Amino acid dipepetide frequency for Cohaesibacter sp. ES.047

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.438AlaAla: 11.438 ± 0.116	1.054AlaCys: 1.054 ± 0.031	6.045AlaAsp: 6.045 ± 0.077	6.667AlaGlu: 6.667 ± 0.081	4.228AlaPhe: 4.228 ± 0.062	7.909AlaGly: 7.909 ± 0.083	2.048AlaHis: 2.048 ± 0.039	6.622AlaIle: 6.622 ± 0.072	4.688AlaLys: 4.688 ± 0.069	11.42AlaLeu: 11.42 ± 0.107	3.331AlaMet: 3.331 ± 0.048	3.227AlaAsn: 3.227 ± 0.054	4.196AlaPro: 4.196 ± 0.062	3.526AlaGln: 3.526 ± 0.06	6.165AlaArg: 6.165 ± 0.07	6.546AlaSer: 6.546 ± 0.074	5.227AlaThr: 5.227 ± 0.066	7.119AlaVal: 7.119 ± 0.068	1.123AlaTrp: 1.123 ± 0.03	2.424AlaTyr: 2.424 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.914CysAla: 0.914 ± 0.026	0.125CysCys: 0.125 ± 0.011	0.592CysAsp: 0.592 ± 0.02	0.588CysGlu: 0.588 ± 0.022	0.392CysPhe: 0.392 ± 0.017	0.918CysGly: 0.918 ± 0.026	0.282CysHis: 0.282 ± 0.016	0.477CysIle: 0.477 ± 0.02	0.325CysLys: 0.325 ± 0.015	1.046CysLeu: 1.046 ± 0.026	0.198CysMet: 0.198 ± 0.012	0.28CysAsn: 0.28 ± 0.016	0.47CysPro: 0.47 ± 0.021	0.314CysGln: 0.314 ± 0.016	0.562CysArg: 0.562 ± 0.023	0.606CysSer: 0.606 ± 0.019	0.456CysThr: 0.456 ± 0.02	0.614CysVal: 0.614 ± 0.021	0.12CysTrp: 0.12 ± 0.011	0.241CysTyr: 0.241 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.131AspAla: 6.131 ± 0.079	0.582AspCys: 0.582 ± 0.021	3.515AspAsp: 3.515 ± 0.067	4.089AspGlu: 4.089 ± 0.059	2.391AspPhe: 2.391 ± 0.044	5.015AspGly: 5.015 ± 0.073	1.517AspHis: 1.517 ± 0.037	3.761AspIle: 3.761 ± 0.053	2.515AspLys: 2.515 ± 0.05	6.441AspLeu: 6.441 ± 0.08	1.685AspMet: 1.685 ± 0.034	1.747AspAsn: 1.747 ± 0.034	3.217AspPro: 3.217 ± 0.048	2.155AspGln: 2.155 ± 0.045	3.807AspArg: 3.807 ± 0.054	2.507AspSer: 2.507 ± 0.047	2.684AspThr: 2.684 ± 0.05	4.194AspVal: 4.194 ± 0.054	0.99AspTrp: 0.99 ± 0.029	1.749AspTyr: 1.749 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.571GluAla: 7.571 ± 0.091	0.451GluCys: 0.451 ± 0.019	3.623GluAsp: 3.623 ± 0.05	4.216GluGlu: 4.216 ± 0.066	1.929GluPhe: 1.929 ± 0.039	4.456GluGly: 4.456 ± 0.057	1.274GluHis: 1.274 ± 0.028	3.882GluIle: 3.882 ± 0.053	3.125GluLys: 3.125 ± 0.047	5.689GluLeu: 5.689 ± 0.075	1.849GluMet: 1.849 ± 0.037	2.036GluAsn: 2.036 ± 0.042	2.569GluPro: 2.569 ± 0.048	2.616GluGln: 2.616 ± 0.053	4.152GluArg: 4.152 ± 0.056	2.711GluSer: 2.711 ± 0.048	3.84GluThr: 3.84 ± 0.055	3.915GluVal: 3.915 ± 0.059	0.713GluTrp: 0.713 ± 0.022	1.021GluTyr: 1.021 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.154PheAla: 4.154 ± 0.064	0.488PheCys: 0.488 ± 0.019	2.842PheAsp: 2.842 ± 0.049	2.458PheGlu: 2.458 ± 0.043	1.615PhePhe: 1.615 ± 0.045	3.615PheGly: 3.615 ± 0.057	0.798PheHis: 0.798 ± 0.023	2.093PheIle: 2.093 ± 0.044	1.417PheLys: 1.417 ± 0.033	3.716PheLeu: 3.716 ± 0.055	0.993PheMet: 0.993 ± 0.027	1.237PheAsn: 1.237 ± 0.03	1.505PhePro: 1.505 ± 0.036	1.094PheGln: 1.094 ± 0.027	1.981PheArg: 1.981 ± 0.035	2.698PheSer: 2.698 ± 0.046	1.932PheThr: 1.932 ± 0.043	2.891PheVal: 2.891 ± 0.046	0.582PheTrp: 0.582 ± 0.024	1.0PheTyr: 1.0 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	7.395GlyAla: 7.395 ± 0.087	0.859GlyCys: 0.859 ± 0.029	4.281GlyAsp: 4.281 ± 0.053	4.634GlyGlu: 4.634 ± 0.063	3.504GlyPhe: 3.504 ± 0.056	6.064GlyGly: 6.064 ± 0.1	1.816GlyHis: 1.816 ± 0.036	4.856GlyIle: 4.856 ± 0.064	3.817GlyLys: 3.817 ± 0.061	8.567GlyLeu: 8.567 ± 0.089	2.339GlyMet: 2.339 ± 0.041	2.397GlyAsn: 2.397 ± 0.043	2.89GlyPro: 2.89 ± 0.045	2.731GlyGln: 2.731 ± 0.051	4.577GlyArg: 4.577 ± 0.066	4.776GlySer: 4.776 ± 0.065	4.248GlyThr: 4.248 ± 0.067	5.558GlyVal: 5.558 ± 0.068	1.22GlyTrp: 1.22 ± 0.03	2.313GlyTyr: 2.313 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	1.934HisAla: 1.934 ± 0.041	0.272HisCys: 0.272 ± 0.015	1.268HisAsp: 1.268 ± 0.034	1.182HisGlu: 1.182 ± 0.037	0.97HisPhe: 0.97 ± 0.026	1.789HisGly: 1.789 ± 0.034	0.604HisHis: 0.604 ± 0.025	1.198HisIle: 1.198 ± 0.03	0.776HisLys: 0.776 ± 0.023	2.137HisLeu: 2.137 ± 0.041	0.63HisMet: 0.63 ± 0.022	0.601HisAsn: 0.601 ± 0.018	1.328HisPro: 1.328 ± 0.03	0.736HisGln: 0.736 ± 0.025	1.271HisArg: 1.271 ± 0.028	1.169HisSer: 1.169 ± 0.027	0.891HisThr: 0.891 ± 0.025	1.44HisVal: 1.44 ± 0.032	0.322HisTrp: 0.322 ± 0.015	0.62HisTyr: 0.62 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.105IleAla: 7.105 ± 0.077	0.695IleCys: 0.695 ± 0.024	4.052IleAsp: 4.052 ± 0.05	4.178IleGlu: 4.178 ± 0.057	2.096IlePhe: 2.096 ± 0.046	5.169IleGly: 5.169 ± 0.065	1.086IleHis: 1.086 ± 0.029	3.095IleIle: 3.095 ± 0.062	2.375IleLys: 2.375 ± 0.039	5.708IleLeu: 5.708 ± 0.067	1.364IleMet: 1.364 ± 0.035	1.916IleAsn: 1.916 ± 0.04	2.597IlePro: 2.597 ± 0.046	1.467IleGln: 1.467 ± 0.028	3.248IleArg: 3.248 ± 0.052	4.014IleSer: 4.014 ± 0.055	3.084IleThr: 3.084 ± 0.052	4.236IleVal: 4.236 ± 0.064	0.726IleTrp: 0.726 ± 0.022	1.391IleTyr: 1.391 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	5.241LysAla: 5.241 ± 0.078	0.257LysCys: 0.257 ± 0.013	2.688LysAsp: 2.688 ± 0.049	2.59LysGlu: 2.59 ± 0.042	1.149LysPhe: 1.149 ± 0.033	3.484LysGly: 3.484 ± 0.054	0.845LysHis: 0.845 ± 0.024	2.342LysIle: 2.342 ± 0.045	2.162LysLys: 2.162 ± 0.049	4.07LysLeu: 4.07 ± 0.057	1.181LysMet: 1.181 ± 0.029	1.261LysAsn: 1.261 ± 0.03	2.357LysPro: 2.357 ± 0.045	1.583LysGln: 1.583 ± 0.038	2.874LysArg: 2.874 ± 0.045	2.756LysSer: 2.756 ± 0.046	2.614LysThr: 2.614 ± 0.045	2.963LysVal: 2.963 ± 0.044	0.484LysTrp: 0.484 ± 0.02	0.827LysTyr: 0.827 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	10.932LeuAla: 10.932 ± 0.108	1.013LeuCys: 1.013 ± 0.029	6.386LeuAsp: 6.386 ± 0.077	5.957LeuGlu: 5.957 ± 0.066	4.079LeuPhe: 4.079 ± 0.061	7.699LeuGly: 7.699 ± 0.082	1.846LeuHis: 1.846 ± 0.032	5.901LeuIle: 5.901 ± 0.074	4.639LeuLys: 4.639 ± 0.052	9.625LeuLeu: 9.625 ± 0.125	2.78LeuMet: 2.78 ± 0.047	3.131LeuAsn: 3.131 ± 0.051	4.872LeuPro: 4.872 ± 0.067	2.926LeuGln: 2.926 ± 0.044	5.499LeuArg: 5.499 ± 0.074	7.583LeuSer: 7.583 ± 0.082	5.47LeuThr: 5.47 ± 0.066	7.19LeuVal: 7.19 ± 0.08	1.077LeuTrp: 1.077 ± 0.03	2.247LeuTyr: 2.247 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.181MetAla: 3.181 ± 0.045	0.163MetCys: 0.163 ± 0.009	1.45MetAsp: 1.45 ± 0.032	1.506MetGlu: 1.506 ± 0.035	0.785MetPhe: 0.785 ± 0.026	2.043MetGly: 2.043 ± 0.046	0.537MetHis: 0.537 ± 0.02	1.74MetIle: 1.74 ± 0.038	1.294MetLys: 1.294 ± 0.034	2.765MetLeu: 2.765 ± 0.049	0.824MetMet: 0.824 ± 0.025	0.913MetAsn: 0.913 ± 0.024	1.522MetPro: 1.522 ± 0.036	1.002MetGln: 1.002 ± 0.026	1.799MetArg: 1.799 ± 0.035	2.009MetSer: 2.009 ± 0.035	2.08MetThr: 2.08 ± 0.038	2.0MetVal: 2.0 ± 0.039	0.196MetTrp: 0.196 ± 0.011	0.354MetTyr: 0.354 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.294AsnAla: 3.294 ± 0.053	0.324AsnCys: 0.324 ± 0.02	1.734AsnAsp: 1.734 ± 0.038	1.842AsnGlu: 1.842 ± 0.036	1.141AsnPhe: 1.141 ± 0.026	2.753AsnGly: 2.753 ± 0.056	0.698AsnHis: 0.698 ± 0.024	1.696AsnIle: 1.696 ± 0.039	1.352AsnLys: 1.352 ± 0.034	3.098AsnLeu: 3.098 ± 0.05	0.822AsnMet: 0.822 ± 0.024	1.084AsnAsn: 1.084 ± 0.04	1.92AsnPro: 1.92 ± 0.039	1.083AsnGln: 1.083 ± 0.026	2.004AsnArg: 2.004 ± 0.042	1.749AsnSer: 1.749 ± 0.038	1.401AsnThr: 1.401 ± 0.034	2.075AsnVal: 2.075 ± 0.044	0.524AsnTrp: 0.524 ± 0.019	0.777AsnTyr: 0.777 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.291ProAla: 4.291 ± 0.065	0.372ProCys: 0.372 ± 0.017	3.583ProAsp: 3.583 ± 0.05	3.442ProGlu: 3.442 ± 0.056	2.06ProPhe: 2.06 ± 0.04	3.305ProGly: 3.305 ± 0.047	1.018ProHis: 1.018 ± 0.029	2.643ProIle: 2.643 ± 0.054	1.991ProLys: 1.991 ± 0.04	4.237ProLeu: 4.237 ± 0.057	1.198ProMet: 1.198 ± 0.031	1.494ProAsn: 1.494 ± 0.032	1.813ProPro: 1.813 ± 0.045	1.598ProGln: 1.598 ± 0.034	2.147ProArg: 2.147 ± 0.044	2.943ProSer: 2.943 ± 0.046	2.34ProThr: 2.34 ± 0.044	3.651ProVal: 3.651 ± 0.051	0.58ProTrp: 0.58 ± 0.023	1.195ProTyr: 1.195 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.667GlnAla: 3.667 ± 0.061	0.238GlnCys: 0.238 ± 0.013	1.808GlnAsp: 1.808 ± 0.037	1.753GlnGlu: 1.753 ± 0.035	1.23GlnPhe: 1.23 ± 0.025	2.275GlnGly: 2.275 ± 0.04	0.681GlnHis: 0.681 ± 0.023	2.266GlnIle: 2.266 ± 0.039	1.541GlnLys: 1.541 ± 0.034	3.119GlnLeu: 3.119 ± 0.056	1.117GlnMet: 1.117 ± 0.029	1.109GlnAsn: 1.109 ± 0.03	1.573GlnPro: 1.573 ± 0.034	1.477GlnGln: 1.477 ± 0.043	2.082GlnArg: 2.082 ± 0.038	2.432GlnSer: 2.432 ± 0.046	2.169GlnThr: 2.169 ± 0.044	2.198GlnVal: 2.198 ± 0.045	0.422GlnTrp: 0.422 ± 0.016	0.669GlnTyr: 0.669 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	5.539ArgAla: 5.539 ± 0.066	0.485ArgCys: 0.485 ± 0.019	3.451ArgAsp: 3.451 ± 0.052	3.497ArgGlu: 3.497 ± 0.047	2.509ArgPhe: 2.509 ± 0.044	3.681ArgGly: 3.681 ± 0.056	1.417ArgHis: 1.417 ± 0.033	3.695ArgIle: 3.695 ± 0.052	2.768ArgLys: 2.768 ± 0.051	6.447ArgLeu: 6.447 ± 0.085	1.71ArgMet: 1.71 ± 0.034	2.009ArgAsn: 2.009 ± 0.04	2.58ArgPro: 2.58 ± 0.045	2.386ArgGln: 2.386 ± 0.047	3.881ArgArg: 3.881 ± 0.068	3.819ArgSer: 3.819 ± 0.048	2.887ArgThr: 2.887 ± 0.046	3.862ArgVal: 3.862 ± 0.052	0.757ArgTrp: 0.757 ± 0.024	1.504ArgTyr: 1.504 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.065SerAla: 6.065 ± 0.067	0.545SerCys: 0.545 ± 0.024	3.862SerAsp: 3.862 ± 0.049	3.777SerGlu: 3.777 ± 0.053	2.718SerPhe: 2.718 ± 0.053	5.699SerGly: 5.699 ± 0.072	1.351SerHis: 1.351 ± 0.034	3.69SerIle: 3.69 ± 0.054	2.629SerLys: 2.629 ± 0.047	6.471SerLeu: 6.471 ± 0.074	1.794SerMet: 1.794 ± 0.037	2.042SerAsn: 2.042 ± 0.041	2.713SerPro: 2.713 ± 0.044	2.088SerGln: 2.088 ± 0.041	3.492SerArg: 3.492 ± 0.057	3.974SerSer: 3.974 ± 0.069	2.993SerThr: 2.993 ± 0.052	4.355SerVal: 4.355 ± 0.062	0.792SerTrp: 0.792 ± 0.023	1.618SerTyr: 1.618 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.272ThrAla: 5.272 ± 0.06	0.491ThrCys: 0.491 ± 0.02	3.079ThrAsp: 3.079 ± 0.057	2.994ThrGlu: 2.994 ± 0.052	2.009ThrPhe: 2.009 ± 0.033	4.741ThrGly: 4.741 ± 0.058	1.094ThrHis: 1.094 ± 0.026	3.489ThrIle: 3.489 ± 0.049	2.093ThrLys: 2.093 ± 0.039	5.66ThrLeu: 5.66 ± 0.065	1.425ThrMet: 1.425 ± 0.032	1.633ThrAsn: 1.633 ± 0.037	2.807ThrPro: 2.807 ± 0.05	1.573ThrGln: 1.573 ± 0.033	2.911ThrArg: 2.911 ± 0.045	3.313ThrSer: 3.313 ± 0.051	2.716ThrThr: 2.716 ± 0.051	3.905ThrVal: 3.905 ± 0.06	0.574ThrTrp: 0.574 ± 0.02	1.292ThrTyr: 1.292 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	7.559ValAla: 7.559 ± 0.076	0.682ValCys: 0.682 ± 0.022	4.159ValAsp: 4.159 ± 0.061	4.326ValGlu: 4.326 ± 0.063	2.728ValPhe: 2.728 ± 0.045	5.321ValGly: 5.321 ± 0.069	1.309ValHis: 1.309 ± 0.028	4.331ValIle: 4.331 ± 0.061	2.852ValLys: 2.852 ± 0.051	6.679ValLeu: 6.679 ± 0.078	2.004ValMet: 2.004 ± 0.038	2.126ValAsn: 2.126 ± 0.035	3.258ValPro: 3.258 ± 0.055	1.992ValGln: 1.992 ± 0.041	3.939ValArg: 3.939 ± 0.049	4.748ValSer: 4.748 ± 0.058	4.251ValThr: 4.251 ± 0.053	5.145ValVal: 5.145 ± 0.068	0.847ValTrp: 0.847 ± 0.028	1.48ValTyr: 1.48 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.044TrpAla: 1.044 ± 0.028	0.124TrpCys: 0.124 ± 0.01	0.691TrpAsp: 0.691 ± 0.026	0.56TrpGlu: 0.56 ± 0.022	0.547TrpPhe: 0.547 ± 0.02	0.834TrpGly: 0.834 ± 0.025	0.335TrpHis: 0.335 ± 0.016	0.721TrpIle: 0.721 ± 0.024	0.502TrpLys: 0.502 ± 0.019	1.532TrpLeu: 1.532 ± 0.035	0.372TrpMet: 0.372 ± 0.016	0.41TrpAsn: 0.41 ± 0.016	0.62TrpPro: 0.62 ± 0.023	0.632TrpGln: 0.632 ± 0.022	0.881TrpArg: 0.881 ± 0.026	0.834TrpSer: 0.834 ± 0.024	0.683TrpThr: 0.683 ± 0.023	0.803TrpVal: 0.803 ± 0.028	0.201TrpTrp: 0.201 ± 0.012	0.271TrpTyr: 0.271 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.278TyrAla: 2.278 ± 0.045	0.3TyrCys: 0.3 ± 0.015	1.581TyrAsp: 1.581 ± 0.033	1.382TyrGlu: 1.382 ± 0.031	1.03TyrPhe: 1.03 ± 0.027	2.075TyrGly: 2.075 ± 0.038	0.581TyrHis: 0.581 ± 0.02	1.103TyrIle: 1.103 ± 0.028	0.869TyrLys: 0.869 ± 0.029	2.426TyrLeu: 2.426 ± 0.045	0.545TyrMet: 0.545 ± 0.021	0.718TyrAsn: 0.718 ± 0.023	1.094TyrPro: 1.094 ± 0.029	0.845TyrGln: 0.845 ± 0.024	1.609TyrArg: 1.609 ± 0.037	1.48TyrSer: 1.48 ± 0.032	1.106TyrThr: 1.106 ± 0.034	1.623TyrVal: 1.623 ± 0.036	0.346TyrTrp: 0.346 ± 0.015	0.663TyrTyr: 0.663 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4413 proteins (1404519 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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