Amino acid dipepetide frequency for Streptomyces phyllanthi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.377AlaAla: 19.377 ± 0.117	1.07AlaCys: 1.07 ± 0.02	8.045AlaAsp: 8.045 ± 0.062	8.671AlaGlu: 8.671 ± 0.08	3.424AlaPhe: 3.424 ± 0.033	12.377AlaGly: 12.377 ± 0.081	2.845AlaHis: 2.845 ± 0.038	3.413AlaIle: 3.413 ± 0.041	2.773AlaLys: 2.773 ± 0.039	13.84AlaLeu: 13.84 ± 0.105	2.382AlaMet: 2.382 ± 0.031	1.978AlaAsn: 1.978 ± 0.031	6.738AlaPro: 6.738 ± 0.057	3.537AlaGln: 3.537 ± 0.037	10.038AlaArg: 10.038 ± 0.08	6.042AlaSer: 6.042 ± 0.044	6.941AlaThr: 6.941 ± 0.058	12.028AlaVal: 12.028 ± 0.068	1.792AlaTrp: 1.792 ± 0.026	2.798AlaTyr: 2.798 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.073CysAla: 1.073 ± 0.023	0.102CysCys: 0.102 ± 0.007	0.478CysAsp: 0.478 ± 0.013	0.419CysGlu: 0.419 ± 0.014	0.231CysPhe: 0.231 ± 0.011	0.976CysGly: 0.976 ± 0.019	0.206CysHis: 0.206 ± 0.009	0.151CysIle: 0.151 ± 0.007	0.115CysLys: 0.115 ± 0.006	0.766CysLeu: 0.766 ± 0.018	0.125CysMet: 0.125 ± 0.007	0.132CysAsn: 0.132 ± 0.007	0.483CysPro: 0.483 ± 0.014	0.177CysGln: 0.177 ± 0.008	0.622CysArg: 0.622 ± 0.016	0.441CysSer: 0.441 ± 0.012	0.511CysThr: 0.511 ± 0.013	0.697CysVal: 0.697 ± 0.016	0.124CysTrp: 0.124 ± 0.006	0.156CysTyr: 0.156 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.259AspAla: 7.259 ± 0.055	0.442AspCys: 0.442 ± 0.014	3.7AspAsp: 3.7 ± 0.04	3.966AspGlu: 3.966 ± 0.04	1.723AspPhe: 1.723 ± 0.027	6.566AspGly: 6.566 ± 0.059	1.454AspHis: 1.454 ± 0.025	2.045AspIle: 2.045 ± 0.028	1.21AspLys: 1.21 ± 0.027	6.239AspLeu: 6.239 ± 0.045	0.872AspMet: 0.872 ± 0.016	1.025AspAsn: 1.025 ± 0.02	4.517AspPro: 4.517 ± 0.034	1.563AspGln: 1.563 ± 0.024	4.953AspArg: 4.953 ± 0.055	2.757AspSer: 2.757 ± 0.035	3.384AspThr: 3.384 ± 0.034	4.773AspVal: 4.773 ± 0.039	1.045AspTrp: 1.045 ± 0.025	1.134AspTyr: 1.134 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	7.493GluAla: 7.493 ± 0.072	0.382GluCys: 0.382 ± 0.012	3.015GluAsp: 3.015 ± 0.039	3.784GluGlu: 3.784 ± 0.045	1.537GluPhe: 1.537 ± 0.024	4.47GluGly: 4.47 ± 0.04	1.523GluHis: 1.523 ± 0.026	2.29GluIle: 2.29 ± 0.039	1.54GluLys: 1.54 ± 0.027	6.837GluLeu: 6.837 ± 0.056	0.879GluMet: 0.879 ± 0.016	1.125GluAsn: 1.125 ± 0.019	3.502GluPro: 3.502 ± 0.044	2.334GluGln: 2.334 ± 0.03	5.494GluArg: 5.494 ± 0.059	2.774GluSer: 2.774 ± 0.033	3.022GluThr: 3.022 ± 0.032	4.499GluVal: 4.499 ± 0.04	0.823GluTrp: 0.823 ± 0.018	1.23GluTyr: 1.23 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.506PheAla: 3.506 ± 0.04	0.261PheCys: 0.261 ± 0.01	1.966PheAsp: 1.966 ± 0.027	1.492PheGlu: 1.492 ± 0.024	0.89PhePhe: 0.89 ± 0.021	3.005PheGly: 3.005 ± 0.037	0.641PheHis: 0.641 ± 0.017	0.706PheIle: 0.706 ± 0.017	0.536PheLys: 0.536 ± 0.015	2.596PheLeu: 2.596 ± 0.032	0.42PheMet: 0.42 ± 0.013	0.609PheAsn: 0.609 ± 0.016	1.393PhePro: 1.393 ± 0.023	0.709PheGln: 0.709 ± 0.016	1.909PheArg: 1.909 ± 0.027	1.528PheSer: 1.528 ± 0.022	2.129PheThr: 2.129 ± 0.029	2.261PheVal: 2.261 ± 0.033	0.442PheTrp: 0.442 ± 0.014	0.593PheTyr: 0.593 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.797GlyAla: 10.797 ± 0.079	0.829GlyCys: 0.829 ± 0.019	5.373GlyAsp: 5.373 ± 0.049	5.274GlyGlu: 5.274 ± 0.052	2.921GlyPhe: 2.921 ± 0.038	8.762GlyGly: 8.762 ± 0.072	2.331GlyHis: 2.331 ± 0.032	3.446GlyIle: 3.446 ± 0.035	2.457GlyLys: 2.457 ± 0.033	9.261GlyLeu: 9.261 ± 0.063	1.968GlyMet: 1.968 ± 0.026	1.882GlyAsn: 1.882 ± 0.026	5.206GlyPro: 5.206 ± 0.053	2.699GlyGln: 2.699 ± 0.036	7.77GlyArg: 7.77 ± 0.062	5.575GlySer: 5.575 ± 0.058	6.656GlyThr: 6.656 ± 0.058	7.431GlyVal: 7.431 ± 0.056	1.691GlyTrp: 1.691 ± 0.026	2.288GlyTyr: 2.288 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	2.605HisAla: 2.605 ± 0.037	0.216HisCys: 0.216 ± 0.009	1.372HisAsp: 1.372 ± 0.025	1.254HisGlu: 1.254 ± 0.021	0.652HisPhe: 0.652 ± 0.016	2.445HisGly: 2.445 ± 0.03	0.72HisHis: 0.72 ± 0.019	0.689HisIle: 0.689 ± 0.015	0.356HisLys: 0.356 ± 0.011	2.415HisLeu: 2.415 ± 0.033	0.359HisMet: 0.359 ± 0.011	0.4HisAsn: 0.4 ± 0.013	1.774HisPro: 1.774 ± 0.027	0.687HisGln: 0.687 ± 0.016	2.152HisArg: 2.152 ± 0.031	1.056HisSer: 1.056 ± 0.02	1.397HisThr: 1.397 ± 0.024	1.698HisVal: 1.698 ± 0.026	0.376HisTrp: 0.376 ± 0.013	0.501HisTyr: 0.501 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.658IleAla: 4.658 ± 0.039	0.282IleCys: 0.282 ± 0.01	2.293IleAsp: 2.293 ± 0.026	2.018IleGlu: 2.018 ± 0.032	0.685IlePhe: 0.685 ± 0.021	3.466IleGly: 3.466 ± 0.041	0.654IleHis: 0.654 ± 0.016	0.853IleIle: 0.853 ± 0.02	0.734IleLys: 0.734 ± 0.019	2.38IleLeu: 2.38 ± 0.034	0.451IleMet: 0.451 ± 0.013	0.716IleAsn: 0.716 ± 0.018	1.801IlePro: 1.801 ± 0.026	0.732IleGln: 0.732 ± 0.02	2.366IleArg: 2.366 ± 0.028	1.671IleSer: 1.671 ± 0.027	2.257IleThr: 2.257 ± 0.033	2.717IleVal: 2.717 ± 0.041	0.382IleTrp: 0.382 ± 0.011	0.529IleTyr: 0.529 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	2.964LysAla: 2.964 ± 0.04	0.12LysCys: 0.12 ± 0.006	1.389LysAsp: 1.389 ± 0.026	1.297LysGlu: 1.297 ± 0.027	0.462LysPhe: 0.462 ± 0.013	1.915LysGly: 1.915 ± 0.031	0.423LysHis: 0.423 ± 0.013	0.842LysIle: 0.842 ± 0.019	0.872LysLys: 0.872 ± 0.027	2.059LysLeu: 2.059 ± 0.032	0.36LysMet: 0.36 ± 0.012	0.505LysAsn: 0.505 ± 0.017	1.379LysPro: 1.379 ± 0.027	0.707LysGln: 0.707 ± 0.018	1.457LysArg: 1.457 ± 0.024	1.171LysSer: 1.171 ± 0.026	1.264LysThr: 1.264 ± 0.027	1.939LysVal: 1.939 ± 0.031	0.29LysTrp: 0.29 ± 0.011	0.5LysTyr: 0.5 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	14.41LeuAla: 14.41 ± 0.092	0.86LeuCys: 0.86 ± 0.02	6.665LeuAsp: 6.665 ± 0.059	4.738LeuGlu: 4.738 ± 0.05	2.597LeuPhe: 2.597 ± 0.032	9.184LeuGly: 9.184 ± 0.073	2.292LeuHis: 2.292 ± 0.03	3.19LeuIle: 3.19 ± 0.04	2.065LeuLys: 2.065 ± 0.03	10.952LeuLeu: 10.952 ± 0.088	1.633LeuMet: 1.633 ± 0.025	1.749LeuAsn: 1.749 ± 0.025	6.364LeuPro: 6.364 ± 0.05	2.186LeuGln: 2.186 ± 0.027	8.767LeuArg: 8.767 ± 0.067	5.437LeuSer: 5.437 ± 0.046	6.888LeuThr: 6.888 ± 0.061	8.78LeuVal: 8.78 ± 0.064	1.356LeuTrp: 1.356 ± 0.022	1.91LeuTyr: 1.91 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.238MetAla: 2.238 ± 0.028	0.136MetCys: 0.136 ± 0.008	0.861MetAsp: 0.861 ± 0.017	0.781MetGlu: 0.781 ± 0.017	0.47MetPhe: 0.47 ± 0.014	1.341MetGly: 1.341 ± 0.026	0.357MetHis: 0.357 ± 0.011	0.627MetIle: 0.627 ± 0.017	0.427MetLys: 0.427 ± 0.011	1.643MetLeu: 1.643 ± 0.024	0.288MetMet: 0.288 ± 0.011	0.429MetAsn: 0.429 ± 0.011	1.102MetPro: 1.102 ± 0.02	0.422MetGln: 0.422 ± 0.014	1.447MetArg: 1.447 ± 0.022	1.28MetSer: 1.28 ± 0.02	1.505MetThr: 1.505 ± 0.021	1.288MetVal: 1.288 ± 0.022	0.221MetTrp: 0.221 ± 0.008	0.341MetTyr: 0.341 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.232AsnAla: 2.232 ± 0.028	0.174AsnCys: 0.174 ± 0.008	1.022AsnAsp: 1.022 ± 0.017	0.893AsnGlu: 0.893 ± 0.017	0.505AsnPhe: 0.505 ± 0.016	2.049AsnGly: 2.049 ± 0.03	0.417AsnHis: 0.417 ± 0.012	0.662AsnIle: 0.662 ± 0.017	0.412AsnLys: 0.412 ± 0.014	1.723AsnLeu: 1.723 ± 0.031	0.292AsnMet: 0.292 ± 0.009	0.475AsnAsn: 0.475 ± 0.017	1.404AsnPro: 1.404 ± 0.022	0.55AsnGln: 0.55 ± 0.015	1.336AsnArg: 1.336 ± 0.021	1.026AsnSer: 1.026 ± 0.022	1.217AsnThr: 1.217 ± 0.027	1.452AsnVal: 1.452 ± 0.026	0.334AsnTrp: 0.334 ± 0.011	0.432AsnTyr: 0.432 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	7.931ProAla: 7.931 ± 0.071	0.346ProCys: 0.346 ± 0.011	4.558ProAsp: 4.558 ± 0.036	4.497ProGlu: 4.497 ± 0.043	1.543ProPhe: 1.543 ± 0.025	6.626ProGly: 6.626 ± 0.065	1.374ProHis: 1.374 ± 0.024	1.277ProIle: 1.277 ± 0.022	1.196ProLys: 1.196 ± 0.025	5.326ProLeu: 5.326 ± 0.046	0.979ProMet: 0.979 ± 0.019	0.931ProAsn: 0.931 ± 0.019	3.403ProPro: 3.403 ± 0.049	1.668ProGln: 1.668 ± 0.03	4.015ProArg: 4.015 ± 0.042	3.362ProSer: 3.362 ± 0.042	3.25ProThr: 3.25 ± 0.036	5.573ProVal: 5.573 ± 0.053	0.934ProTrp: 0.934 ± 0.021	1.49ProTyr: 1.49 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.623GlnAla: 3.623 ± 0.035	0.167GlnCys: 0.167 ± 0.008	1.451GlnAsp: 1.451 ± 0.025	1.547GlnGlu: 1.547 ± 0.026	0.677GlnPhe: 0.677 ± 0.019	2.303GlnGly: 2.303 ± 0.028	0.632GlnHis: 0.632 ± 0.016	1.034GlnIle: 1.034 ± 0.021	0.623GlnLys: 0.623 ± 0.016	3.01GlnLeu: 3.01 ± 0.032	0.447GlnMet: 0.447 ± 0.012	0.533GlnAsn: 0.533 ± 0.015	1.662GlnPro: 1.662 ± 0.035	1.21GlnGln: 1.21 ± 0.028	2.365GlnArg: 2.365 ± 0.029	1.307GlnSer: 1.307 ± 0.022	1.381GlnThr: 1.381 ± 0.02	2.363GlnVal: 2.363 ± 0.031	0.481GlnTrp: 0.481 ± 0.012	0.645GlnTyr: 0.645 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	9.617ArgAla: 9.617 ± 0.078	0.594ArgCys: 0.594 ± 0.014	4.333ArgAsp: 4.333 ± 0.043	4.887ArgGlu: 4.887 ± 0.048	2.402ArgPhe: 2.402 ± 0.03	5.908ArgGly: 5.908 ± 0.053	2.184ArgHis: 2.184 ± 0.031	3.221ArgIle: 3.221 ± 0.035	1.706ArgLys: 1.706 ± 0.029	8.921ArgLeu: 8.921 ± 0.077	1.697ArgMet: 1.697 ± 0.021	1.434ArgAsn: 1.434 ± 0.024	4.917ArgPro: 4.917 ± 0.054	2.321ArgGln: 2.321 ± 0.034	7.758ArgArg: 7.758 ± 0.076	4.211ArgSer: 4.211 ± 0.041	5.534ArgThr: 5.534 ± 0.054	6.023ArgVal: 6.023 ± 0.044	1.371ArgTrp: 1.371 ± 0.022	1.842ArgTyr: 1.842 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.765SerAla: 6.765 ± 0.049	0.435SerCys: 0.435 ± 0.014	2.86SerAsp: 2.86 ± 0.042	2.614SerGlu: 2.614 ± 0.033	1.529SerPhe: 1.529 ± 0.025	6.355SerGly: 6.355 ± 0.053	1.065SerHis: 1.065 ± 0.018	1.437SerIle: 1.437 ± 0.023	1.066SerLys: 1.066 ± 0.026	4.951SerLeu: 4.951 ± 0.045	1.081SerMet: 1.081 ± 0.021	0.933SerAsn: 0.933 ± 0.02	3.333SerPro: 3.333 ± 0.037	1.282SerGln: 1.282 ± 0.023	3.857SerArg: 3.857 ± 0.038	3.143SerSer: 3.143 ± 0.042	3.265SerThr: 3.265 ± 0.042	4.391SerVal: 4.391 ± 0.045	0.956SerTrp: 0.956 ± 0.019	1.268SerTyr: 1.268 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.794ThrAla: 8.794 ± 0.071	0.46ThrCys: 0.46 ± 0.014	3.8ThrAsp: 3.8 ± 0.037	3.462ThrGlu: 3.462 ± 0.034	1.669ThrPhe: 1.669 ± 0.029	6.944ThrGly: 6.944 ± 0.053	1.25ThrHis: 1.25 ± 0.021	1.779ThrIle: 1.779 ± 0.033	1.239ThrLys: 1.239 ± 0.021	5.774ThrLeu: 5.774 ± 0.047	0.95ThrMet: 0.95 ± 0.018	1.092ThrAsn: 1.092 ± 0.024	4.147ThrPro: 4.147 ± 0.04	1.351ThrGln: 1.351 ± 0.022	4.045ThrArg: 4.045 ± 0.042	3.406ThrSer: 3.406 ± 0.04	4.013ThrThr: 4.013 ± 0.052	6.216ThrVal: 6.216 ± 0.054	0.951ThrTrp: 0.951 ± 0.021	1.447ThrTyr: 1.447 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.371ValAla: 10.371 ± 0.066	0.768ValCys: 0.768 ± 0.018	4.951ValAsp: 4.951 ± 0.041	4.795ValGlu: 4.795 ± 0.044	2.478ValPhe: 2.478 ± 0.035	6.463ValGly: 6.463 ± 0.054	1.993ValHis: 1.993 ± 0.03	2.9ValIle: 2.9 ± 0.036	1.773ValLys: 1.773 ± 0.033	9.416ValLeu: 9.416 ± 0.068	1.436ValMet: 1.436 ± 0.024	1.744ValAsn: 1.744 ± 0.027	5.308ValPro: 5.308 ± 0.049	2.051ValGln: 2.051 ± 0.027	7.297ValArg: 7.297 ± 0.054	4.432ValSer: 4.432 ± 0.048	5.821ValThr: 5.821 ± 0.055	7.976ValVal: 7.976 ± 0.073	1.218ValTrp: 1.218 ± 0.021	1.655ValTyr: 1.655 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.608TrpAla: 1.608 ± 0.021	0.156TrpCys: 0.156 ± 0.008	0.898TrpAsp: 0.898 ± 0.017	0.768TrpGlu: 0.768 ± 0.018	0.536TrpPhe: 0.536 ± 0.012	1.092TrpGly: 1.092 ± 0.021	0.378TrpHis: 0.378 ± 0.011	0.58TrpIle: 0.58 ± 0.015	0.394TrpLys: 0.394 ± 0.011	1.79TrpLeu: 1.79 ± 0.03	0.309TrpMet: 0.309 ± 0.01	0.45TrpAsn: 0.45 ± 0.012	0.777TrpPro: 0.777 ± 0.017	0.645TrpGln: 0.645 ± 0.018	1.37TrpArg: 1.37 ± 0.025	0.958TrpSer: 0.958 ± 0.021	1.094TrpThr: 1.094 ± 0.024	0.985TrpVal: 0.985 ± 0.018	0.342TrpTrp: 0.342 ± 0.012	0.39TrpTyr: 0.39 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.787TyrAla: 2.787 ± 0.035	0.186TyrCys: 0.186 ± 0.008	1.598TyrAsp: 1.598 ± 0.033	1.399TyrGlu: 1.399 ± 0.024	0.662TyrPhe: 0.662 ± 0.017	2.37TyrGly: 2.37 ± 0.032	0.386TyrHis: 0.386 ± 0.011	0.508TyrIle: 0.508 ± 0.014	0.42TyrLys: 0.42 ± 0.013	2.122TyrLeu: 2.122 ± 0.029	0.273TyrMet: 0.273 ± 0.01	0.465TyrAsn: 0.465 ± 0.013	1.068TyrPro: 1.068 ± 0.019	0.629TyrGln: 0.629 ± 0.016	1.865TyrArg: 1.865 ± 0.028	1.007TyrSer: 1.007 ± 0.021	1.262TyrThr: 1.262 ± 0.024	1.754TyrVal: 1.754 ± 0.023	0.388TyrTrp: 0.388 ± 0.014	0.488TyrTyr: 0.488 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8637 proteins (2865135 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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