.041AsnPhe: 1.041 ± 0.038	2.63AsnGly: 2.63 ± 0.067	0.45AsnHis: 0.45 ± 0.024	1.337AsnIle: 1.337 ± 0.039	0.673AsnLys: 0.673 ± 0.027	2.593AsnLeu: 2.593 ± 0.054	0.615AsnMet: 0.615 ± 0.027	0.794AsnAsn: 0.794 ± 0.037	1.901AsnPro: 1.901 ± 0.047	0.768AsnGln: 0.768 ± 0.03	1.907AsnArg: 1.907 ± 0.049	1.614AsnSer: 1.614 ± 0.056	1.256AsnThr: 1.256 ± 0.05	1.984AsnVal: 1.984 ± 0.067	0.47AsnTrp: 0.47 ± 0.024	0.802AsnTyr: 0.802 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	6.785ProAla: 6.785 ± 0.103	0.372ProCys: 0.372 ± 0.022	3.676ProAsp: 3.676 ± 0.063	4.01ProGlu: 4.01 ± 0.069	1.912ProPhe: 1.912 ± 0.042	4.825ProGly: 4.825 ± 0.074	0.949ProHis: 0.949 ± 0.035	2.247ProIle: 2.247 ± 0.051	1.602ProLys: 1.602 ± 0.042	4.936ProLeu: 4.936 ± 0.075	1.163ProMet: 1.163 ± 0.03	1.354ProAsn: 1.354 ± 0.038	2.633ProPro: 2.633 ± 0.061	1.825ProGln: 1.825 ± 0.044	2.918ProArg: 2.918 ± 0.058	2.687ProSer: 2.687 ± 0.056	2.307ProThr: 2.307 ± 0.059	4.219ProVal: 4.219 ± 0.07	0.658ProTrp: 0.658 ± 0.028	1.139ProTyr: 1.139 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.155GlnAla: 4.155 ± 0.08	0.236GlnCys: 0.236 ± 0.016	1.589GlnAsp: 1.589 ± 0.041	1.612GlnGlu: 1.612 ± 0.039	1.12GlnPhe: 1.12 ± 0.032	2.718GlnGly: 2.718 ± 0.053	0.632GlnHis: 0.632 ± 0.028	1.752GlnIle: 1.752 ± 0.049	0.973GlnLys: 0.973 ± 0.031	3.203GlnLeu: 3.203 ± 0.056	0.885GlnMet: 0.885 ± 0.034	0.76GlnAsn: 0.76 ± 0.027	1.771GlnPro: 1.771 ± 0.045	1.201GlnGln: 1.201 ± 0.048	2.319GlnArg: 2.319 ± 0.056	1.723GlnSer: 1.723 ± 0.045	1.602GlnThr: 1.602 ± 0.046	2.307GlnVal: 2.307 ± 0.05	0.504GlnTrp: 0.504 ± 0.023	0.674GlnTyr: 0.674 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.724ArgAla: 7.724 ± 0.104	0.492ArgCys: 0.492 ± 0.02	3.775ArgAsp: 3.775 ± 0.068	4.376ArgGlu: 4.376 ± 0.078	2.925ArgPhe: 2.925 ± 0.064	4.656ArgGly: 4.656 ± 0.07	1.533ArgHis: 1.533 ± 0.044	3.97ArgIle: 3.97 ± 0.069	2.454ArgLys: 2.454 ± 0.052	7.53ArgLeu: 7.53 ± 0.114	1.852ArgMet: 1.852 ± 0.049	1.916ArgAsn: 1.916 ± 0.043	3.298ArgPro: 3.298 ± 0.066	2.451ArgGln: 2.451 ± 0.056	4.895ArgArg: 4.895 ± 0.091	3.462ArgSer: 3.462 ± 0.053	2.92ArgThr: 2.92 ± 0.053	4.373ArgVal: 4.373 ± 0.071	1.062ArgTrp: 1.062 ± 0.033	1.724ArgTyr: 1.724 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.735SerAla: 6.735 ± 0.102	0.468SerCys: 0.468 ± 0.023	3.109SerAsp: 3.109 ± 0.064	2.865SerGlu: 2.865 ± 0.055	2.24SerPhe: 2.24 ± 0.052	5.928SerGly: 5.928 ± 0.107	1.057SerHis: 1.057 ± 0.035	2.631SerIle: 2.631 ± 0.063	1.494SerLys: 1.494 ± 0.042	5.38SerLeu: 5.38 ± 0.071	1.259SerMet: 1.259 ± 0.037	1.443SerAsn: 1.443 ± 0.044	2.863SerPro: 2.863 ± 0.053	1.699SerGln: 1.699 ± 0.045	3.546SerArg: 3.546 ± 0.065	3.05SerSer: 3.05 ± 0.074	2.619SerThr: 2.619 ± 0.059	3.773SerVal: 3.773 ± 0.07	0.839SerTrp: 0.839 ± 0.029	1.451SerTyr: 1.451 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.898ThrAla: 5.898 ± 0.116	0.405ThrCys: 0.405 ± 0.022	2.869ThrAsp: 2.869 ± 0.059	2.444ThrGlu: 2.444 ± 0.05	1.777ThrPhe: 1.777 ± 0.044	5.43ThrGly: 5.43 ± 0.094	0.933ThrHis: 0.933 ± 0.03	2.811ThrIle: 2.811 ± 0.066	1.339ThrLys: 1.339 ± 0.039	5.395ThrLeu: 5.395 ± 0.075	1.19ThrMet: 1.19 ± 0.033	1.38ThrAsn: 1.38 ± 0.048	3.171ThrPro: 3.171 ± 0.07	1.465ThrGln: 1.465 ± 0.04	3.105ThrArg: 3.105 ± 0.065	2.844ThrSer: 2.844 ± 0.066	2.494ThrThr: 2.494 ± 0.065	4.019ThrVal: 4.019 ± 0.072	0.58ThrTrp: 0.58 ± 0.027	1.388ThrTyr: 1.388 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	8.594ValAla: 8.594 ± 0.105	0.572ValCys: 0.572 ± 0.023	4.293ValAsp: 4.293 ± 0.075	4.726ValGlu: 4.726 ± 0.084	2.277ValPhe: 2.277 ± 0.048	5.455ValGly: 5.455 ± 0.094	1.251ValHis: 1.251 ± 0.035	3.697ValIle: 3.697 ± 0.067	2.339ValLys: 2.339 ± 0.051	6.849ValLeu: 6.849 ± 0.101	1.746ValMet: 1.746 ± 0.045	2.011ValAsn: 2.011 ± 0.054	3.923ValPro: 3.923 ± 0.064	2.074ValGln: 2.074 ± 0.041	4.387ValArg: 4.387 ± 0.063	4.28ValSer: 4.28 ± 0.08	4.501ValThr: 4.501 ± 0.086	5.117ValVal: 5.117 ± 0.085	0.881ValTrp: 0.881 ± 0.031	1.372ValTyr: 1.372 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.376TrpAla: 1.376 ± 0.038	0.162TrpCys: 0.162 ± 0.012	0.746TrpAsp: 0.746 ± 0.028	0.713TrpGlu: 0.713 ± 0.028	0.578TrpPhe: 0.578 ± 0.026	1.046TrpGly: 1.046 ± 0.035	0.385TrpHis: 0.385 ± 0.02	0.683TrpIle: 0.683 ± 0.03	0.516TrpLys: 0.516 ± 0.021	1.729TrpLeu: 1.729 ± 0.047	0.379TrpMet: 0.379 ± 0.021	0.528TrpAsn: 0.528 ± 0.026	0.722TrpPro: 0.722 ± 0.03	0.668TrpGln: 0.668 ± 0.029	1.296TrpArg: 1.296 ± 0.042	0.875TrpSer: 0.875 ± 0.032	0.741TrpThr: 0.741 ± 0.029	0.829TrpVal: 0.829 ± 0.033	0.249TrpTrp: 0.249 ± 0.016	0.34TrpTyr: 0.34 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.718TyrAla: 2.718 ± 0.058	0.248TyrCys: 0.248 ± 0.015	1.703TyrAsp: 1.703 ± 0.065	1.338TyrGlu: 1.338 ± 0.037	0.953TyrPhe: 0.953 ± 0.031	2.251TyrGly: 2.251 ± 0.061	0.456TyrHis: 0.456 ± 0.025	0.913TyrIle: 0.913 ± 0.031	0.638TyrLys: 0.638 ± 0.028	2.121TyrLeu: 2.121 ± 0.046	0.431TyrMet: 0.431 ± 0.021	0.741TyrAsn: 0.741 ± 0.04	1.09TyrPro: 1.09 ± 0.034	0.72TyrGln: 0.72 ± 0.029	1.851TyrArg: 1.851 ± 0.042	1.459TyrSer: 1.459 ± 0.045	1.151TyrThr: 1.151 ± 0.051	1.602TyrVal: 1.602 ± 0.039	0.348TyrTrp: 0.348 ± 0.022	0.724TyrTyr: 0.724 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3133 proteins (991649 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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