Amino acid dipepetide frequency for Malaciobacter mytili LMG 24559

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.221AlaAla: 3.221 ± 0.095
0.602AlaCys: 0.602 ± 0.035
2.365AlaAsp: 2.365 ± 0.12
2.166AlaGlu: 2.166 ± 0.068
2.935AlaPhe: 2.935 ± 0.077
3.402AlaGly: 3.402 ± 0.126
0.953AlaHis: 0.953 ± 0.033
6.062AlaIle: 6.062 ± 0.116
5.714AlaLys: 5.714 ± 0.133
6.409AlaLeu: 6.409 ± 0.113
1.527AlaMet: 1.527 ± 0.05
3.628AlaAsn: 3.628 ± 0.081
1.301AlaPro: 1.301 ± 0.047
1.892AlaGln: 1.892 ± 0.049
1.598AlaArg: 1.598 ± 0.055
3.904AlaSer: 3.904 ± 0.073
3.355AlaThr: 3.355 ± 0.095
3.393AlaVal: 3.393 ± 0.085
0.375AlaTrp: 0.375 ± 0.02
2.282AlaTyr: 2.282 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.551CysAla: 0.551 ± 0.024
0.127CysCys: 0.127 ± 0.013
0.551CysAsp: 0.551 ± 0.028
0.709CysGlu: 0.709 ± 0.031
0.444CysPhe: 0.444 ± 0.024
0.674CysGly: 0.674 ± 0.033
0.234CysHis: 0.234 ± 0.02
0.731CysIle: 0.731 ± 0.035
0.854CysLys: 0.854 ± 0.031
0.659CysLeu: 0.659 ± 0.029
0.171CysMet: 0.171 ± 0.014
0.56CysAsn: 0.56 ± 0.027
0.378CysPro: 0.378 ± 0.024
0.215CysGln: 0.215 ± 0.016
0.218CysArg: 0.218 ± 0.018
0.658CysSer: 0.658 ± 0.031
0.43CysThr: 0.43 ± 0.024
0.528CysVal: 0.528 ± 0.029
0.062CysTrp: 0.062 ± 0.009
0.33CysTyr: 0.33 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
2.793AspAla: 2.793 ± 0.075
0.471AspCys: 0.471 ± 0.024
2.935AspAsp: 2.935 ± 0.178
4.749AspGlu: 4.749 ± 0.087
3.415AspPhe: 3.415 ± 0.065
3.108AspGly: 3.108 ± 0.228
0.489AspHis: 0.489 ± 0.024
6.073AspIle: 6.073 ± 0.104
5.237AspLys: 5.237 ± 0.084
5.007AspLeu: 5.007 ± 0.084
1.124AspMet: 1.124 ± 0.037
3.339AspAsn: 3.339 ± 0.098
1.083AspPro: 1.083 ± 0.046
0.674AspGln: 0.674 ± 0.03
1.364AspArg: 1.364 ± 0.041
3.265AspSer: 3.265 ± 0.112
3.038AspThr: 3.038 ± 0.334
2.938AspVal: 2.938 ± 0.112
0.339AspTrp: 0.339 ± 0.02
2.469AspTyr: 2.469 ± 0.084
0.0AspXaa: 0.0 ± 0.0
Glu
4.397GluAla: 4.397 ± 0.112
0.525GluCys: 0.525 ± 0.024
4.304GluAsp: 4.304 ± 0.112
6.724GluGlu: 6.724 ± 0.139
3.958GluPhe: 3.958 ± 0.082
3.064GluGly: 3.064 ± 0.108
1.129GluHis: 1.129 ± 0.04
7.27GluIle: 7.27 ± 0.125
7.843GluLys: 7.843 ± 0.133
7.31GluLeu: 7.31 ± 0.149
1.447GluMet: 1.447 ± 0.05
5.841GluAsn: 5.841 ± 0.106
1.477GluPro: 1.477 ± 0.04
2.307GluGln: 2.307 ± 0.056
1.64GluArg: 1.64 ± 0.048
3.148GluSer: 3.148 ± 0.085
2.963GluThr: 2.963 ± 0.083
4.835GluVal: 4.835 ± 0.085
0.375GluTrp: 0.375 ± 0.019
3.195GluTyr: 3.195 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
3.014PheAla: 3.014 ± 0.067
0.563PheCys: 0.563 ± 0.024
3.178PheAsp: 3.178 ± 0.058
4.115PheGlu: 4.115 ± 0.084
3.201PhePhe: 3.201 ± 0.094
2.836PheGly: 2.836 ± 0.061
0.717PheHis: 0.717 ± 0.028
5.549PheIle: 5.549 ± 0.11
4.56PheLys: 4.56 ± 0.087
5.414PheLeu: 5.414 ± 0.13
1.119PheMet: 1.119 ± 0.047
3.392PheAsn: 3.392 ± 0.071
1.202PhePro: 1.202 ± 0.039
1.19PheGln: 1.19 ± 0.044
1.25PheArg: 1.25 ± 0.043
3.841PheSer: 3.841 ± 0.08
2.709PheThr: 2.709 ± 0.061
2.835PheVal: 2.835 ± 0.06
0.42PheTrp: 0.42 ± 0.027
2.325PheTyr: 2.325 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
3.377GlyAla: 3.377 ± 0.11
0.65GlyCys: 0.65 ± 0.031
2.556GlyAsp: 2.556 ± 0.22
3.415GlyGlu: 3.415 ± 0.132
3.107GlyPhe: 3.107 ± 0.066
3.599GlyGly: 3.599 ± 0.258
0.87GlyHis: 0.87 ± 0.034
4.958GlyIle: 4.958 ± 0.083
4.326GlyLys: 4.326 ± 0.073
4.738GlyLeu: 4.738 ± 0.091
1.289GlyMet: 1.289 ± 0.046
2.716GlyAsn: 2.716 ± 0.259
0.843GlyPro: 0.843 ± 0.033
1.265GlyGln: 1.265 ± 0.038
1.515GlyArg: 1.515 ± 0.046
3.313GlySer: 3.313 ± 0.168
2.888GlyThr: 2.888 ± 0.145
3.605GlyVal: 3.605 ± 0.08
0.445GlyTrp: 0.445 ± 0.024
2.493GlyTyr: 2.493 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
0.681HisAla: 0.681 ± 0.027
0.176HisCys: 0.176 ± 0.013
0.623HisAsp: 0.623 ± 0.029
0.819HisGlu: 0.819 ± 0.034
0.842HisPhe: 0.842 ± 0.03
0.796HisGly: 0.796 ± 0.029
0.347HisHis: 0.347 ± 0.022
1.474HisIle: 1.474 ± 0.046
1.356HisLys: 1.356 ± 0.043
1.472HisLeu: 1.472 ± 0.043
0.335HisMet: 0.335 ± 0.021
0.935HisAsn: 0.935 ± 0.034
0.682HisPro: 0.682 ± 0.029
0.508HisGln: 0.508 ± 0.025
0.499HisArg: 0.499 ± 0.025
0.937HisSer: 0.937 ± 0.036
0.827HisThr: 0.827 ± 0.029
0.535HisVal: 0.535 ± 0.026
0.122HisTrp: 0.122 ± 0.012
0.616HisTyr: 0.616 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.087IleAla: 6.087 ± 0.119
0.924IleCys: 0.924 ± 0.036
6.091IleAsp: 6.091 ± 0.135
7.425IleGlu: 7.425 ± 0.098
5.23IlePhe: 5.23 ± 0.103
5.111IleGly: 5.111 ± 0.109
1.23IleHis: 1.23 ± 0.042
8.905IleIle: 8.905 ± 0.144
10.05IleLys: 10.05 ± 0.148
9.712IleLeu: 9.712 ± 0.156
1.669IleMet: 1.669 ± 0.046
6.517IleAsn: 6.517 ± 0.108
2.798IlePro: 2.798 ± 0.067
2.526IleGln: 2.526 ± 0.061
2.312IleArg: 2.312 ± 0.059
7.192IleSer: 7.192 ± 0.11
5.158IleThr: 5.158 ± 0.129
5.544IleVal: 5.544 ± 0.086
0.519IleTrp: 0.519 ± 0.024
3.729IleTyr: 3.729 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
5.453LysAla: 5.453 ± 0.113
0.572LysCys: 0.572 ± 0.026
6.358LysAsp: 6.358 ± 0.101
10.353LysGlu: 10.353 ± 0.183
3.755LysPhe: 3.755 ± 0.079
3.957LysGly: 3.957 ± 0.074
1.351LysHis: 1.351 ± 0.045
9.278LysIle: 9.278 ± 0.135
9.925LysLys: 9.925 ± 0.206
8.575LysLeu: 8.575 ± 0.129
2.161LysMet: 2.161 ± 0.06
7.758LysAsn: 7.758 ± 0.148
2.33LysPro: 2.33 ± 0.054
3.346LysGln: 3.346 ± 0.093
3.077LysArg: 3.077 ± 0.066
5.167LysSer: 5.167 ± 0.099
4.794LysThr: 4.794 ± 0.094
5.604LysVal: 5.604 ± 0.081
0.529LysTrp: 0.529 ± 0.024
4.331LysTyr: 4.331 ± 0.091
0.0LysXaa: 0.0 ± 0.0
Leu
5.544LeuAla: 5.544 ± 0.109
0.91LeuCys: 0.91 ± 0.035
5.49LeuAsp: 5.49 ± 0.089
7.945LeuGlu: 7.945 ± 0.138
5.271LeuPhe: 5.271 ± 0.114
5.175LeuGly: 5.175 ± 0.092
1.318LeuHis: 1.318 ± 0.046
8.693LeuIle: 8.693 ± 0.142
10.302LeuLys: 10.302 ± 0.159
9.208LeuLeu: 9.208 ± 0.161
1.933LeuMet: 1.933 ± 0.053
7.044LeuAsn: 7.044 ± 0.12
2.867LeuPro: 2.867 ± 0.074
2.967LeuGln: 2.967 ± 0.071
2.577LeuArg: 2.577 ± 0.057
6.847LeuSer: 6.847 ± 0.103
4.811LeuThr: 4.811 ± 0.08
5.229LeuVal: 5.229 ± 0.078
0.607LeuTrp: 0.607 ± 0.026
3.732LeuTyr: 3.732 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
1.401MetAla: 1.401 ± 0.047
0.166MetCys: 0.166 ± 0.014
0.911MetAsp: 0.911 ± 0.034
1.084MetGlu: 1.084 ± 0.044
1.068MetPhe: 1.068 ± 0.042
1.301MetGly: 1.301 ± 0.043
0.359MetHis: 0.359 ± 0.019
2.02MetIle: 2.02 ± 0.051
2.124MetLys: 2.124 ± 0.052
2.056MetLeu: 2.056 ± 0.065
0.518MetMet: 0.518 ± 0.026
1.288MetAsn: 1.288 ± 0.04
0.808MetPro: 0.808 ± 0.035
1.013MetGln: 1.013 ± 0.033
0.575MetArg: 0.575 ± 0.027
1.544MetSer: 1.544 ± 0.039
0.979MetThr: 0.979 ± 0.034
1.116MetVal: 1.116 ± 0.038
0.152MetTrp: 0.152 ± 0.012
0.678MetTyr: 0.678 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.402AsnAla: 3.402 ± 0.072
0.572AsnCys: 0.572 ± 0.031
3.407AsnAsp: 3.407 ± 0.246
5.23AsnGlu: 5.23 ± 0.102
3.414AsnPhe: 3.414 ± 0.067
3.05AsnGly: 3.05 ± 0.122
0.961AsnHis: 0.961 ± 0.034
7.817AsnIle: 7.817 ± 0.145
6.754AsnLys: 6.754 ± 0.127
6.588AsnLeu: 6.588 ± 0.098
1.329AsnMet: 1.329 ± 0.041
4.553AsnAsn: 4.553 ± 0.116
1.942AsnPro: 1.942 ± 0.053
1.812AsnGln: 1.812 ± 0.052
2.022AsnArg: 2.022 ± 0.045
5.085AsnSer: 5.085 ± 0.14
3.219AsnThr: 3.219 ± 0.082
2.835AsnVal: 2.835 ± 0.08
0.432AsnTrp: 0.432 ± 0.022
2.817AsnTyr: 2.817 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
1.27ProAla: 1.27 ± 0.044
0.228ProCys: 0.228 ± 0.016
1.11ProAsp: 1.11 ± 0.04
1.419ProGlu: 1.419 ± 0.045
1.548ProPhe: 1.548 ± 0.047
1.026ProGly: 1.026 ± 0.038
0.465ProHis: 0.465 ± 0.025
2.674ProIle: 2.674 ± 0.055
2.414ProLys: 2.414 ± 0.063
2.674ProLeu: 2.674 ± 0.069
0.593ProMet: 0.593 ± 0.025
1.602ProAsn: 1.602 ± 0.047
0.51ProPro: 0.51 ± 0.025
0.798ProGln: 0.798 ± 0.032
0.69ProArg: 0.69 ± 0.032
1.715ProSer: 1.715 ± 0.044
1.616ProThr: 1.616 ± 0.043
1.525ProVal: 1.525 ± 0.088
0.209ProTrp: 0.209 ± 0.015
1.273ProTyr: 1.273 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
1.719GlnAla: 1.719 ± 0.054
0.171GlnCys: 0.171 ± 0.015
1.343GlnAsp: 1.343 ± 0.047
2.549GlnGlu: 2.549 ± 0.06
1.098GlnPhe: 1.098 ± 0.04
1.284GlnGly: 1.284 ± 0.043
0.381GlnHis: 0.381 ± 0.024
2.946GlnIle: 2.946 ± 0.064
3.236GlnLys: 3.236 ± 0.069
2.595GlnLeu: 2.595 ± 0.058
0.685GlnMet: 0.685 ± 0.031
2.229GlnAsn: 2.229 ± 0.053
0.617GlnPro: 0.617 ± 0.03
0.843GlnGln: 0.843 ± 0.033
1.068GlnArg: 1.068 ± 0.038
1.567GlnSer: 1.567 ± 0.043
1.634GlnThr: 1.634 ± 0.047
1.463GlnVal: 1.463 ± 0.034
0.261GlnTrp: 0.261 ± 0.017
0.952GlnTyr: 0.952 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
1.586ArgAla: 1.586 ± 0.046
0.251ArgCys: 0.251 ± 0.017
1.579ArgAsp: 1.579 ± 0.059
1.898ArgGlu: 1.898 ± 0.05
1.474ArgPhe: 1.474 ± 0.047
1.439ArgGly: 1.439 ± 0.045
0.475ArgHis: 0.475 ± 0.026
2.302ArgIle: 2.302 ± 0.056
2.403ArgLys: 2.403 ± 0.068
2.526ArgLeu: 2.526 ± 0.065
0.654ArgMet: 0.654 ± 0.031
1.634ArgAsn: 1.634 ± 0.044
0.735ArgPro: 0.735 ± 0.034
0.825ArgGln: 0.825 ± 0.031
0.973ArgArg: 0.973 ± 0.038
1.246ArgSer: 1.246 ± 0.037
1.302ArgThr: 1.302 ± 0.034
2.188ArgVal: 2.188 ± 0.059
0.201ArgTrp: 0.201 ± 0.014
1.23ArgTyr: 1.23 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
3.328SerAla: 3.328 ± 0.073
0.632SerCys: 0.632 ± 0.031
2.974SerAsp: 2.974 ± 0.131
3.341SerGlu: 3.341 ± 0.107
4.199SerPhe: 4.199 ± 0.082
3.599SerGly: 3.599 ± 0.138
0.924SerHis: 0.924 ± 0.033
6.581SerIle: 6.581 ± 0.121
6.588SerLys: 6.588 ± 0.108
7.12SerLeu: 7.12 ± 0.091
1.503SerMet: 1.503 ± 0.037
4.421SerAsn: 4.421 ± 0.116
1.267SerPro: 1.267 ± 0.043
1.855SerGln: 1.855 ± 0.048
1.63SerArg: 1.63 ± 0.051
4.99SerSer: 4.99 ± 0.143
3.295SerThr: 3.295 ± 0.106
3.203SerVal: 3.203 ± 0.084
0.505SerTrp: 0.505 ± 0.024
2.941SerTyr: 2.941 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
2.949ThrAla: 2.949 ± 0.095
0.415ThrCys: 0.415 ± 0.024
2.149ThrAsp: 2.149 ± 0.078
2.029ThrGlu: 2.029 ± 0.06
2.771ThrPhe: 2.771 ± 0.069
2.751ThrGly: 2.751 ± 0.092
0.856ThrHis: 0.856 ± 0.034
5.554ThrIle: 5.554 ± 0.143
4.919ThrLys: 4.919 ± 0.094
5.886ThrLeu: 5.886 ± 0.15
0.915ThrMet: 0.915 ± 0.034
3.383ThrAsn: 3.383 ± 0.1
1.762ThrPro: 1.762 ± 0.051
1.783ThrGln: 1.783 ± 0.049
1.173ThrArg: 1.173 ± 0.045
3.474ThrSer: 3.474 ± 0.151
3.273ThrThr: 3.273 ± 0.117
2.766ThrVal: 2.766 ± 0.12
0.373ThrTrp: 0.373 ± 0.029
2.191ThrTyr: 2.191 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
3.71ValAla: 3.71 ± 0.086
0.653ValCys: 0.653 ± 0.028
3.348ValAsp: 3.348 ± 0.087
4.052ValGlu: 4.052 ± 0.07
2.819ValPhe: 2.819 ± 0.065
3.236ValGly: 3.236 ± 0.064
0.783ValHis: 0.783 ± 0.032
5.229ValIle: 5.229 ± 0.081
4.944ValLys: 4.944 ± 0.102
5.427ValLeu: 5.427 ± 0.091
1.174ValMet: 1.174 ± 0.04
3.281ValAsn: 3.281 ± 0.09
1.487ValPro: 1.487 ± 0.046
1.478ValGln: 1.478 ± 0.041
1.432ValArg: 1.432 ± 0.042
3.83ValSer: 3.83 ± 0.103
2.801ValThr: 2.801 ± 0.091
3.72ValVal: 3.72 ± 0.112
0.403ValTrp: 0.403 ± 0.022
2.229ValTyr: 2.229 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.386TrpAla: 0.386 ± 0.023
0.073TrpCys: 0.073 ± 0.01
0.383TrpAsp: 0.383 ± 0.02
0.476TrpGlu: 0.476 ± 0.024
0.379TrpPhe: 0.379 ± 0.02
0.407TrpGly: 0.407 ± 0.022
0.182TrpHis: 0.182 ± 0.012
0.635TrpIle: 0.635 ± 0.028
0.48TrpLys: 0.48 ± 0.022
0.699TrpLeu: 0.699 ± 0.026
0.19TrpMet: 0.19 ± 0.016
0.373TrpAsn: 0.373 ± 0.018
0.132TrpPro: 0.132 ± 0.012
0.312TrpGln: 0.312 ± 0.021
0.224TrpArg: 0.224 ± 0.016
0.375TrpSer: 0.375 ± 0.02
0.255TrpThr: 0.255 ± 0.018
0.403TrpVal: 0.403 ± 0.024
0.073TrpTrp: 0.073 ± 0.01
0.31TrpTyr: 0.31 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.214TyrAla: 2.214 ± 0.049
0.403TyrCys: 0.403 ± 0.024
2.255TyrAsp: 2.255 ± 0.057
3.254TyrGlu: 3.254 ± 0.06
2.503TyrPhe: 2.503 ± 0.061
2.155TyrGly: 2.155 ± 0.074
0.558TyrHis: 0.558 ± 0.02
3.977TyrIle: 3.977 ± 0.088
4.644TyrLys: 4.644 ± 0.089
4.393TyrLeu: 4.393 ± 0.089
0.823TyrMet: 0.823 ± 0.032
2.746TyrAsn: 2.746 ± 0.076
1.14TyrPro: 1.14 ± 0.041
1.029TyrGln: 1.029 ± 0.034
1.084TyrArg: 1.084 ± 0.035
2.801TyrSer: 2.801 ± 0.06
2.026TyrThr: 2.026 ± 0.064
1.771TyrVal: 1.771 ± 0.052
0.347TyrTrp: 0.347 ± 0.019
1.824TyrTyr: 1.824 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2879 proteins (928648 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski