Amino acid dipepetide frequency for Canine papillomavirus 22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.736AlaAla: 5.736 ± 0.96
1.912AlaCys: 1.912 ± 1.16
3.824AlaAsp: 3.824 ± 1.422
4.971AlaGlu: 4.971 ± 1.214
2.677AlaPhe: 2.677 ± 0.528
2.294AlaGly: 2.294 ± 0.765
1.912AlaHis: 1.912 ± 0.566
3.442AlaIle: 3.442 ± 1.053
4.589AlaLys: 4.589 ± 1.639
5.354AlaLeu: 5.354 ± 1.61
0.0AlaMet: 0.0 ± 0.0
2.677AlaAsn: 2.677 ± 0.71
5.736AlaPro: 5.736 ± 2.024
1.912AlaGln: 1.912 ± 0.965
3.059AlaArg: 3.059 ± 0.739
6.119AlaSer: 6.119 ± 1.456
3.059AlaThr: 3.059 ± 1.69
3.059AlaVal: 3.059 ± 0.738
0.382AlaTrp: 0.382 ± 0.315
1.53AlaTyr: 1.53 ± 0.391
0.0AlaXaa: 0.0 ± 0.0
Cys
2.677CysAla: 2.677 ± 1.299
1.912CysCys: 1.912 ± 1.22
1.53CysAsp: 1.53 ± 0.858
0.382CysGlu: 0.382 ± 0.329
1.912CysPhe: 1.912 ± 0.965
0.382CysGly: 0.382 ± 0.442
0.382CysHis: 0.382 ± 0.329
1.912CysIle: 1.912 ± 1.208
1.912CysLys: 1.912 ± 0.807
2.294CysLeu: 2.294 ± 0.937
0.382CysMet: 0.382 ± 0.329
1.147CysAsn: 1.147 ± 0.465
1.147CysPro: 1.147 ± 0.688
1.912CysGln: 1.912 ± 0.501
1.912CysArg: 1.912 ± 0.941
1.147CysSer: 1.147 ± 0.728
1.147CysThr: 1.147 ± 0.487
0.382CysVal: 0.382 ± 0.442
1.147CysTrp: 1.147 ± 0.487
0.382CysTyr: 0.382 ± 0.329
0.0CysXaa: 0.0 ± 0.0
Asp
5.354AspAla: 5.354 ± 1.421
3.059AspCys: 3.059 ± 1.309
3.824AspAsp: 3.824 ± 1.345
4.971AspGlu: 4.971 ± 2.579
2.677AspPhe: 2.677 ± 0.467
4.207AspGly: 4.207 ± 1.585
0.765AspHis: 0.765 ± 0.396
3.824AspIle: 3.824 ± 1.678
1.912AspLys: 1.912 ± 0.41
5.736AspLeu: 5.736 ± 1.588
0.0AspMet: 0.0 ± 0.0
1.912AspAsn: 1.912 ± 0.715
7.266AspPro: 7.266 ± 1.916
2.294AspGln: 2.294 ± 0.787
3.059AspArg: 3.059 ± 1.878
4.207AspSer: 4.207 ± 1.222
4.589AspThr: 4.589 ± 1.281
3.442AspVal: 3.442 ± 1.245
1.53AspTrp: 1.53 ± 0.913
0.765AspTyr: 0.765 ± 0.338
0.0AspXaa: 0.0 ± 0.0
Glu
5.736GluAla: 5.736 ± 1.282
0.765GluCys: 0.765 ± 0.389
6.119GluAsp: 6.119 ± 2.328
9.178GluGlu: 9.178 ± 2.458
0.765GluPhe: 0.765 ± 0.49
5.354GluGly: 5.354 ± 1.714
0.765GluHis: 0.765 ± 0.615
1.147GluIle: 1.147 ± 0.689
3.059GluLys: 3.059 ± 1.666
4.207GluLeu: 4.207 ± 0.558
1.147GluMet: 1.147 ± 0.474
2.294GluAsn: 2.294 ± 0.61
3.824GluPro: 3.824 ± 0.817
4.207GluGln: 4.207 ± 1.423
3.059GluArg: 3.059 ± 1.472
4.207GluSer: 4.207 ± 1.097
3.059GluThr: 3.059 ± 0.738
3.059GluVal: 3.059 ± 1.401
0.765GluTrp: 0.765 ± 0.381
0.382GluTyr: 0.382 ± 0.299
0.0GluXaa: 0.0 ± 0.0
Phe
2.677PheAla: 2.677 ± 0.391
1.147PheCys: 1.147 ± 0.571
3.059PheAsp: 3.059 ± 0.972
3.442PheGlu: 3.442 ± 1.578
3.059PhePhe: 3.059 ± 0.856
4.207PheGly: 4.207 ± 0.941
0.382PheHis: 0.382 ± 0.315
2.677PheIle: 2.677 ± 0.979
2.294PheLys: 2.294 ± 1.548
5.354PheLeu: 5.354 ± 2.292
0.382PheMet: 0.382 ± 0.334
1.147PheAsn: 1.147 ± 0.334
1.912PhePro: 1.912 ± 0.442
1.53PheGln: 1.53 ± 0.635
0.765PheArg: 0.765 ± 0.396
2.294PheSer: 2.294 ± 0.647
1.147PheThr: 1.147 ± 0.387
2.294PheVal: 2.294 ± 1.051
0.765PheTrp: 0.765 ± 0.393
1.53PheTyr: 1.53 ± 0.829
0.0PheXaa: 0.0 ± 0.0
Gly
3.059GlyAla: 3.059 ± 0.697
1.53GlyCys: 1.53 ± 0.584
5.736GlyAsp: 5.736 ± 1.989
6.119GlyGlu: 6.119 ± 2.374
2.677GlyPhe: 2.677 ± 0.972
9.943GlyGly: 9.943 ± 2.639
1.147GlyHis: 1.147 ± 0.697
3.442GlyIle: 3.442 ± 0.946
2.677GlyLys: 2.677 ± 0.77
4.589GlyLeu: 4.589 ± 0.913
0.765GlyMet: 0.765 ± 0.658
2.677GlyAsn: 2.677 ± 1.099
8.031GlyPro: 8.031 ± 2.943
3.442GlyGln: 3.442 ± 0.795
10.707GlyArg: 10.707 ± 3.807
8.031GlySer: 8.031 ± 2.191
3.059GlyThr: 3.059 ± 1.332
1.53GlyVal: 1.53 ± 0.708
0.765GlyTrp: 0.765 ± 0.389
1.53GlyTyr: 1.53 ± 0.222
0.0GlyXaa: 0.0 ± 0.0
His
2.294HisAla: 2.294 ± 1.235
1.147HisCys: 1.147 ± 0.334
0.382HisAsp: 0.382 ± 0.329
0.765HisGlu: 0.765 ± 0.396
2.294HisPhe: 2.294 ± 0.647
1.147HisGly: 1.147 ± 0.525
0.765HisHis: 0.765 ± 0.564
0.0HisIle: 0.0 ± 0.0
0.765HisLys: 0.765 ± 0.761
1.147HisLeu: 1.147 ± 0.626
0.765HisMet: 0.765 ± 0.393
1.147HisAsn: 1.147 ± 0.607
1.53HisPro: 1.53 ± 1.418
1.147HisGln: 1.147 ± 0.657
1.912HisArg: 1.912 ± 0.575
2.294HisSer: 2.294 ± 0.427
2.677HisThr: 2.677 ± 0.845
1.147HisVal: 1.147 ± 0.387
0.382HisTrp: 0.382 ± 0.299
1.912HisTyr: 1.912 ± 0.762
0.0HisXaa: 0.0 ± 0.0
Ile
4.589IleAla: 4.589 ± 1.033
0.765IleCys: 0.765 ± 0.393
2.677IleAsp: 2.677 ± 1.566
1.147IleGlu: 1.147 ± 0.605
1.53IlePhe: 1.53 ± 1.025
4.589IleGly: 4.589 ± 1.529
0.765IleHis: 0.765 ± 0.481
1.147IleIle: 1.147 ± 1.064
1.147IleLys: 1.147 ± 0.646
2.677IleLeu: 2.677 ± 0.773
0.765IleMet: 0.765 ± 0.435
0.765IleAsn: 0.765 ± 0.393
1.912IlePro: 1.912 ± 0.875
0.382IleGln: 0.382 ± 0.299
0.765IleArg: 0.765 ± 0.477
2.294IleSer: 2.294 ± 0.92
2.294IleThr: 2.294 ± 0.668
2.294IleVal: 2.294 ± 0.814
1.147IleTrp: 1.147 ± 0.571
2.294IleTyr: 2.294 ± 0.486
0.0IleXaa: 0.0 ± 0.0
Lys
3.059LysAla: 3.059 ± 1.28
1.53LysCys: 1.53 ± 0.465
3.442LysAsp: 3.442 ± 1.004
2.677LysGlu: 2.677 ± 1.233
1.912LysPhe: 1.912 ± 1.022
1.912LysGly: 1.912 ± 0.682
2.294LysHis: 2.294 ± 0.915
1.53LysIle: 1.53 ± 0.47
2.677LysLys: 2.677 ± 0.877
3.824LysLeu: 3.824 ± 0.903
1.147LysMet: 1.147 ± 0.646
1.53LysAsn: 1.53 ± 0.952
0.765LysPro: 0.765 ± 0.465
3.059LysGln: 3.059 ± 1.168
5.736LysArg: 5.736 ± 1.5
4.207LysSer: 4.207 ± 2.045
1.912LysThr: 1.912 ± 0.752
2.677LysVal: 2.677 ± 1.067
0.765LysTrp: 0.765 ± 0.465
1.147LysTyr: 1.147 ± 0.624
0.0LysXaa: 0.0 ± 0.0
Leu
2.677LeuAla: 2.677 ± 0.6
0.765LeuCys: 0.765 ± 0.393
4.971LeuAsp: 4.971 ± 1.304
5.354LeuGlu: 5.354 ± 0.957
4.207LeuPhe: 4.207 ± 0.764
8.413LeuGly: 8.413 ± 1.18
3.059LeuHis: 3.059 ± 1.084
1.912LeuIle: 1.912 ± 0.939
5.354LeuLys: 5.354 ± 1.098
8.031LeuLeu: 8.031 ± 1.762
1.912LeuMet: 1.912 ± 0.975
2.677LeuAsn: 2.677 ± 1.097
4.207LeuPro: 4.207 ± 0.581
4.207LeuGln: 4.207 ± 1.084
4.971LeuArg: 4.971 ± 1.572
7.266LeuSer: 7.266 ± 2.002
3.442LeuThr: 3.442 ± 0.993
4.589LeuVal: 4.589 ± 1.485
0.0LeuTrp: 0.0 ± 0.0
3.442LeuTyr: 3.442 ± 0.738
0.0LeuXaa: 0.0 ± 0.0
Met
1.53MetAla: 1.53 ± 0.722
0.382MetCys: 0.382 ± 0.299
1.53MetAsp: 1.53 ± 0.581
0.382MetGlu: 0.382 ± 0.38
1.147MetPhe: 1.147 ± 0.624
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.765MetIle: 0.765 ± 0.472
1.147MetLys: 1.147 ± 0.324
1.147MetLeu: 1.147 ± 0.627
0.382MetMet: 0.382 ± 0.38
0.765MetAsn: 0.765 ± 0.598
0.765MetPro: 0.765 ± 0.629
1.147MetGln: 1.147 ± 0.324
1.147MetArg: 1.147 ± 0.657
1.53MetSer: 1.53 ± 0.449
0.765MetThr: 0.765 ± 0.629
0.765MetVal: 0.765 ± 0.629
0.382MetTrp: 0.382 ± 0.329
0.382MetTyr: 0.382 ± 0.329
0.0MetXaa: 0.0 ± 0.0
Asn
1.912AsnAla: 1.912 ± 0.897
1.147AsnCys: 1.147 ± 0.465
1.912AsnAsp: 1.912 ± 0.724
1.53AsnGlu: 1.53 ± 0.602
2.294AsnPhe: 2.294 ± 0.853
1.912AsnGly: 1.912 ± 0.711
0.765AsnHis: 0.765 ± 0.506
1.147AsnIle: 1.147 ± 0.624
2.294AsnLys: 2.294 ± 0.856
3.059AsnLeu: 3.059 ± 0.785
0.382AsnMet: 0.382 ± 0.287
1.147AsnAsn: 1.147 ± 0.898
3.824AsnPro: 3.824 ± 1.735
1.147AsnGln: 1.147 ± 0.683
1.912AsnArg: 1.912 ± 0.786
0.765AsnSer: 0.765 ± 0.465
3.059AsnThr: 3.059 ± 0.7
1.53AsnVal: 1.53 ± 0.222
0.382AsnTrp: 0.382 ± 0.299
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
6.501ProAla: 6.501 ± 1.983
1.912ProCys: 1.912 ± 0.616
6.883ProAsp: 6.883 ± 2.261
5.736ProGlu: 5.736 ± 1.755
3.442ProPhe: 3.442 ± 1.174
5.354ProGly: 5.354 ± 2.578
1.147ProHis: 1.147 ± 1.141
1.912ProIle: 1.912 ± 0.744
3.824ProLys: 3.824 ± 1.016
4.971ProLeu: 4.971 ± 1.178
0.765ProMet: 0.765 ± 0.393
1.147ProAsn: 1.147 ± 0.503
10.325ProPro: 10.325 ± 4.986
3.824ProGln: 3.824 ± 1.342
3.442ProArg: 3.442 ± 1.153
6.119ProSer: 6.119 ± 1.963
4.589ProThr: 4.589 ± 0.682
4.971ProVal: 4.971 ± 0.686
1.147ProTrp: 1.147 ± 0.658
1.147ProTyr: 1.147 ± 0.497
0.0ProXaa: 0.0 ± 0.0
Gln
2.294GlnAla: 2.294 ± 0.868
0.382GlnCys: 0.382 ± 0.389
4.207GlnAsp: 4.207 ± 1.263
2.677GlnGlu: 2.677 ± 0.783
1.53GlnPhe: 1.53 ± 0.829
3.824GlnGly: 3.824 ± 1.424
0.765GlnHis: 0.765 ± 0.393
1.53GlnIle: 1.53 ± 0.668
0.382GlnLys: 0.382 ± 0.299
4.207GlnLeu: 4.207 ± 1.478
2.294GlnMet: 2.294 ± 0.979
2.294GlnAsn: 2.294 ± 0.828
3.059GlnPro: 3.059 ± 1.41
2.677GlnGln: 2.677 ± 1.618
2.294GlnArg: 2.294 ± 0.676
3.059GlnSer: 3.059 ± 1.114
2.677GlnThr: 2.677 ± 0.892
2.294GlnVal: 2.294 ± 0.524
0.765GlnTrp: 0.765 ± 0.629
1.147GlnTyr: 1.147 ± 0.334
0.0GlnXaa: 0.0 ± 0.0
Arg
2.677ArgAla: 2.677 ± 1.175
3.059ArgCys: 3.059 ± 1.791
3.824ArgAsp: 3.824 ± 1.106
3.442ArgGlu: 3.442 ± 0.744
2.294ArgPhe: 2.294 ± 0.329
8.413ArgGly: 8.413 ± 5.316
3.059ArgHis: 3.059 ± 0.745
1.53ArgIle: 1.53 ± 0.533
3.824ArgLys: 3.824 ± 0.466
4.971ArgLeu: 4.971 ± 1.12
1.53ArgMet: 1.53 ± 0.87
1.912ArgAsn: 1.912 ± 1.195
4.971ArgPro: 4.971 ± 1.385
2.294ArgGln: 2.294 ± 0.701
8.413ArgArg: 8.413 ± 3.526
3.824ArgSer: 3.824 ± 0.646
2.677ArgThr: 2.677 ± 1.377
4.971ArgVal: 4.971 ± 1.465
0.0ArgTrp: 0.0 ± 0.0
0.382ArgTyr: 0.382 ± 0.329
0.0ArgXaa: 0.0 ± 0.0
Ser
5.354SerAla: 5.354 ± 1.515
1.147SerCys: 1.147 ± 0.646
2.294SerAsp: 2.294 ± 0.848
3.059SerGlu: 3.059 ± 0.444
3.442SerPhe: 3.442 ± 1.44
5.354SerGly: 5.354 ± 1.073
2.677SerHis: 2.677 ± 1.181
2.294SerIle: 2.294 ± 0.822
3.442SerLys: 3.442 ± 0.489
8.031SerLeu: 8.031 ± 1.452
0.765SerMet: 0.765 ± 0.598
1.53SerAsn: 1.53 ± 0.222
6.119SerPro: 6.119 ± 1.405
3.059SerGln: 3.059 ± 1.131
3.059SerArg: 3.059 ± 1.058
9.178SerSer: 9.178 ± 3.164
8.413SerThr: 8.413 ± 1.326
5.354SerVal: 5.354 ± 2.379
0.765SerTrp: 0.765 ± 0.389
1.147SerTyr: 1.147 ± 0.394
0.0SerXaa: 0.0 ± 0.0
Thr
1.147ThrAla: 1.147 ± 0.618
2.294ThrCys: 2.294 ± 0.882
3.059ThrAsp: 3.059 ± 0.867
1.912ThrGlu: 1.912 ± 0.904
1.912ThrPhe: 1.912 ± 0.383
7.266ThrGly: 7.266 ± 2.185
2.294ThrHis: 2.294 ± 0.749
1.53ThrIle: 1.53 ± 0.565
2.294ThrLys: 2.294 ± 1.164
6.119ThrLeu: 6.119 ± 1.585
1.53ThrMet: 1.53 ± 0.514
2.294ThrAsn: 2.294 ± 1.077
5.736ThrPro: 5.736 ± 0.773
2.294ThrGln: 2.294 ± 0.836
3.059ThrArg: 3.059 ± 0.673
4.207ThrSer: 4.207 ± 0.949
1.912ThrThr: 1.912 ± 0.613
4.207ThrVal: 4.207 ± 1.532
0.0ThrTrp: 0.0 ± 0.0
1.912ThrTyr: 1.912 ± 0.836
0.0ThrXaa: 0.0 ± 0.0
Val
3.442ValAla: 3.442 ± 0.823
0.765ValCys: 0.765 ± 0.508
3.442ValAsp: 3.442 ± 1.119
2.677ValGlu: 2.677 ± 0.534
0.765ValPhe: 0.765 ± 0.393
3.442ValGly: 3.442 ± 0.596
1.912ValHis: 1.912 ± 1.031
3.059ValIle: 3.059 ± 1.69
1.912ValLys: 1.912 ± 0.897
3.059ValLeu: 3.059 ± 0.93
0.382ValMet: 0.382 ± 0.315
1.912ValAsn: 1.912 ± 0.784
6.883ValPro: 6.883 ± 1.089
2.294ValGln: 2.294 ± 0.822
3.824ValArg: 3.824 ± 1.5
4.589ValSer: 4.589 ± 0.666
4.971ValThr: 4.971 ± 1.779
5.736ValVal: 5.736 ± 2.302
0.765ValTrp: 0.765 ± 0.396
0.765ValTyr: 0.765 ± 0.381
0.0ValXaa: 0.0 ± 0.0
Trp
0.765TrpAla: 0.765 ± 0.389
0.0TrpCys: 0.0 ± 0.0
0.382TrpAsp: 0.382 ± 0.299
0.382TrpGlu: 0.382 ± 0.329
0.765TrpPhe: 0.765 ± 0.393
1.53TrpGly: 1.53 ± 0.799
0.382TrpHis: 0.382 ± 0.355
0.765TrpIle: 0.765 ± 0.381
0.382TrpLys: 0.382 ± 0.442
1.53TrpLeu: 1.53 ± 0.937
0.0TrpMet: 0.0 ± 0.0
0.765TrpAsn: 0.765 ± 0.381
0.765TrpPro: 0.765 ± 0.381
0.382TrpGln: 0.382 ± 0.329
2.294TrpArg: 2.294 ± 0.701
0.382TrpSer: 0.382 ± 0.329
0.382TrpThr: 0.382 ± 0.329
1.53TrpVal: 1.53 ± 0.602
0.382TrpTrp: 0.382 ± 0.329
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.765TyrAla: 0.765 ± 0.393
0.382TyrCys: 0.382 ± 0.299
2.294TyrAsp: 2.294 ± 0.495
2.294TyrGlu: 2.294 ± 0.441
1.147TyrPhe: 1.147 ± 0.627
1.912TyrGly: 1.912 ± 0.558
0.382TyrHis: 0.382 ± 0.355
0.382TyrIle: 0.382 ± 0.299
1.912TyrLys: 1.912 ± 0.876
1.147TyrLeu: 1.147 ± 0.334
0.382TyrMet: 0.382 ± 0.315
0.382TyrAsn: 0.382 ± 0.299
0.382TyrPro: 0.382 ± 0.315
1.147TyrGln: 1.147 ± 0.324
2.677TyrArg: 2.677 ± 0.951
0.765TyrSer: 0.765 ± 0.435
1.147TyrThr: 1.147 ± 0.602
0.765TyrVal: 0.765 ± 0.396
1.53TyrTrp: 1.53 ± 0.763
1.53TyrTyr: 1.53 ± 0.703
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2616 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski