Amino acid dipepetide frequency for Halodesulfovibrio spirochaetisodalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.398AlaAla: 9.398 ± 0.148	1.306AlaCys: 1.306 ± 0.038	4.782AlaAsp: 4.782 ± 0.087	6.17AlaGlu: 6.17 ± 0.094	3.623AlaPhe: 3.623 ± 0.06	7.073AlaGly: 7.073 ± 0.102	1.909AlaHis: 1.909 ± 0.041	5.417AlaIle: 5.417 ± 0.092	5.024AlaLys: 5.024 ± 0.082	9.423AlaLeu: 9.423 ± 0.123	2.82AlaMet: 2.82 ± 0.06	2.841AlaAsn: 2.841 ± 0.06	3.4AlaPro: 3.4 ± 0.073	3.354AlaGln: 3.354 ± 0.067	4.086AlaArg: 4.086 ± 0.079	5.279AlaSer: 5.279 ± 0.083	4.998AlaThr: 4.998 ± 0.086	6.978AlaVal: 6.978 ± 0.099	0.93AlaTrp: 0.93 ± 0.036	2.404AlaTyr: 2.404 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.117CysAla: 1.117 ± 0.037	0.307CysCys: 0.307 ± 0.022	0.676CysAsp: 0.676 ± 0.031	0.761CysGlu: 0.761 ± 0.034	0.497CysPhe: 0.497 ± 0.022	1.387CysGly: 1.387 ± 0.047	0.407CysHis: 0.407 ± 0.032	0.913CysIle: 0.913 ± 0.033	0.682CysLys: 0.682 ± 0.028	1.153CysLeu: 1.153 ± 0.04	0.413CysMet: 0.413 ± 0.022	0.523CysAsn: 0.523 ± 0.023	0.817CysPro: 0.817 ± 0.036	0.319CysGln: 0.319 ± 0.02	0.644CysArg: 0.644 ± 0.027	0.986CysSer: 0.986 ± 0.033	0.847CysThr: 0.847 ± 0.029	0.909CysVal: 0.909 ± 0.032	0.153CysTrp: 0.153 ± 0.014	0.398CysTyr: 0.398 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.921AspAla: 4.921 ± 0.093	0.675AspCys: 0.675 ± 0.03	2.844AspAsp: 2.844 ± 0.075	3.749AspGlu: 3.749 ± 0.066	2.343AspPhe: 2.343 ± 0.052	3.88AspGly: 3.88 ± 0.106	1.009AspHis: 1.009 ± 0.042	3.88AspIle: 3.88 ± 0.079	2.801AspLys: 2.801 ± 0.064	4.88AspLeu: 4.88 ± 0.086	1.542AspMet: 1.542 ± 0.039	2.032AspAsn: 2.032 ± 0.051	2.222AspPro: 2.222 ± 0.052	1.349AspGln: 1.349 ± 0.04	2.272AspArg: 2.272 ± 0.054	3.069AspSer: 3.069 ± 0.059	3.191AspThr: 3.191 ± 0.106	4.078AspVal: 4.078 ± 0.073	0.686AspTrp: 0.686 ± 0.03	1.62AspTyr: 1.62 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.1GluAla: 6.1 ± 0.086	0.752GluCys: 0.752 ± 0.031	3.406GluAsp: 3.406 ± 0.076	5.377GluGlu: 5.377 ± 0.094	2.524GluPhe: 2.524 ± 0.055	4.323GluGly: 4.323 ± 0.075	1.722GluHis: 1.722 ± 0.039	3.987GluIle: 3.987 ± 0.075	4.54GluLys: 4.54 ± 0.079	7.145GluLeu: 7.145 ± 0.102	1.993GluMet: 1.993 ± 0.046	2.785GluAsn: 2.785 ± 0.054	2.194GluPro: 2.194 ± 0.057	3.091GluGln: 3.091 ± 0.065	3.637GluArg: 3.637 ± 0.07	3.338GluSer: 3.338 ± 0.064	3.3GluThr: 3.3 ± 0.06	4.502GluVal: 4.502 ± 0.064	0.724GluTrp: 0.724 ± 0.029	2.076GluTyr: 2.076 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.66PheAla: 3.66 ± 0.073	0.68PheCys: 0.68 ± 0.024	2.294PheAsp: 2.294 ± 0.054	2.447PheGlu: 2.447 ± 0.047	2.116PhePhe: 2.116 ± 0.062	3.182PheGly: 3.182 ± 0.073	0.754PheHis: 0.754 ± 0.031	2.781PheIle: 2.781 ± 0.06	1.848PheLys: 1.848 ± 0.054	3.874PheLeu: 3.874 ± 0.071	1.22PheMet: 1.22 ± 0.039	1.53PheAsn: 1.53 ± 0.041	1.693PhePro: 1.693 ± 0.042	1.099PheGln: 1.099 ± 0.037	1.73PheArg: 1.73 ± 0.047	3.317PheSer: 3.317 ± 0.059	2.733PheThr: 2.733 ± 0.059	2.801PheVal: 2.801 ± 0.061	0.619PheTrp: 0.619 ± 0.027	1.282PheTyr: 1.282 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.307GlyAla: 6.307 ± 0.105	1.233GlyCys: 1.233 ± 0.039	3.676GlyAsp: 3.676 ± 0.099	4.364GlyGlu: 4.364 ± 0.069	3.213GlyPhe: 3.213 ± 0.065	5.526GlyGly: 5.526 ± 0.128	1.551GlyHis: 1.551 ± 0.051	5.148GlyIle: 5.148 ± 0.072	4.765GlyLys: 4.765 ± 0.08	6.959GlyLeu: 6.959 ± 0.09	2.399GlyMet: 2.399 ± 0.052	2.658GlyAsn: 2.658 ± 0.073	1.749GlyPro: 1.749 ± 0.049	2.296GlyGln: 2.296 ± 0.052	3.319GlyArg: 3.319 ± 0.056	4.355GlySer: 4.355 ± 0.077	4.564GlyThr: 4.564 ± 0.083	5.719GlyVal: 5.719 ± 0.091	0.841GlyTrp: 0.841 ± 0.037	2.466GlyTyr: 2.466 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.814HisAla: 1.814 ± 0.05	0.351HisCys: 0.351 ± 0.02	1.261HisAsp: 1.261 ± 0.041	1.332HisGlu: 1.332 ± 0.04	0.943HisPhe: 0.943 ± 0.034	1.604HisGly: 1.604 ± 0.044	0.535HisHis: 0.535 ± 0.032	1.404HisIle: 1.404 ± 0.04	1.113HisLys: 1.113 ± 0.034	1.968HisLeu: 1.968 ± 0.044	0.58HisMet: 0.58 ± 0.023	0.836HisAsn: 0.836 ± 0.028	1.157HisPro: 1.157 ± 0.038	0.574HisGln: 0.574 ± 0.027	0.93HisArg: 0.93 ± 0.036	1.378HisSer: 1.378 ± 0.038	1.197HisThr: 1.197 ± 0.041	1.39HisVal: 1.39 ± 0.041	0.258HisTrp: 0.258 ± 0.019	0.691HisTyr: 0.691 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.257IleAla: 6.257 ± 0.095	0.907IleCys: 0.907 ± 0.035	3.381IleAsp: 3.381 ± 0.069	4.095IleGlu: 4.095 ± 0.077	2.573IlePhe: 2.573 ± 0.054	4.521IleGly: 4.521 ± 0.075	1.184IleHis: 1.184 ± 0.035	4.014IleIle: 4.014 ± 0.082	3.015IleLys: 3.015 ± 0.062	5.772IleLeu: 5.772 ± 0.095	1.615IleMet: 1.615 ± 0.045	2.364IleAsn: 2.364 ± 0.057	3.15IlePro: 3.15 ± 0.06	1.936IleGln: 1.936 ± 0.05	2.941IleArg: 2.941 ± 0.055	4.125IleSer: 4.125 ± 0.069	4.195IleThr: 4.195 ± 0.082	4.6IleVal: 4.6 ± 0.082	0.587IleTrp: 0.587 ± 0.024	1.584IleTyr: 1.584 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	5.138LysAla: 5.138 ± 0.084	0.513LysCys: 0.513 ± 0.028	3.095LysAsp: 3.095 ± 0.061	4.399LysGlu: 4.399 ± 0.072	1.719LysPhe: 1.719 ± 0.042	3.914LysGly: 3.914 ± 0.074	1.203LysHis: 1.203 ± 0.035	3.148LysIle: 3.148 ± 0.07	4.066LysLys: 4.066 ± 0.082	5.099LysLeu: 5.099 ± 0.081	1.634LysMet: 1.634 ± 0.047	2.337LysAsn: 2.337 ± 0.056	2.2LysPro: 2.2 ± 0.055	2.172LysGln: 2.172 ± 0.048	2.93LysArg: 2.93 ± 0.063	2.803LysSer: 2.803 ± 0.055	2.931LysThr: 2.931 ± 0.057	3.616LysVal: 3.616 ± 0.064	0.491LysTrp: 0.491 ± 0.026	1.577LysTyr: 1.577 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	9.225LeuAla: 9.225 ± 0.114	1.385LeuCys: 1.385 ± 0.041	5.151LeuAsp: 5.151 ± 0.081	6.549LeuGlu: 6.549 ± 0.09	4.178LeuPhe: 4.178 ± 0.088	7.269LeuGly: 7.269 ± 0.095	2.107LeuHis: 2.107 ± 0.053	5.502LeuIle: 5.502 ± 0.087	5.051LeuLys: 5.051 ± 0.084	10.139LeuLeu: 10.139 ± 0.135	2.455LeuMet: 2.455 ± 0.053	3.564LeuAsn: 3.564 ± 0.063	4.858LeuPro: 4.858 ± 0.089	3.449LeuGln: 3.449 ± 0.068	5.051LeuArg: 5.051 ± 0.08	6.772LeuSer: 6.772 ± 0.103	5.951LeuThr: 5.951 ± 0.087	6.654LeuVal: 6.654 ± 0.1	0.971LeuTrp: 0.971 ± 0.041	2.589LeuTyr: 2.589 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.604MetAla: 2.604 ± 0.051	0.321MetCys: 0.321 ± 0.022	1.582MetAsp: 1.582 ± 0.043	1.866MetGlu: 1.866 ± 0.045	1.003MetPhe: 1.003 ± 0.039	2.082MetGly: 2.082 ± 0.05	0.666MetHis: 0.666 ± 0.029	1.319MetIle: 1.319 ± 0.043	1.54MetLys: 1.54 ± 0.046	3.122MetLeu: 3.122 ± 0.066	0.761MetMet: 0.761 ± 0.048	1.214MetAsn: 1.214 ± 0.039	1.347MetPro: 1.347 ± 0.043	1.243MetGln: 1.243 ± 0.041	1.571MetArg: 1.571 ± 0.043	1.747MetSer: 1.747 ± 0.046	1.652MetThr: 1.652 ± 0.039	1.832MetVal: 1.832 ± 0.049	0.262MetTrp: 0.262 ± 0.016	0.718MetTyr: 0.718 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.311AsnAla: 3.311 ± 0.069	0.524AsnCys: 0.524 ± 0.025	1.968AsnAsp: 1.968 ± 0.072	2.149AsnGlu: 2.149 ± 0.05	1.448AsnPhe: 1.448 ± 0.042	2.672AsnGly: 2.672 ± 0.053	0.667AsnHis: 0.667 ± 0.027	2.711AsnIle: 2.711 ± 0.054	1.939AsnLys: 1.939 ± 0.043	3.521AsnLeu: 3.521 ± 0.06	1.138AsnMet: 1.138 ± 0.038	1.445AsnAsn: 1.445 ± 0.043	2.029AsnPro: 2.029 ± 0.055	0.999AsnGln: 0.999 ± 0.036	1.671AsnArg: 1.671 ± 0.044	2.202AsnSer: 2.202 ± 0.046	2.15AsnThr: 2.15 ± 0.06	2.802AsnVal: 2.802 ± 0.062	0.451AsnTrp: 0.451 ± 0.024	1.035AsnTyr: 1.035 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.815ProAla: 3.815 ± 0.079	0.547ProCys: 0.547 ± 0.027	2.661ProAsp: 2.661 ± 0.055	3.998ProGlu: 3.998 ± 0.071	1.939ProPhe: 1.939 ± 0.046	2.434ProGly: 2.434 ± 0.052	0.935ProHis: 0.935 ± 0.032	2.081ProIle: 2.081 ± 0.046	2.154ProLys: 2.154 ± 0.052	3.98ProLeu: 3.98 ± 0.074	1.03ProMet: 1.03 ± 0.038	1.354ProAsn: 1.354 ± 0.039	1.413ProPro: 1.413 ± 0.043	1.658ProGln: 1.658 ± 0.053	1.618ProArg: 1.618 ± 0.049	2.475ProSer: 2.475 ± 0.058	2.131ProThr: 2.131 ± 0.052	3.974ProVal: 3.974 ± 0.069	0.487ProTrp: 0.487 ± 0.022	1.26ProTyr: 1.26 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.2GlnAla: 3.2 ± 0.065	0.42GlnCys: 0.42 ± 0.024	1.683GlnAsp: 1.683 ± 0.047	2.501GlnGlu: 2.501 ± 0.059	1.337GlnPhe: 1.337 ± 0.041	2.265GlnGly: 2.265 ± 0.048	0.881GlnHis: 0.881 ± 0.036	1.948GlnIle: 1.948 ± 0.048	2.156GlnLys: 2.156 ± 0.046	3.538GlnLeu: 3.538 ± 0.075	0.998GlnMet: 0.998 ± 0.033	1.377GlnAsn: 1.377 ± 0.042	1.29GlnPro: 1.29 ± 0.042	1.782GlnGln: 1.782 ± 0.061	1.891GlnArg: 1.891 ± 0.047	1.939GlnSer: 1.939 ± 0.058	1.779GlnThr: 1.779 ± 0.047	2.255GlnVal: 2.255 ± 0.058	0.376GlnTrp: 0.376 ± 0.021	1.068GlnTyr: 1.068 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	3.732ArgAla: 3.732 ± 0.067	0.662ArgCys: 0.662 ± 0.032	2.414ArgAsp: 2.414 ± 0.059	3.345ArgGlu: 3.345 ± 0.072	2.105ArgPhe: 2.105 ± 0.049	2.916ArgGly: 2.916 ± 0.068	0.975ArgHis: 0.975 ± 0.032	3.506ArgIle: 3.506 ± 0.064	3.129ArgLys: 3.129 ± 0.062	4.713ArgLeu: 4.713 ± 0.08	1.517ArgMet: 1.517 ± 0.042	1.977ArgAsn: 1.977 ± 0.051	1.824ArgPro: 1.824 ± 0.044	1.679ArgGln: 1.679 ± 0.053	2.437ArgArg: 2.437 ± 0.052	2.909ArgSer: 2.909 ± 0.06	2.712ArgThr: 2.712 ± 0.05	3.285ArgVal: 3.285 ± 0.065	0.475ArgTrp: 0.475 ± 0.024	1.501ArgTyr: 1.501 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.275SerAla: 5.275 ± 0.082	0.875SerCys: 0.875 ± 0.034	3.036SerAsp: 3.036 ± 0.066	3.661SerGlu: 3.661 ± 0.069	2.819SerPhe: 2.819 ± 0.06	5.311SerGly: 5.311 ± 0.097	1.18SerHis: 1.18 ± 0.035	4.259SerIle: 4.259 ± 0.075	3.121SerLys: 3.121 ± 0.063	6.102SerLeu: 6.102 ± 0.103	1.954SerMet: 1.954 ± 0.046	2.024SerAsn: 2.024 ± 0.05	2.56SerPro: 2.56 ± 0.054	1.946SerGln: 1.946 ± 0.045	2.887SerArg: 2.887 ± 0.059	4.163SerSer: 4.163 ± 0.084	3.415SerThr: 3.415 ± 0.077	4.714SerVal: 4.714 ± 0.076	0.646SerTrp: 0.646 ± 0.028	1.626SerTyr: 1.626 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.266ThrAla: 5.266 ± 0.077	0.773ThrCys: 0.773 ± 0.033	2.864ThrAsp: 2.864 ± 0.054	3.523ThrGlu: 3.523 ± 0.063	2.393ThrPhe: 2.393 ± 0.064	4.892ThrGly: 4.892 ± 0.104	1.226ThrHis: 1.226 ± 0.038	3.921ThrIle: 3.921 ± 0.091	2.509ThrLys: 2.509 ± 0.048	6.057ThrLeu: 6.057 ± 0.091	1.519ThrMet: 1.519 ± 0.045	1.888ThrAsn: 1.888 ± 0.05	3.079ThrPro: 3.079 ± 0.068	1.83ThrGln: 1.83 ± 0.053	2.384ThrArg: 2.384 ± 0.05	3.333ThrSer: 3.333 ± 0.064	3.32ThrThr: 3.32 ± 0.068	4.729ThrVal: 4.729 ± 0.092	0.56ThrTrp: 0.56 ± 0.026	1.681ThrTyr: 1.681 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	6.717ValAla: 6.717 ± 0.099	1.086ValCys: 1.086 ± 0.039	4.014ValAsp: 4.014 ± 0.076	4.892ValGlu: 4.892 ± 0.081	3.095ValPhe: 3.095 ± 0.066	4.851ValGly: 4.851 ± 0.081	1.562ValHis: 1.562 ± 0.051	4.599ValIle: 4.599 ± 0.068	3.428ValLys: 3.428 ± 0.066	7.435ValLeu: 7.435 ± 0.109	1.893ValMet: 1.893 ± 0.05	2.502ValAsn: 2.502 ± 0.05	3.225ValPro: 3.225 ± 0.062	2.545ValGln: 2.545 ± 0.055	3.794ValArg: 3.794 ± 0.061	4.819ValSer: 4.819 ± 0.079	4.428ValThr: 4.428 ± 0.076	5.72ValVal: 5.72 ± 0.087	0.722ValTrp: 0.722 ± 0.031	1.824ValTyr: 1.824 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.859TrpAla: 0.859 ± 0.034	0.163TrpCys: 0.163 ± 0.014	0.605TrpAsp: 0.605 ± 0.027	0.661TrpGlu: 0.661 ± 0.027	0.476TrpPhe: 0.476 ± 0.027	0.734TrpGly: 0.734 ± 0.033	0.268TrpHis: 0.268 ± 0.017	0.639TrpIle: 0.639 ± 0.025	0.643TrpLys: 0.643 ± 0.029	1.127TrpLeu: 1.127 ± 0.037	0.304TrpMet: 0.304 ± 0.018	0.493TrpAsn: 0.493 ± 0.026	0.426TrpPro: 0.426 ± 0.019	0.468TrpGln: 0.468 ± 0.025	0.576TrpArg: 0.576 ± 0.024	0.626TrpSer: 0.626 ± 0.029	0.523TrpThr: 0.523 ± 0.028	0.739TrpVal: 0.739 ± 0.03	0.135TrpTrp: 0.135 ± 0.013	0.294TrpTyr: 0.294 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.499TyrAla: 2.499 ± 0.052	0.431TyrCys: 0.431 ± 0.023	1.65TyrAsp: 1.65 ± 0.046	1.678TyrGlu: 1.678 ± 0.051	1.316TyrPhe: 1.316 ± 0.043	2.27TyrGly: 2.27 ± 0.058	0.575TyrHis: 0.575 ± 0.024	1.641TyrIle: 1.641 ± 0.048	1.46TyrLys: 1.46 ± 0.036	2.862TyrLeu: 2.862 ± 0.056	0.665TyrMet: 0.665 ± 0.028	1.089TyrAsn: 1.089 ± 0.036	1.31TyrPro: 1.31 ± 0.036	0.896TyrGln: 0.896 ± 0.031	1.443TyrArg: 1.443 ± 0.039	1.936TyrSer: 1.936 ± 0.044	1.731TyrThr: 1.731 ± 0.045	1.857TyrVal: 1.857 ± 0.05	0.386TyrTrp: 0.386 ± 0.021	0.913TyrTyr: 0.913 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2803 proteins (889119 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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